Q14BN4 (SLMAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sarcolemmal membrane-associated protein
Short name=Sarcolemmal-associated protein

Gene names

Name:	SLMAP
Synonyms:	KIAA1601, SLAP
ORF Names:	UNQ1847/PRO3577

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	828 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role during myoblast fusion By similarity.
Subunit structure	Homodimer. Interacts with myosin By similarity.
Subcellular location	Cell membrane › sarcolemma; Single-pass type IV membrane protein By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Note: Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule-dependent manner By similarity.
Sequence similarities	Belongs to the SLMAP family. Contains 1 FHA domain.
Sequence caution	The sequence AAQ88776.1 differs from that shown. Reason: Erroneous initiation. The sequence CAH10369.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	muscle contraction Traceable author statement PubMed 9405447. Source: ProtInc protein folding Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to plasma membrane Traceable author statement PubMed 9405447. Source: ProtInc microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell prefoldin complex Inferred from electronic annotation. Source: InterPro sarcolemma Inferred from electronic annotation. Source: UniProtKB-SubCell smooth endoplasmic reticulum Traceable author statement PubMed 9405447. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
OPTN	Q96CV9	2	EBI-1043216,EBI-748974

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14BN4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14BN4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     379-417: VRLEHLQEKTLKECSSLEHLLSKSGGDCTFIHQFIECQK → E

Isoform 3 (identifier: Q14BN4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     379-395: Missing.

Note: Incomplete sequence.

Isoform 4 (identifier: Q14BN4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-348: Missing.
     379-436: Missing.
     798-798: N → NPSILQPVPARIHRPIPGFPDMVIRSIVERK

Isoform 5 (identifier: Q14BN4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-466: Missing.
     799-828: KPWPWMPMLAALVAVTAIVLYVPGLARASP → PSILQPVPAVFIGLFLAFLFWCFGPLW

Isoform 6 (identifier: Q14BN4-6)

The sequence of this isoform differs from the canonical sequence as follows:
     396-417: EHLLSKSGGDCTFIHQFIECQK → GIQVDDFLPKINGSTEKE
     484-510: DDLQGAQSEIEAKQEIQHLRKELIEAQ → GTLTCFYDIVNQGIKSPFAIKSVLDIM
     511-828: Missing.

Isoform 7 (identifier: Q14BN4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     396-428: EHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKA → ADRRRASNQSGRRNKAFKRFVFCFSMFFDSSFG
     429-828: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: Q14BN4-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-466: Missing.
     484-524: Missing.
     754-778: YEKTQTVLSELKLKFEMTEQEKQSI → VKRKDIMSPIMVGLKAKSKSDIHAS
     779-828: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 828	828	Sarcolemmal membrane-associated protein		PRO_0000259662
Regions
	Topological domain	1 – 802	802	Cytoplasmic Potential
	Transmembrane	803 – 823	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	824 – 828	5	Extracellular Potential
	Domain	28 – 85	58	FHA
	Region	1 – 163	163	Necessary for targeting to centrosomes By similarity
	Coiled coil	167 – 202	36	Potential
	Coiled coil	230 – 388	159	Potential
	Coiled coil	477 – 799	323	Potential
Amino acid modifications
	Modified residue	452	1	Phosphoserine Ref.8 Ref.9
Natural variations
	Alternative sequence	1 – 466	466	Missing in isoform 5 and isoform 8.		VSP_021499
	Alternative sequence	1 – 348	348	Missing in isoform 4.		VSP_021500
	Alternative sequence	379 – 436	58	Missing in isoform 4.		VSP_021501
	Alternative sequence	379 – 417	39	VRLEH…IECQK → E in isoform 2.		VSP_021502
	Alternative sequence	379 – 395	17	Missing in isoform 3.		VSP_021503
	Alternative sequence	396 – 428	33	EHLLS…HLTKA → ADRRRASNQSGRRNKAFKRF VFCFSMFFDSSFG in isoform 7.		VSP_021504
	Alternative sequence	396 – 417	22	EHLLS…IECQK → GIQVDDFLPKINGSTEKE in isoform 6.		VSP_021505
	Alternative sequence	429 – 828	400	Missing in isoform 7.		VSP_021506
	Alternative sequence	484 – 524	41	Missing in isoform 8.		VSP_021507
	Alternative sequence	484 – 510	27	DDLQG…LIEAQ → GTLTCFYDIVNQGIKSPFAI KSVLDIM in isoform 6.		VSP_021508
	Alternative sequence	511 – 828	318	Missing in isoform 6.		VSP_021509
	Alternative sequence	754 – 778	25	YEKTQ…EKQSI → VKRKDIMSPIMVGLKAKSKS DIHAS in isoform 8.		VSP_021510
	Alternative sequence	779 – 828	50	Missing in isoform 8.		VSP_021511
	Alternative sequence	798	1	N → NPSILQPVPARIHRPIPGFP DMVIRSIVERK in isoform 4.		VSP_021512
	Alternative sequence	799 – 828	30	KPWPW…ARASP → PSILQPVPAVFIGLFLAFLF WCFGPLW in isoform 5.		VSP_021513
Experimental info
	Sequence conflict	493	1	I → T in AAG41949. Ref.1
	Sequence conflict	515	1	T → A in AAG41949. Ref.1
	Sequence conflict	812	1	A → Q in AAD43014. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 20F5FA38174CA383	FASTA	828	95,198
	10 20 30 40 50 60 MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF 70 80 90 100 110 120 DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC 130 140 150 160 170 180 IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ 190 200 210 220 230 240 MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL 250 260 270 280 290 300 IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL 310 320 330 340 350 360 RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI 370 380 390 400 410 420 EALQADNDFT NERLTALQVR LEHLQEKTLK ECSSLEHLLS KSGGDCTFIH QFIECQKKLI 430 440 450 460 470 480 VEGHLTKAVE ETKLSKENQT RAKESDFSDT LSPSKEKSSD DTTDAQMDEQ DLNEPLAKVS 490 500 510 520 530 540 LLKDDLQGAQ SEIEAKQEIQ HLRKELIEAQ ELARTSKQKC FELQALLEEE RKAYRNQVEE 550 560 570 580 590 600 STKQIQVLQA QLQRLHIDTE NLREEKDSEI TSTRDELLSA RDEILLLHQA AAKVASERDT 610 620 630 640 650 660 DIASLQEELK KVRAELERWR KAASEYEKEI TSLQNSFQLR CQQCEDQQRE EATRLQGELE 670 680 690 700 710 720 KLRKEWNALE TECHSLKREN VLLSSELQRQ EKELHNSQKQ SLELTSDLSI LQMSRKELEN 730 740 750 760 770 780 QVGSLKEQHL RDSADLKTLL SKAENQAKDV QKEYEKTQTV LSELKLKFEM TEQEKQSITD 790 800 810 820 ELKQCKNNLK LLREKGNNKP WPWMPMLAAL VAVTAIVLYV PGLARASP
	Isoform 2 [UniParc]. Checksum: 2A5F92ECEF240518	FASTA	790	90,829
