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Q14CH1

- MOCOS_MOUSE

UniProt

Q14CH1 - MOCOS_MOUSE

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Protein

Molybdenum cofactor sulfurase

Gene

Mocos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.UniRule annotation

Catalytic activityi

Molybdenum cofactor + L-cysteine + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei424 – 4241UniRule annotation

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-HAMAP
  2. molybdenum ion binding Source: UniProtKB-HAMAP
  3. Mo-molybdopterin cofactor sulfurase activity Source: UniProtKB
  4. pyridoxal phosphate binding Source: UniProtKB-HAMAP
  5. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. molybdopterin cofactor metabolic process Source: UniProtKB
  2. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_198541. Molybdenum cofactor biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor sulfuraseUniRule annotation (EC:2.8.1.9UniRule annotation)
Short name:
MCSUniRule annotation
Short name:
MOSUniRule annotation
Short name:
MoCo sulfuraseUniRule annotation
Alternative name(s):
Molybdenum cofactor sulfurtransferaseUniRule annotation
Gene namesi
Name:Mocos
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1915841. Mocos.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Molybdenum cofactor sulfurasePRO_0000249953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation
Modified residuei517 – 5171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14CH1.
PaxDbiQ14CH1.
PRIDEiQ14CH1.

PTM databases

PhosphoSiteiQ14CH1.

Expressioni

Gene expression databases

BgeeiQ14CH1.
CleanExiMM_MOCOS.
GenevestigatoriQ14CH1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063609.

Structurei

3D structure databases

ProteinModelPortaliQ14CH1.
SMRiQ14CH1. Positions 579-697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini704 – 855152MOSCUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.UniRule annotation
Contains 1 MOSC domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG3217.
GeneTreeiENSGT00530000063150.
HOGENOMiHOG000029698.
HOVERGENiHBG081980.
InParanoidiQ14CH1.
KOiK15631.
OMAiGFRCGSE.
OrthoDBiEOG7ZKS98.
PhylomeDBiQ14CH1.
TreeFamiTF105761.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_03050. MOCOS.
InterProiIPR000192. Aminotrans_V_dom.
IPR005302. MoCF_Sase_C.
IPR028886. MoCo_sulfurase.
IPR005303. MOSC_N.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR011037. Pyrv_Knase-like_insert_dom.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
PF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
[Graphical view]
SUPFAMiSSF50800. SSF50800. 2 hits.
SSF53383. SSF53383. 2 hits.
PROSITEiPS51340. MOSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14CH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACGAAERGP EPPAFQRHLE ASTQRLAHGY GLRSMSELRD QEFGRLAGTV
60 70 80 90 100
YLDHAGATLF PQSQLTNFTK DLMENVYGNP HSQNITSKLT HDTVEQVRYR
110 120 130 140 150
ILTHFHTTPE DYIVIFTAGS TAALRLVAEA FPWVSRSPEN SGSHFCYLTD
160 170 180 190 200
NHTSVVGMRK VAAAMSVTSI PVKPEDMWSA EGKDAGACDP DCQLPHLFCY
210 220 230 240 250
PAQSNFSGTR YPLSWVEEVK SGRRSPVNAP GKWFVLLDAA SYVSTSPLDL
260 270 280 290 300
SAHQADFIPI SFYKIFGLPT GLGALLVNKH VAPLLRKGYF GGGTAAAYLA
310 320 330 340 350
GEDFYVPRSS VAERFEDGTI SFLDVIALKH GFDALEHLTG GMVNIQQHTF
360 370 380 390 400
ALVQYTHSAL SSLRYLNGAP VVRIYSDSEF SSPDVQGPII NFNVLDDGGK
410 420 430 440 450
IIGYSQVDKM ASLYNIHLRT GCFCNLGACQ RHLGLSDEMV KKHFQAGHVC
460 470 480 490 500
GDDVDIIDGR PTGSVRISFG YMSTLEDAQA FLRFISTIYL RSPSDQPVPQ
510 520 530 540 550
ASISDAGALT SKSDCHSPQE GSCTDPSVCN GSYPDTNIMD LHPSLSKASS
560 570 580 590 600
AQQTPQDKAA GILNGDPGSH IVTNIYLYPI KSCAAFEVTK WPVGSQGLLY
610 620 630 640 650
DRSWMVVNHN GICMSQKQEP RLCLIQPFID LQQRIMVIKA EGMEPIQVPL
660 670 680 690 700
EEDGEQTQIC QSRVCADRVN TYDCGENVSR WLSKFLGRLC HLIKQSPHFQ
710 720 730 740 750
RNARKTPKKG QPPGTTVALS LVNEAQYLLV NTSSILELQR QLNASDEHGK
760 770 780 790 800
EESFSMKDLI SRFRANIITK GARAFEEEKW DEISIGSLHF QVLGPCHRCQ
810 820 830 840 850
MICINQQTGQ RNQDVFQTLS ESRGRKVNFG VYLMHSYLDL SSPCFLSVGS
860
EVLPVLKDCG VS
Length:862
Mass (Da):95,013
Last modified:August 22, 2006 - v1
Checksum:iE422CF97C6E91878
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113180 mRNA. Translation: AAI13181.1.
BC113786 mRNA. Translation: AAI13787.1.
CCDSiCCDS37750.1.
RefSeqiNP_081055.1. NM_026779.1.
UniGeneiMm.28252.

Genome annotation databases

EnsembliENSMUST00000068006; ENSMUSP00000063609; ENSMUSG00000039616.
GeneIDi68591.
KEGGimmu:68591.
UCSCiuc008egy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113180 mRNA. Translation: AAI13181.1 .
BC113786 mRNA. Translation: AAI13787.1 .
CCDSi CCDS37750.1.
RefSeqi NP_081055.1. NM_026779.1.
UniGenei Mm.28252.

3D structure databases

ProteinModelPortali Q14CH1.
SMRi Q14CH1. Positions 579-697.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000063609.

PTM databases

PhosphoSitei Q14CH1.

Proteomic databases

MaxQBi Q14CH1.
PaxDbi Q14CH1.
PRIDEi Q14CH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068006 ; ENSMUSP00000063609 ; ENSMUSG00000039616 .
GeneIDi 68591.
KEGGi mmu:68591.
UCSCi uc008egy.1. mouse.

Organism-specific databases

CTDi 55034.
MGIi MGI:1915841. Mocos.

Phylogenomic databases

eggNOGi COG3217.
GeneTreei ENSGT00530000063150.
HOGENOMi HOG000029698.
HOVERGENi HBG081980.
InParanoidi Q14CH1.
KOi K15631.
OMAi GFRCGSE.
OrthoDBi EOG7ZKS98.
PhylomeDBi Q14CH1.
TreeFami TF105761.

Enzyme and pathway databases

Reactomei REACT_198541. Molybdenum cofactor biosynthesis.

Miscellaneous databases

NextBioi 327518.
PROi Q14CH1.
SOURCEi Search...

Gene expression databases

Bgeei Q14CH1.
CleanExi MM_MOCOS.
Genevestigatori Q14CH1.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_03050. MOCOS.
InterProi IPR000192. Aminotrans_V_dom.
IPR005302. MoCF_Sase_C.
IPR028886. MoCo_sulfurase.
IPR005303. MOSC_N.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR011037. Pyrv_Knase-like_insert_dom.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
PF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50800. SSF50800. 2 hits.
SSF53383. SSF53383. 2 hits.
PROSITEi PS51340. MOSC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMOCOS_MOUSE
AccessioniPrimary (citable) accession number: Q14CH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3