Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 132D

Gene

TMEM132D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May serve as a cell-surface marker for oligodendrocyte differentiation.1 Publication

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 132D
Alternative name(s):
Mature oligodendrocytes transmembrane protein
Short name:
Mature OL transmembrane protein
Gene namesi
Name:TMEM132D
Synonyms:HBE120, KIAA1944, MOLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29411. TMEM132D.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 915885ExtracellularSequence AnalysisAdd
BLAST
Transmembranei916 – 93621HelicalSequence AnalysisAdd
BLAST
Topological domaini937 – 1099163CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 10991069Transmembrane protein 132DPRO_0000287100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14C87.
PaxDbiQ14C87.
PRIDEiQ14C87.

PTM databases

PhosphoSiteiQ14C87.

Expressioni

Tissue specificityi

Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.1 Publication

Gene expression databases

BgeeiQ14C87.
CleanExiHS_TMEM132D.
GenevestigatoriQ14C87.

Organism-specific databases

HPAiHPA010739.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-5235567,EBI-357253

Protein-protein interaction databases

BioGridi125713. 2 interactions.
IntActiQ14C87. 1 interaction.
STRINGi9606.ENSP00000408581.

Structurei

3D structure databases

ProteinModelPortaliQ14C87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM132 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148422.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ14C87.
KOiK17599.
OMAiNPFGFTN.
OrthoDBiEOG7DJSKK.
PhylomeDBiQ14C87.
TreeFamiTF314981.

Family and domain databases

InterProiIPR026307. TMEM132.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14C87-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCPSEMGTLW HHWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT
60 70 80 90 100
YHINNADVSF FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF
110 120 130 140 150
SIEQVVPQDL MLPSNPFGFT NKFSLNWKLK AHILRDKVYL SRPKVQVLFH
160 170 180 190 200
IMGRDWDDRS AGEKLPCLRV FAFRETREVR GSCRLQGDLG LCVAELELLS
210 220 230 240 250
SWFSPPTVVA GRRKSVDQPE GTPVELYYTV HPGGERGDCV REDARRSNGI
260 270 280 290 300
RTGHSDIDES GPPLQRIGSI FLYQTHRKPS LRELRLDNSV AIHYIPKTVR
310 320 330 340 350
KGDVLTFPVS ISRNSTEDRF TLRAKVKKGV NIIGVRASSP SIWDVKERTD
360 370 380 390 400
YTGKYAPAVI VCQKKAAGSE NSADGASYEV MQIDVEVEEP GDLPATQLVT
410 420 430 440 450
WQVEYPGEIT SDLGVSKIYV SPKDLIGVVP LAMEAEILNT AILTGKTVAV
460 470 480 490 500
PVKVVSVEDD GTVTELLESV ECRSSDEDVI KVSDRCDYVF VNGKEMKGKV
510 520 530 540 550
NVVVNFTYQH LSSPLEMTVW VPRLPLQIEV SDTELNQIKG WRVPIVSSRR
560 570 580 590 600
PAGDSEEEED DERRGRGCTL QYQHAMVRVL TQFVAEAAGP GGHLAHLLGS
610 620 630 640 650
DWQVDITELI NDFMQVEEPR IAKLQGGQIL MGQELGMTTI QILSPLSDTI
660 670 680 690 700
LAEKTITVLD EKVTITDLGV QLVTGLSLSL QLSPGSNRAI FATAVAQELL
710 720 730 740 750
QRPKQEAAIS CWVQFSDGSV TPLDIYDGKD FSLMATSLDE KVVSIHQDPK
760 770 780 790 800
FKWPIIAAET EGQGTLVKVE MVISESCQKS KRKSVLAVGT ANIKVKFGQN
810 820 830 840 850
DANPNTSDSR HTGAGVHMEN NVSDRRPKKP SQEWGSQEGQ YYGSSSMGLM
860 870 880 890 900
EGRGTTTDRS ILQKKKGQES LLDDNSHLQT IPSDLTSFPA QVDLPRSNGE
910 920 930 940 950
MDGNDLMQAS KGLSDLEIGM YALLGVFCLA ILVFLINCVT FALKYRHKQV
960 970 980 990 1000
PFEEQEGMSH SHDWVGLSNR TELLENHINF ASSQDEQITA IDRGMDFEES
1010 1020 1030 1040 1050
KYLLSTNSQK SINGQLFKPL GPIIIDGKDQ KSEPPTSPTS KRKRVKFTTF
1060 1070 1080 1090
TAVSSDDEYP TRNSIVMSSE DDIKWVCQDL DPGDCKELHN YMERLHENV
Length:1,099
Mass (Da):122,309
Last modified:August 22, 2006 - v1
Checksum:i4BA360835180F7B3
GO
Isoform 2 (identifier: Q14C87-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-462: Missing.
     463-481: VTELLESVECRSSDEDVIK → MQRDESSPFPPLFSLTSSQ

Note: No experimental confirmation available.

Show »
Length:637
Mass (Da):70,796
Checksum:iA993439E85FAB42D
GO

Sequence cautioni

The sequence BAB85530.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti696 – 6961A → T in BAC97794. (PubMed:12966072)Curated
Sequence conflicti831 – 8311S → L in AAI14627. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti436 – 4361E → Q.
Corresponds to variant rs12816729 [ dbSNP | Ensembl ].
VAR_053887
Natural varianti460 – 4601D → H.
Corresponds to variant rs12816538 [ dbSNP | Ensembl ].
VAR_053888
Natural varianti878 – 8781L → F.
Corresponds to variant rs555131 [ dbSNP | Ensembl ].
VAR_032264

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 462462Missing in isoform 2. 1 PublicationVSP_025307Add
BLAST
Alternative sequencei463 – 48119VTELL…EDVIK → MQRDESSPFPPLFSLTSSQ in isoform 2. 1 PublicationVSP_025308Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061814 mRNA. Translation: BAC97794.1.
AB075824 mRNA. Translation: BAB85530.1. Different initiation.
BC114626 mRNA. Translation: AAI14627.1.
BC114936 mRNA. Translation: AAI14937.1.
AL833234 mRNA. Translation: CAD38636.1.
AK094656 mRNA. No translation available.
CCDSiCCDS9266.1. [Q14C87-1]
RefSeqiNP_597705.2. NM_133448.2. [Q14C87-1]
UniGeneiHs.507268.

Genome annotation databases

EnsembliENST00000389441; ENSP00000374092; ENSG00000151952. [Q14C87-2]
ENST00000422113; ENSP00000408581; ENSG00000151952. [Q14C87-1]
GeneIDi121256.
KEGGihsa:121256.
UCSCiuc001uia.2. human. [Q14C87-2]
uc009zyl.1. human. [Q14C87-1]

Polymorphism databases

DMDMi121940538.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061814 mRNA. Translation: BAC97794.1.
AB075824 mRNA. Translation: BAB85530.1. Different initiation.
BC114626 mRNA. Translation: AAI14627.1.
BC114936 mRNA. Translation: AAI14937.1.
AL833234 mRNA. Translation: CAD38636.1.
AK094656 mRNA. No translation available.
CCDSiCCDS9266.1. [Q14C87-1]
RefSeqiNP_597705.2. NM_133448.2. [Q14C87-1]
UniGeneiHs.507268.

3D structure databases

ProteinModelPortaliQ14C87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125713. 2 interactions.
IntActiQ14C87. 1 interaction.
STRINGi9606.ENSP00000408581.

PTM databases

PhosphoSiteiQ14C87.

Polymorphism databases

DMDMi121940538.

Proteomic databases

MaxQBiQ14C87.
PaxDbiQ14C87.
PRIDEiQ14C87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389441; ENSP00000374092; ENSG00000151952. [Q14C87-2]
ENST00000422113; ENSP00000408581; ENSG00000151952. [Q14C87-1]
GeneIDi121256.
KEGGihsa:121256.
UCSCiuc001uia.2. human. [Q14C87-2]
uc009zyl.1. human. [Q14C87-1]

Organism-specific databases

CTDi121256.
GeneCardsiGC12M129556.
HGNCiHGNC:29411. TMEM132D.
HPAiHPA010739.
MIMi611257. gene.
neXtProtiNX_Q14C87.
PharmGKBiPA143485654.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148422.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ14C87.
KOiK17599.
OMAiNPFGFTN.
OrthoDBiEOG7DJSKK.
PhylomeDBiQ14C87.
TreeFamiTF314981.

Miscellaneous databases

ChiTaRSiTMEM132D. human.
GenomeRNAii121256.
NextBioi80684.
PROiQ14C87.
SOURCEiSearch...

Gene expression databases

BgeeiQ14C87.
CleanExiHS_TMEM132D.
GenevestigatoriQ14C87.

Family and domain databases

InterProiIPR026307. TMEM132.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes."
    Nomoto H., Yonezawa T., Itoh K., Ono K., Yamamoto K., Oohashi T., Shiraga F., Ohtsuki H., Ninomiya Y.
    J. Biochem. 134:231-238(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 851-1099 (ISOFORM 1).
    Tissue: Amygdala.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 947-1099 (ISOFORM 1).
    Tissue: Amygdala.

Entry informationi

Entry nameiT132D_HUMAN
AccessioniPrimary (citable) accession number: Q14C87
Secondary accession number(s): Q14C96
, Q76M59, Q8N1W9, Q8N3Q5, Q8TF57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 22, 2006
Last modified: January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.