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Protein

Potassium voltage-gated channel subfamily C member 2

Gene

Kcnc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly.1 Publication

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central
  2. ion channel binding Source: UniProtKB

GO - Biological processi

  1. action potential Source: MGI
  2. potassium ion transmembrane transport Source: GO_Central
  3. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 2
Alternative name(s):
Voltage-gated potassium channel Kv3.2
Gene namesi
Name:Kcnc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96668. Kcnc2.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 233233CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini308 – 31710CytoplasmicSequence Analysis
Transmembranei318 – 33821Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei350 – 37223Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini373 – 38513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei386 – 40621Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei457 – 47721Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini478 – 642165CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: UniProtKB
  2. integral component of membrane Source: GO_Central
  3. membrane Source: UniProtKB
  4. perikaryon Source: UniProtKB
  5. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Potassium voltage-gated channel subfamily C member 2PRO_0000310417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14B80.
PRIDEiQ14B80.

PTM databases

PhosphoSiteiQ14B80.

Expressioni

Tissue specificityi

Detected in hippocampus.1 Publication

Developmental stagei

Not detectable in hippocampus from newborns. Detected at low levels in developing hippocampus from day 7 to 12. Levels are much increased after 14 days. Expressed at high and stable levels in hippocampus after 21 days (at protein level).1 Publication

Gene expression databases

GenevestigatoriQ14B80.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ14B80.
SMRiQ14B80. Positions 105-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi441 – 4466Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 10348Gly/Pro-rich (insert)Add
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ14B80.
KOiK04888.
PhylomeDBiQ14B80.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 2 hits.

Sequencei

Sequence statusi: Complete.

Q14B80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA
60 70 80 90 100
GDKLQPLPPP LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP
110 120 130 140 150
GGGREFFFDR HPGVFAYVLN YYRTGKLHCP ADVCGPLFEE ELAFWGIDET
160 170 180 190 200
DVEPCCWMTY RQHRDAEEAL DIFETPDLIG GDPGDDEDLA AKRLGIEDAA
210 220 230 240 250
GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL FFILVSITTF
260 270 280 290 300
CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE
310 320 330 340 350
FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF
360 370 380 390 400
LRVVRFVRIL RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF
410 420 430 440 450
ATMIYYAERV GAQPNDPSAS EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ
460 470 480 490 500
TWSGMLVGAL CALAGVLTIA MPVPVIVNNF GMYYSLAMAK QKLPRKRKKH
510 520 530 540 550
IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN RSVLSGDDST
560 570 580 590 600
GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE
610 620 630 640
KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL
Length:642
Mass (Da):70,503
Last modified:August 22, 2006 - v1
Checksum:i2B9B6D29A40A80E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116289 mRNA. Translation: AAI16290.1.
BC116290 mRNA. Translation: AAI16291.1.
RefSeqiXP_006513748.1. XM_006513685.2.
XP_006513750.1. XM_006513687.2.
XP_006513751.1. XM_006513688.1.
XP_006513752.1. XM_006513689.2.
XP_006513753.1. XM_006513690.1.
UniGeneiMm.336242.

Genome annotation databases

GeneIDi268345.
KEGGimmu:268345.
UCSCiuc007hao.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116289 mRNA. Translation: AAI16290.1.
BC116290 mRNA. Translation: AAI16291.1.
RefSeqiXP_006513748.1. XM_006513685.2.
XP_006513750.1. XM_006513687.2.
XP_006513751.1. XM_006513688.1.
XP_006513752.1. XM_006513689.2.
XP_006513753.1. XM_006513690.1.
UniGeneiMm.336242.

3D structure databases

ProteinModelPortaliQ14B80.
SMRiQ14B80. Positions 105-484.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ14B80.

Proteomic databases

PaxDbiQ14B80.
PRIDEiQ14B80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi268345.
KEGGimmu:268345.
UCSCiuc007hao.1. mouse.

Organism-specific databases

CTDi3747.
MGIiMGI:96668. Kcnc2.

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiQ14B80.
KOiK04888.
PhylomeDBiQ14B80.

Miscellaneous databases

ChiTaRSiKcnc2. mouse.
PROiQ14B80.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ14B80.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons."
    Tansey E.P., Chow A., Rudy B., McBain C.J.
    Hippocampus 12:137-148(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH KCNC1, TISSUE SPECIFICITY.
  3. "Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels."
    Kasten M.R., Rudy B., Anderson M.P.
    J. Physiol. (Lond.) 584:565-582(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKCNC2_MOUSE
AccessioniPrimary (citable) accession number: Q14B80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 22, 2006
Last modified: April 1, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.