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Protein

Deoxyribonuclease

Gene

Dnase1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100UniRule annotation1
Active sitei156UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
DeoxyribonucleaseUniRule annotation
Gene namesi
Name:Dnase1Imported
ORF Names:mCG_126170Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103157. Dnase1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501013445823 – 284DeoxyribonucleaseSequence analysisAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 126UniRule annotation
Disulfide bondi195 ↔ 231Essential for enzymatic activityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

MaxQBiQ14BW6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005980.
ExpressionAtlasiQ14BW6. baseline and differential.

Structurei

3D structure databases

SMRiQ14BW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 274Endo/exonuclease/phosphataseInterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the DNase I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IHHA. Eukaryota.
ENOG410ZR9A. LUCA.
HOVERGENiHBG051368.
KOiK11994.
OMAiRYLFVFR.
OrthoDBiEOG091G0I0B.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiView protein in InterPro
IPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR033125. DNASE_I_2.
IPR005135. Endo/exonuclease/phosphatase.
PfamiView protein in Pfam
PF03372. Exo_endo_phos. 1 hit.
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiView protein in SMART
SM00476. DNaseIc. 1 hit.
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiView protein in PROSITE
PS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14BW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI
60 70 80 90 100
LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE
110 120 130 140 150
QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF
160 170 180 190 200
AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS
210 220 230 240 250
SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN
260 270 280
SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI
Length:284
Mass (Da):32,027
Last modified:August 22, 2006 - v1
Checksum:i8682E20515EEB510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115571 mRNA. Translation: AAI15572.1.
CH466521 Genomic DNA. Translation: EDK97220.1.
CH466521 Genomic DNA. Translation: EDK97221.1.
CH466521 Genomic DNA. Translation: EDK97222.1.
RefSeqiNP_034191.3. NM_010061.5.
XP_006521837.1. XM_006521774.3.
XP_006521838.1. XM_006521775.3.
XP_006521839.1. XM_006521776.3.
UniGeneiMm.291048.
Mm.440565.

Genome annotation databases

GeneIDi13419.
KEGGimmu:13419.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ14BW6_MOUSE
AccessioniPrimary (citable) accession number: Q14BW6
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: July 5, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)