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Q14AX6

- CDK12_MOUSE

UniProt

Q14AX6 - CDK12_MOUSE

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Protein

Cyclin-dependent kinase 12

Gene

Cdk12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.1 Publication

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei752 – 7521ATPPROSITE-ProRule annotation
Active sitei855 – 8551Proton acceptorPROSITE-ProRule annotation
Binding sitei1036 – 10361ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi729 – 7379ATPPROSITE-ProRule annotation
Nucleotide bindingi810 – 8156ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein kinase activity Source: HGNC
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
  3. protein autophosphorylation Source: HGNC
  4. regulation of MAP kinase activity Source: UniProtKB
  5. RNA splicing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 12 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cdc2-related kinase, arginine/serine-rich
Short name:
CrkRS
Cell division cycle 2-related protein kinase 7
Short name:
CDC2-related protein kinase 7
Cell division protein kinase 12
Gene namesi
Name:Cdk12
Synonyms:Crk7, Crkrs, Kiaa0904
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1098802. Cdk12.

Subcellular locationi

Nucleus By similarity. Nucleus speckle By similarity
Note: Colocalized with nuclear speckles throughout interphase.By similarity

GO - Cellular componenti

  1. cyclin K-CDK12 complex Source: Ensembl
  2. nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  3. nuclear speck Source: UniProtKB
  4. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14841484Cyclin-dependent kinase 12PRO_0000314470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571PhosphothreonineBy similarity
Modified residuei73 – 731PhosphotyrosineBy similarity
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei273 – 2731PhosphoserineBy similarity
Modified residuei275 – 2751PhosphoserineBy similarity
Modified residuei300 – 3001PhosphoserineBy similarity
Modified residuei302 – 3021PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity
Modified residuei311 – 3111PhosphoserineBy similarity
Modified residuei317 – 3171PhosphoserineBy similarity
Modified residuei322 – 3221PhosphoserineBy similarity
Modified residuei324 – 3241PhosphoserineBy similarity
Modified residuei331 – 3311PhosphoserineBy similarity
Modified residuei332 – 3321PhosphoserineBy similarity
Modified residuei333 – 3331PhosphoserineBy similarity
Modified residuei337 – 3371PhosphoserineBy similarity
Modified residuei344 – 3441PhosphoserineBy similarity
Modified residuei382 – 3821Phosphoserine2 Publications
Modified residuei384 – 3841Phosphoserine2 Publications
Modified residuei399 – 3991PhosphoserineBy similarity
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei422 – 4221PhosphoserineBy similarity
Modified residuei511 – 5111PhosphothreonineBy similarity
Modified residuei677 – 6771PhosphoserineBy similarity
Modified residuei681 – 6811PhosphoserineBy similarity
Modified residuei688 – 6881PhosphothreonineBy similarity
Modified residuei889 – 8891PhosphothreonineBy similarity
Modified residuei1049 – 10491PhosphoserineBy similarity
Modified residuei1079 – 10791Phosphoserine1 Publication
Modified residuei1240 – 12401PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation at Thr-889 increases kinase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14AX6.
PaxDbiQ14AX6.
PRIDEiQ14AX6.

PTM databases

PhosphoSiteiQ14AX6.

Expressioni

Gene expression databases

BgeeiQ14AX6.
CleanExiMM_CRKRS.
ExpressionAtlasiQ14AX6. baseline and differential.
GenevestigatoriQ14AX6.

Interactioni

Subunit structurei

Interacts with CCNL1 and CCNL2.By similarity

Protein-protein interaction databases

BioGridi213247. 1 interaction.
IntActiQ14AX6. 1 interaction.
MINTiMINT-4119098.

