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Q14B80 (KCNC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 2
Alternative name(s):
Voltage-gated potassium channel Kv3.2
Gene names
Name:Kcnc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Ref.3

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein Ref.2.

Tissue specificity

Detected in hippocampus. Ref.2

Developmental stage

Not detectable in hippocampus from newborns. Detected at low levels in developing hippocampus from day 7 to 12. Levels are much increased after 14 days. Expressed at high and stable levels in hippocampus after 21 days (at protein level). Ref.2

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Potassium voltage-gated channel subfamily C member 2
PRO_0000310417

Regions

Topological domain1 – 233233Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=Segment S1; Potential
Transmembrane287 – 30721Helical; Name=Segment S2; Potential
Topological domain308 – 31710Cytoplasmic Potential
Transmembrane318 – 33821Helical; Name=Segment S3; Potential
Transmembrane350 – 37223Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain373 – 38513Cytoplasmic Potential
Transmembrane386 – 40621Helical; Name=Segment S5; Potential
Transmembrane457 – 47721Helical; Name=Segment S6; Potential
Topological domain478 – 642165Cytoplasmic Potential
Motif441 – 4466Selectivity filter By similarity
Compositional bias56 – 10348Gly/Pro-rich (insert)

Amino acid modifications

Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation2701N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q14B80 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 2B9B6D29A40A80E3

FASTA64270,503
        10         20         30         40         50         60 
MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA GDKLQPLPPP 

        70         80         90        100        110        120 
LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP GGGREFFFDR HPGVFAYVLN 

       130        140        150        160        170        180 
YYRTGKLHCP ADVCGPLFEE ELAFWGIDET DVEPCCWMTY RQHRDAEEAL DIFETPDLIG 

       190        200        210        220        230        240 
GDPGDDEDLA AKRLGIEDAA GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL 

       250        260        270        280        290        300 
FFILVSITTF CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE 

       310        320        330        340        350        360 
FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF LRVVRFVRIL 

       370        380        390        400        410        420 
RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF ATMIYYAERV GAQPNDPSAS 

       430        440        450        460        470        480 
EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ TWSGMLVGAL CALAGVLTIA MPVPVIVNNF 

       490        500        510        520        530        540 
GMYYSLAMAK QKLPRKRKKH IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN 

       550        560        570        580        590        600 
RSVLSGDDST GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE 

       610        620        630        640 
KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons."
Tansey E.P., Chow A., Rudy B., McBain C.J.
Hippocampus 12:137-148(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH KCNC1, TISSUE SPECIFICITY.
[3]"Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels."
Kasten M.R., Rudy B., Anderson M.P.
J. Physiol. (Lond.) 584:565-582(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC116289 mRNA. Translation: AAI16290.1.
BC116290 mRNA. Translation: AAI16291.1.
RefSeqXP_006513748.1. XM_006513685.1.
XP_006513749.1. XM_006513686.1.
XP_006513750.1. XM_006513687.1.
XP_006513751.1. XM_006513688.1.
XP_006513752.1. XM_006513689.1.
XP_006513753.1. XM_006513690.1.
UniGeneMm.336242.

3D structure databases

ProteinModelPortalQ14B80.
SMRQ14B80. Positions 105-484.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ14B80.

Proteomic databases

PaxDbQ14B80.
PRIDEQ14B80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID268345.
KEGGmmu:268345.
UCSCuc007hao.1. mouse.

Organism-specific databases

CTD3747.
MGIMGI:96668. Kcnc2.

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidQ14B80.
KOK04888.
PhylomeDBQ14B80.

Gene expression databases

GenevestigatorQ14B80.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 2 hits.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 2 hits.
ProtoNetSearch...

Other

ChiTaRSKCNC2. mouse.
PROQ14B80.
SOURCESearch...

Entry information

Entry nameKCNC2_MOUSE
AccessionPrimary (citable) accession number: Q14B80
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 22, 2006
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot