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Protein

Rho GTPase-activating protein 19

Gene

ARHGAP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 19
Alternative name(s):
Rho-type GTPase-activating protein 19
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23724. ARHGAP19.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213390.
ENSG00000269891.
PharmGKBiPA134917415.

Polymorphism and mutation databases

BioMutaiARHGAP19.
DMDMi121948181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002804652 – 494Rho GTPase-activating protein 19Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei31PhosphoserineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14CB8.
MaxQBiQ14CB8.
PaxDbiQ14CB8.
PeptideAtlasiQ14CB8.
PRIDEiQ14CB8.

PTM databases

iPTMnetiQ14CB8.
PhosphoSitePlusiQ14CB8.

Expressioni

Tissue specificityi

Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.1 Publication

Gene expression databases

BgeeiENSG00000213390.
ExpressionAtlasiQ14CB8. baseline and differential.
GenevisibleiQ14CB8. HS.

Organism-specific databases

HPAiHPA043231.

Interactioni

Protein-protein interaction databases

BioGridi124412. 13 interactors.
IntActiQ14CB8. 2 interactors.
MINTiMINT-2877769.
STRINGi9606.ENSP00000351333.

Structurei

3D structure databases

ProteinModelPortaliQ14CB8.
SMRiQ14CB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 308Rho-GAPPROSITE-ProRule annotationAdd BLAST207

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPRZ. Eukaryota.
ENOG4110H3V. LUCA.
GeneTreeiENSGT00760000119123.
HOVERGENiHBG055569.
InParanoidiQ14CB8.
KOiK20640.
OMAiICNFVIC.
OrthoDBiEOG091G06NP.
PhylomeDBiQ14CB8.
TreeFamiTF326309.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14CB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR
60 70 80 90 100
HEKPEIFTEL VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS
110 120 130 140 150
LMSLKRKEKG VIFGSPLTEE GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR
160 170 180 190 200
QQILRDALNN GTDIDLESGE FHSNDVATLL KMFLGELPEP LLTHKHFNAH
210 220 230 240 250
LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR NLLKLLLDLL
260 270 280 290 300
YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
310 320 330 340 350
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS
360 370 380 390 400
QKRNRVDSCP HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS
410 420 430 440 450
LTQTPGREPS TSQVQKRARS RSFSGLIKRK VLGNQMMSEK KKKNPTPESV
460 470 480 490
AIGELKGTSK ENRNLLFSGS PAVTMTPTRL KWSEGKKEGK KGFL
Length:494
Mass (Da):55,756
Last modified:August 22, 2006 - v1
Checksum:iEAE8DF3FD1253858
GO
Isoform 2 (identifier: Q14CB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: FL → NSMATTSLGSIRMTLRGSSSCGCCS

Note: No experimental confirmation available.
Show »
Length:517
Mass (Da):57,989
Checksum:iED0204FB3AEA0BFA
GO
Isoform 3 (identifier: Q14CB8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MATEAQSEGEVPARESGRS → MPHQKLSALI

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):54,901
Checksum:i9127F52FD96F4DF7
GO
Isoform 4 (identifier: Q14CB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Note: No experimental confirmation available.
Show »
Length:112
Mass (Da):12,548
Checksum:iA7F67459CA61C860
GO
Isoform 5 (identifier: Q14CB8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-301: VTANDLQENITKLNSGMAFMI → GLVLLPTLEESNTITTHCSLI
     302-494: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,708
Checksum:i7909659144913AEB
GO
Isoform 6 (identifier: Q14CB8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-309: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):52,466
Checksum:iA427B1C7CC5ADEA2
GO
Isoform 7 (identifier: Q14CB8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-346: Missing.

Show »
Length:479
Mass (Da):54,081
Checksum:iB4B5048BCB255B21
GO

Sequence cautioni

The sequence BAB84948 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04165 differs from that shown. Reason: Frameshift at position 280.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28C → Y in AAR02412 (PubMed:17454002).Curated1
Sequence conflicti28C → Y in ABC69298 (PubMed:17454002).Curated1
Sequence conflicti170E → A in CAH18254 (PubMed:17974005).Curated1
Sequence conflicti170E → G in BAC04165 (PubMed:14702039).Curated1
Sequence conflicti420S → L in BAC04165 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031152305Q → R.Corresponds to variant rs17112598dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236951 – 382Missing in isoform 4. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_0236961 – 19MATEA…ESGRS → MPHQKLSALI in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_023697281 – 309Missing in isoform 6. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_023698281 – 301VTAND…MAFMI → GLVLLPTLEESNTITTHCSL I in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_023699302 – 494Missing in isoform 5. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_023700332 – 346Missing in isoform 7. CuratedAdd BLAST15
Alternative sequenceiVSP_023701493 – 494FL → NSMATTSLGSIRMTLRGSSS CGCCS in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA. Translation: ABC69298.1.
AY336750 mRNA. Translation: AAR02412.1.
AK093441 mRNA. Translation: BAC04165.1. Frameshift.
AK074122 mRNA. Translation: BAB84948.1. Different initiation.
AK090447 mRNA. Translation: BAC03428.1.
AK303055 mRNA. Translation: BAG64173.1.
CR749412 mRNA. Translation: CAH18254.1.
AL359385 Genomic DNA. Translation: CAI13728.1.
AL359385 Genomic DNA. Translation: CAI13731.2.
CH471066 Genomic DNA. Translation: EAW49952.1.
BC113888 mRNA. Translation: AAI13889.1.
BC114490 mRNA. Translation: AAI14491.1.
CCDSiCCDS58092.1. [Q14CB8-3]
CCDS73175.1. [Q14CB8-6]
CCDS7454.2. [Q14CB8-1]
RefSeqiNP_001191229.1. NM_001204300.1. [Q14CB8-6]
NP_001243352.1. NM_001256423.1. [Q14CB8-3]
NP_116289.4. NM_032900.5. [Q14CB8-1]
UniGeneiHs.80305.

Genome annotation databases

EnsembliENST00000358308; ENSP00000351058; ENSG00000213390. [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390. [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390. [Q14CB8-3]
GeneIDi84986.
KEGGihsa:84986.
UCSCiuc001kna.5. human. [Q14CB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA. Translation: ABC69298.1.
AY336750 mRNA. Translation: AAR02412.1.
AK093441 mRNA. Translation: BAC04165.1. Frameshift.
AK074122 mRNA. Translation: BAB84948.1. Different initiation.
AK090447 mRNA. Translation: BAC03428.1.
AK303055 mRNA. Translation: BAG64173.1.
CR749412 mRNA. Translation: CAH18254.1.
AL359385 Genomic DNA. Translation: CAI13728.1.
AL359385 Genomic DNA. Translation: CAI13731.2.
CH471066 Genomic DNA. Translation: EAW49952.1.
BC113888 mRNA. Translation: AAI13889.1.
BC114490 mRNA. Translation: AAI14491.1.
CCDSiCCDS58092.1. [Q14CB8-3]
CCDS73175.1. [Q14CB8-6]
CCDS7454.2. [Q14CB8-1]
RefSeqiNP_001191229.1. NM_001204300.1. [Q14CB8-6]
NP_001243352.1. NM_001256423.1. [Q14CB8-3]
NP_116289.4. NM_032900.5. [Q14CB8-1]
UniGeneiHs.80305.

3D structure databases

ProteinModelPortaliQ14CB8.
SMRiQ14CB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124412. 13 interactors.
IntActiQ14CB8. 2 interactors.
MINTiMINT-2877769.
STRINGi9606.ENSP00000351333.

PTM databases

iPTMnetiQ14CB8.
PhosphoSitePlusiQ14CB8.

Polymorphism and mutation databases

BioMutaiARHGAP19.
DMDMi121948181.

Proteomic databases

EPDiQ14CB8.
MaxQBiQ14CB8.
PaxDbiQ14CB8.
PeptideAtlasiQ14CB8.
PRIDEiQ14CB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358308; ENSP00000351058; ENSG00000213390. [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390. [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390. [Q14CB8-3]
GeneIDi84986.
KEGGihsa:84986.
UCSCiuc001kna.5. human. [Q14CB8-1]

Organism-specific databases

CTDi84986.
GeneCardsiARHGAP19.
H-InvDBHIX0009085.
HIX0079267.
HGNCiHGNC:23724. ARHGAP19.
HPAiHPA043231.
MIMi611587. gene.
neXtProtiNX_Q14CB8.
OpenTargetsiENSG00000213390.
ENSG00000269891.
PharmGKBiPA134917415.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPRZ. Eukaryota.
ENOG4110H3V. LUCA.
GeneTreeiENSGT00760000119123.
HOVERGENiHBG055569.
InParanoidiQ14CB8.
KOiK20640.
OMAiICNFVIC.
OrthoDBiEOG091G06NP.
PhylomeDBiQ14CB8.
TreeFamiTF326309.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

GeneWikiiARHGAP19.
GenomeRNAii84986.
PROiQ14CB8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213390.
ExpressionAtlasiQ14CB8. baseline and differential.
GenevisibleiQ14CB8. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG19_HUMAN
AccessioniPrimary (citable) accession number: Q14CB8
Secondary accession number(s): A1XCP1
, B4DZR1, Q14CF2, Q5J8M2, Q5T460, Q5T462, Q68DG6, Q8N9X1, Q8NF34, Q8TEK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 22, 2006
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.