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Q14C86

- GAPD1_HUMAN

UniProt

Q14C86 - GAPD1_HUMAN

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Protein

GTPase-activating protein and VPS9 domain-containing protein 1

Gene

GAPVD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.1 Publication

GO - Molecular functioni

  1. GTPase activating protein binding Source: UniProtKB
  2. GTPase activator activity Source: UniProtKB-KW
  3. guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
  2. positive regulation of GTPase activity Source: GOC
  3. regulation of protein transport Source: UniProtKB
  4. regulation of small GTPase mediated signal transduction Source: InterPro
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating protein and VPS9 domain-containing protein 1
Alternative name(s):
GAPex-5
Rab5-activating protein 6
Gene namesi
Name:GAPVD1
Synonyms:GAPEX5, KIAA1521, RAP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23375. GAPVD1.

Subcellular locationi

Membrane 1 Publication; Peripheral membrane protein 1 Publication. Endosome 1 Publication
Note: Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endosome Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671748.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14781478GTPase-activating protein and VPS9 domain-containing protein 1PRO_0000324771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei390 – 3901Phosphothreonine4 Publications
Modified residuei458 – 4581Phosphothreonine1 Publication
Modified residuei466 – 4661Phosphoserine2 Publications
Modified residuei470 – 4701Phosphothreonine1 Publication
Modified residuei566 – 5661Phosphoserine1 Publication
Modified residuei766 – 7661Phosphoserine1 Publication
Modified residuei902 – 9021Phosphoserine4 Publications
Modified residuei903 – 9031Phosphoserine1 Publication
Modified residuei966 – 9661Phosphoserine1 Publication
Modified residuei1019 – 10191Phosphoserine4 Publications
Modified residuei1096 – 10961Phosphoserine3 Publications
Modified residuei1105 – 11051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14C86.
PaxDbiQ14C86.
PRIDEiQ14C86.

Miscellaneous databases

PMAP-CutDBQ14C86.

Expressioni

Gene expression databases

BgeeiQ14C86.
ExpressionAtlasiQ14C86. baseline and differential.
GenevestigatoriQ14C86.

Organism-specific databases

HPAiHPA029386.
HPA029387.

Interactioni

Subunit structurei

Interacts with TRIP10/CIP4 (By similarity). Interacts with RAB5A.By similarity1 Publication

Protein-protein interaction databases

BioGridi117568. 22 interactions.
IntActiQ14C86. 5 interactions.
MINTiMINT-1631145.

Structurei

3D structure databases

ProteinModelPortaliQ14C86.
SMRiQ14C86. Positions 1263-1477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 353223Ras-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini1338 – 1478141VPS9PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GAPVD1 family.Curated
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
Contains 1 VPS9 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG275317.
GeneTreeiENSGT00530000063341.
HOVERGENiHBG107936.
InParanoidiQ14C86.
OMAiEMVDSNE.
PhylomeDBiQ14C86.
TreeFamiTF105908.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
InterProiIPR001936. RasGAP.
IPR008936. Rho_GTPase_activation_prot.
IPR003123. VPS9.
IPR013995. VPS9_subgr.
[Graphical view]
PfamiPF00616. RasGAP. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view]
SMARTiSM00167. VPS9. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51205. VPS9. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14C86-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ
60 70 80 90 100
QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL
110 120 130 140 150
SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL
160 170 180 190 200
QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL
210 220 230 240 250
HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS DRFRQKVQEM
260 270 280 290 300
VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ
360 370 380 390 400
LAMTGSEEGD PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE
410 420 430 440 450
GLSRTVVYIT YSQLITLVNF MKSVMSGDQL REDRMALDNL LANLPPAKPG
460 470 480 490 500
KSSSLEMTPY NTPQLSPATT PANKKNRLPI ATRSRSRTNM LMDLHMDHEG
510 520 530 540 550
SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL SDGGQGDVPV
560 570 580 590 600
DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET
660 670 680 690 700
VSETWSTDVL GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD
710 720 730 740 750
PCTGSTISET TSEAWSVEVL PSDSEAPDLK QEERLQELES CSGLGSTSDD
760 770 780 790 800
TDVREVSSRP STPGLSVVSG ISATSEDIPN KIEDLRSECS SDFGGKDSVT
810 820 830 840 850
SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV VRPKVHYARP
860 870 880 890 900
SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS
960 970 980 990 1000
PSKDSSRGET EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE
1010 1020 1030 1040 1050
KDKDDLGPDR FSTLTDDPSP RLSAQAQVAE DILDKYRNAI KRTSPSDGAM
1060 1070 1080 1090 1100
ANYESTGDNH DRDLSSKLLY HSDKEVMGDG ESAHDSPRDE ALQNISADDL
1110 1120 1130 1140 1150
PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT HSTRNGLPDH
1160 1170 1180 1190 1200
TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT
1260 1270 1280 1290 1300
TVCVRLLLES KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV
1310 1320 1330 1340 1350
IWQNASEEQL QDAQLAIERS VMNRIFKLAF YPNQDGDILR DQVLHEHIQR
1360 1370 1380 1390 1400
LSKVVTANHR ALQIPEVYLR EAPWPSAQSE IRTISAYKTP RDKVQCILRM
1410 1420 1430 1440 1450
CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS TVQYISSFYA
1460 1470
SCLSGEESYW WMQFTAAVEF IKTIDDRK
Length:1,478
Mass (Da):164,980
Last modified:March 18, 2008 - v2
Checksum:iDD429B0EB207276C
GO
Isoform 2 (identifier: Q14C86-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1057-1074: Missing.

