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Protein

Prokineticin-1

Gene

Prok1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.By similarity3 Publications

GO - Molecular functioni

  • G-protein coupled receptor binding Source: DFLAT
  • growth factor activity Source: UniProtKB-KW

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • angiogenesis Source: UniProtKB-KW
  • circadian rhythm Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • regulation of angiogenesis Source: MGI

Keywordsi

Molecular functionGrowth factor, Mitogen
Biological processAngiogenesis

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin-1Imported
Alternative name(s):
Endocrine-gland-derived vascular endothelial growth factorBy similarity
Short name:
EG-VEGFBy similarity
Gene namesi
Name:Prok1Imported
Synonyms:Pk1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2180370 Prok1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000037745720 – 105Prokineticin-1Sequence analysisAdd BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 38By similarity
Disulfide bondi32 ↔ 50By similarity
Disulfide bondi37 ↔ 78By similarity
Disulfide bondi60 ↔ 86By similarity
Disulfide bondi80 ↔ 96By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ14A28
PRIDEiQ14A28

PTM databases

PhosphoSitePlusiQ14A28

Expressioni

Tissue specificityi

Highly expressed in liver and ovary and weakly expressed in testis and placenta. Expressed in mucosa and mesenchyme of embryonic gut during enteric nervous system development (at protein level). Predominantly expressed in kidney and liver. Also expressed in lung, ovary, placenta and testis. In fetal liver, is restricted to and highly expressed in hepatocytes. In adult kidney, expression is restricted to the endothelial tubule cells. In placenta, expressed throughout gestation.3 Publications

Developmental stagei

In placenta, at 7.5 dpc highly expressed in ectoplacental cone, endoderm and in giant cells, and at 9.5 dpc restricted mainly to the labyrinth layer (at protein level). In placenta, most highly expressed during early gestation (between 9.5 and 10.5 dpc).1 Publication

Gene expression databases

BgeeiENSMUSG00000070368

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: DFLAT
  • growth factor activity Source: UniProtKB-KW

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060617

Structurei

3D structure databases

ProteinModelPortaliQ14A28
SMRiQ14A28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYYQ Eukaryota
ENOG4111YK9 LUCA
GeneTreeiENSGT00390000014799
HOGENOMiHOG000004848
InParanoidiQ14A28
OMAiMCTPLGQ
OrthoDBiEOG091G0U3L
PhylomeDBiQ14A28
TreeFamiTF332732

Family and domain databases

InterProiView protein in InterPro
IPR009523 Prokineticin
IPR023569 Prokineticin_domain
PANTHERiPTHR18821 PTHR18821, 1 hit
PfamiView protein in Pfam
PF06607 Prokineticin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD059788 Prokineticin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q14A28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGAVHIFIM LLLATASDCA VITGACERDI QCGAGTCCAI SLWLRGLRLC
60 70 80 90 100
TPLGREGEEC HPGSHKIPFL RKRQHHTCPC SPSLLCSRFP DGRYRCFRDL

KNANF
Length:105
Mass (Da):11,678
Last modified:August 22, 2006 - v1
Checksum:i0C75428C310B528F
GO
Isoform 21 Publication (identifier: Q14A28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MRGAVHIFIMLLLATASDCAVITG → MKAVVKTK

Show »
Length:89
Mass (Da):10,078
Checksum:i549C8BF0E1AE5F02
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0531171 – 24MRGAV…AVITG → MKAVVKTK in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466607 Genomic DNA Translation: EDL01898.1
BC042707 mRNA Translation: AAH42707.1
BC117006 mRNA Translation: AAI17007.1
BC117008 mRNA Translation: AAI17009.1
AF487281 mRNA Translation: AAM49573.1
CCDSiCCDS38589.1 [Q14A28-1]
RefSeqiNP_001037847.1, NM_001044382.1 [Q14A28-1]
XP_017175073.1, XM_017319584.1
UniGeneiMm.437416
Mm.490697

Genome annotation databases

EnsembliENSMUST00000049852; ENSMUSP00000060617; ENSMUSG00000070368 [Q14A28-1]
ENSMUST00000197758; ENSMUSP00000143197; ENSMUSG00000070368 [Q14A28-2]
GeneIDi246691
KEGGimmu:246691
UCSCiuc008qwv.1 mouse [Q14A28-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPROK1_MOUSE
AccessioniPrimary (citable) accession number: Q14A28
Secondary accession number(s): Q0P609, Q8K457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: August 22, 2006
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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