Potassium voltage-gated channel subfamily C member 2 - Kcnc2

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Q14B80 (KCNC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily C member 2

Alternative name(s):
Voltage-gated potassium channel Kv3.2

Gene names

Name:

Kcnc2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Ref.3
Subunit structure	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 By similarity. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein Ref.2.
Tissue specificity	Detected in hippocampus. Ref.2
Developmental stage	Not detectable in hippocampus from newborns. Detected at low levels in developing hippocampus from day 7 to 12. Levels are much increased after 14 days. Expressed at high and stable levels in hippocampus after 21 days (at protein level). Ref.2
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Sequence similarities	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	action potential Inferred from mutant phenotype Ref.3. Source: MGI protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular_component	voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 642

642

Potassium voltage-gated channel subfamily C member 2

PRO_0000310417

Regions

Topological domain

1 – 233

233

Cytoplasmic Potential

Transmembrane

234 – 254

Helical; Name=Segment S1; Potential

Transmembrane

287 – 307

Helical; Name=Segment S2; Potential

Topological domain

308 – 317

Cytoplasmic Potential

Transmembrane

318 – 338

Helical; Name=Segment S3; Potential

Transmembrane

350 – 372

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

373 – 385

Cytoplasmic Potential

Transmembrane

386 – 406

Helical; Name=Segment S5; Potential

Transmembrane

457 – 477

Helical; Name=Segment S6; Potential

Topological domain

478 – 642

165

Cytoplasmic Potential

Motif

441 – 446

Selectivity filter By similarity

Compositional bias

56 – 103

Gly/Pro-rich (insert)

Amino acid modifications

Glycosylation

263

N-linked (GlcNAc...) Potential

Glycosylation

270

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q14B80 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 2B9B6D29A40A80E3
Show »

FASTA

642

70,503

        10         20         30         40         50         60 
MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA GDKLQPLPPP 

        70         80         90        100        110        120 
LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP GGGREFFFDR HPGVFAYVLN 

       130        140        150        160        170        180 
YYRTGKLHCP ADVCGPLFEE ELAFWGIDET DVEPCCWMTY RQHRDAEEAL DIFETPDLIG 

       190        200        210        220        230        240 
GDPGDDEDLA AKRLGIEDAA GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL 

       250        260        270        280        290        300 
FFILVSITTF CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE 

       310        320        330        340        350        360 
FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF LRVVRFVRIL 

       370        380        390        400        410        420 
RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF ATMIYYAERV GAQPNDPSAS 

       430        440        450        460        470        480 
EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ TWSGMLVGAL CALAGVLTIA MPVPVIVNNF 

       490        500        510        520        530        540 
GMYYSLAMAK QKLPRKRKKH IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN 

       550        560        570        580        590        600 
RSVLSGDDST GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE 

       610        620        630        640 
KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons." Tansey E.P., Chow A., Rudy B., McBain C.J. Hippocampus 12:137-148(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH KCNC1, TISSUE SPECIFICITY.
[3]	"Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels." Kasten M.R., Rudy B., Anderson M.P. J. Physiol. (Lond.) 584:565-582(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC116289 mRNA. Translation: AAI16290.1. BC116290 mRNA. Translation: AAI16291.1.
RefSeq	XP_006513748.1. XM_006513685.1. XP_006513749.1. XM_006513686.1. XP_006513750.1. XM_006513687.1. XP_006513751.1. XM_006513688.1. XP_006513752.1. XM_006513689.1. XP_006513753.1. XM_006513690.1.
UniGene	Mm.336242.
3D structure databases
ProteinModelPortal	Q14B80.
SMR	Q14B80. Positions 4-485.
ModBase	Search...
MobiDB	Search...
PTM databases
PhosphoSite	Q14B80.
Proteomic databases
PaxDb	Q14B80.
PRIDE	Q14B80.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	268345.
UCSC	uc007hao.1. mouse.
Organism-specific databases
MGI	MGI:96668. Kcnc2.
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231012.
HOVERGEN	HBG105862.
InParanoid	Q14B80.
PhylomeDB	Q14B80.
Gene expression databases
Genevestigator	Q14B80.
Family and domain databases
Gene3D	1.20.120.350. 1 hit. 3.30.710.10. 2 hits.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR027359. Channel_four-helix_dom. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003974. K_chnl_volt-dep_Kv3. IPR003131. T1-type_BTB. IPR028325. VG_K_chnl. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF02214. BTB_2. 2 hits. PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01491. KVCHANNEL. PR01498. SHAWCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. SSF54695. 2 hits.
ProtoNet	Search...
Other
ChiTaRS	KCNC2. mouse.
PRO	Q14B80.
SOURCE	Search...

Entry information

Entry name

KCNC2_MOUSE

Accession

Primary (citable) accession number: Q14B80

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	August 22, 2006
Last modified:	April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents