Dnase1

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	100	UniRule annotation		1
Active siteⁱ	156	UniRule annotation		1

GO - Molecular functionⁱ

deoxyribonuclease I activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA catabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	EndonucleaseUniRule annotation, Hydrolase, Nuclease

Molecular function

EndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DeoxyribonucleaseUniRule annotation
Gene namesⁱ	Name:Dnase1Imported ORF Names:mCG_126170Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103157 Dnase1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_5014306910	23 – 284	DeoxyribonucleaseSequence analysisAdd BLAST		262

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	123 ↔ 126	UniRule annotation
Disulfide bondⁱ	195 ↔ 231	Essential for enzymatic activityUniRule annotation

Keywords - PTMⁱ

Disulfide bondUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005980

Bgeeⁱ

ENSMUSG00000005980

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 274	Endo/exonuclease/phosphataseInterPro annotationAdd BLAST		231

Sequence similaritiesⁱ

Belongs to the DNase I family.UniRule annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IHHA Eukaryota ENOG410ZR9A LUCA
HOVERGENⁱ	HBG051368
KEGG Orthology (KO) More...KOⁱ	K11994
OMAⁱ	RYLFVFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B

Family and domain databases

Gene3Dⁱ	3.60.10.101 hit
InterProⁱ	View protein in InterPro IPR018057 Deoxyribonuclease-1_AS IPR016202 DNase_I IPR033125 DNASE_I_2 IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit
PIRSFⁱ	PIRSF000988 DNase_I_euk, 1 hit
PRINTSⁱ	PR00130 DNASEI
SMARTⁱ	View protein in SMART SM00476 DNaseIc, 1 hit
SUPFAMⁱ	SSF56219 SSF56219, 1 hit
PROSITEⁱ	View protein in PROSITE PS00919 DNASE_I_1, 1 hit PS00918 DNASE_I_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q14BW6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI 
        60         70         80         90        100
LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE 
       110        120        130        140        150
QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF 
       160        170        180        190        200
AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS 
       210        220        230        240        250
SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN 
       260        270        280 
SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI

Length:284

Mass (Da):32,027

Last modified:August 22, 2006 - v1

Checksum:ⁱ8682E20515EEB510

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC115571 mRNA Translation: AAI15572.1 CH466521 Genomic DNA Translation: EDK97220.1 CH466521 Genomic DNA Translation: EDK97221.1 CH466521 Genomic DNA Translation: EDK97222.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034191.3, NM_010061.5 XP_006521837.1, XM_006521774.3 XP_006521838.1, XM_006521775.3 XP_006521839.1, XM_006521776.3
UniGeneⁱ	Mm.291048 Mm.440565

Genome annotation databases

GeneIDⁱ	13419
KEGGⁱ	mmu:13419

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q14BW6	P49183 Q712W5 E9Q797 D3YXC7	Mus musculus (Mouse)	284	UniRef100_P49183	Cluster: Deoxyribonuclease-1	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q14BW6	P49183 Q712W5 E9Q797 D3YXC7 P21704 Q91WL7 UPI000A30E626 UPI000A318881 Q14BW7	Mus musculus (Mouse) Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse)	284	UniRef90_P49183	Cluster: Deoxyribonuclease-1	10

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q14BW6	Q92874-2 UPI000C9E08C1 UPI0004BD9194 M3YV93 UPI0006529FD4 M1ENH1 A0A2J8Q5B6 UPI0008F546A6 I3LLH8 UPI00063C69A1 +173	Equus caballus (Horse) Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii) Mustela putorius furo (European domestic ferret) (Mustela furo) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Sus scrofa (Pig) Odobenus rosmarus divergens (Pacific walrus) Dipodomys ordii (Ord's kangaroo rat) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Hipposideros armiger (great roundleaf bat) And more	278	UniRef50_Q92874-2	Cluster: Isoform 2 of Deoxyribonuclease-1-like 2	184

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC115571 mRNA Translation: AAI15572.1 CH466521 Genomic DNA Translation: EDK97220.1 CH466521 Genomic DNA Translation: EDK97221.1 CH466521 Genomic DNA Translation: EDK97222.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034191.3, NM_010061.5 XP_006521837.1, XM_006521774.3 XP_006521838.1, XM_006521775.3 XP_006521839.1, XM_006521776.3
UniGeneⁱ	Mm.291048 Mm.440565

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	13419
KEGGⁱ	mmu:13419

Organism-specific databases

CTDⁱ	1773
MGIⁱ	MGI:103157 Dnase1

Phylogenomic databases

eggNOGⁱ	ENOG410IHHA Eukaryota ENOG410ZR9A LUCA
HOVERGENⁱ	HBG051368
KEGG Orthology (KO) More...KOⁱ	K11994
OMAⁱ	RYLFVFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B

Miscellaneous databases

ChiTaRSⁱ	Dnase1 mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005980

Bgeeⁱ

ENSMUSG00000005980

Family and domain databases

Gene3Dⁱ	3.60.10.101 hit
InterProⁱ	View protein in InterPro IPR018057 Deoxyribonuclease-1_AS IPR016202 DNase_I IPR033125 DNASE_I_2 IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit
PIRSFⁱ	PIRSF000988 DNase_I_euk, 1 hit
PRINTSⁱ	PR00130 DNASEI
SMARTⁱ	View protein in SMART SM00476 DNaseIc, 1 hit
SUPFAMⁱ	SSF56219 SSF56219, 1 hit
PROSITEⁱ	View protein in PROSITE PS00919 DNASE_I_1, 1 hit PS00918 DNASE_I_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q14BW6_MOUSE
Accessionⁱ	Q14BW6Primary (citable) accession number: Q14BW6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 22, 2006
	Last sequence update:	August 22, 2006
	Last modified:	April 25, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q14BW6 (Q14BW6_MOUSE)

Your basket is currently empty. ⁱ

Deoxyribonuclease

Select a section on the left to see content.

Functionⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14BW6 (Q14BW6_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Deoxyribonuclease

Dnase1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