Reviewed, UniProtKB/Swiss-Prot Q14C86 (GAPD1_HUMAN)

Names and origin

Protein names

Recommended name:
    GTPase-activating protein and VPS9 domain-containing protein 1
Alternative name(s):
    Rab5-activating protein 6
    GAPex-5

Gene names

Name:	GAPVD1
Synonyms:	GAPEX5, KIAA1521, RAP6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. Ref.1
Subunit structure	Interacts with TRIP10/CIP4 By similarity. Interacts with RAB5A.
Subcellular location	Membrane; Peripheral membrane protein. Endosome. Note: Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin. Ref.1
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15
Sequence similarities	Belongs to the GAPVD1 family. Contains 1 Ras-GAP domain. Contains 1 VPS9 domain.
Sequence caution	The sequence AAH21119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH21119.1 differs from that shown. Reason: Frameshift at position 742. The sequence BAA90959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA90959.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Endosome Membrane
Coding sequence diversity	Alternative splicing
Molecular function	GTPase activation Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of protein transport Ref.1 Inferred from mutant phenotype. Source: UniProtKB regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Ref.1 Inferred from direct assay. Source: UniProtKB endosome Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTPase activating protein binding Ref.1 Inferred from mutant phenotype. Source: UniProtKB GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW guanyl-nucleotide exchange factor activity Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14C86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14C86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1057-1074: Missing.

Isoform 3 (identifier: Q14C86-3)

The sequence of this isoform differs from the canonical sequence as follows:
     989-1015: Missing.
     1057-1074: Missing.

Isoform 4 (identifier: Q14C86-4)

The sequence of this isoform differs from the canonical sequence as follows:
     557-577: Missing.
     1057-1074: Missing.

Isoform 5 (identifier: Q14C86-5)

The sequence of this isoform differs from the canonical sequence as follows:
     810-835: Missing.

Isoform 6 (identifier: Q14C86-6)

The sequence of this isoform differs from the canonical sequence as follows:
     810-810: G → DFLYILQPKQHFQHIEAEADMRIQLSSS
     1057-1074: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1478	1478	GTPase-activating protein and VPS9 domain-containing protein 1		PRO_0000324771
Regions
	Domain	131 – 353	223	Ras-GAP
	Domain	1338 – 1478	141	VPS9
Amino acid modifications
	Modified residue	390	1	Phosphothreonine Ref.10 Ref.14 Ref.15
	Modified residue	458	1	Phosphothreonine Ref.15
	Modified residue	466	1	Phosphoserine Ref.15
	Modified residue	470	1	Phosphothreonine Ref.15
	Modified residue	566	1	Phosphoserine Ref.15
	Modified residue	569	1	Phosphoserine Ref.13 Ref.15
	Modified residue	742	1	Phosphoserine Ref.9
	Modified residue	746	1	Phosphoserine Ref.9
	Modified residue	747	1	Phosphothreonine Ref.9 Ref.13
	Modified residue	748	1	Phosphoserine Ref.9
	Modified residue	900	1	Phosphoserine Ref.14
	Modified residue	902	1	Phosphoserine Ref.13 Ref.15
	Modified residue	903	1	Phosphoserine Ref.15
	Modified residue	966	1	Phosphoserine Ref.9
	Modified residue	1019	1	Phosphoserine Ref.14 Ref.15
	Modified residue	1096	1	Phosphoserine Ref.9 Ref.11 Ref.13 Ref.15
	Modified residue	1105	1	Phosphoserine Ref.12 Ref.15
Natural variations
	Alternative sequence	557 – 577	21	Missing in isoform 4.		VSP_032358
	Alternative sequence	810 – 835	26	Missing in isoform 5.		VSP_032359
	Alternative sequence	810	1	G → DFLYILQPKQHFQHIEAEAD MRIQLSSS in isoform 6.		VSP_032360
	Alternative sequence	989 – 1015	27	Missing in isoform 3.		VSP_032361
	Alternative sequence	1057 – 1074	18	Missing in isoform 2, isoform 3, isoform 4 and isoform 6.		VSP_032362
Experimental info
	Sequence conflict	294	1	V → E in ABB71126. Ref.1
	Sequence conflict	306	1	C → R in ABB71126. Ref.1
	Sequence conflict	352	1	A → T in BAA90959. Ref.7
	Sequence conflict	366	1	S → C in ABB71126. Ref.1
	Sequence conflict	419	1	N → D in BAA90959. Ref.7
	Sequence conflict	455	1	L → F in ABB71126. Ref.1
	Sequence conflict	471	1	P → L in ABB71126. Ref.1
	Sequence conflict	530	1	M → I in AAH21119. Ref.6
	Sequence conflict	532	1	E → G in BAA90959. Ref.7
	Sequence conflict	741	1	C → F in AAH21119. Ref.6
	Sequence conflict	902	1	S → G in BAA90959. Ref.7
	Sequence conflict	931	1	P → S in AAH13635. Ref.6
	Sequence conflict	1037	1	R → W in ABB71126. Ref.1
	Sequence conflict	1162	1	L → S in ABB71126. Ref.1
	Sequence conflict	1425	1	V → L in ABB71126. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: DD429B0EB207276C	FASTA	1,478	164,980
	10 20 30 40 50 60 MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII 70 80 90 100 110 120 TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL 130 140 150 160 170 180 NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI 190 200 210 220 230 240 LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS 250 260 270 280 290 300 DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 310 320 330 340 350 360 EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD 370 380 390 400 410 420 PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF 430 440 450 460 470 480 MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI 490 500 510 520 530 540 ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL 550 560 570 580 590 600 SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 610 620 630 640 650 660 AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL 670 680 690 700 710 720 GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL 730 740 750 760 770 780 PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN 790 800 810 820 830 840 KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV 850 860 870 880 890 900 VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS 910 920 930 940 950 960 RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET 970 980 990 1000 1010 1020 EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP 1030 1040 1050 1060 1070 1080 RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG 1090 1100 1110 1120 1130 1140 ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT 1150 1160 1170 1180 1190 1200 HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL 1210 1220 1230 1240 1250 1260 ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES 1270 1280 1290 1300 1310 1320 KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS 1330 1340 1350 1360 1370 1380 VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE 1390 1400 1410 1420 1430 1440 IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS 1450 1460 1470 TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
	Isoform 2. Checksum: FC321A20FB94016F	FASTA	1,460	162,898
	10 20 30 40 50 60 MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII 70 80 90 100 110 120 TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL 130 140 150 160 170 180 NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI 190 200 210 220 230 240 LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS 250 260 270 280 290 300 DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 310 320 330 340 350 360 EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD 370 380 390 400 410 420 PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF 430 440 450 460 470 480 MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI 490 500 510 520 530 540 ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL 550 560 570 580 590 600 SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 610 620 630 640 650 660 AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL 670 680 690 700 710 720 GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL 730 740 750 760 770 780 PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN 790 800 810 820 830 840 KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV 850 860 870 880 890 900 VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS 910 920 930 940 950 960 RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET 970 980 990 1000 1010 1020 EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP 1030 1040 1050 1060 1070 1080 RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTEVMG DGESAHDSPR DEALQNISAD 1090 1100 1110 1120 1130 1140 DLPDSASQAA HPQDSAFSYR DAKKKLRLAL CSADSVAFPV LTHSTRNGLP DHTDPEDNEI 1150 1160 1170 1180 1190 1200 VCFLKVQIAE AINLQDKNLM AQLQETMRCV CRFDNRTCRK LLASIAEDYR KRAPYIAYLT 1210 1220 1230 1240 1250 1260 RCRQGLQTTQ AHLERLLQRV LRDKEVANRY FTTVCVRLLL ESKEKKIREF IQDFQKLTAA 1270 1280 1290 1300 1310 1320 DDKTAQVEDF LQFLYGAMAQ DVIWQNASEE QLQDAQLAIE RSVMNRIFKL AFYPNQDGDI 1330 1340 1350 1360 1370 1380 LRDQVLHEHI QRLSKVVTAN HRALQIPEVY LREAPWPSAQ SEIRTISAYK TPRDKVQCIL 1390 1400 1410 1420 1430 1440 RMCSTIMNLL SLANEDSVPG ADDFVPVLVF VLIKANPPCL LSTVQYISSF YASCLSGEES 1450 1460 YWWMQFTAAV EFIKTIDDRK
	Isoform 3. Checksum: C0F51AB2B99F64A5	FASTA	1,433	159,755
	10 20 30 40 50 60 MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII 70 80 90 100 110 120 TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL 130 140 150 160 170 180 NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI 190 200 210 220 230 240 LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS 250 260 270 280 290 300 DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 310 320 330 340 350 360 EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD 370 380 390 400 410 420 PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF 430 440 450 460 470 480 MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI 490 500 510 520 530 540 ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL 550 560 570 580 590 600 SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 610 620 630 640 650 660 AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL 670 680 690 700 710 720 GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL 730 740 750 760 770 780 PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN 790 800 810 820 830 840 KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV 850 860 870 880 890 900 VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS 910 920 930 940 950 960 RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET 970 980 990 1000 1010 1020 EERKDSDDEK SDRNRPWWRK RFVSAMPKDD PSPRLSAQAQ VAEDILDKYR NAIKRTSPSD 1030 1040 1050 1060 1070 1080 GAMANYESTE VMGDGESAHD SPRDEALQNI SADDLPDSAS QAAHPQDSAF SYRDAKKKLR 1090 1100 1110 1120 1130 1140 LALCSADSVA FPVLTHSTRN GLPDHTDPED NEIVCFLKVQ IAEAINLQDK NLMAQLQETM 1150 1160 1170 1180 1190 1200 RCVCRFDNRT CRKLLASIAE DYRKRAPYIA YLTRCRQGLQ TTQAHLERLL QRVLRDKEVA 1210 1220 1230 1240 1250 1260 NRYFTTVCVR LLLESKEKKI REFIQDFQKL TAADDKTAQV EDFLQFLYGA MAQDVIWQNA 1270 1280 1290 1300 1310 1320 SEEQLQDAQL AIERSVMNRI FKLAFYPNQD GDILRDQVLH EHIQRLSKVV TANHRALQIP 1330 1340 1350 1360 1370 1380 EVYLREAPWP SAQSEIRTIS AYKTPRDKVQ CILRMCSTIM NLLSLANEDS VPGADDFVPV 1390 1400 1410 1420 1430 LVFVLIKANP PCLLSTVQYI SSFYASCLSG EESYWWMQFT AAVEFIKTID DRK
	Isoform 4. Checksum: D4B3957383169E05	FASTA	1,439	160,606
