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Q14B80

- KCNC2_MOUSE

UniProt

Q14B80 - KCNC2_MOUSE

Protein

Potassium voltage-gated channel subfamily C member 2

Gene

Kcnc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly.1 Publication

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. action potential Source: MGI
    2. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 2
    Alternative name(s):
    Voltage-gated potassium channel Kv3.2
    Gene namesi
    Name:Kcnc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96668. Kcnc2.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 642642Potassium voltage-gated channel subfamily C member 2PRO_0000310417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ14B80.
    PRIDEiQ14B80.

    PTM databases

    PhosphoSiteiQ14B80.

    Expressioni

    Tissue specificityi

    Detected in hippocampus.1 Publication

    Developmental stagei

    Not detectable in hippocampus from newborns. Detected at low levels in developing hippocampus from day 7 to 12. Levels are much increased after 14 days. Expressed at high and stable levels in hippocampus after 21 days (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriQ14B80.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ14B80.
    SMRiQ14B80. Positions 105-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 233233CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 31710CytoplasmicSequence Analysis
    Topological domaini373 – 38513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini478 – 642165CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei234 – 25421Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37223Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei457 – 47721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi441 – 4466Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 10348Gly/Pro-rich (insert)Add
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiQ14B80.
    KOiK04888.
    PhylomeDBiQ14B80.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 2 hits.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 2 hits.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q14B80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA    50
    GDKLQPLPPP LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP 100
    GGGREFFFDR HPGVFAYVLN YYRTGKLHCP ADVCGPLFEE ELAFWGIDET 150
    DVEPCCWMTY RQHRDAEEAL DIFETPDLIG GDPGDDEDLA AKRLGIEDAA 200
    GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL FFILVSITTF 250
    CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE 300
    FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF 350
    LRVVRFVRIL RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF 400
    ATMIYYAERV GAQPNDPSAS EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ 450
    TWSGMLVGAL CALAGVLTIA MPVPVIVNNF GMYYSLAMAK QKLPRKRKKH 500
    IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN RSVLSGDDST 550
    GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE 600
    KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL 642
    Length:642
    Mass (Da):70,503
    Last modified:August 22, 2006 - v1
    Checksum:i2B9B6D29A40A80E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116289 mRNA. Translation: AAI16290.1.
    BC116290 mRNA. Translation: AAI16291.1.
    RefSeqiXP_006513748.1. XM_006513685.1.
    XP_006513749.1. XM_006513686.1.
    XP_006513750.1. XM_006513687.1.
    XP_006513751.1. XM_006513688.1.
    XP_006513752.1. XM_006513689.1.
    XP_006513753.1. XM_006513690.1.
    UniGeneiMm.336242.

    Genome annotation databases

    GeneIDi268345.
    KEGGimmu:268345.
    UCSCiuc007hao.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC116289 mRNA. Translation: AAI16290.1 .
    BC116290 mRNA. Translation: AAI16291.1 .
    RefSeqi XP_006513748.1. XM_006513685.1.
    XP_006513749.1. XM_006513686.1.
    XP_006513750.1. XM_006513687.1.
    XP_006513751.1. XM_006513688.1.
    XP_006513752.1. XM_006513689.1.
    XP_006513753.1. XM_006513690.1.
    UniGenei Mm.336242.

    3D structure databases

    ProteinModelPortali Q14B80.
    SMRi Q14B80. Positions 105-484.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q14B80.

    Proteomic databases

    PaxDbi Q14B80.
    PRIDEi Q14B80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 268345.
    KEGGi mmu:268345.
    UCSCi uc007hao.1. mouse.

    Organism-specific databases

    CTDi 3747.
    MGIi MGI:96668. Kcnc2.

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi Q14B80.
    KOi K04888.
    PhylomeDBi Q14B80.

    Miscellaneous databases

    ChiTaRSi KCNC2. mouse.
    PROi Q14B80.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q14B80.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 2 hits.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 2 hits.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons."
      Tansey E.P., Chow A., Rudy B., McBain C.J.
      Hippocampus 12:137-148(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH KCNC1, TISSUE SPECIFICITY.
    3. "Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels."
      Kasten M.R., Rudy B., Anderson M.P.
      J. Physiol. (Lond.) 584:565-582(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiKCNC2_MOUSE
    AccessioniPrimary (citable) accession number: Q14B80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3