Show »
Length:1,460
Mass (Da):162,898
Checksum:iFC321A20FB94016F
GO
Isoform 3 (identifier: Q14C86-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1015: Missing.
     1057-1074: Missing.

Show »
Length:1,433
Mass (Da):159,755
Checksum:iC0F51AB2B99F64A5
GO
Isoform 4 (identifier: Q14C86-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-577: Missing.
     1057-1074: Missing.

Show »
Length:1,439
Mass (Da):160,606
Checksum:iD4B3957383169E05
GO
Isoform 5 (identifier: Q14C86-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-835: Missing.

Show »
Length:1,452
Mass (Da):162,231
Checksum:iD139984862F731BB
GO
Isoform 6 (identifier: Q14C86-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-810: G → DFLYILQPKQHFQHIEAEADMRIQLSSS
     1057-1074: Missing.

Show »
Length:1,487
Mass (Da):166,168
Checksum:i9065582BC51473FB
GO

Sequence cautioni

The sequence AAH21119.1 differs from that shown. Reason: Frameshift at position 742. Curated
The sequence AAH21119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90959.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA90959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA96045.3 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti294 – 2941V → E in ABB71126. (PubMed:16410077)Curated
Sequence conflicti306 – 3061C → R in ABB71126. (PubMed:16410077)Curated
Sequence conflicti352 – 3521A → T in BAA90959. (PubMed:14702039)Curated
Sequence conflicti366 – 3661S → C in ABB71126. (PubMed:16410077)Curated
Sequence conflicti419 – 4191N → D in BAA90959. (PubMed:14702039)Curated
Sequence conflicti455 – 4551L → F in ABB71126. (PubMed:16410077)Curated
Sequence conflicti471 – 4711P → L in ABB71126. (PubMed:16410077)Curated
Sequence conflicti530 – 5301M → I in AAH21119. (PubMed:15489334)Curated
Sequence conflicti532 – 5321E → G in BAA90959. (PubMed:14702039)Curated
Sequence conflicti741 – 7411C → F in AAH21119. (PubMed:15489334)Curated
Sequence conflicti902 – 9021S → G in BAA90959. (PubMed:14702039)Curated
Sequence conflicti931 – 9311P → S in AAH13635. (PubMed:15489334)Curated
Sequence conflicti1037 – 10371R → W in ABB71126. (PubMed:16410077)Curated
Sequence conflicti1162 – 11621L → S in ABB71126. (PubMed:16410077)Curated
Sequence conflicti1425 – 14251V → L in ABB71126. (PubMed:16410077)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei557 – 57721Missing in isoform 4. 1 PublicationVSP_032358Add
BLAST
Alternative sequencei810 – 83526Missing in isoform 5. 1 PublicationVSP_032359Add
BLAST
Alternative sequencei810 – 8101G → DFLYILQPKQHFQHIEAEAD MRIQLSSS in isoform 6. 1 PublicationVSP_032360
Alternative sequencei989 – 101527Missing in isoform 3. 1 PublicationVSP_032361Add
BLAST
Alternative sequencei1057 – 107418Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 3 PublicationsVSP_032362Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ233254 mRNA. Translation: ABB71126.1.
AB040954 mRNA. Translation: BAA96045.3. Different initiation.
AL627223, AL354710 Genomic DNA. Translation: CAH71014.2.
AL627223, AL354710 Genomic DNA. Translation: CAO03611.1.
AL354710, AL627223 Genomic DNA. Translation: CAQ08737.1.
AL627223, AL354710 Genomic DNA. Translation: CAO03610.1.
AL354710, AL627223 Genomic DNA. Translation: CAQ08735.1.
AL354710, AL627223 Genomic DNA. Translation: CAQ08736.1.
CH471090 Genomic DNA. Translation: EAW87622.1.
CH471090 Genomic DNA. Translation: EAW87623.1.
BC013635 mRNA. Translation: AAH13635.1.
BC021119 mRNA. Translation: AAH21119.1. Sequence problems.
BC114937 mRNA. Translation: AAI14938.1.
BC114962 mRNA. Translation: AAI14963.1.
AK000126 mRNA. Translation: BAA90959.1. Sequence problems.
AL080196 mRNA. Translation: CAB45770.1.
AL834325 mRNA. Translation: CAD38993.1.
CCDSiCCDS65130.1. [Q14C86-4]
CCDS65131.1. [Q14C86-2]
CCDS65132.1. [Q14C86-1]
PIRiT12506.
RefSeqiNP_001269608.1. NM_001282679.1. [Q14C86-1]
NP_001269609.1. NM_001282680.1. [Q14C86-2]
NP_001269610.1. NM_001282681.1. [Q14C86-4]
NP_056450.2. NM_015635.3. [Q14C86-6]
XP_005251958.1. XM_005251901.1. [Q14C86-2]
XP_005251961.1. XM_005251904.1. [Q14C86-3]
XP_006717105.1. XM_006717042.1. [Q14C86-2]
XP_006717106.1. XM_006717043.1. [Q14C86-2]
XP_006717107.1. XM_006717044.1. [Q14C86-4]
UniGeneiHs.495134.