	10 20 30 40 50 60 MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF 70 80 90 100 110 120 DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC 130 140 150 160 170 180 IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ 190 200 210 220 230 240 MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL 250 260 270 280 290 300 IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL 310 320 330 340 350 360 RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI 370 380 390 400 410 420 EALQADNDFT NERLTALQEK LIVEGHLTKA VEETKLSKEN QTRAKESDFS DTLSPSKEKS 430 440 450 460 470 480 SDDTTDAQMD EQDLNEPLAK VSLLKDDLQG AQSEIEAKQE IQHLRKELIE AQELARTSKQ 490 500 510 520 530 540 KCFELQALLE EERKAYRNQV EESTKQIQVL QAQLQRLHID TENLREEKDS EITSTRDELL 550 560 570 580 590 600 SARDEILLLH QAAAKVASER DTDIASLQEE LKKVRAELER WRKAASEYEK EITSLQNSFQ 610 620 630 640 650 660 LRCQQCEDQQ REEATRLQGE LEKLRKEWNA LETECHSLKR ENVLLSSELQ RQEKELHNSQ 670 680 690 700 710 720 KQSLELTSDL SILQMSRKEL ENQVGSLKEQ HLRDSADLKT LLSKAENQAK DVQKEYEKTQ 730 740 750 760 770 780 TVLSELKLKF EMTEQEKQSI TDELKQCKNN LKLLREKGNN KPWPWMPMLA ALVAVTAIVL 790 YVPGLARASP
	Isoform 3 [UniParc]. Checksum: 17BCE2C5B6243F6C	FASTA	811	93,203
	10 20 30 40 50 60 MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF 70 80 90 100 110 120 DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC 130 140 150 160 170 180 IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ 190 200 210 220 230 240 MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL 250 260 270 280 290 300 IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL 310 320 330 340 350 360 RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI 370 380 390 400 410 420 EALQADNDFT NERLTALQEH LLSKSGGDCT FIHQFIECQK KLIVEGHLTK AVEETKLSKE 430 440 450 460 470 480 NQTRAKESDF SDTLSPSKEK SSDDTTDAQM DEQDLNEPLA KVSLLKDDLQ GAQSEIEAKQ 490 500 510 520 530 540 EIQHLRKELI EAQELARTSK QKCFELQALL EEERKAYRNQ VEESTKQIQV LQAQLQRLHI 550 560 570 580 590 600 DTENLREEKD SEITSTRDEL LSARDEILLL HQAAAKVASE RDTDIASLQE ELKKVRAELE 610 620 630 640 650 660 RWRKAASEYE KEITSLQNSF QLRCQQCEDQ QREEATRLQG ELEKLRKEWN ALETECHSLK 670 680 690 700 710 720 RENVLLSSEL QRQEKELHNS QKQSLELTSD LSILQMSRKE LENQVGSLKE QHLRDSADLK 730 740 750 760 770 780 TLLSKAENQA KDVQKEYEKT QTVLSELKLK FEMTEQEKQS ITDELKQCKN NLKLLREKGN 790 800 810 NKPWPWMPML AALVAVTAIV LYVPGLARAS P
	Isoform 4 [UniParc]. Checksum: 28B281416FD23FCD	FASTA	452	52,228
	10 20 30 40 50 60 MEEKEQELQA KIEALQADND FTNERLTALQ ENQTRAKESD FSDTLSPSKE KSSDDTTDAQ 70 80 90 100 110 120 MDEQDLNEPL AKVSLLKDDL QGAQSEIEAK QEIQHLRKEL IEAQELARTS KQKCFELQAL 130 140 150 160 170 180 LEEERKAYRN QVEESTKQIQ VLQAQLQRLH IDTENLREEK DSEITSTRDE LLSARDEILL 190 200 210 220 230 240 LHQAAAKVAS ERDTDIASLQ EELKKVRAEL ERWRKAASEY EKEITSLQNS FQLRCQQCED 250 260 270 280 290 300 QQREEATRLQ GELEKLRKEW NALETECHSL KRENVLLSSE LQRQEKELHN SQKQSLELTS 310 320 330 340 350 360 DLSILQMSRK ELENQVGSLK EQHLRDSADL KTLLSKAENQ AKDVQKEYEK TQTVLSELKL 370 380 390 400 410 420 KFEMTEQEKQ SITDELKQCK NNLKLLREKG NNPSILQPVP ARIHRPIPGF PDMVIRSIVE 430 440 450 RKKPWPWMPM LAALVAVTAI VLYVPGLARA SP
	Isoform 5 [UniParc]. Checksum: DAEFBF630F5C6443	FASTA	359	41,896
	10 20 30 40 50 60 MDEQDLNEPL AKVSLLKDDL QGAQSEIEAK QEIQHLRKEL IEAQELARTS KQKCFELQAL 70 80 90 100 110 120 LEEERKAYRN QVEESTKQIQ VLQAQLQRLH IDTENLREEK DSEITSTRDE LLSARDEILL 130 140 150 160 170 180 LHQAAAKVAS ERDTDIASLQ EELKKVRAEL ERWRKAASEY EKEITSLQNS FQLRCQQCED 190 200 210 220 230 240 QQREEATRLQ GELEKLRKEW NALETECHSL KRENVLLSSE LQRQEKELHN SQKQSLELTS 250 260 270 280 290 300 DLSILQMSRK ELENQVGSLK EQHLRDSADL KTLLSKAENQ AKDVQKEYEK TQTVLSELKL 310 320 330 340 350 KFEMTEQEKQ SITDELKQCK NNLKLLREKG NNPSILQPVP AVFIGLFLAF LFWCFGPLW
	Isoform 6 [UniParc]. Checksum: 2A77ABF7E61C8418	FASTA	506	57,531
	10 20 30 40 50 60 MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF 70 80 90 100 110 120 DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC 130 140 150 160 170 180 IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ 190 200 210 220 230 240 MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL 250 260 270 280 290 300 IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL 310 320 330 340 350 360 RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI 370 380 390 400 410 420 EALQADNDFT NERLTALQVR LEHLQEKTLK ECSSLGIQVD DFLPKINGST EKEKLIVEGH 430 440 450 460 470 480 LTKAVEETKL SKENQTRAKE SDFSDTLSPS KEKSSDDTTD AQMDEQDLNE PLAKVSLLKG 490 500 TLTCFYDIVN QGIKSPFAIK SVLDIM
	Isoform 7 [UniParc]. Checksum: 103B2A7E6103D7DF	FASTA	428	49,177