	10 20 30 40 50 60 MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII 70 80 90 100 110 120 TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL 130 140 150 160 170 180 NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI 190 200 210 220 230 240 LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS 250 260 270 280 290 300 DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 310 320 330 340 350 360 EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD 370 380 390 400 410 420 PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF 430 440 450 460 470 480 MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI 490 500 510 520 530 540 ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL 550 560 570 580 590 600 SDGGQGDVPV DENKLHGPSN RSNSVSSLDL EGESVSELGA GPSGSNGVEA LQLLEHEQAT 610 620 630 640 650 660 TQDNLDDKLR KFEIRDMMGL TDDRDISETV SETWSTDVLG SDFDPNIDED RLQEIAGAAA 670 680 690 700 710 720 ENMLGSLLCL PGSGSVLLDP CTGSTISETT SEAWSVEVLP SDSEAPDLKQ EERLQELESC 730 740 750 760 770 780 SGLGSTSDDT DVREVSSRPS TPGLSVVSGI SATSEDIPNK IEDLRSECSS DFGGKDSVTS 790 800 810 820 830 840 PDMDEITHGA HQLTSPPSQS ESLLAMFDPL SSHEGASAVV RPKVHYARPS HPPPDPPILE 850 860 870 880 890 900 GAVGGNEARL PNFGSHVLTP AEMEAFKQRH SYPERLVRSR SSDIVSSVRR PMSDPSWNRR 910 920 930 940 950 960 PGNEERELPP AAAIGATSLV AAPHSSSSSP SKDSSRGETE ERKDSDDEKS DRNRPWWRKR 970 980 990 1000 1010 1020 FVSAMPKAPI PFRKKEKQEK DKDDLGPDRF STLTDDPSPR LSAQAQVAED ILDKYRNAIK 1030 1040 1050 1060 1070 1080 RTSPSDGAMA NYESTEVMGD GESAHDSPRD EALQNISADD LPDSASQAAH PQDSAFSYRD 1090 1100 1110 1120 1130 1140 AKKKLRLALC SADSVAFPVL THSTRNGLPD HTDPEDNEIV CFLKVQIAEA INLQDKNLMA 1150 1160 1170 1180 1190 1200 QLQETMRCVC RFDNRTCRKL LASIAEDYRK RAPYIAYLTR CRQGLQTTQA HLERLLQRVL 1210 1220 1230 1240 1250 1260 RDKEVANRYF TTVCVRLLLE SKEKKIREFI QDFQKLTAAD DKTAQVEDFL QFLYGAMAQD 1270 1280 1290 1300 1310 1320 VIWQNASEEQ LQDAQLAIER SVMNRIFKLA FYPNQDGDIL RDQVLHEHIQ RLSKVVTANH 1330 1340 1350 1360 1370 1380 RALQIPEVYL REAPWPSAQS EIRTISAYKT PRDKVQCILR MCSTIMNLLS LANEDSVPGA 1390 1400 1410 1420 1430 DDFVPVLVFV LIKANPPCLL STVQYISSFY ASCLSGEESY WWMQFTAAVE FIKTIDDRK
	Isoform 5. Checksum: D139984862F731BB	FASTA	1,452	162,231
	10 20 30 40 50 60 MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII 70 80 90 100 110 120 TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL 130 140 150 160 170 180 NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI 190 200 210 220 230 240 LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS 250 260 270 280 290 300 DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 310 320 330 340 350 360 EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD 370 380 390 400 410 420 PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF 430 440 450 460 470 480 MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI 490 500 510 520 530 540 ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL 550 560 570 580 590 600 SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 610 620 630 640 650 660 AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL 670 680 690 700 710 720 GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL 730 740 750 760 770 780 PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN 790 800 810 820 830 840 KIEDLRSECS SDFGGKDSVT SPDMDEITHG ASAVVRPKVH YARPSHPPPD PPILEGAVGG 850 860 870 880 890 900 NEARLPNFGS HVLTPAEMEA FKQRHSYPER LVRSRSSDIV SSVRRPMSDP SWNRRPGNEE 910 920 930 940 950 960 RELPPAAAIG ATSLVAAPHS SSSSPSKDSS RGETEERKDS DDEKSDRNRP WWRKRFVSAM 970 980 990 1000 1010 1020 PKAPIPFRKK EKQEKDKDDL GPDRFSTLTD DPSPRLSAQA QVAEDILDKY RNAIKRTSPS 1030 1040 1050 1060 1070 1080 DGAMANYEST GDNHDRDLSS KLLYHSDKEV MGDGESAHDS PRDEALQNIS ADDLPDSASQ 1090 1100 1110 1120 1130 1140 AAHPQDSAFS YRDAKKKLRL ALCSADSVAF PVLTHSTRNG LPDHTDPEDN EIVCFLKVQI 1150 1160 1170 1180 1190 1200 AEAINLQDKN LMAQLQETMR CVCRFDNRTC RKLLASIAED YRKRAPYIAY LTRCRQGLQT 1210 1220 1230 1240 1250 1260 TQAHLERLLQ RVLRDKEVAN RYFTTVCVRL LLESKEKKIR EFIQDFQKLT AADDKTAQVE 1270 1280 1290 1300 1310 1320 DFLQFLYGAM AQDVIWQNAS EEQLQDAQLA IERSVMNRIF KLAFYPNQDG DILRDQVLHE 1330 1340 1350 1360 1370 1380 HIQRLSKVVT ANHRALQIPE VYLREAPWPS AQSEIRTISA YKTPRDKVQC ILRMCSTIMN 1390 1400 1410 1420 1430 1440 LLSLANEDSV PGADDFVPVL VFVLIKANPP CLLSTVQYIS SFYASCLSGE ESYWWMQFTA 1450 AVEFIKTIDD RK
	Isoform 6. Checksum: 9065582BC51473FB	FASTA	1,487	166,168
	10 20 30 40 50 60 MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII 70 80 90 100 110 120 TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL 130 140 150 160 170 180 NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI 190 200 210 220 230 240 LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS 250 260 270 280 290 300 DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 310 320 330 340 350 360 EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD 370 380 390 400 410 420 PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF 430 440 450 460 470 480 MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI 490 500 510 520 530 540 ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL 550 560 570 580 590 600 SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 