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Q14AI0

- DCC1_MOUSE

UniProt

Q14AI0 - DCC1_MOUSE

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Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. maintenance of mitotic sister chromatid cohesion Source: UniProtKB
  3. post-translational protein acetylation Source: UniProtKB
  4. regulation of DNA replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene namesi
Name:DSCC1
Synonyms:DCC1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1919357. Dscc1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. chromatin Source: UniProtKB
  2. chromosome, centromeric region Source: Ensembl
  3. nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Sister chromatid cohesion protein DCC1PRO_0000318065Add
BLAST

Proteomic databases

MaxQBiQ14AI0.
PRIDEiQ14AI0.

PTM databases

PhosphoSiteiQ14AI0.

Expressioni

Gene expression databases

BgeeiQ14AI0.
ExpressionAtlasiQ14AI0. baseline and differential.
GenevestigatoriQ14AI0.

Interactioni

Subunit structurei

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ14AI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCC1 family.Curated

Phylogenomic databases

eggNOGiNOG250437.
GeneTreeiENSGT00390000017400.
HOGENOMiHOG000008115.
HOVERGENiHBG105358.
InParanoidiQ14AI0.
KOiK11271.
OrthoDBiEOG7M6D7D.
PhylomeDBiQ14AI0.
TreeFamiTF106104.

Family and domain databases

InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamiPF09724. DUF2036. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14AI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPPSASRRT REEVDATLQV AKLNATELLP TVHCLSFSSG TGGAATGDFC
60 70 80 90 100
LLELEPALCQ QLEAGDSFVI RGDKDEQAVL CSKDKTYDLK IADTSNMLLF
110 120 130 140 150
IPGCKTPDQL KEEETPSAIV HTEIFGFSNN YWELRRCRPK LKKLKRLLME
160 170 180 190 200
NTYEGPDSQK EEDASRSKYT TEDLLNHIQA SEEEIMAQLQ VLNACEIGGY
210 220 230 240 250
WRILEFDYEI KLLNHVTQLV DSESWSLDRV PLTVCLQELG PLEPEEMIEH
260 270 280 290 300
CLKCYGKRYV DKDDVYFELD ADKICRVTAE MLLQNAVKFN LAEFQEVWQQ
310 320 330 340 350
SVPEGMTTRL DQLKGLALVD RNSRPEIIFL LKVDDLPEGT QDRFNSLFSL
360 370 380 390
REKWTEEDIT PYIQDLCGEK QTIGALLTKY SRSSMQNGIK VYNSRRLIS
Length:399
Mass (Da):45,522
Last modified:August 22, 2006 - v1
Checksum:i7AF16514EF64D9E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099382 mRNA. Translation: AAH99382.1.
BC116833 mRNA. Translation: AAI16834.1.
BC116835 mRNA. Translation: AAI16836.1.
CCDSiCCDS27473.1.
RefSeqiNP_898912.2. NM_183089.2.
UniGeneiMm.486550.

Genome annotation databases

EnsembliENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422.
GeneIDi72107.
KEGGimmu:72107.
UCSCiuc007vrw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099382 mRNA. Translation: AAH99382.1 .
BC116833 mRNA. Translation: AAI16834.1 .
BC116835 mRNA. Translation: AAI16836.1 .
CCDSi CCDS27473.1.
RefSeqi NP_898912.2. NM_183089.2.
UniGenei Mm.486550.

3D structure databases

ProteinModelPortali Q14AI0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q14AI0.

Proteomic databases

MaxQBi Q14AI0.
PRIDEi Q14AI0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023059 ; ENSMUSP00000023059 ; ENSMUSG00000022422 .
GeneIDi 72107.
KEGGi mmu:72107.
UCSCi uc007vrw.1. mouse.

Organism-specific databases

CTDi 79075.
MGIi MGI:1919357. Dscc1.

Phylogenomic databases

eggNOGi NOG250437.
GeneTreei ENSGT00390000017400.
HOGENOMi HOG000008115.
HOVERGENi HBG105358.
InParanoidi Q14AI0.
KOi K11271.
OrthoDBi EOG7M6D7D.
PhylomeDBi Q14AI0.
TreeFami TF106104.

Miscellaneous databases

NextBioi 335454.
PROi Q14AI0.
SOURCEi Search...

Gene expression databases

Bgeei Q14AI0.
ExpressionAtlasi Q14AI0. baseline and differential.
Genevestigatori Q14AI0.

Family and domain databases

InterProi IPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view ]
Pfami PF09724. DUF2036. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Oocyte.

Entry informationi

Entry nameiDCC1_MOUSE
AccessioniPrimary (citable) accession number: Q14AI0
Secondary accession number(s): Q4FZL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3