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Q14CM0

- FRPD4_HUMAN

UniProt

Q14CM0 - FRPD4_HUMAN

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Protein

FERM and PDZ domain-containing protein 4

Gene

FRMPD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.1 Publication

GO - Molecular functioni

  1. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of synapse structural plasticity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 4
Alternative name(s):
PDZ domain-containing protein 10
PSD-95-interacting regulator of spine morphogenesis
Short name:
Preso
Gene namesi
Name:FRMPD4
Synonyms:KIAA0316, PDZD10, PDZK10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:29007. FRMPD4.

Subcellular locationi

Cell projectiondendritic spine 1 Publication

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
  2. dendritic spine Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi102 – 1021R → A: Abolishes the interaction with ARHGEF7. Mutant overexpression in cultured neurons does not induce a significant increase in spine density contrary to wild type. 1 Publication
Mutagenesisi1319 – 13224Missing: Abolishes the interaction with DLG1, DLG2, DLG3 and DLG4/PSD95. Reduces protein localization to dendritic spines. 1 Publication
Mutagenesisi1320 – 13201T → D: Abolishes the interaction with DLG4/PSD95. Reduces protein localization to dendritic spines. 1 Publication

Organism-specific databases

PharmGKBiPA134977575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13221322FERM and PDZ domain-containing protein 4PRO_0000307132Add
BLAST

Proteomic databases

MaxQBiQ14CM0.
PaxDbiQ14CM0.
PRIDEiQ14CM0.

PTM databases

PhosphoSiteiQ14CM0.

Expressioni

Gene expression databases

BgeeiQ14CM0.
CleanExiHS_FRMPD4.
GenevestigatoriQ14CM0.

Organism-specific databases

HPAiHPA035580.

Interactioni

Subunit structurei

Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain.1 Publication

Protein-protein interaction databases

BioGridi115105. 2 interactions.
IntActiQ14CM0. 4 interactions.
MINTiMINT-2795491.
STRINGi9606.ENSP00000370057.

Structurei

3D structure databases

ProteinModelPortaliQ14CM0.
SMRiQ14CM0. Positions 33-66, 87-151, 206-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6634WWPROSITE-ProRule annotationAdd
BLAST
Domaini78 – 15578PDZPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 519316FERMPROSITE-ProRule annotationAdd
BLAST

Domaini

The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate.1 Publication

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG237011.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000090222.
HOVERGENiHBG106593.
InParanoidiQ14CM0.
OMAiQETGTEN.
OrthoDBiEOG7W419W.
PhylomeDBiQ14CM0.
TreeFamiTF316497.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14CM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVFSFVKIA KLSSHRTKSS GWPPPSGTWG LSQVPPYGWE MTANRDGRDY
60 70 80 90 100
FINHMTQAIP FDDPRLESCQ IIPPAPRKVE MRRDPVLGFG FVAGSEKPVV
110 120 130 140 150
VRSVTPGGPS EGKLIPGDQI VMINDEPVSA APRERVIDLV RSCKESILLT
160 170 180 190 200
VIQPYPSPKS AFISAAKKAR LKSNPVKVRF SEEVIINGQV SETVKDNSLL
210 220 230 240 250
FMPNVLKVYL ENGQTKSFRF DCSTSIKDVI LTLQEKLSIK GIEHFSLMLE
260 270 280 290 300
QRTEGAGTKL LLLHEQETLT QVTQRPSSHK MRCLFRISFV PKDPIDLLRR
310 320 330 340 350
DPVAFEYLYV QSCNDVVQER FGPELKYDIA LRLAALQMYI ATVTTKQTQK
360 370 380 390 400
ISLKYIEKEW GLETFLPSAV LQSMKEKNIK KALSHLVKAN QNLVPPGKKL
410 420 430 440 450
SALQAKVHYL KFLSDLRLYG GRVFKATLVQ AEKRSEVTLL VGPRYGISHV
460 470 480 490 500
INTKTNLVAL LADFSHVNRI EMFSEEESLV RVELHVLDVK PITLLMESSD
510 520 530 540 550
AMNLACLTAG YYRLLVDSRR SIFNMANKKN TATQETGPEN KGKHNLLGPD
560 570 580 590 600
WNCIPQMTTF IGEGEQEAQI TYIDSKQKTV EITDSTMCPK EHRHLYIDNA
610 620 630 640 650
YSSDGLNQQL SQPGEAPCEA DYRSLAQRSL LTLSGPETLK KAQESPRGAK
660 670 680 690 700
VSFIFGDFAL DDGISPPTLG YETLLDEGPE MLEKQRNLYI GSANDMKGLD
710 720 730 740 750
LTPEAEGIQF VENSVYANIG DVKSFQAAEG IEEPLLHDIC YAENTDDAED
760 770 780 790 800
EDEVSCEEDL VVGEMNQPAI LNLSGSSDDI IDLTSLPPPE GDDNEDDFLL
810 820 830 840 850
RSLNMAIAAP PPGFRDSSDE EDSQSQAASF PEDKEKGSSL QNDEIPVSLI
860 870 880 890 900
DAVPTSAEGK CEKGLDNAVV STLGALEALS VSEEQQTSDN SGVAILRAYS
910 920 930 940 950
PESSSDSGNE TNSSEMTESS ELATAQKQSE NLSRMFLATH EGYHPLAEEQ
960 970 980 990 1000
TEFPASKTPA GGLPPKSSHA LAARPATDLP PKVVPSKQLL HSDHMEMEPE
1010 1020 1030 1040 1050
TMETKSVTDY FSKLHMGSVA YSCTSKRKSK LADGEGKAPP NGNTTGKKQQ
1060 1070 1080 1090 1100
GTKTAEMEEE ASGKFGTVSS RDSQHLSTFN LERTAFRKDS QRWYVATEGG
1110 1120 1130 1140 1150
MAEKSGLEAA TGKTFPRASG LGAREAEGKE EGAPDGETSD GSGLGQGDRF
1160 1170 1180 1190 1200
LTDVTCASSA KDLDNPEDAD SSTCDHPSKL PEADESVARL CDYHLAKRMS
1210 1220 1230 1240 1250
SLQSEGHFSL QSSQGSSVDA GCGTGSSGSA CATPVESPLC PSLGKHLIPD
1260 1270 1280 1290 1300
ASGKGVNYIP SEERAPGLPN HGATFKELHP QTEGMCPRMT VPALHTAINT
1310 1320
EPLFGTLRDG CHRLPKIKET TV
Length:1,322
Mass (Da):144,379
Last modified:August 22, 2006 - v1
Checksum:i79B73E41B89E2D08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301A → T in BAA20774. (PubMed:9205841)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002314 mRNA. Translation: BAA20774.3.
AK289694 mRNA. Translation: BAF82383.1.
BC113700 mRNA. Translation: AAI13701.1.
BC113702 mRNA. Translation: AAI13703.1.
CCDSiCCDS35201.1.
RefSeqiNP_055543.2. NM_014728.3.
UniGeneiHs.657507.

