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Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene namesi
Name:DSCC1
Synonyms:DCC1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919357. Dscc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Sister chromatid cohesion protein DCC1PRO_0000318065Add
BLAST

Proteomic databases

MaxQBiQ14AI0.
PRIDEiQ14AI0.

PTM databases

PhosphoSiteiQ14AI0.

Expressioni

Gene expression databases

BgeeiQ14AI0.
ExpressionAtlasiQ14AI0. baseline and differential.
GenevisibleiQ14AI0. MM.

Interactioni

Subunit structurei

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023059.

Structurei

3D structure databases

ProteinModelPortaliQ14AI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCC1 family.Curated

Phylogenomic databases

eggNOGiNOG250437.
GeneTreeiENSGT00390000017400.
HOGENOMiHOG000008115.
HOVERGENiHBG105358.
InParanoidiQ14AI0.
KOiK11271.
OrthoDBiEOG7M6D7D.
PhylomeDBiQ14AI0.
TreeFamiTF106104.

Family and domain databases

InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamiPF09724. DUF2036. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14AI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPSASRRT REEVDATLQV AKLNATELLP TVHCLSFSSG TGGAATGDFC
60 70 80 90 100
LLELEPALCQ QLEAGDSFVI RGDKDEQAVL CSKDKTYDLK IADTSNMLLF
110 120 130 140 150
IPGCKTPDQL KEEETPSAIV HTEIFGFSNN YWELRRCRPK LKKLKRLLME
160 170 180 190 200
NTYEGPDSQK EEDASRSKYT TEDLLNHIQA SEEEIMAQLQ VLNACEIGGY
210 220 230 240 250
WRILEFDYEI KLLNHVTQLV DSESWSLDRV PLTVCLQELG PLEPEEMIEH
260 270 280 290 300
CLKCYGKRYV DKDDVYFELD ADKICRVTAE MLLQNAVKFN LAEFQEVWQQ
310 320 330 340 350
SVPEGMTTRL DQLKGLALVD RNSRPEIIFL LKVDDLPEGT QDRFNSLFSL
360 370 380 390
REKWTEEDIT PYIQDLCGEK QTIGALLTKY SRSSMQNGIK VYNSRRLIS
Length:399
Mass (Da):45,522
Last modified:August 22, 2006 - v1
Checksum:i7AF16514EF64D9E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099382 mRNA. Translation: AAH99382.1.
BC116833 mRNA. Translation: AAI16834.1.
BC116835 mRNA. Translation: AAI16836.1.
CCDSiCCDS27473.1.
RefSeqiNP_898912.2. NM_183089.2.
UniGeneiMm.486550.

Genome annotation databases

EnsembliENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422.
GeneIDi72107.
KEGGimmu:72107.
UCSCiuc007vrw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099382 mRNA. Translation: AAH99382.1.
BC116833 mRNA. Translation: AAI16834.1.
BC116835 mRNA. Translation: AAI16836.1.
CCDSiCCDS27473.1.
RefSeqiNP_898912.2. NM_183089.2.
UniGeneiMm.486550.

3D structure databases

ProteinModelPortaliQ14AI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023059.

PTM databases

PhosphoSiteiQ14AI0.

Proteomic databases

MaxQBiQ14AI0.
PRIDEiQ14AI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422.
GeneIDi72107.
KEGGimmu:72107.
UCSCiuc007vrw.1. mouse.

Organism-specific databases

CTDi79075.
MGIiMGI:1919357. Dscc1.

Phylogenomic databases

eggNOGiNOG250437.
GeneTreeiENSGT00390000017400.
HOGENOMiHOG000008115.
HOVERGENiHBG105358.
InParanoidiQ14AI0.
KOiK11271.
OrthoDBiEOG7M6D7D.
PhylomeDBiQ14AI0.
TreeFamiTF106104.

Miscellaneous databases

NextBioi335454.
PROiQ14AI0.
SOURCEiSearch...

Gene expression databases

BgeeiQ14AI0.
ExpressionAtlasiQ14AI0. baseline and differential.
GenevisibleiQ14AI0. MM.

Family and domain databases

InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamiPF09724. DUF2036. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Oocyte.

Entry informationi

Entry nameiDCC1_MOUSE
AccessioniPrimary (citable) accession number: Q14AI0
Secondary accession number(s): Q4FZL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: June 24, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.