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Q14C87 (T132D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 132D
Alternative name(s):
Mature oligodendrocytes transmembrane protein
Short name=Mature OL transmembrane protein
Gene names
Name:TMEM132D
Synonyms:HBE120, KIAA1944, MOLT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1099 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May serve as a cell-surface marker for oligodendrocyte differentiation. Ref.1

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis. Ref.1

Sequence similarities

Belongs to the TMEM132 family.

Sequence caution

The sequence BAB85530.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of phosphatase activity

Inferred from direct assay PubMed 19389623. Source: UniProtKB

   Cellular_componentintegral component of membrane

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP1CAP621362EBI-5235567,EBI-357253

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14C87-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14C87-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-462: Missing.
     463-481: VTELLESVECRSSDEDVIK → MQRDESSPFPPLFSLTSSQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 10991069Transmembrane protein 132D
PRO_0000287100

Regions

Topological domain31 – 915885Extracellular Potential
Transmembrane916 – 93621Helical; Potential
Topological domain937 – 1099163Cytoplasmic Potential

Amino acid modifications

Glycosylation5051N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 462462Missing in isoform 2.
VSP_025307
Alternative sequence463 – 48119VTELL…EDVIK → MQRDESSPFPPLFSLTSSQ in isoform 2.
VSP_025308
Natural variant4361E → Q.
Corresponds to variant rs12816729 [ dbSNP | Ensembl ].
VAR_053887
Natural variant4601D → H.
Corresponds to variant rs12816538 [ dbSNP | Ensembl ].
VAR_053888
Natural variant8781L → F.
Corresponds to variant rs555131 [ dbSNP | Ensembl ].
VAR_032264

Experimental info

Sequence conflict6961A → T in BAC97794. Ref.1
Sequence conflict8311S → L in AAI14627. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 4BA360835180F7B3

FASTA1,099122,309
        10         20         30         40         50         60 
MCPSEMGTLW HHWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT YHINNADVSF 

        70         80         90        100        110        120 
FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF SIEQVVPQDL MLPSNPFGFT 

       130        140        150        160        170        180 
NKFSLNWKLK AHILRDKVYL SRPKVQVLFH IMGRDWDDRS AGEKLPCLRV FAFRETREVR 

       190        200        210        220        230        240 
GSCRLQGDLG LCVAELELLS SWFSPPTVVA GRRKSVDQPE GTPVELYYTV HPGGERGDCV 

       250        260        270        280        290        300 
REDARRSNGI RTGHSDIDES GPPLQRIGSI FLYQTHRKPS LRELRLDNSV AIHYIPKTVR 

       310        320        330        340        350        360 
KGDVLTFPVS ISRNSTEDRF TLRAKVKKGV NIIGVRASSP SIWDVKERTD YTGKYAPAVI 

       370        380        390        400        410        420 
VCQKKAAGSE NSADGASYEV MQIDVEVEEP GDLPATQLVT WQVEYPGEIT SDLGVSKIYV 

       430        440        450        460        470        480 
SPKDLIGVVP LAMEAEILNT AILTGKTVAV PVKVVSVEDD GTVTELLESV ECRSSDEDVI 

       490        500        510        520        530        540 
KVSDRCDYVF VNGKEMKGKV NVVVNFTYQH LSSPLEMTVW VPRLPLQIEV SDTELNQIKG 

       550        560        570        580        590        600 
WRVPIVSSRR PAGDSEEEED DERRGRGCTL QYQHAMVRVL TQFVAEAAGP GGHLAHLLGS 

       610        620        630        640        650        660 
DWQVDITELI NDFMQVEEPR IAKLQGGQIL MGQELGMTTI QILSPLSDTI LAEKTITVLD 

       670        680        690        700        710        720 
EKVTITDLGV QLVTGLSLSL QLSPGSNRAI FATAVAQELL QRPKQEAAIS CWVQFSDGSV 

