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Protein

Multifunctional fusion protein

Gene

Cacng6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to stabilize the calcium channel in an inactivated (closed) state.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Voltage-dependent calcium channel gamma subunitUniRule annotation
Voltage-dependent calcium channel gamma-6 subunitUniRule annotation
Gene namesi
Name:Cacng6Imported
ORF Names:mCG_118262Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1859168. Cacng6.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 63HelicalUniRule annotationAdd BLAST23
Transmembranei139 – 163HelicalUniRule annotationAdd BLAST25
Transmembranei170 – 189HelicalUniRule annotationAdd BLAST20
Transmembranei217 – 241HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000078815.
ExpressionAtlasiQ14C42. baseline and differential.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IWHM. Eukaryota.
ENOG4111I1Z. LUCA.
HOVERGENiHBG003868.
KOiK04871.
OMAiGEANCTY.
OrthoDBiEOG091G0HUO.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR008370. VDCC_g6su.
IPR008368. VDCC_gsu.
PfamiView protein in Pfam
PF13903. Claudin_2. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01794. VDCCGAMMA6.

Sequencei

Sequence statusi: Complete.

Q14C42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA
60 70 80 90 100
TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR
110 120 130 140 150
ETCGPAELPG EANCTYFKFF TTGENARIFQ RTTKKEVNLA AAVIAVLGLT
160 170 180 190 200
AMALGCLCVI MVLSKGAESL LRLGAVCFGL SGLLLFVSLE VFRHSVGALL
210 220 230 240 250
QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS
260
LCPKWGGPTA
Length:260
Mass (Da):28,145
Last modified:August 22, 2006 - v1
Checksum:i583C326BE6D88C80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115457 mRNA. Translation: AAI15458.1.
CH466627 Genomic DNA. Translation: EDL31180.1.
RefSeqiNP_573446.1. NM_133183.2.
UniGeneiMm.424047.
Mm.463590.

Genome annotation databases

GeneIDi54378.
KEGGimmu:54378.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ14C42_MOUSE
AccessioniPrimary (citable) accession number: Q14C42
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)