Dnase1

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	100	UniRule annotation		1
Active siteⁱ	156	UniRule annotation		1

GO - Molecular functionⁱ

deoxyribonuclease I activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

DNA catabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	EndonucleaseUniRule annotation, Hydrolase, Nuclease

Molecular function

EndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DeoxyribonucleaseUniRule annotation
Gene namesⁱ	Name:Dnase1Imported ORF Names:mCG_126170Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103157. Dnase1.

Subcellular locationⁱ

GO - Cellular componentⁱ

extracellular exosome Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_5010134458	23 – 284	DeoxyribonucleaseSequence analysisAdd BLAST		262

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	123 ↔ 126	UniRule annotation
Disulfide bondⁱ	195 ↔ 231	Essential for enzymatic activityUniRule annotation

Keywords - PTMⁱ

Disulfide bondUniRule annotation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14BW6.

MaxQBⁱ

Q14BW6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005980.
ExpressionAtlasⁱ	Q14BW6. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q14BW6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 274	Endo/exonuclease/phosphataseInterPro annotationAdd BLAST		231

Sequence similaritiesⁱ

Belongs to the DNase I family.UniRule annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IHHA. Eukaryota. ENOG410ZR9A. LUCA.
HOVERGENⁱ	HBG051368.
KEGG Orthology (KO) More...KOⁱ	K11994.
OMAⁱ	RYLFVFR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B.

Family and domain databases

Gene3Dⁱ	3.60.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I. IPR033125. DNASE_I_2. IPR005135. Endo/exonuclease/phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372. Exo_endo_phos. 1 hit.
PIRSFⁱ	PIRSF000988. DNase_I_euk. 1 hit.
PRINTSⁱ	PR00130. DNASEI.
SMARTⁱ	View protein in SMART SM00476. DNaseIc. 1 hit.
SUPFAMⁱ	SSF56219. SSF56219. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q14BW6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRYTGLMGTL LTLVNLLQLA GTLRIAAFNI RTFGETKMSN ATLSVYFVKI 
        60         70         80         90        100
LSRYDIAVIQ EVRDSHLVAV GKLLDELNRD KPDTYRYVVS EPLGRKSYKE 
       110        120        130        140        150
QYLFVYRPDQ VSILDSYQYD DGCEPCGNDT FSREPAIVKF FSPYTEVQEF 
       160        170        180        190        200
AIVPLHAAPT EAVSEIDALY DVYLDVWQKW GLEDIMFMGD FNAGCSYVTS 
       210        220        230        240        250
SQWSSIRLRT SPIFQWLIPD SADTTVTSTH CAYDRIVVAG ALLQAAVVPN 
       260        270        280 
SAVPFDFQAE YGLSNQLAEA ISDHYPVEVT LRKI

Length:284

Mass (Da):32,027

Last modified:August 22, 2006 - v1

Checksum:ⁱ8682E20515EEB510

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC115571 mRNA. Translation: AAI15572.1. CH466521 Genomic DNA. Translation: EDK97220.1. CH466521 Genomic DNA. Translation: EDK97221.1. CH466521 Genomic DNA. Translation: EDK97222.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_034191.3. NM_010061.5. XP_006521837.1. XM_006521774.3. XP_006521838.1. XM_006521775.3. XP_006521839.1. XM_006521776.3.
UniGeneⁱ	Mm.291048. Mm.440565.

Genome annotation databases

GeneIDⁱ	13419.
KEGGⁱ	mmu:13419.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC115571 mRNA. Translation: AAI15572.1. CH466521 Genomic DNA. Translation: EDK97220.1. CH466521 Genomic DNA. Translation: EDK97221.1. CH466521 Genomic DNA. Translation: EDK97222.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_034191.3. NM_010061.5. XP_006521837.1. XM_006521774.3. XP_006521838.1. XM_006521775.3. XP_006521839.1. XM_006521776.3.
UniGeneⁱ	Mm.291048. Mm.440565.

3D structure databases

SMRⁱ	Q14BW6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14BW6.

MaxQBⁱ

Q14BW6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	13419.
KEGGⁱ	mmu:13419.

Organism-specific databases

CTDⁱ	1773.
MGIⁱ	MGI:103157. Dnase1.

Phylogenomic databases

eggNOGⁱ	ENOG410IHHA. Eukaryota. ENOG410ZR9A. LUCA.
HOVERGENⁱ	HBG051368.
KEGG Orthology (KO) More...KOⁱ	K11994.
OMAⁱ	RYLFVFR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B.

Miscellaneous databases

ChiTaRSⁱ	Dnase1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005980.
ExpressionAtlasⁱ	Q14BW6. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.60.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I. IPR033125. DNASE_I_2. IPR005135. Endo/exonuclease/phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372. Exo_endo_phos. 1 hit.
PIRSFⁱ	PIRSF000988. DNase_I_euk. 1 hit.
PRINTSⁱ	PR00130. DNASEI.
SMARTⁱ	View protein in SMART SM00476. DNaseIc. 1 hit.
SUPFAMⁱ	SSF56219. SSF56219. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q14BW6_MOUSE
Accessionⁱ	Q14BW6Primary (citable) accession number: Q14BW6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 22, 2006
	Last sequence update:	August 22, 2006
	Last modified:	July 5, 2017
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14BW6 (Q14BW6_MOUSE)

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Deoxyribonuclease

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