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Protein
Submitted name:

Opioid receptor, kappa 1

Gene

Oprk1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Opioid receptor, kappa 1Imported
Submitted name:
Opioid receptor, kappa 1, isoform CRA_aImported
Gene namesi
Name:Oprk1Imported
ORF Names:mCG_14371Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97439. Oprk1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 85HelicalSequence analysisAdd BLAST29
Transmembranei97 – 119HelicalSequence analysisAdd BLAST23
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei180 – 199HelicalSequence analysisAdd BLAST20
Transmembranei224 – 251HelicalSequence analysisAdd BLAST28
Transmembranei272 – 296HelicalSequence analysisAdd BLAST25
Transmembranei311 – 333HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000025905.

Structurei

3D structure databases

SMRiQ14AL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 330G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
KOiK04214.
OMAiVRNTVQD.
OrthoDBiEOG091G0HEN.

Family and domain databases

CDDicd15091. 7tmA_Kappa_opioid_R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000452. Kappa_opi_rcpt.
IPR001418. Opioid_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00532. KAPPAOPIOIDR.
PR00384. OPIOIDR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14AL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPIQIFRG DPGPTCSPSA CLLPNSSSWF PNWAESDSNG SVGSEDQQLE
60 70 80 90 100
SAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN
110 120 130 140 150
LALADALVTT TMPFQSAVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT
160 170 180 190 200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLASSVG ISAIVLGGTK
210 220 230 240 250
VREDVDVIEC SLQFPDDEYS WWDLFMKICV FVFAFVIPVL IIIVCYTLMI
260 270 280 290 300
LRLKSVRLLS GSREKDRNLR RITKLVLVVV AVFIICWTPI HIFILVEALG
310 320 330 340 350
STSHSTAALS SYYFCIALGY TNSSLNPVLY AFLDENFKRC FRDFCFPIKM
360 370 380
RMERQSTNRV RNTVQDPASM RDVGGMNKPV
Length:380
Mass (Da):42,652
Last modified:August 22, 2006 - v1
Checksum:iFA4FC947D4545318
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116795 mRNA. Translation: AAI16796.1.
BC119026 mRNA. Translation: AAI19027.1.
CH466536 Genomic DNA. Translation: EDL14259.1.
RefSeqiNP_001191300.1. NM_001204371.1.
NP_035141.1. NM_011011.2.
UniGeneiMm.7977.

Genome annotation databases

GeneIDi18387.
KEGGimmu:18387.

Similar proteinsi

Entry informationi

Entry nameiQ14AL5_MOUSE
AccessioniPrimary (citable) accession number: Q14AL5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)