UniProtKB - Q14A12 (Q14A12_MOUSE)
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Protein
Submitted name:
RAS-related C3 botulinum substrate 3
Gene
Rac3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
- GTPase activity Source: Ensembl
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: Ensembl
- cell projection assembly Source: Ensembl
- cerebral cortex GABAergic interneuron development Source: Ensembl
- homeostasis of number of cells within a tissue Source: Ensembl
- neuromuscular process controlling balance Source: Ensembl
- neuron projection development Source: Ensembl
- positive regulation of cell adhesion mediated by integrin Source: Ensembl
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
- regulation of neuron maturation Source: Ensembl
- small GTPase mediated signal transduction Source: InterPro
- synaptic transmission, GABAergic Source: Ensembl
Keywordsi
| Ligand | GTP-bindingSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
| Protein namesi | Submitted name: RAS-related C3 botulinum substrate 3ImportedSubmitted name: RAS-related C3 botulinum substrate 3, isoform CRA_bImported |
| Gene namesi | Name:Rac3Imported ORF Names:mCG_2150Imported |
| Organismi | Mus musculus (Mouse)Imported |
| Taxonomic identifieri | 10090 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
| MGIi | MGI:2180784. Rac3. |
Subcellular locationi
GO - Cellular componenti
- cell periphery Source: Ensembl
- cytosol Source: Ensembl
- endomembrane system Source: Ensembl
- extracellular exosome Source: Ensembl
- filamentous actin Source: Ensembl
- growth cone Source: Ensembl
- membrane Source: UniProtKB-KW
- neuronal cell body Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
MembraneSAAS annotationExpressioni
Gene expression databases
| Bgeei | ENSMUSG00000018012. |
| ExpressionAtlasi | Q14A12. baseline and differential. |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
| eggNOGi | KOG0393. Eukaryota. COG1100. LUCA. |
| HOVERGENi | HBG009351. |
| KOi | K07861. |
| OMAi | GKKCTMF. |
| OrthoDBi | EOG091G0KCM. |
Family and domain databases
| InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. |
| Pfami | View protein in Pfam PF00071. Ras. 1 hit. |
| SUPFAMi | SSF52540. SSF52540. 1 hit. |
| TIGRFAMsi | TIGR00231. small_GTP. 1 hit. |
| PROSITEi | View protein in PROSITE PS51420. RHO. 1 hit. |
Sequencei
Sequence statusi: Complete.
Q14A12-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP
60 70 80 90 100
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE
110 120 130 140 150
VRHHCPHTPI LLVGTKLDLR DDKDTIERLR DKKLAPITYP QGLAMAREIG
160 170 180 190
SVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKPGKKCT VF
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC117028 mRNA. Translation: AAI17029.1. BC119041 mRNA. Translation: AAI19042.1. CH466558 Genomic DNA. Translation: EDL34796.1. |
| RefSeqi | NP_573486.1. NM_133223.4. |
| UniGenei | Mm.34008. |
Genome annotation databases
| GeneIDi | 170758. |
| KEGGi | mmu:170758. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | Q14A12_MOUSE | |
| Accessioni | Q14A12Primary (citable) accession number: Q14A12 | |
| Entry historyi | Integrated into UniProtKB/TrEMBL: | August 22, 2006 |
| Last sequence update: | August 22, 2006 | |
| Last modified: | July 5, 2017 | |
| This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
