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Protein

UBX domain-containing protein 2B

Gene

UBXN2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:UBXN2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27035. UBXN2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408394.

Polymorphism and mutation databases

BioMutaiUBXN2B.
DMDMi121946691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 331330UBX domain-containing protein 2BPRO_0000315228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei59 – 591PhosphothreonineCombined sources
Modified residuei231 – 2311PhosphoserineCombined sources
Modified residuei234 – 2341PhosphoserineBy similarity
Modified residuei235 – 2351PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14CS0.
MaxQBiQ14CS0.
PaxDbiQ14CS0.
PRIDEiQ14CS0.

PTM databases

iPTMnetiQ14CS0.
PhosphoSiteiQ14CS0.

Expressioni

Gene expression databases

BgeeiQ14CS0.
CleanExiHS_UBXN2B.
ExpressionAtlasiQ14CS0. baseline and differential.
GenevisibleiQ14CS0. HS.

Organism-specific databases

HPAiHPA045278.

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CRXO431863EBI-1993619,EBI-748171
HEL-S-70V9HW803EBI-1993619,EBI-10175326
INCA1Q0VD863EBI-1993619,EBI-6509505
MEOX1P502213EBI-1993619,EBI-2864512
NGLY1Q96IV03EBI-1993619,EBI-6165879
VAT1LQ9HCJ63EBI-1993619,EBI-10234766

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126491. 16 interactions.
IntActiQ14CS0. 8 interactions.
STRINGi9606.ENSP00000382507.

Structurei

3D structure databases

ProteinModelPortaliQ14CS0.
SMRiQ14CS0. Positions 140-208, 215-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 20666SEPPROSITE-ProRule annotationAdd
BLAST
Domaini252 – 32978UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NSFL1C family.Curated
Contains 1 SEP domain.PROSITE-ProRule annotation
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiQ14CS0.
OMAiHVNLDME.
OrthoDBiEOG7ZKSBB.
PhylomeDBiQ14CS0.
TreeFamiTF312973.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14CS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK
60 70 80 90 100
ATVFKSPRTP PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRASGDD KSKSFTGGGY RLGSSFCKRS EYIYGENQLQ DVQILLKLWS
160 170 180 190 200
NGFSLDDGEL RPYNEPTNAQ FLESVKRGEI PLELQRLVHG GQVNLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAVVLI
260 270 280 290 300
DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRNFIVQSR PEFAALDFIL
310 320 330
VTSFPNKELT DESLTLLEAD ILNTVLLQQL K
Length:331
Mass (Da):37,077
Last modified:August 22, 2006 - v1
Checksum:i7CE8029B9E56A867
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126300 mRNA. Translation: BAG54305.1.
BC113645 mRNA. Translation: AAI13646.1.
CCDSiCCDS43741.1.
RefSeqiNP_001071087.1. NM_001077619.1.
UniGeneiHs.155572.

Genome annotation databases

EnsembliENST00000399598; ENSP00000382507; ENSG00000215114.
GeneIDi137886.
KEGGihsa:137886.
UCSCiuc003xtl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126300 mRNA. Translation: BAG54305.1.
BC113645 mRNA. Translation: AAI13646.1.
CCDSiCCDS43741.1.
RefSeqiNP_001071087.1. NM_001077619.1.
UniGeneiHs.155572.

3D structure databases

ProteinModelPortaliQ14CS0.
SMRiQ14CS0. Positions 140-208, 215-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126491. 16 interactions.
IntActiQ14CS0. 8 interactions.
STRINGi9606.ENSP00000382507.

PTM databases

iPTMnetiQ14CS0.
PhosphoSiteiQ14CS0.

Polymorphism and mutation databases

BioMutaiUBXN2B.
DMDMi121946691.

Proteomic databases

EPDiQ14CS0.
MaxQBiQ14CS0.
PaxDbiQ14CS0.
PRIDEiQ14CS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399598; ENSP00000382507; ENSG00000215114.
GeneIDi137886.
KEGGihsa:137886.
UCSCiuc003xtl.3. human.

Organism-specific databases

CTDi137886.
GeneCardsiUBXN2B.
HGNCiHGNC:27035. UBXN2B.
HPAiHPA045278.
MIMi610686. gene.
neXtProtiNX_Q14CS0.
PharmGKBiPA162408394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiQ14CS0.
OMAiHVNLDME.
OrthoDBiEOG7ZKSBB.
PhylomeDBiQ14CS0.
TreeFamiTF312973.

Miscellaneous databases

ChiTaRSiUBXN2B. human.
GenomeRNAii137886.
PROiQ14CS0.
SOURCEiSearch...

Gene expression databases

BgeeiQ14CS0.
CleanExiHS_UBXN2B.
ExpressionAtlasiQ14CS0. baseline and differential.
GenevisibleiQ14CS0. HS.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis."
    Uchiyama K., Totsukawa G., Puhka M., Kaneko Y., Jokitalo E., Dreveny I., Beuron F., Zhang X., Freemont P., Kondo H.
    Dev. Cell 11:803-816(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND THR-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-235, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUBX2B_HUMAN
AccessioniPrimary (citable) accession number: Q14CS0
Secondary accession number(s): B3KWZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.