UniProtKB - Q14C42 (Q14C42_MOUSE)
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Protein
Multifunctional fusion protein
Gene
Cacng6
Organism
Mus musculus (Mouse)
Status
Functioni
Thought to stabilize the calcium channel in an inactivated (closed) state.UniRule annotation
GO - Molecular functioni
- calcium channel activity Source: UniProtKB-KW
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Multifunctional fusion proteinUniRule annotationIncluding the following 2 domains: Voltage-dependent calcium channel gamma subunitUniRule annotation Voltage-dependent calcium channel gamma-6 subunitUniRule annotation |
Gene namesi | Name:Cacng6Imported ORF Names:mCG_118262Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1859168. Cacng6. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 63 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 139 – 163 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 170 – 189 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 217 – 241 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneInteractioni
Subunit structurei
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.UniRule annotation
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationSAAS annotationPhylogenomic databases
eggNOGi | ENOG410IWHM. Eukaryota. ENOG4111I1Z. LUCA. |
HOVERGENi | HBG003868. |
KOi | K04871. |
OMAi | GEANCTY. |
OrthoDBi | EOG091G0HUO. |
Family and domain databases
InterProi | View protein in InterPro IPR004031. PMP22/EMP/MP20/Claudin. IPR008370. VDCC_g6su. IPR008368. VDCC_gsu. |
Pfami | View protein in Pfam PF13903. Claudin_2. 1 hit. |
PRINTSi | PR01792. VDCCGAMMA. PR01794. VDCCGAMMA6. |
i Sequence
Sequence statusi: Complete.
Q14C42-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMWSNFFMQE EDRRRTAVGR RRAQEQQNLG LTPEREGKIK LGLLVAIVGA
60 70 80 90 100
TLAVLAVGTE FWVELNTYKT NGSAVCEAAH LGLWKVCIKR LWQADVPAGR
110 120 130 140 150
ETCGPAELPG EANCTYFKFF TTGENARIFQ RTTKKEVNLA AAVIAVLGLT
160 170 180 190 200
AMALGCLCVI MVLSKGAESL LRLGAVCFGL SGLLLFVSLE VFRHSVGALL
210 220 230 240 250
QGVNPETPPA PRLAYEYSWS LGCGVGAGLI LLLGGVCFLL LTLPSWPWRS
260
LCPKWGGPTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC115457 mRNA. Translation: AAI15458.1. CH466627 Genomic DNA. Translation: EDL31180.1. |
RefSeqi | NP_573446.1. NM_133183.2. |
UniGenei | Mm.424047. Mm.463590. |
Genome annotation databases
GeneIDi | 54378. |
KEGGi | mmu:54378. |
Similar proteinsi
Entry informationi
Entry namei | Q14C42_MOUSE | |
Accessioni | Q14C42Primary (citable) accession number: Q14C42 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 22, 2006 |
Last sequence update: | August 22, 2006 | |
Last modified: | March 28, 2018 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |