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Q14B80

- KCNC2_MOUSE

UniProt

Q14B80 - KCNC2_MOUSE

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Protein

Potassium voltage-gated channel subfamily C member 2

Gene
Kcnc2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly.1 Publication

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. action potential Source: MGI
  2. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 2
Alternative name(s):
Voltage-gated potassium channel Kv3.2
Gene namesi
Name:Kcnc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96668. Kcnc2.

Subcellular locationi

Membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 233233Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Transmembranei287 – 30721Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Topological domaini308 – 31710Cytoplasmic Reviewed prediction
Transmembranei318 – 33821Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Transmembranei350 – 37223Helical; Voltage-sensor; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini373 – 38513Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei386 – 40621Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Transmembranei457 – 47721Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini478 – 642165Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Potassium voltage-gated channel subfamily C member 2PRO_0000310417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi263 – 2631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi270 – 2701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14B80.
PRIDEiQ14B80.

PTM databases

PhosphoSiteiQ14B80.

Expressioni

Tissue specificityi

Detected in hippocampus.1 Publication

Developmental stagei

Not detectable in hippocampus from newborns. Detected at low levels in developing hippocampus from day 7 to 12. Levels are much increased after 14 days. Expressed at high and stable levels in hippocampus after 21 days (at protein level).1 Publication

Gene expression databases

GenevestigatoriQ14B80.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ14B80.
SMRiQ14B80. Positions 105-484.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi441 – 4466Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 10348Gly/Pro-rich (insert)Add
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ14B80.
KOiK04888.
PhylomeDBiQ14B80.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 2 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 2 hits.

Sequencei

Sequence statusi: Complete.

Q14B80-1 [UniParc]FASTAAdd to Basket

« Hide

MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA    50
GDKLQPLPPP LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP 100
GGGREFFFDR HPGVFAYVLN YYRTGKLHCP ADVCGPLFEE ELAFWGIDET 150
DVEPCCWMTY RQHRDAEEAL DIFETPDLIG GDPGDDEDLA AKRLGIEDAA 200
GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL FFILVSITTF 250
CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE 300
FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF 350
LRVVRFVRIL RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF 400
ATMIYYAERV GAQPNDPSAS EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ 450
TWSGMLVGAL CALAGVLTIA MPVPVIVNNF GMYYSLAMAK QKLPRKRKKH 500
IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN RSVLSGDDST 550
GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE 600
KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL 642
Length:642
Mass (Da):70,503
Last modified:August 22, 2006 - v1
Checksum:i2B9B6D29A40A80E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116289 mRNA. Translation: AAI16290.1.
BC116290 mRNA. Translation: AAI16291.1.
RefSeqiXP_006513748.1. XM_006513685.1.
XP_006513749.1. XM_006513686.1.
XP_006513750.1. XM_006513687.1.
XP_006513751.1. XM_006513688.1.
XP_006513752.1. XM_006513689.1.
XP_006513753.1. XM_006513690.1.
UniGeneiMm.336242.

Genome annotation databases

GeneIDi268345.
KEGGimmu:268345.
UCSCiuc007hao.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC116289 mRNA. Translation: AAI16290.1 .
BC116290 mRNA. Translation: AAI16291.1 .
RefSeqi XP_006513748.1. XM_006513685.1.
XP_006513749.1. XM_006513686.1.
XP_006513750.1. XM_006513687.1.
XP_006513751.1. XM_006513688.1.
XP_006513752.1. XM_006513689.1.
XP_006513753.1. XM_006513690.1.
UniGenei Mm.336242.

3D structure databases

ProteinModelPortali Q14B80.
SMRi Q14B80. Positions 105-484.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q14B80.

Proteomic databases

PaxDbi Q14B80.
PRIDEi Q14B80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 268345.
KEGGi mmu:268345.
UCSCi uc007hao.1. mouse.

Organism-specific databases

CTDi 3747.
MGIi MGI:96668. Kcnc2.

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi Q14B80.
KOi K04888.
PhylomeDBi Q14B80.

Miscellaneous databases

ChiTaRSi KCNC2. mouse.
PROi Q14B80.
SOURCEi Search...

Gene expression databases

Genevestigatori Q14B80.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 2 hits.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons."
    Tansey E.P., Chow A., Rudy B., McBain C.J.
    Hippocampus 12:137-148(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH KCNC1, TISSUE SPECIFICITY.
  3. "Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels."
    Kasten M.R., Rudy B., Anderson M.P.
    J. Physiol. (Lond.) 584:565-582(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKCNC2_MOUSE
AccessioniPrimary (citable) accession number: Q14B80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 22, 2006
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi