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Protein

Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Gene

Ptcd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial RNA-binding protein that has a role in mitochondrial translation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
Alternative name(s):
28S ribosomal protein S39, mitochondrial
Short name:
MRP-S39
Gene namesi
Name:Ptcd3
Synonyms:Mrps39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917206. Ptcd3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 10MitochondrionSequence analysis10
ChainiPRO_000030502911 – 685Pentatricopeptide repeat domain-containing protein 3, mitochondrialAdd BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ14C51.
MaxQBiQ14C51.
PaxDbiQ14C51.
PeptideAtlasiQ14C51.
PRIDEiQ14C51.

PTM databases

iPTMnetiQ14C51.
PhosphoSitePlusiQ14C51.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063884.
CleanExiMM_PTCD3.
ExpressionAtlasiQ14C51. baseline and differential.
GenevisibleiQ14C51. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Associated with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).By similarity

Protein-protein interaction databases

BioGridi213775. 1 interactor.
STRINGi10090.ENSMUSP00000080743.

Structurei

3D structure databases

ProteinModelPortaliQ14C51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati150 – 184PPR 1Add BLAST35
Repeati185 – 220PPR 2Add BLAST36
Repeati254 – 288PPR 3Add BLAST35
Repeati289 – 329PPR 4Add BLAST41
Repeati330 – 366PPR 5Add BLAST37
Repeati367 – 407PPR 6Add BLAST41
Repeati412 – 446PPR 7Add BLAST35
Repeati454 – 488PPR 8Add BLAST35
Repeati489 – 523PPR 9Add BLAST35
Repeati572 – 606PPR 10Add BLAST35

Sequence similaritiesi

Belongs to the PTCD3 family.Curated
Contains 10 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4422. Eukaryota.
ENOG410XNQS. LUCA.
GeneTreeiENSGT00390000016876.
HOVERGENiHBG068809.
InParanoidiQ14C51.
KOiK17659.
OMAiAPHYKYH.
OrthoDBiEOG091G03F0.
PhylomeDBiQ14C51.
TreeFamiTF320158.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
[Graphical view]
PfamiPF13041. PPR_2. 1 hit.
PF13812. PPR_3. 1 hit.
[Graphical view]
PROSITEiPS51375. PPR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14C51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVAARR LSFRSGLVLL QTTRGTGVCE PKVCCRFYAG TESLPKVEGS
60 70 80 90 100
DITGIEEIVI PKKKTWDKVA VLQALASTVN RDPTAAPYVF HDDPYLIPTS
110 120 130 140 150
ALESRSFLLA KKSGETAAKF IINSYPKYFQ KDIAEPHIPC LMPEYFEPQI
160 170 180 190 200
EDVSEAALEE RIRLRKVRAS VDMFDQLLQA GTTVSLETTN SLLDLLCYYG
210 220 230 240 250
DQEPPADYPF QQTEHLENLE EAAEENNQTS KMESGPWKAQ NNAERIFALM
260 270 280 290 300
PEKNARSYCT MIRGMVKHRA YAQALNVYTE LLNNRLSADV YTFNALIEAK
310 320 330 340 350
TFILNEKFEE KWNDILDLLK HMVAQKVKPN LQTFNTILKG LRKCYSLGRI
360 370 380 390 400
PALQILREMK HIGIEPSLAT YHHIIHLFYP RDLSAIKMPS LIIYDIMNEL
410 420 430 440 450
EGRTFSPQDL DDGRFFQLAM SVCSSLRDLE LAYQVHRLLN TGDNRKLVGH
460 470 480 490 500
DPLRKVYYSK FFSLICSLEQ IDVTLKWYKD LIPSVFLPHY QIFIGLLQAL
510 520 530 540 550
DVANRLELVP QIWKDSKEYS HTFRDALREE VLMLMARDKH PPELQVAFAD
560 570 580 590 600
CAADIKSTYE DQSARQPAFD WPANPLQYIA VLFLRGGRSQ EAWKMLELFK
610 620 630 640 650
KHKKIPRNEL LEEFMDTAKA SGSTALAIEV VKLASAFSLP IGESLAQRVV
660 670 680
MDFTVDPEQK EALGNLTELN SSDGESSSDS DSDDK
Length:685
Mass (Da):77,796
Last modified:October 2, 2007 - v2
Checksum:i10BD1C0ACC348BAE
GO

Sequence cautioni

The sequence BAB28668 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279T → A in AAI15435 (PubMed:15489334).Curated1
Sequence conflicti563S → G in AAI15435 (PubMed:15489334).Curated1
Sequence conflicti589S → T in AAI15435 (PubMed:15489334).Curated1
Sequence conflicti603K → N in AAI15435 (PubMed:15489334).Curated1
Sequence conflicti605I → T in BAE26826 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013131 mRNA. Translation: BAB28668.1. Different initiation.
AK146005 mRNA. Translation: BAE26826.1.
BC060687 mRNA. Translation: AAH60687.1.
BC084595 mRNA. Translation: AAH84595.1.
BC115434 mRNA. Translation: AAI15435.1.
CCDSiCCDS20235.1.
RefSeqiNP_081551.2. NM_027275.3.
UniGeneiMm.30256.

Genome annotation databases

EnsembliENSMUST00000082094; ENSMUSP00000080743; ENSMUSG00000063884.
GeneIDi69956.
KEGGimmu:69956.
UCSCiuc009chq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013131 mRNA. Translation: BAB28668.1. Different initiation.
AK146005 mRNA. Translation: BAE26826.1.
BC060687 mRNA. Translation: AAH60687.1.
BC084595 mRNA. Translation: AAH84595.1.
BC115434 mRNA. Translation: AAI15435.1.
CCDSiCCDS20235.1.
RefSeqiNP_081551.2. NM_027275.3.
UniGeneiMm.30256.

3D structure databases

ProteinModelPortaliQ14C51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213775. 1 interactor.
STRINGi10090.ENSMUSP00000080743.

PTM databases

iPTMnetiQ14C51.
PhosphoSitePlusiQ14C51.

Proteomic databases

EPDiQ14C51.
MaxQBiQ14C51.
PaxDbiQ14C51.
PeptideAtlasiQ14C51.
PRIDEiQ14C51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082094; ENSMUSP00000080743; ENSMUSG00000063884.
GeneIDi69956.
KEGGimmu:69956.
UCSCiuc009chq.1. mouse.

Organism-specific databases

CTDi55037.
MGIiMGI:1917206. Ptcd3.

Phylogenomic databases

eggNOGiKOG4422. Eukaryota.
ENOG410XNQS. LUCA.
GeneTreeiENSGT00390000016876.
HOVERGENiHBG068809.
InParanoidiQ14C51.
KOiK17659.
OMAiAPHYKYH.
OrthoDBiEOG091G03F0.
PhylomeDBiQ14C51.
TreeFamiTF320158.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ14C51.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063884.
CleanExiMM_PTCD3.
ExpressionAtlasiQ14C51. baseline and differential.
GenevisibleiQ14C51. MM.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
[Graphical view]
PfamiPF13041. PPR_2. 1 hit.
PF13812. PPR_3. 1 hit.
[Graphical view]
PROSITEiPS51375. PPR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTCD3_MOUSE
AccessioniPrimary (citable) accession number: Q14C51
Secondary accession number(s): Q3UKH5
, Q5XG65, Q6P9N5, Q9CZ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.