Structurei

3D structure databases

ProteinModelPortaliQ14AX6.
SMRiQ14AX6. Positions 637-1044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini723 – 1016294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 393257Ser-richAdd
BLAST
Compositional biasi406 – 4127Poly-Ala
Compositional biasi524 – 703180Pro-richAdd
BLAST
Compositional biasi1234 – 127643Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120511.
HOGENOMiHOG000049118.
HOVERGENiHBG050852.
InParanoidiQ14AX6.
KOiK08819.
OMAiYSTRSHP.
OrthoDBiEOG76DTSM.
PhylomeDBiQ14AX6.
TreeFamiTF101060.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14AX6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNSERHGGK KDGSGGASGT SQPSSGGGSS NSRERHRLVS KHKRHKSKHS
60 70 80 90 100
KDVGLVTPEA ASLGTIIKPL VEYDDISSDS DTFSDDTAFK SDRRENEERR
110 120 130 140 150
GTDRSDRLHR HRHHQHRRSR DLLKTKQTEK EKNQEVSKSG SMKDRVSGSS
160 170 180 190 200
KRSVEGSDDY GKAQLSKSGS KESRSSKMHK EKTRKERELK SGYKDRSKSH
210 220 230 240 250
RKRETPKSYK TVASPKRRSR SPHRKWSDSS KQDDSPSGAS YGQDYDLSPP
260 270 280 290 300
RSHTSSNYDS YKKSPGSTSR RQSISPPYKE PSAYQSSTRS PSPYSRRQRS
310 320 330 340 350
VSPYSRRRSS SYERSGSYSG RSPSPYGRRR SSSPFLSKRS LSRSPLPSRK
360 370 380 390 400
SMKSRSRSPA YSRHSSSHSK KKRSGSRSRH SSISPVRLPL NSSLGAELSR
410 420 430 440 450
KKKERAAAAA AAKMDGKESK SSPIILPKKE KLEVKESGLE SKKLPRSIKS
460 470 480 490 500
EKSTPDTELV TVAHSNPEVK HCLDTGKVRL DENLQKHPAK DLKAQGTKDV
510 520 530 540 550
KPVAPKEVIV TSKETETSEK ETLPPLPTIT SPPPLPATTP PPQTPPLPPL
560 570 580 590 600
PPLPAIPLQP PLPPPQPPFS QVPVSSTSIL PSSPHPRTST LSSQTNSQPP
610 620 630 640 650
VQVSMKTQVS ITAAIPHLKT STLPPLPLPP LLPGDDDMDS PKETLPSKPA
660 670 680 690 700
KKEKEQRTRH LLTDLPLPPE LPGGDPSPPD SPEPKAITPP QQPYKKRPKI
710 720 730 740 750
CCPRYGERRQ TESDWGKRCV DKFDIIGIIG EGTYGQVYKA KDKDTGELVA
760 770 780 790 800
LKKVRLDNEK EGFPITAIRE IKILRQLVHQ SVVNMKEIVT DKQDALDFKK
810 820 830 840 850
DKGAFYLVFE YMDHDLMGLL ESGLVHFSED HIKSFMKQLM EGLDYCHKKN
860 870 880 890 900
FLHRDIKCSN ILLNNSGQIK LADFGLARLY NSEESRPYTN KVITLWYRPP
910 920 930 940 950
ELLLGEERYT PAIDVWSCGC ILGELFTKKP IFQANLELAQ LELISRLCGS
960 970 980 990 1000
PCPAVWPDVI KLPYFNTMKP KKQYRRRLRE EFSFIPSAAL DLLDHMLTLD
1010 1020 1030 1040 1050
PSKRCTAEQT LQSDFLKDVE LSKMAPPDLP HWQDCHELWS KKRRRQRQSG
1060 1070 1080 1090 1100
IVIEDPPPSK ASRKETTSGT TAEPVKNNSP APPQPAPVKA EPGPGDAVGL
1110 1120 1130 1140 1150
GDITQQLNQS ELAVLLNLLQ SQTDLSIPQM AQLLNIHSNP EMQQQLEALN
1160 1170 1180 1190 1200
QSISALTEAS SQQQDSESIA PEESLKEVPS VPVVLPPAEQ TTPEASNTPA
1210 1220 1230 1240 1250
DMQNVLAVLL SQLMKTQEPA GNLEENTNDK NSGPQGPRRT PTMPQEEAAA
1260 1270 1280 1290 1300
CPPHILPPEK RPPEPPGPPP PPPPPPLVEG DLSSAPQELN PAVTAALLQL
1310 1320 1330 1340 1350
LSQPEAEPPG HLPHEHQALR PMEYSTRSHP NRTYGNTDGP ETGFSSADTD
1360 1370 1380 1390 1400
ERSSGPALTE SLVQTPVKNR TFSGSVSHLG ESNSYQGTGS VQFPGDQDLR
1410 1420 1430 1440 1450
FTRVPLALHS VVGQPFLKSE GNSNSVVHAE TKLQNYGELG PGTTGANSSG
1460 1470 1480
TTLQWGGPAQ SYGKPYRGAA RVLPRGGRGR GVPY
Length:1,484
Mass (Da):163,681
Last modified:January 15, 2008 - v2
Checksum:i5FCEE8D1903DF803
GO
Isoform 2 (identifier: Q14AX6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1258: ACPPHILPP → GKQTGHESH
     1259-1484: Missing.

