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Protein

Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Gene

Ptcd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial RNA-binding protein that has a role in mitochondrial translation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
Alternative name(s):
28S ribosomal protein S39, mitochondrial
Short name:
MRP-S39
Gene namesi
Name:Ptcd3
Synonyms:Mrps39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917206. Ptcd3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1010MitochondrionSequence analysis
Chaini11 – 685675Pentatricopeptide repeat domain-containing protein 3, mitochondrialPRO_0000305029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ14C51.
MaxQBiQ14C51.
PaxDbiQ14C51.
PeptideAtlasiQ14C51.
PRIDEiQ14C51.

PTM databases

iPTMnetiQ14C51.
PhosphoSiteiQ14C51.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063884.
CleanExiMM_PTCD3.
GenevisibleiQ14C51. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Associated with the 12S mitochondrial rRNA (12S mt-rRNA) (By similarity).By similarity

Protein-protein interaction databases

BioGridi213775. 1 interaction.
STRINGi10090.ENSMUSP00000080743.

Structurei

3D structure databases

ProteinModelPortaliQ14C51.
SMRiQ14C51. Positions 257-375, 587-638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati150 – 18435PPR 1Add
BLAST
Repeati185 – 22036PPR 2Add
BLAST
Repeati254 – 28835PPR 3Add
BLAST
Repeati289 – 32941PPR 4Add
BLAST
Repeati330 – 36637PPR 5Add
BLAST
Repeati367 – 40741PPR 6Add
BLAST
Repeati412 – 44635PPR 7Add
BLAST
Repeati454 – 48835PPR 8Add
BLAST
Repeati489 – 52335PPR 9Add
BLAST
Repeati572 – 60635PPR 10Add
BLAST

Sequence similaritiesi

Belongs to the PTCD3 family.Curated
Contains 10 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4422. Eukaryota.
ENOG410XNQS. LUCA.
GeneTreeiENSGT00390000016876.
HOVERGENiHBG068809.
InParanoidiQ14C51.
KOiK17659.
OMAiAPHYKYH.
OrthoDBiEOG091G03F0.
PhylomeDBiQ14C51.
TreeFamiTF320158.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
[Graphical view]
PfamiPF13041. PPR_2. 1 hit.
PF13812. PPR_3. 1 hit.
[Graphical view]
PROSITEiPS51375. PPR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14C51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVAARR LSFRSGLVLL QTTRGTGVCE PKVCCRFYAG TESLPKVEGS
60 70 80 90 100
DITGIEEIVI PKKKTWDKVA VLQALASTVN RDPTAAPYVF HDDPYLIPTS
110 120 130 140 150
ALESRSFLLA KKSGETAAKF IINSYPKYFQ KDIAEPHIPC LMPEYFEPQI
160 170 180 190 200
EDVSEAALEE RIRLRKVRAS VDMFDQLLQA GTTVSLETTN SLLDLLCYYG
210 220 230 240 250
DQEPPADYPF QQTEHLENLE EAAEENNQTS KMESGPWKAQ NNAERIFALM
260 270 280 290 300
PEKNARSYCT MIRGMVKHRA YAQALNVYTE LLNNRLSADV YTFNALIEAK
310 320 330 340 350
TFILNEKFEE KWNDILDLLK HMVAQKVKPN LQTFNTILKG LRKCYSLGRI
360 370 380 390 400
PALQILREMK HIGIEPSLAT YHHIIHLFYP RDLSAIKMPS LIIYDIMNEL
410 420 430 440 450
EGRTFSPQDL DDGRFFQLAM SVCSSLRDLE LAYQVHRLLN TGDNRKLVGH
460 470 480 490 500
DPLRKVYYSK FFSLICSLEQ IDVTLKWYKD LIPSVFLPHY QIFIGLLQAL
510 520 530 540 550
DVANRLELVP QIWKDSKEYS HTFRDALREE VLMLMARDKH PPELQVAFAD
560 570 580 590 600
CAADIKSTYE DQSARQPAFD WPANPLQYIA VLFLRGGRSQ EAWKMLELFK
610 620 630 640 650
KHKKIPRNEL LEEFMDTAKA SGSTALAIEV VKLASAFSLP IGESLAQRVV
660 670 680
MDFTVDPEQK EALGNLTELN SSDGESSSDS DSDDK
Length:685
Mass (Da):77,796
Last modified:October 2, 2007 - v2
Checksum:i10BD1C0ACC348BAE
GO

Sequence cautioni

The sequence BAB28668 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791T → A in AAI15435 (PubMed:15489334).Curated
Sequence conflicti563 – 5631S → G in AAI15435 (PubMed:15489334).Curated
Sequence conflicti589 – 5891S → T in AAI15435 (PubMed:15489334).Curated
Sequence conflicti603 – 6031K → N in AAI15435 (PubMed:15489334).Curated
Sequence conflicti605 – 6051I → T in BAE26826 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013131 mRNA. Translation: BAB28668.1. Different initiation.
AK146005 mRNA. Translation: BAE26826.1.
BC060687 mRNA. Translation: AAH60687.1.
BC084595 mRNA. Translation: AAH84595.1.
BC115434 mRNA. Translation: AAI15435.1.
CCDSiCCDS20235.1.
RefSeqiNP_081551.2. NM_027275.3.
UniGeneiMm.30256.

Genome annotation databases

EnsembliENSMUST00000082094; ENSMUSP00000080743; ENSMUSG00000063884.
GeneIDi69956.
KEGGimmu:69956.
UCSCiuc009chq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013131 mRNA. Translation: BAB28668.1. Different initiation.
AK146005 mRNA. Translation: BAE26826.1.
BC060687 mRNA. Translation: AAH60687.1.
BC084595 mRNA. Translation: AAH84595.1.
BC115434 mRNA. Translation: AAI15435.1.
CCDSiCCDS20235.1.
RefSeqiNP_081551.2. NM_027275.3.
UniGeneiMm.30256.

3D structure databases

ProteinModelPortaliQ14C51.
SMRiQ14C51. Positions 257-375, 587-638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213775. 1 interaction.
STRINGi10090.ENSMUSP00000080743.

PTM databases

iPTMnetiQ14C51.
PhosphoSiteiQ14C51.

Proteomic databases

EPDiQ14C51.
MaxQBiQ14C51.
PaxDbiQ14C51.
PeptideAtlasiQ14C51.
PRIDEiQ14C51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082094; ENSMUSP00000080743; ENSMUSG00000063884.
GeneIDi69956.
KEGGimmu:69956.
UCSCiuc009chq.1. mouse.

Organism-specific databases

CTDi55037.
MGIiMGI:1917206. Ptcd3.

Phylogenomic databases

eggNOGiKOG4422. Eukaryota.
ENOG410XNQS. LUCA.
GeneTreeiENSGT00390000016876.
HOVERGENiHBG068809.
InParanoidiQ14C51.
KOiK17659.
OMAiAPHYKYH.
OrthoDBiEOG091G03F0.
PhylomeDBiQ14C51.
TreeFamiTF320158.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ14C51.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063884.
CleanExiMM_PTCD3.
GenevisibleiQ14C51. MM.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
[Graphical view]
PfamiPF13041. PPR_2. 1 hit.
PF13812. PPR_3. 1 hit.
[Graphical view]
PROSITEiPS51375. PPR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTCD3_MOUSE
AccessioniPrimary (citable) accession number: Q14C51
Secondary accession number(s): Q3UKH5
, Q5XG65, Q6P9N5, Q9CZ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.