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Q14CB8

- RHG19_HUMAN

UniProt

Q14CB8 - RHG19_HUMAN

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Protein

Rho GTPase-activating protein 19

Gene

ARHGAP19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: Reactome
  2. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 19
Alternative name(s):
Rho-type GTPase-activating protein 19
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23724. ARHGAP19.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917415.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Rho GTPase-activating protein 19PRO_0000280465Add
BLAST

Proteomic databases

MaxQBiQ14CB8.
PaxDbiQ14CB8.
PRIDEiQ14CB8.

PTM databases

PhosphoSiteiQ14CB8.

Expressioni

Tissue specificityi

Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.1 Publication

Gene expression databases

BgeeiQ14CB8.
ExpressionAtlasiQ14CB8. baseline and differential.
GenevestigatoriQ14CB8.

Organism-specific databases

HPAiHPA043231.

Interactioni

Protein-protein interaction databases

BioGridi124412. 6 interactions.
IntActiQ14CB8. 1 interaction.
MINTiMINT-2877769.

Structurei

3D structure databases

ProteinModelPortaliQ14CB8.
SMRiQ14CB8. Positions 93-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 308207Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG241354.
GeneTreeiENSGT00760000119123.
HOVERGENiHBG055569.
InParanoidiQ14CB8.
OMAiIRQFNKH.
PhylomeDBiQ14CB8.
TreeFamiTF326309.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14CB8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR
60 70 80 90 100
HEKPEIFTEL VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS
110 120 130 140 150
LMSLKRKEKG VIFGSPLTEE GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR
160 170 180 190 200
QQILRDALNN GTDIDLESGE FHSNDVATLL KMFLGELPEP LLTHKHFNAH
210 220 230 240 250
LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR NLLKLLLDLL
260 270 280 290 300
YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
310 320 330 340 350
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS
360 370 380 390 400
QKRNRVDSCP HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS
410 420 430 440 450
LTQTPGREPS TSQVQKRARS RSFSGLIKRK VLGNQMMSEK KKKNPTPESV
460 470 480 490
AIGELKGTSK ENRNLLFSGS PAVTMTPTRL KWSEGKKEGK KGFL
Length:494
Mass (Da):55,756
Last modified:August 22, 2006 - v1
Checksum:iEAE8DF3FD1253858
GO
Isoform 2 (identifier: Q14CB8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: FL → NSMATTSLGSIRMTLRGSSSCGCCS

Note: No experimental confirmation available.

Show »
Length:517
Mass (Da):57,989
Checksum:iED0204FB3AEA0BFA
GO
Isoform 3 (identifier: Q14CB8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MATEAQSEGEVPARESGRS → MPHQKLSALI

Note: No experimental confirmation available.

Show »
Length:485
Mass (Da):54,901
Checksum:i9127F52FD96F4DF7
GO
Isoform 4 (identifier: Q14CB8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Note: No experimental confirmation available.

Show »
Length:112
Mass (Da):12,548
Checksum:iA7F67459CA61C860
GO
Isoform 5 (identifier: Q14CB8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-301: VTANDLQENITKLNSGMAFMI → GLVLLPTLEESNTITTHCSLI
     302-494: Missing.

Note: No experimental confirmation available.

Show »
Length:301
Mass (Da):33,708
Checksum:i7909659144913AEB
GO
Isoform 6 (identifier: Q14CB8-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-309: Missing.

Note: No experimental confirmation available.

Show »
Length:465
Mass (Da):52,466
Checksum:iA427B1C7CC5ADEA2
GO
Isoform 7 (identifier: Q14CB8-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-346: Missing.

Show »
Length:479
Mass (Da):54,081
Checksum:iB4B5048BCB255B21
GO

Sequence cautioni

The sequence BAB84948.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04165.1 differs from that shown. Reason: Frameshift at position 280. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281C → Y in AAR02412. (PubMed:17454002)Curated
Sequence conflicti28 – 281C → Y in ABC69298. (PubMed:17454002)Curated
Sequence conflicti170 – 1701E → A in CAH18254. (PubMed:17974005)Curated
Sequence conflicti170 – 1701E → G in BAC04165. (PubMed:14702039)Curated
Sequence conflicti420 – 4201S → L in BAC04165. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti305 – 3051Q → R.
Corresponds to variant rs17112598 [ dbSNP | Ensembl ].
VAR_031152

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 382382Missing in isoform 4. 1 PublicationVSP_023695Add
BLAST
Alternative sequencei1 – 1919MATEA…ESGRS → MPHQKLSALI in isoform 3. 1 PublicationVSP_023696Add
BLAST
Alternative sequencei281 – 30929Missing in isoform 6. 1 PublicationVSP_023697Add
BLAST
Alternative sequencei281 – 30121VTAND…MAFMI → GLVLLPTLEESNTITTHCSL I in isoform 5. 1 PublicationVSP_023698Add
BLAST
Alternative sequencei302 – 494193Missing in isoform 5. 1 PublicationVSP_023699Add
BLAST
Alternative sequencei332 – 34615Missing in isoform 7. CuratedVSP_023700Add
BLAST
Alternative sequencei493 – 4942FL → NSMATTSLGSIRMTLRGSSS CGCCS in isoform 2. 1 PublicationVSP_023701

