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Protein

Protein phosphatase 1J

Gene

Ppm1j

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1J (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform zeta
Short name:
PP2C-zeta
Gene namesi
Name:Ppm1j
Synonyms:Ppp2cz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919137. Ppm1j.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Protein phosphatase 1JPRO_0000289059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ149T7.
PaxDbiQ149T7.
PRIDEiQ149T7.

PTM databases

PhosphoSiteiQ149T7.

Expressioni

Tissue specificityi

Specifically expressed in the testicular germ cells.1 Publication

Gene expression databases

BgeeiQ149T7.
CleanExiMM_PPM1J.
GenevestigatoriQ149T7.

Interactioni

Subunit structurei

Interacts with UBE2I/UBC9.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ149T7.
SMRiQ149T7. Positions 258-311, 372-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 499397PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG314780.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ149T7.
KOiK17504.
OMAiDHNLKVC.
OrthoDBiEOG7F511J.
PhylomeDBiQ149T7.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q149T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNRVRSAVA HLVSSGGTSS QRSKSPDLPN ATSAPPAAQE TPKSSREKPG
60 70 80 90 100
NQVGAPQKTA ETTVSFSRPT FLQLSPGGLR RADDHAGRAV QSPPDTGRRL
110 120 130 140 150
PWSTGYAEVI NAGKSRHNED QACCEVVYVE SRRSRSVTGV SREPSHNQGF
160 170 180 190 200
CFYYWGLFDG HAGGGAAEMA SRLLHRHIRE QLKDLVEILK DPLPPPLCLP
210 220 230 240 250
STPGTPGAPS PSQLVSPQSC WSPQKEVTHD SLIVGAIENA FHLMDEQMAR
260 270 280 290 300
ERRGHQVEGG CCALVVLYLL GKMYVANAGD SRAIIVRNGE IIPMSREFTP
310 320 330 340 350
ETERQRLQLL GFLKPELLGS EFTHLEFPRR VQPKELGQRM LYRDQNMTGW
360 370 380 390 400
AYKKIEVEDL RFPLVCGEGK KARVMATIGV TRGLGDHNLK VCSSTLSIKP
410 420 430 440 450
FLSCFPEVRV YDLTQYEHCP DDVLVLGTDG LWDVTNDSEV AATVDRVLSS
460 470 480 490 500
YEPNDPSRYT ALAQALVLGA RGIPRDRGWR LPNNKLGSGD DISVFVIPLG

GPGSSYS
Length:507
Mass (Da):55,550
Last modified:August 22, 2006 - v1
Checksum:i4754E503AA8A7FE2
GO

Sequence cautioni

The sequence BAB26156.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → A in AAO72079 (PubMed:12633878).Curated
Sequence conflicti61 – 622Missing in AAO72079 (PubMed:12633878).Curated
Sequence conflicti78 – 781G → GET in AAO72079 (PubMed:12633878).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184802 mRNA. Translation: AAO72079.1.
BC117498 mRNA. Translation: AAI17499.1.
BC121788 mRNA. Translation: AAI21789.1.
AK009235 mRNA. Translation: BAB26156.1. Different initiation.
CCDSiCCDS17703.1.
RefSeqiNP_082258.2. NM_027982.2.
UniGeneiMm.379204.

Genome annotation databases

EnsembliENSMUST00000002298; ENSMUSP00000002298; ENSMUSG00000002228.
GeneIDi71887.
KEGGimmu:71887.
UCSCiuc008quk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184802 mRNA. Translation: AAO72079.1.
BC117498 mRNA. Translation: AAI17499.1.
BC121788 mRNA. Translation: AAI21789.1.
AK009235 mRNA. Translation: BAB26156.1. Different initiation.
CCDSiCCDS17703.1.
RefSeqiNP_082258.2. NM_027982.2.
UniGeneiMm.379204.

3D structure databases

ProteinModelPortaliQ149T7.
SMRiQ149T7. Positions 258-311, 372-501.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ149T7.

Proteomic databases

MaxQBiQ149T7.
PaxDbiQ149T7.
PRIDEiQ149T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002298; ENSMUSP00000002298; ENSMUSG00000002228.
GeneIDi71887.
KEGGimmu:71887.
UCSCiuc008quk.1. mouse.

Organism-specific databases

CTDi333926.
MGIiMGI:1919137. Ppm1j.

Phylogenomic databases

eggNOGiNOG314780.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ149T7.
KOiK17504.
OMAiDHNLKVC.
OrthoDBiEOG7F511J.
PhylomeDBiQ149T7.
TreeFamiTF314700.

Miscellaneous databases

NextBioi334852.
PROiQ149T7.
SOURCEiSearch...

Gene expression databases

BgeeiQ149T7.
CleanExiMM_PPM1J.
GenevestigatoriQ149T7.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9."
    Kashiwaba M., Katsura K., Ohnishi M., Sasaki M., Tanaka H., Nishimune Y., Kobayashi T., Tamura S.
    FEBS Lett. 538:197-202(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH UBE2I, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-507.
    Strain: C57BL/6J.
    Tissue: Tongue.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPM1J_MOUSE
AccessioniPrimary (citable) accession number: Q149T7
Secondary accession number(s): Q810X6, Q9D7H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.