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Q14AI0 (DCC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene names
Name:DSCC1
Synonyms:DCC1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 By similarity.

Subunit structure

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the DCC1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Sister chromatid cohesion protein DCC1
PRO_0000318065

Sequences

Sequence LengthMass (Da)Tools
Q14AI0 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 7AF16514EF64D9E5

FASTA39945,522
        10         20         30         40         50         60 
MSPPSASRRT REEVDATLQV AKLNATELLP TVHCLSFSSG TGGAATGDFC LLELEPALCQ 

        70         80         90        100        110        120 
QLEAGDSFVI RGDKDEQAVL CSKDKTYDLK IADTSNMLLF IPGCKTPDQL KEEETPSAIV 

       130        140        150        160        170        180 
HTEIFGFSNN YWELRRCRPK LKKLKRLLME NTYEGPDSQK EEDASRSKYT TEDLLNHIQA 

       190        200        210        220        230        240 
SEEEIMAQLQ VLNACEIGGY WRILEFDYEI KLLNHVTQLV DSESWSLDRV PLTVCLQELG 

       250        260        270        280        290        300 
PLEPEEMIEH CLKCYGKRYV DKDDVYFELD ADKICRVTAE MLLQNAVKFN LAEFQEVWQQ 

       310        320        330        340        350        360 
SVPEGMTTRL DQLKGLALVD RNSRPEIIFL LKVDDLPEGT QDRFNSLFSL REKWTEEDIT 

       370        380        390 
PYIQDLCGEK QTIGALLTKY SRSSMQNGIK VYNSRRLIS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Oocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099382 mRNA. Translation: AAH99382.1.
BC116833 mRNA. Translation: AAI16834.1.
BC116835 mRNA. Translation: AAI16836.1.
CCDSCCDS27473.1.
RefSeqNP_898912.2. NM_183089.2.
UniGeneMm.486550.

3D structure databases

ProteinModelPortalQ14AI0.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ14AI0.

Proteomic databases

PRIDEQ14AI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422.
GeneID72107.
KEGGmmu:72107.
UCSCuc007vrw.1. mouse.

Organism-specific databases

CTD79075.
MGIMGI:1919357. Dscc1.

Phylogenomic databases

eggNOGNOG250437.
GeneTreeENSGT00390000017400.
HOGENOMHOG000008115.
HOVERGENHBG105358.
KOK11271.
OrthoDBEOG7M6D7D.
PhylomeDBQ14AI0.
TreeFamTF106104.

Gene expression databases

ArrayExpressQ14AI0.
BgeeQ14AI0.
GenevestigatorQ14AI0.

Family and domain databases

InterProIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamPF09724. DUF2036. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335454.
PROQ14AI0.
SOURCESearch...

Entry information

Entry nameDCC1_MOUSE
AccessionPrimary (citable) accession number: Q14AI0
Secondary accession number(s): Q4FZL5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot