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Protein

Prokineticin-1

Gene

Prok1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.By similarity3 Publications

GO - Molecular functioni

  • G-protein coupled receptor binding Source: DFLAT

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • angiogenesis Source: UniProtKB-KW
  • circadian rhythm Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • regulation of angiogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin-1Imported
Alternative name(s):
Endocrine-gland-derived vascular endothelial growth factorBy similarity
Short name:
EG-VEGFBy similarity
Gene namesi
Name:Prok1Imported
Synonyms:Pk1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2180370. Prok1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 10586Prokineticin-1Sequence analysisPRO_0000377457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 38By similarity
Disulfide bondi32 ↔ 50By similarity
Disulfide bondi37 ↔ 78By similarity
Disulfide bondi60 ↔ 86By similarity
Disulfide bondi80 ↔ 96By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ14A28.
PRIDEiQ14A28.

PTM databases

PhosphoSiteiQ14A28.

Expressioni

Tissue specificityi

Highly expressed in liver and ovary and weakly expressed in testis and placenta. Expressed in mucosa and mesenchyme of embryonic gut during enteric nervous system development (at protein level). Predominantly expressed in kidney and liver. Also expressed in lung, ovary, placenta and testis. In fetal liver, is restricted to and highly expressed in hepatocytes. In adult kidney, expression is restricted to the endothelial tubule cells. In placenta, expressed throughout gestation.3 Publications

Developmental stagei

In placenta, at 7.5 dpc highly expressed in ectoplacental cone, endoderm and in giant cells, and at 9.5 dpc restricted mainly to the labyrinth layer (at protein level). In placenta, most highly expressed during early gestation (between 9.5 and 10.5 dpc).1 Publication

Gene expression databases

BgeeiENSMUSG00000070368.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: DFLAT

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060617.

Structurei

3D structure databases

ProteinModelPortaliQ14A28.
SMRiQ14A28. Positions 20-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYYQ. Eukaryota.
ENOG4111YK9. LUCA.
GeneTreeiENSGT00390000014799.
HOGENOMiHOG000004848.
InParanoidiQ14A28.
OMAiRKRQHHT.
OrthoDBiEOG091G0U3L.
PhylomeDBiQ14A28.
TreeFamiTF332732.

Family and domain databases

InterProiIPR009523. Prokineticin.
IPR023569. Prokineticin_domain.
[Graphical view]
PANTHERiPTHR18821. PTHR18821. 1 hit.
PfamiPF06607. Prokineticin. 1 hit.
[Graphical view]
ProDomiPD059788. Prokineticin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q14A28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGAVHIFIM LLLATASDCA VITGACERDI QCGAGTCCAI SLWLRGLRLC
60 70 80 90 100
TPLGREGEEC HPGSHKIPFL RKRQHHTCPC SPSLLCSRFP DGRYRCFRDL

KNANF
Length:105
Mass (Da):11,678
Last modified:August 22, 2006 - v1
Checksum:i0C75428C310B528F
GO
Isoform 21 Publication (identifier: Q14A28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MRGAVHIFIMLLLATASDCAVITG → MKAVVKTK

Show »
Length:89
Mass (Da):10,078
Checksum:i549C8BF0E1AE5F02
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424MRGAV…AVITG → MKAVVKTK in isoform 2. 1 PublicationVSP_053117Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466607 Genomic DNA. Translation: EDL01898.1.
BC042707 mRNA. Translation: AAH42707.1.
BC117006 mRNA. Translation: AAI17007.1.
BC117008 mRNA. Translation: AAI17009.1.
AF487281 mRNA. Translation: AAM49573.1.
CCDSiCCDS38589.1. [Q14A28-1]
RefSeqiNP_001037847.1. NM_001044382.1. [Q14A28-1]
UniGeneiMm.490697.

Genome annotation databases

EnsembliENSMUST00000049852; ENSMUSP00000060617; ENSMUSG00000070368. [Q14A28-1]
ENSMUST00000197758; ENSMUSP00000143197; ENSMUSG00000070368. [Q14A28-2]
GeneIDi246691.
KEGGimmu:246691.
UCSCiuc008qwv.1. mouse. [Q14A28-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466607 Genomic DNA. Translation: EDL01898.1.
BC042707 mRNA. Translation: AAH42707.1.
BC117006 mRNA. Translation: AAI17007.1.
BC117008 mRNA. Translation: AAI17009.1.
AF487281 mRNA. Translation: AAM49573.1.
CCDSiCCDS38589.1. [Q14A28-1]
RefSeqiNP_001037847.1. NM_001044382.1. [Q14A28-1]
UniGeneiMm.490697.

3D structure databases

ProteinModelPortaliQ14A28.
SMRiQ14A28. Positions 20-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060617.

PTM databases

PhosphoSiteiQ14A28.

Proteomic databases

PaxDbiQ14A28.
PRIDEiQ14A28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049852; ENSMUSP00000060617; ENSMUSG00000070368. [Q14A28-1]
ENSMUST00000197758; ENSMUSP00000143197; ENSMUSG00000070368. [Q14A28-2]
GeneIDi246691.
KEGGimmu:246691.
UCSCiuc008qwv.1. mouse. [Q14A28-1]

Organism-specific databases

CTDi84432.
MGIiMGI:2180370. Prok1.

Phylogenomic databases

eggNOGiENOG410IYYQ. Eukaryota.
ENOG4111YK9. LUCA.
GeneTreeiENSGT00390000014799.
HOGENOMiHOG000004848.
InParanoidiQ14A28.
OMAiRKRQHHT.
OrthoDBiEOG091G0U3L.
PhylomeDBiQ14A28.
TreeFamiTF332732.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ14A28.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070368.

Family and domain databases

InterProiIPR009523. Prokineticin.
IPR023569. Prokineticin_domain.
[Graphical view]
PANTHERiPTHR18821. PTHR18821. 1 hit.
PfamiPF06607. Prokineticin. 1 hit.
[Graphical view]
ProDomiPD059788. Prokineticin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiPROK1_MOUSE
AccessioniPrimary (citable) accession number: Q14A28
Secondary accession number(s): Q0P609, Q8K457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.