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Q14CH1

- MOCOS_MOUSE

UniProt

Q14CH1 - MOCOS_MOUSE

Protein

Molybdenum cofactor sulfurase

Gene

Mocos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.UniRule annotation

    Catalytic activityi

    Molybdenum cofactor + L-cysteine + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei424 – 4241UniRule annotation

    GO - Molecular functioni

    1. lyase activity Source: UniProtKB-HAMAP
    2. molybdenum ion binding Source: UniProtKB-HAMAP
    3. Mo-molybdopterin cofactor sulfurase activity Source: UniProtKB
    4. pyridoxal phosphate binding Source: UniProtKB-HAMAP
    5. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. molybdopterin cofactor metabolic process Source: UniProtKB
    2. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Molybdenum cofactor biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_198541. Molybdenum cofactor biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Molybdenum cofactor sulfuraseUniRule annotation (EC:2.8.1.9UniRule annotation)
    Short name:
    MCSUniRule annotation
    Short name:
    MOSUniRule annotation
    Short name:
    MoCo sulfuraseUniRule annotation
    Alternative name(s):
    Molybdenum cofactor sulfurtransferaseUniRule annotation
    Gene namesi
    Name:Mocos
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1915841. Mocos.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Molybdenum cofactor sulfurasePRO_0000249953Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation
    Modified residuei517 – 5171PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14CH1.
    PaxDbiQ14CH1.
    PRIDEiQ14CH1.

    PTM databases

    PhosphoSiteiQ14CH1.

    Expressioni

    Gene expression databases

    BgeeiQ14CH1.
    CleanExiMM_MOCOS.
    GenevestigatoriQ14CH1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000063609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14CH1.
    SMRiQ14CH1. Positions 579-697.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini704 – 855152MOSCUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.UniRule annotation
    Contains 1 MOSC domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3217.
    GeneTreeiENSGT00530000063150.
    HOGENOMiHOG000029698.
    HOVERGENiHBG081980.
    InParanoidiQ14CH1.
    KOiK15631.
    OMAiGFRCGSE.
    OrthoDBiEOG7ZKS98.
    PhylomeDBiQ14CH1.
    TreeFamiTF105761.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_03050. MOCOS.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR005302. MoCF_Sase_C.
    IPR028886. MoCo_sulfurase.
    IPR005303. MOSC_N.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR011037. Pyrv_Knase-like_insert_dom.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    PF03473. MOSC. 1 hit.
    PF03476. MOSC_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50800. SSF50800. 2 hits.
    SSF53383. SSF53383. 2 hits.
    PROSITEiPS51340. MOSC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14CH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACGAAERGP EPPAFQRHLE ASTQRLAHGY GLRSMSELRD QEFGRLAGTV    50
    YLDHAGATLF PQSQLTNFTK DLMENVYGNP HSQNITSKLT HDTVEQVRYR 100
    ILTHFHTTPE DYIVIFTAGS TAALRLVAEA FPWVSRSPEN SGSHFCYLTD 150
    NHTSVVGMRK VAAAMSVTSI PVKPEDMWSA EGKDAGACDP DCQLPHLFCY 200
    PAQSNFSGTR YPLSWVEEVK SGRRSPVNAP GKWFVLLDAA SYVSTSPLDL 250
    SAHQADFIPI SFYKIFGLPT GLGALLVNKH VAPLLRKGYF GGGTAAAYLA 300
    GEDFYVPRSS VAERFEDGTI SFLDVIALKH GFDALEHLTG GMVNIQQHTF 350
    ALVQYTHSAL SSLRYLNGAP VVRIYSDSEF SSPDVQGPII NFNVLDDGGK 400
    IIGYSQVDKM ASLYNIHLRT GCFCNLGACQ RHLGLSDEMV KKHFQAGHVC 450
    GDDVDIIDGR PTGSVRISFG YMSTLEDAQA FLRFISTIYL RSPSDQPVPQ 500
    ASISDAGALT SKSDCHSPQE GSCTDPSVCN GSYPDTNIMD LHPSLSKASS 550
    AQQTPQDKAA GILNGDPGSH IVTNIYLYPI KSCAAFEVTK WPVGSQGLLY 600
    DRSWMVVNHN GICMSQKQEP RLCLIQPFID LQQRIMVIKA EGMEPIQVPL 650
    EEDGEQTQIC QSRVCADRVN TYDCGENVSR WLSKFLGRLC HLIKQSPHFQ 700
    RNARKTPKKG QPPGTTVALS LVNEAQYLLV NTSSILELQR QLNASDEHGK 750
    EESFSMKDLI SRFRANIITK GARAFEEEKW DEISIGSLHF QVLGPCHRCQ 800
    MICINQQTGQ RNQDVFQTLS ESRGRKVNFG VYLMHSYLDL SSPCFLSVGS 850
    EVLPVLKDCG VS 862
    Length:862
    Mass (Da):95,013
    Last modified:August 22, 2006 - v1
    Checksum:iE422CF97C6E91878
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113180 mRNA. Translation: AAI13181.1.
    BC113786 mRNA. Translation: AAI13787.1.
    CCDSiCCDS37750.1.
    RefSeqiNP_081055.1. NM_026779.1.
    UniGeneiMm.28252.

    Genome annotation databases

    EnsembliENSMUST00000068006; ENSMUSP00000063609; ENSMUSG00000039616.
    GeneIDi68591.
    KEGGimmu:68591.
    UCSCiuc008egy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC113180 mRNA. Translation: AAI13181.1 .
    BC113786 mRNA. Translation: AAI13787.1 .
    CCDSi CCDS37750.1.
    RefSeqi NP_081055.1. NM_026779.1.
    UniGenei Mm.28252.

    3D structure databases

    ProteinModelPortali Q14CH1.
    SMRi Q14CH1. Positions 579-697.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000063609.

    PTM databases

    PhosphoSitei Q14CH1.

    Proteomic databases

    MaxQBi Q14CH1.
    PaxDbi Q14CH1.
    PRIDEi Q14CH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068006 ; ENSMUSP00000063609 ; ENSMUSG00000039616 .
    GeneIDi 68591.
    KEGGi mmu:68591.
    UCSCi uc008egy.1. mouse.

    Organism-specific databases

    CTDi 55034.
    MGIi MGI:1915841. Mocos.

    Phylogenomic databases

    eggNOGi COG3217.
    GeneTreei ENSGT00530000063150.
    HOGENOMi HOG000029698.
    HOVERGENi HBG081980.
    InParanoidi Q14CH1.
    KOi K15631.
    OMAi GFRCGSE.
    OrthoDBi EOG7ZKS98.
    PhylomeDBi Q14CH1.
    TreeFami TF105761.

    Enzyme and pathway databases

    Reactomei REACT_198541. Molybdenum cofactor biosynthesis.

    Miscellaneous databases

    NextBioi 327518.
    PROi Q14CH1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14CH1.
    CleanExi MM_MOCOS.
    Genevestigatori Q14CH1.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_03050. MOCOS.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR005302. MoCF_Sase_C.
    IPR028886. MoCo_sulfurase.
    IPR005303. MOSC_N.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR011037. Pyrv_Knase-like_insert_dom.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    PF03473. MOSC. 1 hit.
    PF03476. MOSC_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50800. SSF50800. 2 hits.
    SSF53383. SSF53383. 2 hits.
    PROSITEi PS51340. MOSC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMOCOS_MOUSE
    AccessioniPrimary (citable) accession number: Q14CH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3