	10 20 30 40 50 60 MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF 70 80 90 100 110 120 DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC 130 140 150 160 170 180 IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ 190 200 210 220 230 240 MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL 250 260 270 280 290 300 IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL 310 320 330 340 350 360 RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI 370 380 390 400 410 420 EALQADNDFT NERLTALQVR LEHLQEKTLK ECSSLADRRR ASNQSGRRNK AFKRFVFCFS MFFDSSFG
	Isoform 8 [UniParc]. Checksum: 84CA2BC512502DF9	FASTA	271	31,437
	10 20 30 40 50 60 MDEQDLNEPL AKVSLLKALL EEERKAYRNQ VEESTKQIQV LQAQLQRLHI DTENLREEKD 70 80 90 100 110 120 SEITSTRDEL LSARDEILLL HQAAAKVASE RDTDIASLQE ELKKVRAELE RWRKAASEYE 130 140 150 160 170 180 KEITSLQNSF QLRCQQCEDQ QREEATRLQG ELEKLRKEWN ALETECHSLK RENVLLSSEL 190 200 210 220 230 240 QRQEKELHNS QKQSLELTSD LSILQMSRKE LENQVGSLKE QHLRDSADLK TLLSKAENQA 250 260 270 KDVQKEVKRK DIMSPIMVGL KAKSKSDIHA S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins." Wielowieyski P.A., Sevinc S., Guzzo R., Salih M., Wigle J.T., Tuana B.S. J. Biol. Chem. 275:38474-38481(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING. Tissue: Heart.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Umbilical cord blood.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Thymus.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-828. Tissue: Fetal liver and Uterus.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[7]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-828 (ISOFORM 3). Tissue: Brain.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF304450 mRNA. Translation: AAG41949.1. AF100750 mRNA. Translation: AAD43014.1. AY358410 mRNA. Translation: AAQ88776.1. Different initiation. AK124200 mRNA. Translation: BAC85803.1. AL834538 mRNA. Translation: CAD39194.1. CR627321 mRNA. Translation: CAH10369.1. Different initiation. BC114627 mRNA. Translation: AAI14628.1. BC115701 mRNA. Translation: AAI15702.1. AB046821 mRNA. Translation: BAB13427.1.
IPI	IPI00026691. IPI00030531. IPI00432472. IPI00446339. IPI00791574. IPI00794462. IPI00794566. IPI00795406.
RefSeq	NP_009090.2. NM_007159.2.
UniGene	Hs.476432.
3D structure databases
ProteinModelPortal	Q14BN4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14BN4. 18 interactions.
MINT	MINT-7006290.
PTM databases
PhosphoSite	Q14BN4.
Polymorphism databases
DMDM	118597508.
Proteomic databases
PaxDb	Q14BN4.
PRIDE	Q14BN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295951; ENSP00000295951; ENSG00000163681. ENST00000295952; ENSP00000295952; ENSG00000163681. ENST00000383718; ENSP00000373224; ENSG00000163681. ENST00000416870; ENSP00000412342; ENSG00000163681. ENST00000428312; ENSP00000398661; ENSG00000163681. ENST00000449503; ENSP00000412945; ENSG00000163681.
GeneID	7871.
KEGG	hsa:7871.
UCSC	uc003djc.1. human. uc003djd.1. human. uc003dje.1. human. uc003djf.1. human. uc003djg.1. human. uc003djh.3. human. uc003dji.1. human.
Organism-specific databases
CTD	7871.
GeneCards	GC03P057802.
H-InvDB	HIX0003396.
HGNC	HGNC:16643. SLMAP.
HPA	HPA002357. HPA002358.
MIM	602701. gene.
neXtProt	NX_Q14BN4.
PharmGKB	PA38179.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1716.
HOVERGEN	HBG082442.
OMA	RTSKQKC.
Gene expression databases
ArrayExpress	Q14BN4.
Bgee	Q14BN4.
Genevestigator	Q14BN4.
Family and domain databases
Gene3D	2.60.200.20. 1 hit.
InterPro	IPR000253. FHA_dom. IPR002777. PFD_beta-like. IPR008984. SMAD_FHA_domain. [Graphical view]
Pfam	PF00498. FHA. 1 hit. PF01920. Prefoldin_2. 1 hit. [Graphical view]
SMART	SM00240. FHA. 1 hit. [Graphical view]
SUPFAM	SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS50006. FHA_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLMAP. human.
GenomeRNAi	7871.
NextBio	30324.
SOURCE	Search...

Entry information

Entry name

SLMAP_HUMAN

Accession

Primary (citable) accession number: Q14BN4
Secondary accession number(s): Q14C95 , Q6AI54, Q6UXC9, Q6ZVQ8, Q8NCW9, Q9H297, Q9HCH1, Q9Y681

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	August 22, 2006
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.