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Q14C87

- T132D_HUMAN

UniProt

Q14C87 - T132D_HUMAN

Protein

Transmembrane protein 132D

Gene

TMEM132D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    May serve as a cell-surface marker for oligodendrocyte differentiation.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 132D
    Alternative name(s):
    Mature oligodendrocytes transmembrane protein
    Short name:
    Mature OL transmembrane protein
    Gene namesi
    Name:TMEM132D
    Synonyms:HBE120, KIAA1944, MOLT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29411. TMEM132D.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485654.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 10991069Transmembrane protein 132DPRO_0000287100Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ14C87.
    PRIDEiQ14C87.

    PTM databases

    PhosphoSiteiQ14C87.

    Expressioni

    Tissue specificityi

    Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.1 Publication

    Gene expression databases

    BgeeiQ14C87.
    CleanExiHS_TMEM132D.
    GenevestigatoriQ14C87.

    Organism-specific databases

    HPAiHPA010739.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1CAP621362EBI-5235567,EBI-357253

    Protein-protein interaction databases

    BioGridi125713. 2 interactions.
    IntActiQ14C87. 1 interaction.
    STRINGi9606.ENSP00000408581.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14C87.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 915885ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini937 – 1099163CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei916 – 93621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM132 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148422.
    HOGENOMiHOG000154481.
    HOVERGENiHBG108534.
    InParanoidiQ14C87.
    KOiK17599.
    OMAiSSPSIWD.
    OrthoDBiEOG7DJSKK.
    PhylomeDBiQ14C87.
    TreeFamiTF314981.

    Family and domain databases

    InterProiIPR026307. TMEM132.
    [Graphical view]
    PANTHERiPTHR13388. PTHR13388. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14C87-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCPSEMGTLW HHWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT     50
    YHINNADVSF FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF 100
    SIEQVVPQDL MLPSNPFGFT NKFSLNWKLK AHILRDKVYL SRPKVQVLFH 150
    IMGRDWDDRS AGEKLPCLRV FAFRETREVR GSCRLQGDLG LCVAELELLS 200
    SWFSPPTVVA GRRKSVDQPE GTPVELYYTV HPGGERGDCV REDARRSNGI 250
    RTGHSDIDES GPPLQRIGSI FLYQTHRKPS LRELRLDNSV AIHYIPKTVR 300
    KGDVLTFPVS ISRNSTEDRF TLRAKVKKGV NIIGVRASSP SIWDVKERTD 350
    YTGKYAPAVI VCQKKAAGSE NSADGASYEV MQIDVEVEEP GDLPATQLVT 400
    WQVEYPGEIT SDLGVSKIYV SPKDLIGVVP LAMEAEILNT AILTGKTVAV 450
    PVKVVSVEDD GTVTELLESV ECRSSDEDVI KVSDRCDYVF VNGKEMKGKV 500
    NVVVNFTYQH LSSPLEMTVW VPRLPLQIEV SDTELNQIKG WRVPIVSSRR 550
    PAGDSEEEED DERRGRGCTL QYQHAMVRVL TQFVAEAAGP GGHLAHLLGS 600
    DWQVDITELI NDFMQVEEPR IAKLQGGQIL MGQELGMTTI QILSPLSDTI 650
    LAEKTITVLD EKVTITDLGV QLVTGLSLSL QLSPGSNRAI FATAVAQELL 700
    QRPKQEAAIS CWVQFSDGSV TPLDIYDGKD FSLMATSLDE KVVSIHQDPK 750
    FKWPIIAAET EGQGTLVKVE MVISESCQKS KRKSVLAVGT ANIKVKFGQN 800
    DANPNTSDSR HTGAGVHMEN NVSDRRPKKP SQEWGSQEGQ YYGSSSMGLM 850
    EGRGTTTDRS ILQKKKGQES LLDDNSHLQT IPSDLTSFPA QVDLPRSNGE 900
    MDGNDLMQAS KGLSDLEIGM YALLGVFCLA ILVFLINCVT FALKYRHKQV 950
    PFEEQEGMSH SHDWVGLSNR TELLENHINF ASSQDEQITA IDRGMDFEES 1000
    KYLLSTNSQK SINGQLFKPL GPIIIDGKDQ KSEPPTSPTS KRKRVKFTTF 1050
    TAVSSDDEYP TRNSIVMSSE DDIKWVCQDL DPGDCKELHN YMERLHENV 1099
    Length:1,099
    Mass (Da):122,309
    Last modified:August 22, 2006 - v1
    Checksum:i4BA360835180F7B3
    GO
    Isoform 2 (identifier: Q14C87-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-462: Missing.
         463-481: VTELLESVECRSSDEDVIK → MQRDESSPFPPLFSLTSSQ

    Note: No experimental confirmation available.

