ID   Q14C42_MOUSE            Unreviewed;       260 AA.
AC   Q14C42;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   24-JAN-2024, entry version 114.
DE   RecName: Full=Voltage-dependent calcium channel gamma-6 subunit {ECO:0000256|RuleBase:RU363085};
GN   Name=Cacng6 {ECO:0000313|EMBL:AAI15458.1,
GN   ECO:0000313|MGI:MGI:1859168};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI15458.1};
RN   [1] {ECO:0000313|EMBL:AAI15458.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI15458.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC       contain CACNA1C as pore-forming subunit.
CC       {ECO:0000256|RuleBase:RU363085}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU363085}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU363085}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR   EMBL; BC115457; AAI15458.1; -; mRNA.
DR   RefSeq; NP_573446.1; NM_133183.2.
DR   AlphaFoldDB; Q14C42; -.
DR   SMR; Q14C42; -.
DR   Antibodypedia; 32772; 130 antibodies from 19 providers.
DR   DNASU; 54378; -.
DR   GeneID; 54378; -.
DR   KEGG; mmu:54378; -.
DR   AGR; MGI:1859168; -.
DR   CTD; 59285; -.
DR   MGI; MGI:1859168; Cacng6.
DR   VEuPathDB; HostDB:ENSMUSG00000078815; -.
DR   OMA; PWQRCLP; -.
DR   OrthoDB; 4230292at2759; -.
DR   PhylomeDB; Q14C42; -.
DR   BioGRID-ORCS; 54378; 3 hits in 76 CRISPR screens.
DR   ExpressionAtlas; Q14C42; baseline and differential.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008370; VDCC_g6su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   PANTHER; PTHR15025; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED; 1.
DR   PANTHER; PTHR15025:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT; 1.
DR   Pfam; PF13903; Claudin_2; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01794; VDCCGAMMA6.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU363085};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|RuleBase:RU363085};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU363085};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU363085};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU363085}; Membrane {ECO:0000256|RuleBase:RU363085};
KW   Transmembrane {ECO:0000256|RuleBase:RU363085};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363085};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU363085}.
FT   TRANSMEM        41..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   TRANSMEM        139..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   TRANSMEM        217..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
SQ   SEQUENCE   260 AA;  28145 MW;  583C326BE6D88C80 CRC64;
     MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA TLAVLAVGTE
     FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR ETCGPAELPG EANCTYFKFF
     TTGENARIFQ RTTKKEVNLA AAVIAVLGLT AMALGCLCVI MVLSKGAESL LRLGAVCFGL
     SGLLLFVSLE VFRHSVGALL QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL
     LTLPSWPWRS LCPKWGGPTA
//