       730        740        750        760        770        780 
TPLDIYDGKD FSLMATSLDE KVVSIHQDPK FKWPIIAAET EGQGTLVKVE MVISESCQKS 

       790        800        810        820        830        840 
KRKSVLAVGT ANIKVKFGQN DANPNTSDSR HTGAGVHMEN NVSDRRPKKP SQEWGSQEGQ 

       850        860        870        880        890        900 
YYGSSSMGLM EGRGTTTDRS ILQKKKGQES LLDDNSHLQT IPSDLTSFPA QVDLPRSNGE 

       910        920        930        940        950        960 
MDGNDLMQAS KGLSDLEIGM YALLGVFCLA ILVFLINCVT FALKYRHKQV PFEEQEGMSH 

       970        980        990       1000       1010       1020 
SHDWVGLSNR TELLENHINF ASSQDEQITA IDRGMDFEES KYLLSTNSQK SINGQLFKPL 

      1030       1040       1050       1060       1070       1080 
GPIIIDGKDQ KSEPPTSPTS KRKRVKFTTF TAVSSDDEYP TRNSIVMSSE DDIKWVCQDL 

      1090 
DPGDCKELHN YMERLHENV 

« Hide

Isoform 2 [UniParc].

Checksum: A993439E85FAB42D
Show »

FASTA63770,796

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes."
Nomoto H., Yonezawa T., Itoh K., Ono K., Yamamoto K., Oohashi T., Shiraga F., Ohtsuki H., Ninomiya Y.
J. Biochem. 134:231-238(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 851-1099 (ISOFORM 1).
Tissue: Amygdala.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 947-1099 (ISOFORM 1).
Tissue: Amygdala.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB061814 mRNA. Translation: BAC97794.1.
AB075824 mRNA. Translation: BAB85530.1. Different initiation.
BC114626 mRNA. Translation: AAI14627.1.
BC114936 mRNA. Translation: AAI14937.1.
AL833234 mRNA. Translation: CAD38636.1.
AK094656 mRNA. No translation available.
RefSeqNP_597705.2. NM_133448.2.
UniGeneHs.507268.

3D structure databases

ProteinModelPortalQ14C87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125713. 2 interactions.
IntActQ14C87. 1 interaction.
STRING9606.ENSP00000408581.

PTM databases

PhosphoSiteQ14C87.

Polymorphism databases

DMDM121940538.

Proteomic databases

PaxDbQ14C87.
PRIDEQ14C87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389441; ENSP00000374092; ENSG00000151952. [Q14C87-2]
ENST00000422113; ENSP00000408581; ENSG00000151952. [Q14C87-1]
GeneID121256.
KEGGhsa:121256.
UCSCuc001uia.2. human. [Q14C87-2]
uc009zyl.1. human. [Q14C87-1]

Organism-specific databases

CTD121256.
GeneCardsGC12M129556.
HGNCHGNC:29411. TMEM132D.
HPAHPA010739.
MIM611257. gene.
neXtProtNX_Q14C87.
PharmGKBPA143485654.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148422.
HOGENOMHOG000154481.
HOVERGENHBG108534.
InParanoidQ14C87.
KOK17599.
OMASSPSIWD.
OrthoDBEOG7DJSKK.
PhylomeDBQ14C87.
TreeFamTF314981.

Gene expression databases

BgeeQ14C87.
CleanExHS_TMEM132D.
GenevestigatorQ14C87.

Family and domain databases

InterProIPR026307. TMEM132.
[Graphical view]
PANTHERPTHR13388. PTHR13388. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi121256.
NextBio80684.
PROQ14C87.
SOURCESearch...

Entry information

Entry nameT132D_HUMAN
AccessionPrimary (citable) accession number: Q14C87
Secondary accession number(s): Q14C96 expand/collapse secondary AC list , Q76M59, Q8N1W9, Q8N3Q5, Q8TF57
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 22, 2006
Last modified: March 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM