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Q14C86

- GAPD1_HUMAN

UniProt

Q14C86 - GAPD1_HUMAN

Protein

GTPase-activating protein and VPS9 domain-containing protein 1

Gene

GAPVD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.1 Publication

    GO - Molecular functioni

    1. GTPase activating protein binding Source: UniProtKB
    2. GTPase activator activity Source: UniProtKB-KW
    3. guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. positive regulation of GTPase activity Source: GOC
    3. regulation of protein transport Source: UniProtKB
    4. regulation of small GTPase mediated signal transduction Source: InterPro
    5. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation, Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase-activating protein and VPS9 domain-containing protein 1
    Alternative name(s):
    GAPex-5
    Rab5-activating protein 6
    Gene namesi
    Name:GAPVD1
    Synonyms:GAPEX5, KIAA1521, RAP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23375. GAPVD1.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication. Endosome 1 Publication
    Note: Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endosome Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671748.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14781478GTPase-activating protein and VPS9 domain-containing protein 1PRO_0000324771Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei390 – 3901Phosphothreonine4 Publications
    Modified residuei458 – 4581Phosphothreonine1 Publication
    Modified residuei466 – 4661Phosphoserine2 Publications
    Modified residuei470 – 4701Phosphothreonine1 Publication
    Modified residuei566 – 5661Phosphoserine1 Publication
    Modified residuei766 – 7661Phosphoserine1 Publication
    Modified residuei902 – 9021Phosphoserine4 Publications
    Modified residuei903 – 9031Phosphoserine1 Publication
    Modified residuei966 – 9661Phosphoserine1 Publication
    Modified residuei1019 – 10191Phosphoserine4 Publications
    Modified residuei1096 – 10961Phosphoserine3 Publications
    Modified residuei1105 – 11051PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14C86.
    PaxDbiQ14C86.
    PRIDEiQ14C86.

    Miscellaneous databases

    PMAP-CutDBQ14C86.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14C86.
    BgeeiQ14C86.
    GenevestigatoriQ14C86.

    Organism-specific databases

    HPAiHPA029386.
    HPA029387.

    Interactioni

    Subunit structurei

    Interacts with TRIP10/CIP4 By similarity. Interacts with RAB5A.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi117568. 17 interactions.
    IntActiQ14C86. 4 interactions.
    MINTiMINT-1631145.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14C86.
    SMRiQ14C86. Positions 1263-1477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 353223Ras-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini1338 – 1478141VPS9PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GAPVD1 family.Curated
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
    Contains 1 VPS9 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275317.
    HOVERGENiHBG107936.
    OMAiEMVDSNE.
    PhylomeDBiQ14C86.
    TreeFamiTF105908.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    InterProiIPR001936. RasGAP.
    IPR008936. Rho_GTPase_activation_prot.
    IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    [Graphical view]
    PfamiPF00616. RasGAP. 1 hit.
    PF02204. VPS9. 1 hit.
    [Graphical view]
    SMARTiSM00167. VPS9. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51205. VPS9. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14C86-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ     50
    QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL 100
    SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL 150
    QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL 200
    HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS DRFRQKVQEM 250
    VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 300
    EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ 350
    LAMTGSEEGD PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE 400
    GLSRTVVYIT YSQLITLVNF MKSVMSGDQL REDRMALDNL LANLPPAKPG 450
    KSSSLEMTPY NTPQLSPATT PANKKNRLPI ATRSRSRTNM LMDLHMDHEG 500
    SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL SDGGQGDVPV 550
    DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 600
    AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET 650
    VSETWSTDVL GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD 700
    PCTGSTISET TSEAWSVEVL PSDSEAPDLK QEERLQELES CSGLGSTSDD 750
    TDVREVSSRP STPGLSVVSG ISATSEDIPN KIEDLRSECS SDFGGKDSVT 800
    SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV VRPKVHYARP 850
    SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS 900
    RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS 950
    PSKDSSRGET EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE 1000
    KDKDDLGPDR FSTLTDDPSP RLSAQAQVAE DILDKYRNAI KRTSPSDGAM 1050
    ANYESTGDNH DRDLSSKLLY HSDKEVMGDG ESAHDSPRDE ALQNISADDL 1100
    PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT HSTRNGLPDH 1150
    TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL 1200
    ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT 1250
    TVCVRLLLES KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV 1300
    IWQNASEEQL QDAQLAIERS VMNRIFKLAF YPNQDGDILR DQVLHEHIQR 1350
    LSKVVTANHR ALQIPEVYLR EAPWPSAQSE IRTISAYKTP RDKVQCILRM 1400
    CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS TVQYISSFYA 1450
    SCLSGEESYW WMQFTAAVEF IKTIDDRK 1478
    Length:1,478
    Mass (Da):164,980
    Last modified:March 18, 2008 - v2
    Checksum:iDD429B0EB207276C
    GO
    Isoform 2 (identifier: Q14C86-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1057-1074: Missing.

    Show »
    Length:1,460
    Mass (Da):162,898
    Checksum:iFC321A20FB94016F
    GO
    Isoform 3 (identifier: Q14C86-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         989-1015: Missing.
         1057-1074: Missing.

    Show »
    Length:1,433
    Mass (Da):159,755
    Checksum:iC0F51AB2B99F64A5
    GO
    Isoform 4 (identifier: Q14C86-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         557-577: Missing.
         1057-1074: Missing.

    Show »
    Length:1,439
    Mass (Da):160,606
    Checksum:iD4B3957383169E05
    GO
    Isoform 5 (identifier: Q14C86-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         810-835: Missing.

    Show »
    Length:1,452
    Mass (Da):162,231
    Checksum:iD139984862F731BB
    GO
    Isoform 6 (identifier: Q14C86-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         810-810: G → DFLYILQPKQHFQHIEAEADMRIQLSSS
         1057-1074: Missing.

    Show »
    Length:1,487
    Mass (Da):166,168
    Checksum:i9065582BC51473FB
    GO

    Sequence cautioni

    The sequence BAA90959.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH21119.1 differs from that shown. Reason: Frameshift at position 742.
    The sequence AAH21119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA90959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA96045.3 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti294 – 2941V → E in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti306 – 3061C → R in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti352 – 3521A → T in BAA90959. (PubMed:14702039)Curated
    Sequence conflicti366 – 3661S → C in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti419 – 4191N → D in BAA90959. (PubMed:14702039)Curated
    Sequence conflicti455 – 4551L → F in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti471 – 4711P → L in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti530 – 5301M → I in AAH21119. (PubMed:15489334)Curated
    Sequence conflicti532 – 5321E → G in BAA90959. (PubMed:14702039)Curated
    Sequence conflicti741 – 7411C → F in AAH21119. (PubMed:15489334)Curated
    Sequence conflicti902 – 9021S → G in BAA90959. (PubMed:14702039)Curated
    Sequence conflicti931 – 9311P → S in AAH13635. (PubMed:15489334)Curated
    Sequence conflicti1037 – 10371R → W in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti1162 – 11621L → S in ABB71126. (PubMed:16410077)Curated
    Sequence conflicti1425 – 14251V → L in ABB71126. (PubMed:16410077)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei557 – 57721Missing in isoform 4. 1 PublicationVSP_032358Add
    BLAST
    Alternative sequencei810 – 83526Missing in isoform 5. 1 PublicationVSP_032359Add
    BLAST
    Alternative sequencei810 – 8101G → DFLYILQPKQHFQHIEAEAD MRIQLSSS in isoform 6. 1 PublicationVSP_032360
    Alternative sequencei989 – 101527Missing in isoform 3. 1 PublicationVSP_032361Add
    BLAST
    Alternative sequencei1057 – 107418Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 3 PublicationsVSP_032362Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ233254 mRNA. Translation: ABB71126.1.
    AB040954 mRNA. Translation: BAA96045.3. Different initiation.
    AL627223, AL354710 Genomic DNA. Translation: CAH71014.2.
    AL627223, AL354710 Genomic DNA. Translation: CAO03611.1.
    AL354710, AL627223 Genomic DNA. Translation: CAQ08737.1.
    AL627223, AL354710 Genomic DNA. Translation: CAO03610.1.
    AL354710, AL627223 Genomic DNA. Translation: CAQ08735.1.
    AL354710, AL627223 Genomic DNA. Translation: CAQ08736.1.
    CH471090 Genomic DNA. Translation: EAW87622.1.
    CH471090 Genomic DNA. Translation: EAW87623.1.
    BC013635 mRNA. Translation: AAH13635.1.
    BC021119 mRNA. Translation: AAH21119.1. Sequence problems.
    BC114937 mRNA. Translation: AAI14938.1.
    BC114962 mRNA. Translation: AAI14963.1.
    AK000126 mRNA. Translation: BAA90959.1. Sequence problems.
    AL080196 mRNA. Translation: CAB45770.1.
    AL834325 mRNA. Translation: CAD38993.1.
    CCDSiCCDS35138.1. [Q14C86-6]
    CCDS65130.1. [Q14C86-4]
    CCDS65131.1. [Q14C86-2]
    CCDS65132.1. [Q14C86-1]
    PIRiT12506.
    RefSeqiNP_001269608.1. NM_001282679.1. [Q14C86-1]
    NP_001269609.1. NM_001282680.1. [Q14C86-2]
    NP_001269610.1. NM_001282681.1. [Q14C86-4]
    XP_005251958.1. XM_005251901.1. [Q14C86-2]
    XP_005251961.1. XM_005251904.1. [Q14C86-3]
    XP_006717105.1. XM_006717042.1. [Q14C86-2]
    XP_006717106.1. XM_006717043.1. [Q14C86-2]
    XP_006717107.1. XM_006717044.1. [Q14C86-4]
    UniGeneiHs.495134.

