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Protein

Metabotropic glutamate receptor 2

Gene

Grm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451GlutamateBy similarity
Binding sitei216 – 2161GlutamateBy similarity
Binding sitei295 – 2951GlutamateBy similarity
Binding sitei377 – 3771GlutamateBy similarity

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI
  • group II metabotropic glutamate receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 2
Short name:
mGluR2
Gene namesi
Name:Grm2
Synonyms:Gprc1b, Mglur2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1351339. Grm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 568550ExtracellularSequence analysisAdd
BLAST
Transmembranei569 – 58921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini590 – 60415CytoplasmicSequence analysisAdd
BLAST
Transmembranei605 – 62521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini626 – 6338ExtracellularSequence analysis
Transmembranei634 – 65118Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini652 – 67928CytoplasmicSequence analysisAdd
BLAST
Transmembranei680 – 70021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini701 – 72626ExtracellularSequence analysisAdd
BLAST
Transmembranei727 – 74721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini748 – 76013CytoplasmicSequence analysisAdd
BLAST
Transmembranei761 – 78121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini782 – 79817ExtracellularSequence analysisAdd
BLAST
Transmembranei799 – 81921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini820 – 87253CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 872854Metabotropic glutamate receptor 2PRO_0000306249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 92By similarity
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi234 ↔ 518By similarity
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence analysis
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi355 ↔ 362By similarity
Disulfide bondi400 ↔ 407By similarity
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi500 ↔ 519By similarity
Disulfide bondi504 ↔ 522By similarity
Disulfide bondi525 ↔ 537By similarity
Disulfide bondi540 ↔ 553By similarity
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14BI2.
PaxDbiQ14BI2.
PRIDEiQ14BI2.

PTM databases

PhosphoSiteiQ14BI2.

Expressioni

Tissue specificityi

Detected in neurons in brain cortex (at protein level).2 Publications

Gene expression databases

BgeeiQ14BI2.
CleanExiMM_GRM2.
ExpressionAtlasiQ14BI2. baseline and differential.
GenevisibleiQ14BI2. MM.

Interactioni

Subunit structurei

Interacts with GRASP (By similarity). Interacts with HTR2A.By similarity1 Publication

Protein-protein interaction databases

IntActiQ14BI2. 2 interactions.
MINTiMINT-6594401.
STRINGi10090.ENSMUSP00000023959.

Structurei

3D structure databases

ProteinModelPortaliQ14BI2.
SMRiQ14BI2. Positions 22-824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1683Glutamate bindingBy similarity
Regioni677 – 6859Important for interaction with HTR2ABy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000110900.
HOVERGENiHBG107965.
InParanoidiQ14BI2.
KOiK04605.
OMAiCSDPCKK.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ14BI2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001458. GPCR_3_mtglu_rcpt_2.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01052. MTABOTROPC2R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14BI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLLRFLAL LLLRGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEEC
60 70 80 90 100
GPVNEHRGIQ RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE
110 120 130 140 150
QALDFVRASL SRGADGSRHI CPDGSYATLS DAPTAITGVI GGSYSDVSIQ
160 170 180 190 200
VANLLRLFQI PQISYASTSA KLSDKSRYDY FARTVPPDFF QAKAMAEILR
210 220 230 240 250
FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK VGRAMSRAAF
260 270 280 290 300
EGVVRALLQK PSARVAVLFT RSEDARELLA ATQRLNASFT WVASDGWGAL
310 320 330 340 350
ESVVAGSERA AEGAITIELA SYPISDFASY FQNLDPWNNS RNPWFREFWE
360 370 380 390 400
ERFRCSFRQR DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC
410 420 430 440 450
PNTTRLCDAM RPVNGRRLYK DFVLNVKFDA PFRPADTDDE VRFDRFGDGI
460 470 480 490 500
GRYNIFTYLR AGNGRYRYQK VGYWAEGLTL DTSIIPWASP SAGTLPASRC
510 520 530 540 550
SEPCLQNEVK SVQPGEVCCW LCIPCQPYEY RLDEFTCADC GLGYWPNASL
560 570 580 590 600
TGCFELPQEY IRWGDAWAVG PVTIACLGAL ATLFVLGVFV RHNATPVVKA
610 620 630 640 650
SGRELCYILL GGVFLCYCMT FIFIAKPSTA VCTLRRLGLG TAFSVCYSAL
660 670 680 690 700
LTKTNRIARI FGGAREGAQR PRFISPASQV AICLALISGQ LLIVAAWLVV
710 720 730 740 750
EAPGIGKETA PERREVVTLR CNHRDASMLG SLAYNVLLIA LCTLYAFKTR
760 770 780 790 800
KCPENFNEAK FIGFTMYTTC IIWLAFLPIF YVTSSDYRVQ TTTMCVSVSL
810 820 830 840 850
SGSVVLGCLF APKLHIILFQ PQKNVVSHRA PTSRFGSAAP RASANLGQGS
860 870
GSQLVPTVCN GREVVDSTTS SL
Length:872
Mass (Da):95,887
Last modified:October 2, 2007 - v2
Checksum:iFE1726B0684E256D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152452 Genomic DNA. No translation available.
BC115866 mRNA. Translation: AAI15867.1.
CCDSiCCDS52914.1.
RefSeqiNP_001153825.1. NM_001160353.1.
UniGeneiMm.410822.
Mm.424639.

Genome annotation databases

EnsembliENSMUST00000023959; ENSMUSP00000023959; ENSMUSG00000023192.
GeneIDi108068.
KEGGimmu:108068.
UCSCiuc009rkj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152452 Genomic DNA. No translation available.
BC115866 mRNA. Translation: AAI15867.1.
CCDSiCCDS52914.1.
RefSeqiNP_001153825.1. NM_001160353.1.
UniGeneiMm.410822.
Mm.424639.

3D structure databases

ProteinModelPortaliQ14BI2.
SMRiQ14BI2. Positions 22-824.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14BI2. 2 interactions.
MINTiMINT-6594401.
STRINGi10090.ENSMUSP00000023959.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ14BI2.

Proteomic databases

MaxQBiQ14BI2.
PaxDbiQ14BI2.
PRIDEiQ14BI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023959; ENSMUSP00000023959; ENSMUSG00000023192.
GeneIDi108068.
KEGGimmu:108068.
UCSCiuc009rkj.3. mouse.

Organism-specific databases

CTDi2912.
MGIiMGI:1351339. Grm2.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000110900.
HOVERGENiHBG107965.
InParanoidiQ14BI2.
KOiK04605.
OMAiCSDPCKK.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ14BI2.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi359978.
PROiQ14BI2.
SOURCEiSearch...

Gene expression databases

BgeeiQ14BI2.
CleanExiMM_GRM2.
ExpressionAtlasiQ14BI2. baseline and differential.
GenevisibleiQ14BI2. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001458. GPCR_3_mtglu_rcpt_2.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01052. MTABOTROPC2R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-470.
  3. Cited for: INTERACTION WITH HTR2A, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function."
    Moreno J.L., Muguruza C., Umali A., Mortillo S., Holloway T., Pilar-Cuellar F., Mocci G., Seto J., Callado L.F., Neve R.L., Milligan G., Sealfon S.C., Lopez-Gimenez J.F., Meana J.J., Benson D.L., Gonzalez-Maeso J.
    J. Biol. Chem. 287:44301-44319(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGRM2_MOUSE
AccessioniPrimary (citable) accession number: Q14BI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.