Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q149T7

- PPM1J_MOUSE

UniProt

Q149T7 - PPM1J_MOUSE

Protein

Protein phosphatase 1J

Gene

Ppm1j

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. protein serine/threonine phosphatase activity Source: MGI

    GO - Biological processi

    1. protein dephosphorylation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1J (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 2C isoform zeta
    Short name:
    PP2C-zeta
    Gene namesi
    Name:Ppm1j
    Synonyms:Ppp2cz
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1919137. Ppm1j.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Protein phosphatase 1JPRO_0000289059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ149T7.
    PRIDEiQ149T7.

    PTM databases

    PhosphoSiteiQ149T7.

    Expressioni

    Tissue specificityi

    Specifically expressed in the testicular germ cells.1 Publication

    Gene expression databases

    BgeeiQ149T7.
    CleanExiMM_PPM1J.
    GenevestigatoriQ149T7.

    Interactioni

    Subunit structurei

    Interacts with UBE2I/UBC9.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ149T7.
    SMRiQ149T7. Positions 258-311, 372-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini119 – 499381PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiNOG314780.
    GeneTreeiENSGT00530000063231.
    HOGENOMiHOG000251606.
    HOVERGENiHBG105802.
    InParanoidiQ149T7.
    KOiK17504.
    OMAiDHNLKVC.
    OrthoDBiEOG7F511J.
    PhylomeDBiQ149T7.
    TreeFamiTF314700.

    Family and domain databases

    Gene3Di3.60.40.10. 3 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q149T7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNRVRSAVA HLVSSGGTSS QRSKSPDLPN ATSAPPAAQE TPKSSREKPG    50
    NQVGAPQKTA ETTVSFSRPT FLQLSPGGLR RADDHAGRAV QSPPDTGRRL 100
    PWSTGYAEVI NAGKSRHNED QACCEVVYVE SRRSRSVTGV SREPSHNQGF 150
    CFYYWGLFDG HAGGGAAEMA SRLLHRHIRE QLKDLVEILK DPLPPPLCLP 200
    STPGTPGAPS PSQLVSPQSC WSPQKEVTHD SLIVGAIENA FHLMDEQMAR 250
    ERRGHQVEGG CCALVVLYLL GKMYVANAGD SRAIIVRNGE IIPMSREFTP 300
    ETERQRLQLL GFLKPELLGS EFTHLEFPRR VQPKELGQRM LYRDQNMTGW 350
    AYKKIEVEDL RFPLVCGEGK KARVMATIGV TRGLGDHNLK VCSSTLSIKP 400
    FLSCFPEVRV YDLTQYEHCP DDVLVLGTDG LWDVTNDSEV AATVDRVLSS 450
    YEPNDPSRYT ALAQALVLGA RGIPRDRGWR LPNNKLGSGD DISVFVIPLG 500
    GPGSSYS 507
    Length:507
    Mass (Da):55,550
    Last modified:August 22, 2006 - v1
    Checksum:i4754E503AA8A7FE2
    GO

    Sequence cautioni

    The sequence BAB26156.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51V → A in AAO72079. (PubMed:12633878)Curated
    Sequence conflicti61 – 622Missing in AAO72079. (PubMed:12633878)Curated
    Sequence conflicti78 – 781G → GET in AAO72079. (PubMed:12633878)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184802 mRNA. Translation: AAO72079.1.
    BC117498 mRNA. Translation: AAI17499.1.
    BC121788 mRNA. Translation: AAI21789.1.
    AK009235 mRNA. Translation: BAB26156.1. Different initiation.
    CCDSiCCDS17703.1.
    RefSeqiNP_082258.2. NM_027982.2.
    UniGeneiMm.379204.

    Genome annotation databases

    EnsembliENSMUST00000002298; ENSMUSP00000002298; ENSMUSG00000002228.
    GeneIDi71887.
    KEGGimmu:71887.
    UCSCiuc008quk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184802 mRNA. Translation: AAO72079.1 .
    BC117498 mRNA. Translation: AAI17499.1 .
    BC121788 mRNA. Translation: AAI21789.1 .
    AK009235 mRNA. Translation: BAB26156.1 . Different initiation.
    CCDSi CCDS17703.1.
    RefSeqi NP_082258.2. NM_027982.2.
    UniGenei Mm.379204.

    3D structure databases

    ProteinModelPortali Q149T7.
    SMRi Q149T7. Positions 258-311, 372-501.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q149T7.

    PTM databases

    PhosphoSitei Q149T7.

    Proteomic databases

    PaxDbi Q149T7.
    PRIDEi Q149T7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002298 ; ENSMUSP00000002298 ; ENSMUSG00000002228 .
    GeneIDi 71887.
    KEGGi mmu:71887.
    UCSCi uc008quk.1. mouse.

    Organism-specific databases

    CTDi 333926.
    MGIi MGI:1919137. Ppm1j.

    Phylogenomic databases

    eggNOGi NOG314780.
    GeneTreei ENSGT00530000063231.
    HOGENOMi HOG000251606.
    HOVERGENi HBG105802.
    InParanoidi Q149T7.
    KOi K17504.
    OMAi DHNLKVC.
    OrthoDBi EOG7F511J.
    PhylomeDBi Q149T7.
    TreeFami TF314700.

    Miscellaneous databases

    NextBioi 334852.
    PROi Q149T7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q149T7.
    CleanExi MM_PPM1J.
    Genevestigatori Q149T7.

    Family and domain databases

    Gene3Di 3.60.40.10. 3 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9."
      Kashiwaba M., Katsura K., Ohnishi M., Sasaki M., Tanaka H., Nishimune Y., Kobayashi T., Tamura S.
      FEBS Lett. 538:197-202(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH UBE2I, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-507.
      Strain: C57BL/6J.
      Tissue: Tongue.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPPM1J_MOUSE
    AccessioniPrimary (citable) accession number: Q149T7
    Secondary accession number(s): Q810X6, Q9D7H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3