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Protein

Probable palmitoyltransferase ZDHHC11

Gene

Zdhhc11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC11 (EC:2.3.1.225)
Alternative name(s):
DHHC-containing protein 10
Zinc finger DHHC domain-containing protein 11
Short name:
DHHC-11
Gene namesi
Name:Zdhhc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1918414. Zdhhc11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004137641 – 347Probable palmitoyltransferase ZDHHC11Add BLAST347

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ14AK4.
PRIDEiQ14AK4.

PTM databases

PhosphoSitePlusiQ14AK4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069189.
GenevisibleiQ14AK4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089075.

Structurei

3D structure databases

SMRiQ14AK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 178DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000120122.
HOVERGENiHBG059666.
InParanoidiQ14AK4.
KOiK20027.
OMAiHLIAITI.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ14AK4.
TreeFamiTF317498.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14AK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEMNICGIN KNWVLPEAQE NNVKKFLPRP LSRVNGWSPP LHSFQAISWI
60 70 80 90 100
TYLAMSIVTF GIFIPFLPYS WKYAANIVMG GVFIFHLIVH LIAITIDPAD
110 120 130 140 150
TNVRLKKDYT QPVPAFDRSK HTHVIQNQYC HLCEVTASKK AKHCSACNKC
160 170 180 190 200
VSGFDHHCKW LNNCVGRRNY WFFFWSVASA AVGILGVMII LCYICIQYFV
210 220 230 240 250
NPDELRTDPL YKEIISENTW LLFLSLWPVP VKTPIVLSIA VMALLLAIAS
260 270 280 290 300
FVMLGHLLIF HLYLITKNMS TFDYLMKTRF KKNLHPAEEK ELPLQKKGDL
310 320 330 340
PQEKSDNWAW PKSPPRVGSQ KFPVSTLSPK SSVCFVASPP KICHSED
Length:347
Mass (Da):39,660
Last modified:September 5, 2006 - v2
Checksum:i1D2C92540424C697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668948 mRNA. Translation: AAU89702.1.
CT010471 Genomic DNA. No translation available.
BC116803 mRNA. Translation: AAI16804.2.
BC116807 mRNA. Translation: AAI16808.2.
CCDSiCCDS36729.1.
RefSeqiNP_081980.1. NM_027704.2.
UniGeneiMm.66995.

Genome annotation databases

EnsembliENSMUST00000091493; ENSMUSP00000089075; ENSMUSG00000069189.
GeneIDi71164.
KEGGimmu:71164.
UCSCiuc007ren.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY668948 mRNA. Translation: AAU89702.1.
CT010471 Genomic DNA. No translation available.
BC116803 mRNA. Translation: AAI16804.2.
BC116807 mRNA. Translation: AAI16808.2.
CCDSiCCDS36729.1.
RefSeqiNP_081980.1. NM_027704.2.
UniGeneiMm.66995.

3D structure databases

SMRiQ14AK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089075.

PTM databases

PhosphoSitePlusiQ14AK4.

Proteomic databases

PaxDbiQ14AK4.
PRIDEiQ14AK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091493; ENSMUSP00000089075; ENSMUSG00000069189.
GeneIDi71164.
KEGGimmu:71164.
UCSCiuc007ren.1. mouse.

Organism-specific databases

CTDi79844.
MGIiMGI:1918414. Zdhhc11.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000120122.
HOVERGENiHBG059666.
InParanoidiQ14AK4.
KOiK20027.
OMAiHLIAITI.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ14AK4.
TreeFamiTF317498.

Miscellaneous databases

PROiPR:Q14AK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069189.
GenevisibleiQ14AK4. MM.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDH11_MOUSE
AccessioniPrimary (citable) accession number: Q14AK4
Secondary accession number(s): Q5Y5T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: September 5, 2006
Last modified: April 12, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.