610 620 630 640 650 660 AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL 670 680 690 700 710 720 GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL 730 740 750 760 770 780 PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN 790 800 810 820 830 840 KIEDLRSECS SDFGGKDSVT SPDMDEITHD FLYILQPKQH FQHIEAEADM RIQLSSSAHQ 850 860 870 880 890 900 LTSPPSQSES LLAMFDPLSS HEGASAVVRP KVHYARPSHP PPDPPILEGA VGGNEARLPN 910 920 930 940 950 960 FGSHVLTPAE MEAFKQRHSY PERLVRSRSS DIVSSVRRPM SDPSWNRRPG NEERELPPAA 970 980 990 1000 1010 1020 AIGATSLVAA PHSSSSSPSK DSSRGETEER KDSDDEKSDR NRPWWRKRFV SAMPKAPIPF 1030 1040 1050 1060 1070 1080 RKKEKQEKDK DDLGPDRFST LTDDPSPRLS AQAQVAEDIL DKYRNAIKRT SPSDGAMANY 1090 1100 1110 1120 1130 1140 ESTEVMGDGE SAHDSPRDEA LQNISADDLP DSASQAAHPQ DSAFSYRDAK KKLRLALCSA 1150 1160 1170 1180 1190 1200 DSVAFPVLTH STRNGLPDHT DPEDNEIVCF LKVQIAEAIN LQDKNLMAQL QETMRCVCRF 1210 1220 1230 1240 1250 1260 DNRTCRKLLA SIAEDYRKRA PYIAYLTRCR QGLQTTQAHL ERLLQRVLRD KEVANRYFTT 1270 1280 1290 1300 1310 1320 VCVRLLLESK EKKIREFIQD FQKLTAADDK TAQVEDFLQF LYGAMAQDVI WQNASEEQLQ 1330 1340 1350 1360 1370 1380 DAQLAIERSV MNRIFKLAFY PNQDGDILRD QVLHEHIQRL SKVVTANHRA LQIPEVYLRE 1390 1400 1410 1420 1430 1440 APWPSAQSEI RTISAYKTPR DKVQCILRMC STIMNLLSLA NEDSVPGADD FVPVLVFVLI 1450 1460 1470 1480 KANPPCLLST VQYISSFYAS CLSGEESYWW MQFTAAVEFI KTIDDRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis." Hunker C.M., Galvis A., Kruk I., Giambini H., Veisaga M.L., Barbieri M.A. Biochem. Biophys. Res. Commun. 340:967-975(2006) [PubMed: 16410077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB5A.
[2]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Placenta.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-996 (ISOFORM 5). Tissue: Colon.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 675-1478 (ISOFORM 6). Tissue: Testis.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742; SER-746; THR-747; SER-748; SER-966 AND SER-1096, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390, MASS SPECTROMETRY. Tissue: Epithelium.
[11]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1096, MASS SPECTROMETRY. Tissue: Epithelium.
[12]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1105, MASS SPECTROMETRY.
[13]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-569; THR-747; SER-902 AND SER-1096, MASS SPECTROMETRY.
[14]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; SER-900 AND SER-1019, MASS SPECTROMETRY.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; THR-458; SER-466; THR-470; SER-566; SER-569; SER-902; SER-903; SER-1019; SER-1096 AND SER-1105, MASS SPECTROMETRY.
[16]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ233254 mRNA. Translation: ABB71126.1. AB040954 mRNA. Translation: BAA96045.3. Different initiation. AL354710 Genomic DNA. No translation available. AL627223 Genomic DNA. No translation available. CH471090 Genomic DNA. Translation: EAW87622.1. CH471090 Genomic DNA. Translation: EAW87623.1. BC013635 mRNA. Translation: AAH13635.1. BC021119 mRNA. Translation: AAH21119.1. Sequence problems. BC114937 mRNA. Translation: AAI14938.1. BC114962 mRNA. Translation: AAI14963.1. AK000126 mRNA. Translation: BAA90959.1. Sequence problems. AL080196 mRNA. Translation: CAB45770.1. AL834325 mRNA. Translation: CAD38993.1.
IPI	IPI00292753. IPI00302156. IPI00852719. IPI00873087. IPI00883910. IPI00888069.
PIR	T12506.
RefSeq	NP_056450.2.
UniGene	Hs.495134
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14C86. 3 interactions.
Proteomic databases
PRIDE	Q14C86.
Genome annotation databases
Ensembl	ENSG00000165219. Homo sapiens. [Contig view]
GeneID	26130.
KEGG	hsa:26130.
Organism-specific databases
GeneCards	GC09P127063.
HGNC	HGNC:23375. GAPVD1.
MIM	611714. gene.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q14C86.
OMA	Q14C86. EMVDSNE.
Gene expression databases
ArrayExpress	Q14C86.
Bgee	Q14C86.
Family and domain databases
InterPro	IPR001936. RasGAP. IPR003123. VPS9. IPR013995. VPS9_sub. [Graphical view]
Pfam	PF00616. RasGAP. 1 hit. PF02204. VPS9. 1 hit. [Graphical view]
SMART	SM00167. VPS9. 1 hit. [Graphical view]
PROSITE	PS00509. RAS_GTPASE_ACTIV_1. False negative. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. PS51205. VPS9. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48153.
PMAP-CutDB	Q14C86.
SOURCE	Search...

Entry information

Entry name

GAPD1_HUMAN

Accession

Primary (citable) accession number: Q14C86
Secondary accession number(s): A8MYK3 , Q14C76, Q2Q1W1, Q8ND92, Q8WU86, Q96CZ4, Q9NXQ1, Q9P207, Q9Y4N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	June 16, 2009
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)