Genome annotation databases

EnsembliENST00000380682; ENSP00000370057; ENSG00000169933.
GeneIDi9758.
KEGGihsa:9758.
UCSCiuc004cuz.2. human.

Polymorphism databases

DMDMi121948742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002314 mRNA. Translation: BAA20774.3 .
AK289694 mRNA. Translation: BAF82383.1 .
BC113700 mRNA. Translation: AAI13701.1 .
BC113702 mRNA. Translation: AAI13703.1 .
CCDSi CCDS35201.1.
RefSeqi NP_055543.2. NM_014728.3.
UniGenei Hs.657507.

3D structure databases

ProteinModelPortali Q14CM0.
SMRi Q14CM0. Positions 33-66, 87-151, 206-514.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115105. 2 interactions.
IntActi Q14CM0. 4 interactions.
MINTi MINT-2795491.
STRINGi 9606.ENSP00000370057.

PTM databases

PhosphoSitei Q14CM0.

Polymorphism databases

DMDMi 121948742.

Proteomic databases

MaxQBi Q14CM0.
PaxDbi Q14CM0.
PRIDEi Q14CM0.

Protocols and materials databases

DNASUi 9758.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380682 ; ENSP00000370057 ; ENSG00000169933 .
GeneIDi 9758.
KEGGi hsa:9758.
UCSCi uc004cuz.2. human.

Organism-specific databases

CTDi 9758.
GeneCardsi GC0XP012066.
H-InvDB HIX0016653.
HGNCi HGNC:29007. FRMPD4.
HPAi HPA035580.
MIMi 300838. gene.
neXtProti NX_Q14CM0.
PharmGKBi PA134977575.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237011.
GeneTreei ENSGT00530000063201.
HOGENOMi HOG000090222.
HOVERGENi HBG106593.
InParanoidi Q14CM0.
OMAi QETGTEN.
OrthoDBi EOG7W419W.
PhylomeDBi Q14CM0.
TreeFami TF316497.

Miscellaneous databases

ChiTaRSi FRMPD4. human.
GenomeRNAii 9758.
NextBioi 36727.
PROi Q14CM0.
SOURCEi Search...

Gene expression databases

Bgeei Q14CM0.
CleanExi HS_FRMPD4.
Genevestigatori Q14CM0.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis."
    Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E.
    J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DLG1; DLG2; DLG3; DLG4; ARHGEF7 AND PHOSPHATIDYLINOSITOL-4,5-BIPHOSPHATE, DOMAIN FERM, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-102; 1319-GLU--VAL-1322 AND THR-1320.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiFRPD4_HUMAN
AccessioniPrimary (citable) accession number: Q14CM0
Secondary accession number(s): A8K0X9, O15032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3