Dnase1

Functionⁱ

Sites

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Active siteⁱ	100 – 100	1	UniRule annotation Automatic assertion according to rulesⁱ PIRSR:PIRSR000988-1
Active siteⁱ	156 – 156	1	UniRule annotation Automatic assertion according to rulesⁱ PIRSR:PIRSR000988-1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DeoxyribonucleaseUniRule annotation Automatic assertion according to rulesⁱ PIRNR:PIRNR000988
Gene namesⁱ	Name:Dnase1Imported Automatic assertion inferred from database entriesⁱ EMBL:AAI15572.1 MGI:103157 ORF Names:mCG_126170Imported Automatic assertion inferred from database entriesⁱ EMBL:EDK97220.1
Organismⁱ	Mus musculus (Mouse)Imported Automatic assertion inferred from database entriesⁱ EMBL:AAI15572.1
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103157. Dnase1.

Subcellular locationⁱ

GO - Cellular componentⁱ

extracellular exosome Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Signal peptideⁱ	1 – 22	22	Sequence analysis Automatic assertion according to rulesⁱ SAM:SignalP			Add BLAST
Chainⁱ	23 – 284	262	DeoxyribonucleaseSequence analysis Automatic assertion according to rulesⁱ SAM:SignalP		PRO_5007922996	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Disulfide bondⁱ	123 ↔ 126		UniRule annotation Automatic assertion according to rulesⁱ PIRSR:PIRSR000988-2
Disulfide bondⁱ	195 ↔ 231		Essential for enzymatic activityUniRule annotation Automatic assertion according to rulesⁱ PIRSR:PIRSR000988-2

Keywords - PTMⁱ

Disulfide bondUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005980.

Bgeeⁱ

ENSMUSG00000005980.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000006136.

STRINGⁱ

10090.ENSMUSP00000006136.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	47 – 274	228	Endo/exonuclease/phosphataseInterPro annotation Automatic assertion inferred from signature matchⁱ Pfam:PF03372			Add BLAST

Sequence similaritiesⁱ

Belongs to the DNase I family.UniRule annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IHHA. Eukaryota. ENOG410ZR9A. LUCA.
GeneTreeⁱ	ENSGT00390000013146.
HOVERGENⁱ	HBG051368.
KOⁱ	K11994.
OMAⁱ	TSTHCAY.
OrthoDBⁱ	EOG091G0I0B.

Family and domain databases

Gene3Dⁱ	3.60.10.10. 1 hit.
InterProⁱ	IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I. IPR033125. DNASE_I_2. IPR005135. Endo/exonuclease/phosphatase. [Graphical view]
PANTHERⁱ	PTHR11371. PTHR11371. 1 hit.
Pfamⁱ	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000988. DNase_I_euk. 1 hit.
PRINTSⁱ	PR00130. DNASEI.
SMARTⁱ	SM00476. DNaseIc. 1 hit. [Graphical view]
SUPFAMⁱ	SSF56219. SSF56219. 1 hit.
PROSITEⁱ	PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q14BW6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI 
        60         70         80         90        100
LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE 
       110        120        130        140        150
QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF 
       160        170        180        190        200
AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS 
       210        220        230        240        250
SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN 
       260        270        280 
SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI

Length:284

Mass (Da):32,027

Last modified:August 22, 2006 - v1

Checksum:ⁱ8682E20515EEB510

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC115571 mRNA. Translation: AAI15572.1. CH466521 Genomic DNA. Translation: EDK97220.1. CH466521 Genomic DNA. Translation: EDK97221.1. CH466521 Genomic DNA. Translation: EDK97222.1.
RefSeqⁱ	NP_034191.3. NM_010061.5. XP_006521837.1. XM_006521774.2. XP_006521838.1. XM_006521775.2. XP_006521839.1. XM_006521776.2.
UniGeneⁱ	Mm.291048. Mm.440565.

Genome annotation databases

GeneIDⁱ	13419.
KEGGⁱ	mmu:13419.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC115571 mRNA. Translation: AAI15572.1. CH466521 Genomic DNA. Translation: EDK97220.1. CH466521 Genomic DNA. Translation: EDK97221.1. CH466521 Genomic DNA. Translation: EDK97222.1.
RefSeqⁱ	NP_034191.3. NM_010061.5. XP_006521837.1. XM_006521774.2. XP_006521838.1. XM_006521775.2. XP_006521839.1. XM_006521776.2.
UniGeneⁱ	Mm.291048. Mm.440565.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000006136.

STRINGⁱ

10090.ENSMUSP00000006136.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	13419.
KEGGⁱ	mmu:13419.

Organism-specific databases

CTDⁱ	1773.
MGIⁱ	MGI:103157. Dnase1.

Phylogenomic databases

eggNOGⁱ	ENOG410IHHA. Eukaryota. ENOG410ZR9A. LUCA.
GeneTreeⁱ	ENSGT00390000013146.
HOVERGENⁱ	HBG051368.
KOⁱ	K11994.
OMAⁱ	TSTHCAY.
OrthoDBⁱ	EOG091G0I0B.

Miscellaneous databases

ChiTaRSⁱ	Dnase1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005980.

Bgeeⁱ

ENSMUSG00000005980.

Family and domain databases

Gene3Dⁱ	3.60.10.10. 1 hit.
InterProⁱ	IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I. IPR033125. DNASE_I_2. IPR005135. Endo/exonuclease/phosphatase. [Graphical view]
PANTHERⁱ	PTHR11371. PTHR11371. 1 hit.
Pfamⁱ	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000988. DNase_I_euk. 1 hit.
PRINTSⁱ	PR00130. DNASEI.
SMARTⁱ	SM00476. DNaseIc. 1 hit. [Graphical view]
SUPFAMⁱ	SSF56219. SSF56219. 1 hit.
PROSITEⁱ	PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

Q14BW6_MOUSE

Accessionⁱ

Primary (citable) accession number: Q14BW6

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Proteomics identificationCombined sources

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14BW6 (Q14BW6_MOUSE)

UniProt

Q14BW6 - Q14BW6_MOUSE

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Deoxyribonuclease

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