UniProtKB - Q14BW6 (Q14BW6_MOUSE)
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Protein
Deoxyribonuclease
Gene
Dnase1
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 100 | UniRule annotation | 1 | |
Active sitei | 156 | UniRule annotation | 1 |
GO - Molecular functioni
- deoxyribonuclease I activity Source: Ensembl
GO - Biological processi
- DNA catabolic process Source: InterPro
Keywordsi
Molecular function | EndonucleaseUniRule annotation, Hydrolase, Nuclease |
Names & Taxonomyi
Protein namesi | Recommended name: DeoxyribonucleaseUniRule annotation |
Gene namesi | Name:Dnase1Imported ORF Names:mCG_126170Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:103157 Dnase1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014306910 | 23 – 284 | DeoxyribonucleaseSequence analysisAdd BLAST | 262 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 123 ↔ 126 | UniRule annotation | ||
Disulfide bondi | 195 ↔ 231 | Essential for enzymatic activityUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 274 | Endo/exonuclease/phosphataseInterPro annotationAdd BLAST | 231 |
Sequence similaritiesi
Belongs to the DNase I family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | ENOG410IHHA Eukaryota ENOG410ZR9A LUCA |
HOVERGENi | HBG051368 |
KOi | K11994 |
OMAi | RYLFVFR |
OrthoDBi | EOG091G0I0B |
Family and domain databases
Gene3Di | 3.60.10.101 hit |
InterProi | View protein in InterPro IPR018057 Deoxyribonuclease-1_AS IPR016202 DNase_I IPR033125 DNASE_I_2 IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase |
Pfami | View protein in Pfam PF03372 Exo_endo_phos, 1 hit |
PIRSFi | PIRSF000988 DNase_I_euk, 1 hit |
PRINTSi | PR00130 DNASEI |
SMARTi | View protein in SMART SM00476 DNaseIc, 1 hit |
SUPFAMi | SSF56219 SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS00919 DNASE_I_1, 1 hit PS00918 DNASE_I_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q14BW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI
60 70 80 90 100
LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE
110 120 130 140 150
QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF
160 170 180 190 200
AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS
210 220 230 240 250
SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN
260 270 280
SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC115571 mRNA Translation: AAI15572.1 CH466521 Genomic DNA Translation: EDK97220.1 CH466521 Genomic DNA Translation: EDK97221.1 CH466521 Genomic DNA Translation: EDK97222.1 |
RefSeqi | NP_034191.3, NM_010061.5 XP_006521837.1, XM_006521774.3 XP_006521838.1, XM_006521775.3 XP_006521839.1, XM_006521776.3 |
UniGenei | Mm.291048 Mm.440565 |
Genome annotation databases
GeneIDi | 13419 |
KEGGi | mmu:13419 |
Similar proteinsi
Entry informationi
Entry namei | Q14BW6_MOUSE | |
Accessioni | Q14BW6Primary (citable) accession number: Q14BW6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 22, 2006 |
Last sequence update: | August 22, 2006 | |
Last modified: | April 25, 2018 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |