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Q14CM0 (FRPD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FERM and PDZ domain-containing protein 4
Alternative name(s):
PDZ domain-containing protein 10
PSD-95-interacting regulator of spine morphogenesis
Short name=Preso
Gene names
Name:FRMPD4
Synonyms:KIAA0316, PDZD10, PDZK10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1322 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. Ref.5

Subunit structure

Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain. Ref.5

Subcellular location

Cell projectiondendritic spine Ref.5.

Domain

The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate. Ref.5

Sequence similarities

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 WW domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13221322FERM and PDZ domain-containing protein 4
PRO_0000307132

Regions

Domain33 – 6634WW
Domain78 – 15578PDZ
Domain204 – 519316FERM

Experimental info

Mutagenesis1021R → A: Abolishes the interaction with ARHGEF7. Mutant overexpression in cultured neurons does not induce a significant increase in spine density contrary to wild type. Ref.5
Mutagenesis1319 – 13224Missing: Abolishes the interaction with DLG1, DLG2, DLG3 and DLG4/PSD95. Reduces protein localization to dendritic spines. Ref.5
Mutagenesis13201T → D: Abolishes the interaction with DLG4/PSD95. Reduces protein localization to dendritic spines. Ref.5
Sequence conflict1301A → T in BAA20774. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q14CM0 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 79B73E41B89E2D08

FASTA1,322144,379
        10         20         30         40         50         60 
MDVFSFVKIA KLSSHRTKSS GWPPPSGTWG LSQVPPYGWE MTANRDGRDY FINHMTQAIP 

        70         80         90        100        110        120 
FDDPRLESCQ IIPPAPRKVE MRRDPVLGFG FVAGSEKPVV VRSVTPGGPS EGKLIPGDQI 

       130        140        150        160        170        180 
VMINDEPVSA APRERVIDLV RSCKESILLT VIQPYPSPKS AFISAAKKAR LKSNPVKVRF 

       190        200        210        220        230        240 
SEEVIINGQV SETVKDNSLL FMPNVLKVYL ENGQTKSFRF DCSTSIKDVI LTLQEKLSIK 

       250        260        270        280        290        300 
GIEHFSLMLE QRTEGAGTKL LLLHEQETLT QVTQRPSSHK MRCLFRISFV PKDPIDLLRR 

       310        320        330        340        350        360 
DPVAFEYLYV QSCNDVVQER FGPELKYDIA LRLAALQMYI ATVTTKQTQK ISLKYIEKEW 

       370        380        390        400        410        420 
GLETFLPSAV LQSMKEKNIK KALSHLVKAN QNLVPPGKKL SALQAKVHYL KFLSDLRLYG 

       430        440        450        460        470        480 
GRVFKATLVQ AEKRSEVTLL VGPRYGISHV INTKTNLVAL LADFSHVNRI EMFSEEESLV 

       490        500        510        520        530        540 
RVELHVLDVK PITLLMESSD AMNLACLTAG YYRLLVDSRR SIFNMANKKN TATQETGPEN 

       550        560        570        580        590        600 
KGKHNLLGPD WNCIPQMTTF IGEGEQEAQI TYIDSKQKTV EITDSTMCPK EHRHLYIDNA 

       610        620        630        640        650        660 
YSSDGLNQQL SQPGEAPCEA DYRSLAQRSL LTLSGPETLK KAQESPRGAK VSFIFGDFAL 

       670        680        690        700        710        720 
DDGISPPTLG YETLLDEGPE MLEKQRNLYI GSANDMKGLD LTPEAEGIQF VENSVYANIG 

       730        740        750        760        770        780 
DVKSFQAAEG IEEPLLHDIC YAENTDDAED EDEVSCEEDL VVGEMNQPAI LNLSGSSDDI 

       790        800        810        820        830        840 
IDLTSLPPPE GDDNEDDFLL RSLNMAIAAP PPGFRDSSDE EDSQSQAASF PEDKEKGSSL 

