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Protein

UBX domain-containing protein 2B

Gene

UBXN2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:UBXN2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27035. UBXN2B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi137886.
OpenTargetsiENSG00000215114.
PharmGKBiPA162408394.

Polymorphism and mutation databases

BioMutaiUBXN2B.
DMDMi121946691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003152282 – 331UBX domain-containing protein 2BAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei59PhosphothreonineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphoserineBy similarity1
Modified residuei235PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14CS0.
MaxQBiQ14CS0.
PaxDbiQ14CS0.
PeptideAtlasiQ14CS0.
PRIDEiQ14CS0.

PTM databases

iPTMnetiQ14CS0.
PhosphoSitePlusiQ14CS0.

Expressioni

Gene expression databases

BgeeiENSG00000215114.
CleanExiHS_UBXN2B.
ExpressionAtlasiQ14CS0. baseline and differential.
GenevisibleiQ14CS0. HS.

Organism-specific databases

HPAiHPA045278.

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126491. 27 interactors.
IntActiQ14CS0. 17 interactors.
STRINGi9606.ENSP00000382507.

Structurei

3D structure databases

ProteinModelPortaliQ14CS0.
SMRiQ14CS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 206SEPPROSITE-ProRule annotationAdd BLAST66
Domaini252 – 329UBXPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the NSFL1C family.Curated

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiQ14CS0.
OMAiFIIQSRP.
OrthoDBiEOG091G0QFZ.
PhylomeDBiQ14CS0.
TreeFamiTF312973.

Family and domain databases

InterProiView protein in InterPro
IPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
PfamiView protein in Pfam
PF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
SMARTiView protein in SMART
SM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14CS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK
60 70 80 90 100
ATVFKSPRTP PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRASGDD KSKSFTGGGY RLGSSFCKRS EYIYGENQLQ DVQILLKLWS
160 170 180 190 200
NGFSLDDGEL RPYNEPTNAQ FLESVKRGEI PLELQRLVHG GQVNLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAVVLI
260 270 280 290 300
DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRNFIVQSR PEFAALDFIL
310 320 330
VTSFPNKELT DESLTLLEAD ILNTVLLQQL K
Length:331
Mass (Da):37,077
Last modified:August 22, 2006 - v1
Checksum:i7CE8029B9E56A867
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126300 mRNA. Translation: BAG54305.1.
BC113645 mRNA. Translation: AAI13646.1.
CCDSiCCDS43741.1.
RefSeqiNP_001071087.1. NM_001077619.1.
NP_001317464.1. NM_001330535.1.
UniGeneiHs.155572.

Genome annotation databases

EnsembliENST00000399598; ENSP00000382507; ENSG00000215114.
GeneIDi137886.
KEGGihsa:137886.
UCSCiuc003xtl.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBX2B_HUMAN
AccessioniPrimary (citable) accession number: Q14CS0
Secondary accession number(s): B3KWZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: July 5, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families