Show »
Length:1,258
Mass (Da):139,883
Checksum:iF21408B379D9EFB5
GO
Isoform 3 (identifier: Q14AX6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1258: Missing.

Note: No experimental confirmation available.

Show »
Length:1,475
Mass (Da):162,755
Checksum:i53626C566777F0CA
GO

Sequence cautioni

The sequence CAM21270.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461L → I in AAL69526. 1 PublicationCurated
Sequence conflicti363 – 3631R → S in AAL69526. 1 PublicationCurated
Sequence conflicti377 – 3771R → H in AAL69526. 1 PublicationCurated
Sequence conflicti425 – 4273ILP → FCL in BAC98047. (PubMed:14621295)Curated
Sequence conflicti496 – 4961G → V in AAL69526. 1 PublicationCurated
Sequence conflicti562 – 5621L → V in AAL69526. 1 PublicationCurated
Sequence conflicti854 – 8541R → Q in AAL69526. 1 PublicationCurated
Sequence conflicti863 – 8631L → V in AAL69526. 1 PublicationCurated
Sequence conflicti870 – 8701K → R in AAL69526. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1250 – 12589ACPPHILPP → GKQTGHESH in isoform 2. 2 PublicationsVSP_030285
Alternative sequencei1250 – 12589Missing in isoform 3. 1 PublicationVSP_030286
Alternative sequencei1259 – 1484226Missing in isoform 2. 2 PublicationsVSP_030287Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072295 mRNA. Translation: AAL69526.1.
AL591205 Genomic DNA. Translation: CAM21267.1.
AL591205 Genomic DNA. Translation: CAM21268.1.
AL591205 Genomic DNA. Translation: CAM21269.1.
AL591205 Genomic DNA. Translation: CAM21270.1. Sequence problems.
BC116645 mRNA. Translation: AAI16646.1.
AK129237 mRNA. Translation: BAC98047.1.
CCDSiCCDS25342.1. [Q14AX6-2]
CCDS48901.1. [Q14AX6-1]
CCDS48902.1. [Q14AX6-3]
RefSeqiNP_001103096.1. NM_001109626.1. [Q14AX6-1]
NP_001103098.1. NM_001109628.1. [Q14AX6-3]
NP_081228.2. NM_026952.2. [Q14AX6-2]
UniGeneiMm.260516.
Mm.486492.
Mm.488484.

