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Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 6

Gene

Htr6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine (Serotonin) receptor 6Imported
Gene namesi
Name:Htr6Imported
ORF Names:mCG_9086Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1196627. Htr6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 51HelicalSequence analysisAdd BLAST24
Transmembranei63 – 80HelicalSequence analysisAdd BLAST18
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Transmembranei143 – 166HelicalSequence analysisAdd BLAST24
Transmembranei186 – 209HelicalSequence analysisAdd BLAST24
Transmembranei265 – 286HelicalSequence analysisAdd BLAST22
Transmembranei306 – 325HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000028747.
ExpressionAtlasiQ14AW8. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 322G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
KOiK04162.
OMAiCDCISPG.
OrthoDBiEOG091G06VI.

Family and domain databases

CDDicd15054. 7tmA_5-HT6. 1 hit.
InterProiView protein in InterPro
IPR002232. 5HT6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14AW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIAL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG KARTSAPGQC RLLASLPYVL VASGVTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGTA TAGQALETLQ VPRTPRPGME
260 270 280 290 300
SADSRRLTTK HSRKALKASL TLGILLSMFF VTWLPFFVAS IAQAVCDCIS
310 320 330 340 350
PGLFDVLTWL GYCNSTMNPI IYPLFMRDFK RALGRFVPCV HCPPEHRASP
360 370 380 390 400
ASPSMWTSHS GARPGLSLQQ VLPLPLPPNS DSDSASGGTS GLQLTAQLLL
410 420 430 440
PGEATRDPPP PTRAPTVVNF FVTDSVEPEI RQHPLGSPMN
Length:440
Mass (Da):46,998
Last modified:August 22, 2006 - v1
Checksum:i4440CDEBE01FEF0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116652 mRNA. Translation: AAI16653.1.
BC116653 mRNA. Translation: AAI16654.1.
CH466615 Genomic DNA. Translation: EDL13293.1.
RefSeqiNP_067333.1. NM_021358.2.
XP_011248498.1. XM_011250196.2.
UniGeneiMm.291096.

Genome annotation databases

GeneIDi15565.
KEGGimmu:15565.

Similar proteinsi

Entry informationi

Entry nameiQ14AW8_MOUSE
AccessioniPrimary (citable) accession number: Q14AW8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: August 30, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)