    Genome annotation databases

    EnsembliENST00000265956; ENSP00000265956; ENSG00000165219. [Q14C86-5]
    ENST00000297933; ENSP00000297933; ENSG00000165219. [Q14C86-2]
    ENST00000312123; ENSP00000309582; ENSG00000165219. [Q14C86-4]
    ENST00000394104; ENSP00000377664; ENSG00000165219. [Q14C86-1]
    ENST00000394105; ENSP00000377665; ENSG00000165219. [Q14C86-6]
    ENST00000470056; ENSP00000419767; ENSG00000165219. [Q14C86-3]
    ENST00000495955; ENSP00000419063; ENSG00000165219. [Q14C86-1]
    GeneIDi26130.
    KEGGihsa:26130.
    UCSCiuc004bpp.3. human. [Q14C86-6]
    uc004bpq.3. human. [Q14C86-2]
    uc004bpr.3. human. [Q14C86-4]
    uc004bps.3. human. [Q14C86-3]
    uc010mwx.3. human. [Q14C86-1]
    uc010mwy.1. human. [Q14C86-5]

    Polymorphism databases

    DMDMi172046859.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ233254 mRNA. Translation: ABB71126.1 .
    AB040954 mRNA. Translation: BAA96045.3 . Different initiation.
    AL627223 , AL354710 Genomic DNA. Translation: CAH71014.2 .
    AL627223 , AL354710 Genomic DNA. Translation: CAO03611.1 .
    AL354710 , AL627223 Genomic DNA. Translation: CAQ08737.1 .
    AL627223 , AL354710 Genomic DNA. Translation: CAO03610.1 .
    AL354710 , AL627223 Genomic DNA. Translation: CAQ08735.1 .
    AL354710 , AL627223 Genomic DNA. Translation: CAQ08736.1 .
    CH471090 Genomic DNA. Translation: EAW87622.1 .
    CH471090 Genomic DNA. Translation: EAW87623.1 .
    BC013635 mRNA. Translation: AAH13635.1 .
    BC021119 mRNA. Translation: AAH21119.1 . Sequence problems.
    BC114937 mRNA. Translation: AAI14938.1 .
    BC114962 mRNA. Translation: AAI14963.1 .
    AK000126 mRNA. Translation: BAA90959.1 . Sequence problems.
    AL080196 mRNA. Translation: CAB45770.1 .
    AL834325 mRNA. Translation: CAD38993.1 .
    CCDSi CCDS35138.1. [Q14C86-6 ]
    CCDS65130.1. [Q14C86-4 ]
    CCDS65131.1. [Q14C86-2 ]
    CCDS65132.1. [Q14C86-1 ]
    PIRi T12506.
    RefSeqi NP_001269608.1. NM_001282679.1. [Q14C86-1 ]
    NP_001269609.1. NM_001282680.1. [Q14C86-2 ]
    NP_001269610.1. NM_001282681.1. [Q14C86-4 ]
    XP_005251958.1. XM_005251901.1. [Q14C86-2 ]
    XP_005251961.1. XM_005251904.1. [Q14C86-3 ]
    XP_006717105.1. XM_006717042.1. [Q14C86-2 ]
    XP_006717106.1. XM_006717043.1. [Q14C86-2 ]
    XP_006717107.1. XM_006717044.1. [Q14C86-4 ]
    UniGenei Hs.495134.