    Show »
    Length:637
    Mass (Da):70,796
    Checksum:iA993439E85FAB42D
    GO

    Sequence cautioni

    The sequence BAB85530.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti696 – 6961A → T in BAC97794. (PubMed:12966072)Curated
    Sequence conflicti831 – 8311S → L in AAI14627. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti436 – 4361E → Q.
    Corresponds to variant rs12816729 [ dbSNP | Ensembl ].
    VAR_053887
    Natural varianti460 – 4601D → H.
    Corresponds to variant rs12816538 [ dbSNP | Ensembl ].
    VAR_053888
    Natural varianti878 – 8781L → F.
    Corresponds to variant rs555131 [ dbSNP | Ensembl ].
    VAR_032264

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 462462Missing in isoform 2. 1 PublicationVSP_025307Add
    BLAST
    Alternative sequencei463 – 48119VTELL…EDVIK → MQRDESSPFPPLFSLTSSQ in isoform 2. 1 PublicationVSP_025308Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061814 mRNA. Translation: BAC97794.1.
    AB075824 mRNA. Translation: BAB85530.1. Different initiation.
    BC114626 mRNA. Translation: AAI14627.1.
    BC114936 mRNA. Translation: AAI14937.1.
    AL833234 mRNA. Translation: CAD38636.1.
    AK094656 mRNA. No translation available.
    CCDSiCCDS9266.1. [Q14C87-1]
    RefSeqiNP_597705.2. NM_133448.2. [Q14C87-1]
    UniGeneiHs.507268.

    Genome annotation databases

    EnsembliENST00000389441; ENSP00000374092; ENSG00000151952. [Q14C87-2]
    ENST00000422113; ENSP00000408581; ENSG00000151952. [Q14C87-1]
    GeneIDi121256.
    KEGGihsa:121256.
    UCSCiuc001uia.2. human. [Q14C87-2]
    uc009zyl.1. human. [Q14C87-1]

    Polymorphism databases

    DMDMi121940538.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061814 mRNA. Translation: BAC97794.1 .
    AB075824 mRNA. Translation: BAB85530.1 . Different initiation.
    BC114626 mRNA. Translation: AAI14627.1 .
    BC114936 mRNA. Translation: AAI14937.1 .
    AL833234 mRNA. Translation: CAD38636.1 .
    AK094656 mRNA. No translation available.
    CCDSi CCDS9266.1. [Q14C87-1 ]
    RefSeqi NP_597705.2. NM_133448.2. [Q14C87-1 ]
    UniGenei Hs.507268.

    3D structure databases

    ProteinModelPortali Q14C87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125713. 2 interactions.
    IntActi Q14C87. 1 interaction.
    STRINGi 9606.ENSP00000408581.

    PTM databases

    PhosphoSitei Q14C87.

    Polymorphism databases

    DMDMi 121940538.

    Proteomic databases

    PaxDbi Q14C87.
    PRIDEi Q14C87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389441 ; ENSP00000374092 ; ENSG00000151952 . [Q14C87-2 ]
    ENST00000422113 ; ENSP00000408581 ; ENSG00000151952 . [Q14C87-1 ]
    GeneIDi 121256.
    KEGGi hsa:121256.
    UCSCi uc001uia.2. human. [Q14C87-2 ]
    uc009zyl.1. human. [Q14C87-1 ]

    Organism-specific databases

    CTDi 121256.
    GeneCardsi GC12M129556.
    HGNCi HGNC:29411. TMEM132D.
    HPAi HPA010739.
    MIMi 611257. gene.
    neXtProti NX_Q14C87.
    PharmGKBi PA143485654.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148422.
    HOGENOMi HOG000154481.
    HOVERGENi HBG108534.
    InParanoidi Q14C87.
    KOi K17599.
    OMAi SSPSIWD.
    OrthoDBi EOG7DJSKK.
    PhylomeDBi Q14C87.
    TreeFami TF314981.

    Miscellaneous databases

    GenomeRNAii 121256.
    NextBioi 80684.
    PROi Q14C87.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14C87.
    CleanExi HS_TMEM132D.
    Genevestigatori Q14C87.

    Family and domain databases

    InterProi IPR026307. TMEM132.
    [Graphical view ]
    PANTHERi PTHR13388. PTHR13388. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes."
      Nomoto H., Yonezawa T., Itoh K., Ono K., Yamamoto K., Oohashi T., Shiraga F., Ohtsuki H., Ninomiya Y.
      J. Biochem. 134:231-238(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 851-1099 (ISOFORM 1).
      Tissue: Amygdala.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 947-1099 (ISOFORM 1).
      Tissue: Amygdala.

    Entry informationi

    Entry nameiT132D_HUMAN
    AccessioniPrimary (citable) accession number: Q14C87
    Secondary accession number(s): Q14C96
    , Q76M59, Q8N1W9, Q8N3Q5, Q8TF57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3