       850        860        870        880        890        900 
QNDEIPVSLI DAVPTSAEGK CEKGLDNAVV STLGALEALS VSEEQQTSDN SGVAILRAYS 

       910        920        930        940        950        960 
PESSSDSGNE TNSSEMTESS ELATAQKQSE NLSRMFLATH EGYHPLAEEQ TEFPASKTPA 

       970        980        990       1000       1010       1020 
GGLPPKSSHA LAARPATDLP PKVVPSKQLL HSDHMEMEPE TMETKSVTDY FSKLHMGSVA 

      1030       1040       1050       1060       1070       1080 
YSCTSKRKSK LADGEGKAPP NGNTTGKKQQ GTKTAEMEEE ASGKFGTVSS RDSQHLSTFN 

      1090       1100       1110       1120       1130       1140 
LERTAFRKDS QRWYVATEGG MAEKSGLEAA TGKTFPRASG LGAREAEGKE EGAPDGETSD 

      1150       1160       1170       1180       1190       1200 
GSGLGQGDRF LTDVTCASSA KDLDNPEDAD SSTCDHPSKL PEADESVARL CDYHLAKRMS 

      1210       1220       1230       1240       1250       1260 
SLQSEGHFSL QSSQGSSVDA GCGTGSSGSA CATPVESPLC PSLGKHLIPD ASGKGVNYIP 

      1270       1280       1290       1300       1310       1320 
SEERAPGLPN HGATFKELHP QTEGMCPRMT VPALHTAINT EPLFGTLRDG CHRLPKIKET 


TV 

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References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]Ohara O., Nagase T., Kikuno R., Nomura N.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis."
Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E.
J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH DLG1; DLG2; DLG3; DLG4; ARHGEF7 AND PHOSPHATIDYLINOSITOL-4,5-BIPHOSPHATE, DOMAIN FERM, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-102; 1319-GLU--VAL-1322 AND THR-1320.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002314 mRNA. Translation: BAA20774.3.
AK289694 mRNA. Translation: BAF82383.1.
BC113700 mRNA. Translation: AAI13701.1.
BC113702 mRNA. Translation: AAI13703.1.
CCDSCCDS35201.1.
RefSeqNP_055543.2. NM_014728.3.
UniGeneHs.657507.

3D structure databases

ProteinModelPortalQ14CM0.
SMRQ14CM0. Positions 33-66, 87-151, 206-442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115105. 2 interactions.
IntActQ14CM0. 4 interactions.
MINTMINT-2795491.
STRING9606.ENSP00000370057.

PTM databases

PhosphoSiteQ14CM0.

Polymorphism databases

DMDM121948742.

Proteomic databases

MaxQBQ14CM0.
PaxDbQ14CM0.
PRIDEQ14CM0.

Protocols and materials databases

DNASU9758.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380682; ENSP00000370057; ENSG00000169933.
GeneID9758.
KEGGhsa:9758.
UCSCuc004cuz.2. human.

Organism-specific databases

CTD9758.
GeneCardsGC0XP012066.
H-InvDBHIX0016653.
HGNCHGNC:29007. FRMPD4.
HPAHPA035580.
MIM300838. gene.
neXtProtNX_Q14CM0.
PharmGKBPA134977575.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237011.
HOGENOMHOG000090222.
HOVERGENHBG106593.
OMAQETGTEN.
OrthoDBEOG7W419W.
PhylomeDBQ14CM0.
TreeFamTF316497.

Gene expression databases

BgeeQ14CM0.
CleanExHS_FRMPD4.
GenevestigatorQ14CM0.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR001202. WW_dom.
[Graphical view]
PfamPF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFRMPD4. human.
GenomeRNAi9758.
NextBio36727.
PROQ14CM0.
SOURCESearch...

Entry information

Entry nameFRPD4_HUMAN
AccessionPrimary (citable) accession number: Q14CM0
Secondary accession number(s): A8K0X9, O15032
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM