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Protein

Deoxyribonuclease

Gene

Dnase1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100UniRule annotation1
Active sitei156UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
DeoxyribonucleaseUniRule annotation
Gene namesi
Name:Dnase1Imported
ORF Names:mCG_126170Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103157 Dnase1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501430691023 – 284DeoxyribonucleaseSequence analysisAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 126UniRule annotation
Disulfide bondi195 ↔ 231Essential for enzymatic activityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000005980

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 274Endo/exonuclease/phosphataseInterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the DNase I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IHHA Eukaryota
ENOG410ZR9A LUCA
HOVERGENiHBG051368
KOiK11994
OMAiRYLFVFR
OrthoDBiEOG091G0I0B

Family and domain databases

Gene3Di3.60.10.101 hit
InterProiView protein in InterPro
IPR018057 Deoxyribonuclease-1_AS
IPR016202 DNase_I
IPR033125 DNASE_I_2
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PIRSFiPIRSF000988 DNase_I_euk, 1 hit
PRINTSiPR00130 DNASEI
SMARTiView protein in SMART
SM00476 DNaseIc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919 DNASE_I_1, 1 hit
PS00918 DNASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14BW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI
60 70 80 90 100
LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE
110 120 130 140 150
QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF
160 170 180 190 200
AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS
210 220 230 240 250
SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN
260 270 280
SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI
Length:284
Mass (Da):32,027
Last modified:August 22, 2006 - v1
Checksum:i8682E20515EEB510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115571 mRNA Translation: AAI15572.1
CH466521 Genomic DNA Translation: EDK97220.1
CH466521 Genomic DNA Translation: EDK97221.1
CH466521 Genomic DNA Translation: EDK97222.1
RefSeqiNP_034191.3, NM_010061.5
XP_006521837.1, XM_006521774.3
XP_006521838.1, XM_006521775.3
XP_006521839.1, XM_006521776.3
UniGeneiMm.291048
Mm.440565

Genome annotation databases

GeneIDi13419
KEGGimmu:13419

Similar proteinsi

Entry informationi

Entry nameiQ14BW6_MOUSE
AccessioniPrimary (citable) accession number: Q14BW6
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)