Genome annotation databases

EnsembliENST00000297933; ENSP00000297933; ENSG00000165219. [Q14C86-2]
ENST00000312123; ENSP00000309582; ENSG00000165219. [Q14C86-4]
ENST00000394104; ENSP00000377664; ENSG00000165219. [Q14C86-1]
ENST00000394105; ENSP00000377665; ENSG00000165219. [Q14C86-6]
ENST00000470056; ENSP00000419767; ENSG00000165219. [Q14C86-3]
ENST00000495955; ENSP00000419063; ENSG00000165219. [Q14C86-1]
GeneIDi26130.
KEGGihsa:26130.
UCSCiuc004bpp.3. human. [Q14C86-6]
uc004bpq.3. human. [Q14C86-2]
uc004bpr.3. human. [Q14C86-4]
uc004bps.3. human. [Q14C86-3]
uc010mwx.3. human. [Q14C86-1]
uc010mwy.1. human. [Q14C86-5]

Polymorphism databases

DMDMi172046859.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ233254 mRNA. Translation: ABB71126.1 .
AB040954 mRNA. Translation: BAA96045.3 . Different initiation.
AL627223 , AL354710 Genomic DNA. Translation: CAH71014.2 .
AL627223 , AL354710 Genomic DNA. Translation: CAO03611.1 .
AL354710 , AL627223 Genomic DNA. Translation: CAQ08737.1 .
AL627223 , AL354710 Genomic DNA. Translation: CAO03610.1 .
AL354710 , AL627223 Genomic DNA. Translation: CAQ08735.1 .
AL354710 , AL627223 Genomic DNA. Translation: CAQ08736.1 .
CH471090 Genomic DNA. Translation: EAW87622.1 .
CH471090 Genomic DNA. Translation: EAW87623.1 .
BC013635 mRNA. Translation: AAH13635.1 .
BC021119 mRNA. Translation: AAH21119.1 . Sequence problems.
BC114937 mRNA. Translation: AAI14938.1 .
BC114962 mRNA. Translation: AAI14963.1 .
AK000126 mRNA. Translation: BAA90959.1 . Sequence problems.
AL080196 mRNA. Translation: CAB45770.1 .
AL834325 mRNA. Translation: CAD38993.1 .
CCDSi CCDS65130.1. [Q14C86-4 ]
CCDS65131.1. [Q14C86-2 ]
CCDS65132.1. [Q14C86-1 ]
PIRi T12506.
RefSeqi NP_001269608.1. NM_001282679.1. [Q14C86-1 ]
NP_001269609.1. NM_001282680.1. [Q14C86-2 ]
NP_001269610.1. NM_001282681.1. [Q14C86-4 ]
NP_056450.2. NM_015635.3. [Q14C86-6 ]
XP_005251958.1. XM_005251901.1. [Q14C86-2 ]
XP_005251961.1. XM_005251904.1. [Q14C86-3 ]
XP_006717105.1. XM_006717042.1. [Q14C86-2 ]
XP_006717106.1. XM_006717043.1. [Q14C86-2 ]
XP_006717107.1. XM_006717044.1. [Q14C86-4 ]
UniGenei Hs.495134.

