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Q14CB8 (RHG19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho GTPase-activating protein 19
Alternative name(s):
Rho-type GTPase-activating protein 19
Gene names
Name:ARHGAP19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.

Subcellular location

Nucleus Ref.1.

Tissue specificity

Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary. Ref.1

Sequence similarities

Contains 1 Rho-GAP domain.

Sequence caution

The sequence BAB84948.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC04165.1 differs from that shown. Reason: Frameshift at position 280.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14CB8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14CB8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: FL → NSMATTSLGSIRMTLRGSSSCGCCS
Note: No experimental confirmation available.
Isoform 3 (identifier: Q14CB8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MATEAQSEGEVPARESGRS → MPHQKLSALI
Note: No experimental confirmation available.
Isoform 4 (identifier: Q14CB8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q14CB8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     281-301: VTANDLQENITKLNSGMAFMI → GLVLLPTLEESNTITTHCSLI
     302-494: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q14CB8-6)

The sequence of this isoform differs from the canonical sequence as follows:
     281-309: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q14CB8-7)

The sequence of this isoform differs from the canonical sequence as follows:
     332-346: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Rho GTPase-activating protein 19
PRO_0000280465

Regions

Domain102 – 308207Rho-GAP

Natural variations

Alternative sequence1 – 382382Missing in isoform 4.
VSP_023695
Alternative sequence1 – 1919MATEA…ESGRS → MPHQKLSALI in isoform 3.
VSP_023696
Alternative sequence281 – 30929Missing in isoform 6.
VSP_023697
Alternative sequence281 – 30121VTAND…MAFMI → GLVLLPTLEESNTITTHCSL I in isoform 5.
VSP_023698
Alternative sequence302 – 494193Missing in isoform 5.
VSP_023699
Alternative sequence332 – 34615Missing in isoform 7.
VSP_023700
Alternative sequence493 – 4942FL → NSMATTSLGSIRMTLRGSSS CGCCS in isoform 2.
VSP_023701
Natural variant3051Q → R.
Corresponds to variant rs17112598 [ dbSNP | Ensembl ].
VAR_031152

Experimental info

Sequence conflict281C → Y in AAR02412. Ref.1
Sequence conflict281C → Y in ABC69298. Ref.1
Sequence conflict1701E → A in CAH18254. Ref.4
Sequence conflict1701E → G in BAC04165. Ref.2
Sequence conflict4201S → L in BAC04165. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: EAE8DF3FD1253858

FASTA49455,756
        10         20         30         40         50         60 
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL 

        70         80         90        100        110        120 
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE 

       130        140        150        160        170        180 
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL 

       190        200        210        220        230        240 
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR 

       250        260        270        280        290        300 
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM 

       310        320        330        340        350        360 
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP 

       370        380        390        400        410        420 
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS 

       430        440        450        460        470        480 
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL 

       490 
KWSEGKKEGK KGFL 

« Hide

Isoform 2 [UniParc].

Checksum: ED0204FB3AEA0BFA
Show »

FASTA51757,989
Isoform 3 [UniParc].

Checksum: 9127F52FD96F4DF7
Show »

FASTA48554,901
Isoform 4 [UniParc].

Checksum: A7F67459CA61C860
Show »

FASTA11212,548
Isoform 5 [UniParc].

Checksum: 7909659144913AEB
Show »

FASTA30133,708
Isoform 6 [UniParc].

Checksum: A427B1C7CC5ADEA2
Show »

FASTA46552,466
Isoform 7 [UniParc].

Checksum: B4B5048BCB255B21
Show »

FASTA47954,081

References

« Hide 'large scale' references
[1]"Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues."
Lv L., Xu J., Zhao S., Chen C., Zhao X., Gu S., Ji C., Xie Y., Mao Y.
DNA Seq. 18:184-189(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Testis.
[3]"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-427 (ISOFORM 5).
Tissue: Spleen.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Bone marrow.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ338460 mRNA. Translation: ABC69298.1.
AY336750 mRNA. Translation: AAR02412.1.
AK093441 mRNA. Translation: BAC04165.1. Frameshift.
AK074122 mRNA. Translation: BAB84948.1. Different initiation.
AK090447 mRNA. Translation: BAC03428.1.
AK303055 mRNA. Translation: BAG64173.1.
CR749412 mRNA. Translation: CAH18254.1.
AL359385 Genomic DNA. Translation: CAI13728.1.
AL359385 Genomic DNA. Translation: CAI13731.2.
CH471066 Genomic DNA. Translation: EAW49952.1.
BC113888 mRNA. Translation: AAI13889.1.
BC114490 mRNA. Translation: AAI14491.1.
CCDSCCDS58092.1. [Q14CB8-3]
CCDS7454.2. [Q14CB8-1]
RefSeqNP_001191229.1. NM_001204300.1. [Q14CB8-6]
NP_001243352.1. NM_001256423.1. [Q14CB8-3]
NP_116289.4. NM_032900.5. [Q14CB8-1]
UniGeneHs.80305.

3D structure databases

ProteinModelPortalQ14CB8.
SMRQ14CB8. Positions 93-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124412. 6 interactions.
IntActQ14CB8. 1 interaction.
MINTMINT-2877769.

PTM databases

PhosphoSiteQ14CB8.

Polymorphism databases

DMDM121948181.

Proteomic databases

MaxQBQ14CB8.
PaxDbQ14CB8.
PRIDEQ14CB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358531; ENSP00000351333; ENSG00000213390. [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390. [Q14CB8-3]
GeneID84986.
KEGGhsa:84986.
UCSCuc001kna.4. human. [Q14CB8-3]
uc001knb.3. human. [Q14CB8-1]
uc009xvj.3. human. [Q14CB8-6]

Organism-specific databases

CTD84986.
GeneCardsGC10M098757.
GC10M098971.
H-InvDBHIX0009085.
HIX0079267.
HGNCHGNC:23724. ARHGAP19.
HPAHPA043231.
MIM611587. gene.
neXtProtNX_Q14CB8.
PharmGKBPA134917415.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241354.
HOVERGENHBG055569.
OMAIRQFNKH.
PhylomeDBQ14CB8.
TreeFamTF326309.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ14CB8.
BgeeQ14CB8.
GenevestigatorQ14CB8.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
PROSITEPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiARHGAP19.
GenomeRNAi84986.
NextBio75560.
PROQ14CB8.
SOURCESearch...

Entry information

Entry nameRHG19_HUMAN
AccessionPrimary (citable) accession number: Q14CB8
Secondary accession number(s): A1XCP1 expand/collapse secondary AC list , B4DZR1, Q14CF2, Q5J8M2, Q5T460, Q5T462, Q68DG6, Q8N9X1, Q8NF34, Q8TEK1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM