ID   Q14AD9_MOUSE            Unreviewed;       141 AA.
AC   Q14AD9;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   03-MAY-2023, entry version 80.
DE   RecName: Full=Granulocyte-macrophage colony-stimulating factor {ECO:0000256|ARBA:ARBA00018697};
DE   AltName: Full=Colony-stimulating factor {ECO:0000256|ARBA:ARBA00029601};
GN   Name=Csf2 {ECO:0000313|EMBL:AAI16881.1, ECO:0000313|MGI:MGI:1339752};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI16881.1};
RN   [1] {ECO:0000313|EMBL:AAI16881.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI16881.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC       hematopoietic precursor cells from various lineages, including
CC       granulocytes, macrophages, eosinophils and erythrocytes.
CC       {ECO:0000256|ARBA:ARBA00003164}.
CC   -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC       of two head-to-head hexamers of two alpha, two beta, and two ligand
CC       subunits. {ECO:0000256|ARBA:ARBA00025874}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the GM-CSF family.
CC       {ECO:0000256|ARBA:ARBA00009378}.
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DR   EMBL; BC116878; AAI16879.1; -; mRNA.
DR   EMBL; BC116880; AAI16881.1; -; mRNA.
DR   AlphaFoldDB; Q14AD9; -.
DR   AGR; MGI:1339752; -.
DR   MGI; MGI:1339752; Csf2.
DR   ChiTaRS; Csf2; mouse.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000773; GM_colony-stim-fac.
DR   PANTHER; PTHR10059:SF0; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; 1.
DR   PANTHER; PTHR10059; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GM-CSF; 1.
DR   Pfam; PF01109; GM_CSF; 1.
DR   PRINTS; PR00693; GMCSFACTOR.
DR   SMART; SM00040; CSF2; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00702; GM_CSF; 1.
PE   2: Evidence at transcript level;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..141
FT                   /note="Granulocyte-macrophage colony-stimulating factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014306908"
SQ   SEQUENCE   141 AA;  16133 MW;  209C660B4FF77349 CRC64;
     MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL NEEVEVVSNE
     FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT YCPPTPETDC ETQVTTYADF
     IDSLKTFLTD IPFECKKPVQ K
//