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Q14AI0

- DCC1_MOUSE

UniProt

Q14AI0 - DCC1_MOUSE

Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. maintenance of mitotic sister chromatid cohesion Source: UniProtKB
    3. post-translational protein acetylation Source: UniProtKB
    4. regulation of DNA replication Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sister chromatid cohesion protein DCC1
    Alternative name(s):
    Defective in sister chromatid cohesion protein 1 homolog
    Gene namesi
    Name:DSCC1
    Synonyms:DCC1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1919357. Dscc1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. chromatin Source: UniProtKB
    2. chromosome, centromeric region Source: Ensembl
    3. nucleoplasm Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Sister chromatid cohesion protein DCC1PRO_0000318065Add
    BLAST

    Proteomic databases

    PRIDEiQ14AI0.

    PTM databases

    PhosphoSiteiQ14AI0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14AI0.
    BgeeiQ14AI0.
    GenevestigatoriQ14AI0.

    Interactioni

    Subunit structurei

    Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ14AI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCC1 family.Curated

    Phylogenomic databases

    eggNOGiNOG250437.
    GeneTreeiENSGT00390000017400.
    HOGENOMiHOG000008115.
    HOVERGENiHBG105358.
    KOiK11271.
    OrthoDBiEOG7M6D7D.
    PhylomeDBiQ14AI0.
    TreeFamiTF106104.

    Family and domain databases

    InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
    [Graphical view]
    PfamiPF09724. DUF2036. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14AI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPPSASRRT REEVDATLQV AKLNATELLP TVHCLSFSSG TGGAATGDFC    50
    LLELEPALCQ QLEAGDSFVI RGDKDEQAVL CSKDKTYDLK IADTSNMLLF 100
    IPGCKTPDQL KEEETPSAIV HTEIFGFSNN YWELRRCRPK LKKLKRLLME 150
    NTYEGPDSQK EEDASRSKYT TEDLLNHIQA SEEEIMAQLQ VLNACEIGGY 200
    WRILEFDYEI KLLNHVTQLV DSESWSLDRV PLTVCLQELG PLEPEEMIEH 250
    CLKCYGKRYV DKDDVYFELD ADKICRVTAE MLLQNAVKFN LAEFQEVWQQ 300
    SVPEGMTTRL DQLKGLALVD RNSRPEIIFL LKVDDLPEGT QDRFNSLFSL 350
    REKWTEEDIT PYIQDLCGEK QTIGALLTKY SRSSMQNGIK VYNSRRLIS 399
    Length:399
    Mass (Da):45,522
    Last modified:August 22, 2006 - v1
    Checksum:i7AF16514EF64D9E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099382 mRNA. Translation: AAH99382.1.
    BC116833 mRNA. Translation: AAI16834.1.
    BC116835 mRNA. Translation: AAI16836.1.
    CCDSiCCDS27473.1.
    RefSeqiNP_898912.2. NM_183089.2.
    UniGeneiMm.486550.

    Genome annotation databases

    EnsembliENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422.
    GeneIDi72107.
    KEGGimmu:72107.
    UCSCiuc007vrw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099382 mRNA. Translation: AAH99382.1 .
    BC116833 mRNA. Translation: AAI16834.1 .
    BC116835 mRNA. Translation: AAI16836.1 .
    CCDSi CCDS27473.1.
    RefSeqi NP_898912.2. NM_183089.2.
    UniGenei Mm.486550.

    3D structure databases

    ProteinModelPortali Q14AI0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q14AI0.

    Proteomic databases

    PRIDEi Q14AI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023059 ; ENSMUSP00000023059 ; ENSMUSG00000022422 .
    GeneIDi 72107.
    KEGGi mmu:72107.
    UCSCi uc007vrw.1. mouse.

    Organism-specific databases

    CTDi 79075.
    MGIi MGI:1919357. Dscc1.

    Phylogenomic databases

    eggNOGi NOG250437.
    GeneTreei ENSGT00390000017400.
    HOGENOMi HOG000008115.
    HOVERGENi HBG105358.
    KOi K11271.
    OrthoDBi EOG7M6D7D.
    PhylomeDBi Q14AI0.
    TreeFami TF106104.

    Miscellaneous databases

    NextBioi 335454.
    PROi Q14AI0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14AI0.
    Bgeei Q14AI0.
    Genevestigatori Q14AI0.

    Family and domain databases

    InterProi IPR019128. Sister_chromatid_cohesion_Dcc1.
    [Graphical view ]
    Pfami PF09724. DUF2036. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Oocyte.

    Entry informationi

    Entry nameiDCC1_MOUSE
    AccessioniPrimary (citable) accession number: Q14AI0
    Secondary accession number(s): Q4FZL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3