    3D structure databases

    ProteinModelPortali Q14C86.
    SMRi Q14C86. Positions 1263-1477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117568. 17 interactions.
    IntActi Q14C86. 4 interactions.
    MINTi MINT-1631145.

    Polymorphism databases

    DMDMi 172046859.

    Proteomic databases

    MaxQBi Q14C86.
    PaxDbi Q14C86.
    PRIDEi Q14C86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265956 ; ENSP00000265956 ; ENSG00000165219 . [Q14C86-5 ]
    ENST00000297933 ; ENSP00000297933 ; ENSG00000165219 . [Q14C86-2 ]
    ENST00000312123 ; ENSP00000309582 ; ENSG00000165219 . [Q14C86-4 ]
    ENST00000394104 ; ENSP00000377664 ; ENSG00000165219 . [Q14C86-1 ]
    ENST00000394105 ; ENSP00000377665 ; ENSG00000165219 . [Q14C86-6 ]
    ENST00000470056 ; ENSP00000419767 ; ENSG00000165219 . [Q14C86-3 ]
    ENST00000495955 ; ENSP00000419063 ; ENSG00000165219 . [Q14C86-1 ]
    GeneIDi 26130.
    KEGGi hsa:26130.
    UCSCi uc004bpp.3. human. [Q14C86-6 ]
    uc004bpq.3. human. [Q14C86-2 ]
    uc004bpr.3. human. [Q14C86-4 ]
    uc004bps.3. human. [Q14C86-3 ]
    uc010mwx.3. human. [Q14C86-1 ]
    uc010mwy.1. human. [Q14C86-5 ]

    Organism-specific databases

    CTDi 26130.
    GeneCardsi GC09P128024.
    H-InvDB HIX0008383.
    HGNCi HGNC:23375. GAPVD1.
    HPAi HPA029386.
    HPA029387.
    MIMi 611714. gene.
    neXtProti NX_Q14C86.
    PharmGKBi PA142671748.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275317.
    HOVERGENi HBG107936.
    OMAi EMVDSNE.
    PhylomeDBi Q14C86.
    TreeFami TF105908.

    Miscellaneous databases

    ChiTaRSi GAPVD1. human.
    GeneWikii GAPVD1.
    GenomeRNAii 26130.
    NextBioi 48153.
    PMAP-CutDB Q14C86.
    PROi Q14C86.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14C86.
    Bgeei Q14C86.
    Genevestigatori Q14C86.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    InterProi IPR001936. RasGAP.
    IPR008936. Rho_GTPase_activation_prot.
    IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    [Graphical view ]
    Pfami PF00616. RasGAP. 1 hit.
    PF02204. VPS9. 1 hit.
    [Graphical view ]
    SMARTi SM00167. VPS9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51205. VPS9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis."
      Hunker C.M., Galvis A., Kruk I., Giambini H., Veisaga M.L., Barbieri M.A.
      Biochem. Biophys. Res. Commun. 340:967-975(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB5A.
    2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Placenta.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-996 (ISOFORM 5).
      Tissue: Colon.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 675-1478 (ISOFORM 6).
      Tissue: Testis.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; THR-458; SER-466; THR-470; SER-566; SER-902; SER-903; SER-1019 AND SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-766; SER-902 AND SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; SER-902; SER-966 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGAPD1_HUMAN
    AccessioniPrimary (citable) accession number: Q14C86
    Secondary accession number(s): A8MYK3
    , B0QZ62, B0QZ63, B0QZ64, Q14C76, Q2Q1W1, Q8ND92, Q8WU86, Q96CZ4, Q9NXQ1, Q9P207, Q9Y4N0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3