Genome annotation databases

EnsembliENSMUST00000003203; ENSMUSP00000003203; ENSMUSG00000003119. [Q14AX6-2]
ENSMUST00000107538; ENSMUSP00000103162; ENSMUSG00000003119. [Q14AX6-1]
ENSMUST00000107539; ENSMUSP00000103163; ENSMUSG00000003119. [Q14AX6-3]
GeneIDi69131.
KEGGimmu:69131.
UCSCiuc007lfr.2. mouse. [Q14AX6-1]
uc007lfs.2. mouse. [Q14AX6-2]
uc007lfu.2. mouse. [Q14AX6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072295 mRNA. Translation: AAL69526.1 .
AL591205 Genomic DNA. Translation: CAM21267.1 .
AL591205 Genomic DNA. Translation: CAM21268.1 .
AL591205 Genomic DNA. Translation: CAM21269.1 .
AL591205 Genomic DNA. Translation: CAM21270.1 . Sequence problems.
BC116645 mRNA. Translation: AAI16646.1 .
AK129237 mRNA. Translation: BAC98047.1 .
CCDSi CCDS25342.1. [Q14AX6-2 ]
CCDS48901.1. [Q14AX6-1 ]
CCDS48902.1. [Q14AX6-3 ]
RefSeqi NP_001103096.1. NM_001109626.1. [Q14AX6-1 ]
NP_001103098.1. NM_001109628.1. [Q14AX6-3 ]
NP_081228.2. NM_026952.2. [Q14AX6-2 ]
UniGenei Mm.260516.
Mm.486492.
Mm.488484.

3D structure databases

ProteinModelPortali Q14AX6.
SMRi Q14AX6. Positions 637-1044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213247. 1 interaction.
IntActi Q14AX6. 1 interaction.
MINTi MINT-4119098.

PTM databases

PhosphoSitei Q14AX6.

Proteomic databases

MaxQBi Q14AX6.
PaxDbi Q14AX6.
PRIDEi Q14AX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003203 ; ENSMUSP00000003203 ; ENSMUSG00000003119 . [Q14AX6-2 ]
ENSMUST00000107538 ; ENSMUSP00000103162 ; ENSMUSG00000003119 . [Q14AX6-1 ]
ENSMUST00000107539 ; ENSMUSP00000103163 ; ENSMUSG00000003119 . [Q14AX6-3 ]
GeneIDi 69131.
KEGGi mmu:69131.
UCSCi uc007lfr.2. mouse. [Q14AX6-1 ]
uc007lfs.2. mouse. [Q14AX6-2 ]
uc007lfu.2. mouse. [Q14AX6-3 ]

Organism-specific databases

CTDi 51755.
MGIi MGI:1098802. Cdk12.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120511.
HOGENOMi HOG000049118.
HOVERGENi HBG050852.
InParanoidi Q14AX6.
KOi K08819.
OMAi YSTRSHP.
OrthoDBi EOG76DTSM.
PhylomeDBi Q14AX6.
TreeFami TF101060.

Miscellaneous databases

ChiTaRSi Cdk12. mouse.
NextBioi 328674.
PROi Q14AX6.
SOURCEi Search...

Gene expression databases

Bgeei Q14AX6.
CleanExi MM_CRKRS.
ExpressionAtlasi Q14AX6. baseline and differential.
Genevestigatori Q14AX6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a putative SR-related protein kinase that is differentially expressed in the embryonic nervous system."
    Lin S.-F., Chen H.-H., Fann M.-J.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-1484 (ISOFORM 3).
    Tissue: Embryonic tail.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382; SER-384 AND SER-1079, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND SER-384, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. "The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes."
    Blazek D., Kohoutek J., Bartholomeeusen K., Johansen E., Hulinkova P., Luo Z., Cimermancic P., Ule J., Peterlin B.M.
    Genes Dev. 25:2158-2172(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCDK12_MOUSE
AccessioniPrimary (citable) accession number: Q14AX6
Secondary accession number(s): A2A530
, A2A531, B1AQH7, Q6ZQ27, Q8R457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3