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA. Translation: ABC69298.1.
AY336750 mRNA. Translation: AAR02412.1.
AK093441 mRNA. Translation: BAC04165.1. Frameshift.
AK074122 mRNA. Translation: BAB84948.1. Different initiation.
AK090447 mRNA. Translation: BAC03428.1.
AK303055 mRNA. Translation: BAG64173.1.
CR749412 mRNA. Translation: CAH18254.1.
AL359385 Genomic DNA. Translation: CAI13728.1.
AL359385 Genomic DNA. Translation: CAI13731.2.
CH471066 Genomic DNA. Translation: EAW49952.1.
BC113888 mRNA. Translation: AAI13889.1.
BC114490 mRNA. Translation: AAI14491.1.
CCDSiCCDS58092.1. [Q14CB8-3]
CCDS73175.1. [Q14CB8-6]
CCDS7454.2. [Q14CB8-1]
RefSeqiNP_001191229.1. NM_001204300.1. [Q14CB8-6]
NP_001243352.1. NM_001256423.1. [Q14CB8-3]
NP_116289.4. NM_032900.5. [Q14CB8-1]
UniGeneiHs.80305.

Genome annotation databases

EnsembliENST00000358308; ENSP00000351058; ENSG00000213390. [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390. [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390. [Q14CB8-3]
GeneIDi84986.
KEGGihsa:84986.
UCSCiuc001kna.4. human. [Q14CB8-3]
uc001knb.3. human. [Q14CB8-1]
uc009xvj.3. human. [Q14CB8-6]

Polymorphism databases

DMDMi121948181.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA. Translation: ABC69298.1 .
AY336750 mRNA. Translation: AAR02412.1 .
AK093441 mRNA. Translation: BAC04165.1 . Frameshift.
AK074122 mRNA. Translation: BAB84948.1 . Different initiation.
AK090447 mRNA. Translation: BAC03428.1 .
AK303055 mRNA. Translation: BAG64173.1 .
CR749412 mRNA. Translation: CAH18254.1 .
AL359385 Genomic DNA. Translation: CAI13728.1 .
AL359385 Genomic DNA. Translation: CAI13731.2 .
CH471066 Genomic DNA. Translation: EAW49952.1 .
BC113888 mRNA. Translation: AAI13889.1 .
BC114490 mRNA. Translation: AAI14491.1 .
CCDSi CCDS58092.1. [Q14CB8-3 ]
CCDS73175.1. [Q14CB8-6 ]
CCDS7454.2. [Q14CB8-1 ]
RefSeqi NP_001191229.1. NM_001204300.1. [Q14CB8-6 ]
NP_001243352.1. NM_001256423.1. [Q14CB8-3 ]
NP_116289.4. NM_032900.5. [Q14CB8-1 ]
UniGenei Hs.80305.

3D structure databases

ProteinModelPortali Q14CB8.
SMRi Q14CB8. Positions 93-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124412. 6 interactions.
IntActi Q14CB8. 1 interaction.
MINTi MINT-2877769.

PTM databases

PhosphoSitei Q14CB8.

Polymorphism databases

DMDMi 121948181.

Proteomic databases

MaxQBi Q14CB8.
PaxDbi Q14CB8.
PRIDEi Q14CB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358308 ; ENSP00000351058 ; ENSG00000213390 . [Q14CB8-6 ]
ENST00000358531 ; ENSP00000351333 ; ENSG00000213390 . [Q14CB8-1 ]
ENST00000371027 ; ENSP00000360066 ; ENSG00000213390 . [Q14CB8-3 ]
GeneIDi 84986.
KEGGi hsa:84986.
UCSCi uc001kna.4. human. [Q14CB8-3 ]
uc001knb.3. human. [Q14CB8-1 ]
uc009xvj.3. human. [Q14CB8-6 ]

Organism-specific databases

CTDi 84986.
GeneCardsi GC10M098971.
H-InvDB HIX0009085.
HIX0079267.
HGNCi HGNC:23724. ARHGAP19.
HPAi HPA043231.
MIMi 611587. gene.
neXtProti NX_Q14CB8.
PharmGKBi PA134917415.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241354.
GeneTreei ENSGT00760000119123.
HOVERGENi HBG055569.
InParanoidi Q14CB8.
OMAi IRQFNKH.
PhylomeDBi Q14CB8.
TreeFami TF326309.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

GeneWikii ARHGAP19.
GenomeRNAii 84986.
NextBioi 75560.
PROi Q14CB8.
SOURCEi Search...

Gene expression databases

Bgeei Q14CB8.
ExpressionAtlasi Q14CB8. baseline and differential.
Genevestigatori Q14CB8.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues."
    Lv L., Xu J., Zhao S., Chen C., Zhao X., Gu S., Ji C., Xie Y., Mao Y.
    DNA Seq. 18:184-189(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  3. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-427 (ISOFORM 5).
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).

Entry informationi

Entry nameiRHG19_HUMAN
AccessioniPrimary (citable) accession number: Q14CB8
Secondary accession number(s): A1XCP1
, B4DZR1, Q14CF2, Q5J8M2, Q5T460, Q5T462, Q68DG6, Q8N9X1, Q8NF34, Q8TEK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3