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Protein

Unique cartilage matrix-associated protein

Gene

Ucma

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.1 Publication

GO - Biological processi

  • negative regulation of osteoblast differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Unique cartilage matrix-associated protein
Alternative name(s):
Upper zone of growth plate and cartilage matrix associated protein
Cleaved into the following chain:
Alternative name(s):
Gla-rich protein
Short name:
GRP
Gene namesi
Name:Ucma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915777. Ucma.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Extracellular matrix, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000034706528 – 138Unique cartilage matrix-associated proteinAdd BLAST111
PropeptideiPRO_000034706628 – 64Ucma-N1 PublicationAdd BLAST37
ChainiPRO_000034706765 – 138Unique cartilage matrix-associated protein C-terminal fragmentAdd BLAST74

Post-translational modificationi

Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
Sulfated on one or two tyrosine residues within the tryptic peptide 121-135.1 Publication

Keywords - PTMi

Sulfation

Proteomic databases

PaxDbiQ14BU0.
PRIDEiQ14BU0.

Expressioni

Tissue specificityi

Predominantly expressed in resting chondrocytes.1 Publication

Developmental stagei

Transiently expressed in the developing mouse skeleton between day E13.5 of embryonic development and 5 months of postnatal development. Absent in undifferentiated mesenchymal cells. Isoforms 1 and 3 are significantly increased with the onset of chondrogenesis, whereas Isoforms 2 and 4 are detected at a later stage.2 Publications

Inductioni

Expression inhibited by TGFB1, and weakly inhibited by BMP2.1 Publication

Gene expression databases

BgeeiENSMUSG00000026668.
GenevisibleiQ14BU0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110662.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 122Sequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the UCMA family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IY09. Eukaryota.
ENOG4111U8I. LUCA.
GeneTreeiENSGT00390000011492.
HOGENOMiHOG000253965.
HOVERGENiHBG098812.
InParanoidiQ14BU0.
OMAiYLYNRHH.
OrthoDBiEOG091G10F8.
PhylomeDBiQ14BU0.
TreeFamiTF332568.

Family and domain databases

InterProiView protein in InterPro
IPR031386. UCMA.
PfamiView protein in Pfam
PF17085. UCMA. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14BU0-1) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWRRVILLS SLLALVLLCM LQEGTSASVG SRQAAAEGVQ EGVKQKIFMQ
60 70 80 90 100
ESDASNFLKR RGKRSPKSRD EVNAENRQRL RDDELRREYY EEQRNEFENF
110 120 130
VEEQRDEQEE RTREAVEQWR QWHYDGLYPS YLYNRQNI
Length:138
Mass (Da):16,579
Last modified:August 22, 2006 - v1
Checksum:i11914F39960348DC
GO
Isoform 2 (identifier: Q14BU0-2) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F2

The sequence of this isoform differs from the canonical sequence as follows:
     20-42: MLQEGTSASVGSRQAAAEGVQEG → S

Show »
Length:116
Mass (Da):14,421
Checksum:iC11712CC2196184D
GO
Isoform 3 (identifier: Q14BU0-3) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F3

The sequence of this isoform differs from the canonical sequence as follows:
     74-106: Missing.

Show »
Length:105
Mass (Da):12,235
Checksum:i6F165579608C833C
GO
Isoform 4 (identifier: Q14BU0-4) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F4

The sequence of this isoform differs from the canonical sequence as follows:
     20-42: MLQEGTSASVGSRQAAAEGVQEG → S
     74-106: Missing.

Show »
Length:83
Mass (Da):10,077
Checksum:iAF10EB403DA27266
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03505120 – 42MLQEG…GVQEG → S in isoform 2 and isoform 4. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_04080774 – 106Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF529510 mRNA. Translation: ABP88975.1.
EU368184 mRNA. Translation: ABY65726.1.
FJ217397 mRNA. Translation: ACO35746.1.
FJ217398 mRNA. Translation: ACO35747.1.
FJ217399 mRNA. Translation: ACO35748.1.
FJ217400 mRNA. Translation: ACO35749.1.
AK003750 mRNA. Translation: BAB22978.2.
BX682541, AL928662 Genomic DNA. Translation: CAM21763.1.
BX682541, AL928662 Genomic DNA. Translation: CAM21764.1.
AL928662, BX682541 Genomic DNA. Translation: CAM22576.1.
AL928662, BX682541 Genomic DNA. Translation: CAM22577.1.
CH466542 Genomic DNA. Translation: EDL07955.1.
BC115608 mRNA. Translation: AAI15609.1.
BC115609 mRNA. Translation: AAI15610.1.
CCDSiCCDS15661.1. [Q14BU0-2]
CCDS50489.1. [Q14BU0-1]
CCDS50490.1. [Q14BU0-3]
CCDS84467.1. [Q14BU0-4]
RefSeqiNP_001107030.1. NM_001113558.2. [Q14BU0-1]
NP_001159404.1. NM_001165932.1. [Q14BU0-3]
NP_001298137.1. NM_001311208.1. [Q14BU0-4]
NP_081030.1. NM_026754.3. [Q14BU0-2]
UniGeneiMm.27791.

Genome annotation databases

EnsembliENSMUST00000027978; ENSMUSP00000027978; ENSMUSG00000026668. [Q14BU0-2]
ENSMUST00000115010; ENSMUSP00000110662; ENSMUSG00000026668. [Q14BU0-1]
ENSMUST00000167607; ENSMUSP00000126371; ENSMUSG00000026668. [Q14BU0-3]
ENSMUST00000195688; ENSMUSP00000141304; ENSMUSG00000026668. [Q14BU0-4]
GeneIDi68527.
KEGGimmu:68527.
UCSCiuc008ife.2. mouse. [Q14BU0-2]
uc008iff.2. mouse. [Q14BU0-1]
uc012bov.1. mouse. [Q14BU0-3]
uc012bow.1. mouse. [Q14BU0-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUCMA_MOUSE
AccessioniPrimary (citable) accession number: Q14BU0
Secondary accession number(s): C9W8R6
, C9W8R7, C9W8R8, C9W8R9, Q9D1A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 22, 2006
Last modified: July 5, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families