3D structure databases

ProteinModelPortali Q14C86.
SMRi Q14C86. Positions 1263-1477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117568. 22 interactions.
IntActi Q14C86. 5 interactions.
MINTi MINT-1631145.

Polymorphism databases

DMDMi 172046859.

Proteomic databases

MaxQBi Q14C86.
PaxDbi Q14C86.
PRIDEi Q14C86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297933 ; ENSP00000297933 ; ENSG00000165219 . [Q14C86-2 ]
ENST00000312123 ; ENSP00000309582 ; ENSG00000165219 . [Q14C86-4 ]
ENST00000394104 ; ENSP00000377664 ; ENSG00000165219 . [Q14C86-1 ]
ENST00000394105 ; ENSP00000377665 ; ENSG00000165219 . [Q14C86-6 ]
ENST00000470056 ; ENSP00000419767 ; ENSG00000165219 . [Q14C86-3 ]
ENST00000495955 ; ENSP00000419063 ; ENSG00000165219 . [Q14C86-1 ]
GeneIDi 26130.
KEGGi hsa:26130.
UCSCi uc004bpp.3. human. [Q14C86-6 ]
uc004bpq.3. human. [Q14C86-2 ]
uc004bpr.3. human. [Q14C86-4 ]
uc004bps.3. human. [Q14C86-3 ]
uc010mwx.3. human. [Q14C86-1 ]
uc010mwy.1. human. [Q14C86-5 ]

Organism-specific databases

CTDi 26130.
GeneCardsi GC09P128024.
H-InvDB HIX0008383.
HGNCi HGNC:23375. GAPVD1.
HPAi HPA029386.
HPA029387.
MIMi 611714. gene.
neXtProti NX_Q14C86.
PharmGKBi PA142671748.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275317.
GeneTreei ENSGT00530000063341.
HOVERGENi HBG107936.
InParanoidi Q14C86.
OMAi EMVDSNE.
PhylomeDBi Q14C86.
TreeFami TF105908.

Miscellaneous databases

ChiTaRSi GAPVD1. human.
GeneWikii GAPVD1.
GenomeRNAii 26130.
NextBioi 48153.
PMAP-CutDB Q14C86.
PROi Q14C86.
SOURCEi Search...

Gene expression databases

Bgeei Q14C86.
ExpressionAtlasi Q14C86. baseline and differential.
Genevestigatori Q14C86.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
InterProi IPR001936. RasGAP.
IPR008936. Rho_GTPase_activation_prot.
IPR003123. VPS9.
IPR013995. VPS9_subgr.
[Graphical view ]
Pfami PF00616. RasGAP. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view ]
SMARTi SM00167. VPS9. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51205. VPS9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis."
    Hunker C.M., Galvis A., Kruk I., Giambini H., Veisaga M.L., Barbieri M.A.
    Biochem. Biophys. Res. Commun. 340:967-975(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB5A.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Placenta.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-996 (ISOFORM 5).
    Tissue: Colon.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 675-1478 (ISOFORM 6).
    Tissue: Testis.
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; THR-458; SER-466; THR-470; SER-566; SER-902; SER-903; SER-1019 AND SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-766; SER-902 AND SER-1096, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390; SER-902; SER-966 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGAPD1_HUMAN
AccessioniPrimary (citable) accession number: Q14C86
Secondary accession number(s): A8MYK3
, B0QZ62, B0QZ63, B0QZ64, Q14C76, Q2Q1W1, Q8ND92, Q8WU86, Q96CZ4, Q9NXQ1, Q9P207, Q9Y4N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 26, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3