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Q149T7 (PPM1J_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1J

EC=3.1.3.16
Alternative name(s):
Protein phosphatase 2C isoform zeta
Short name=PP2C-zeta
Gene names
Name:Ppm1j
Synonyms:Ppp2cz
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with UBE2I/UBC9. Ref.1

Tissue specificity

Specifically expressed in the testicular germ cells. Ref.1

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence BAB26156.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Protein phosphatase 1J
PRO_0000289059

Regions

Domain119 – 499381PP2C-like

Amino acid modifications

Modified residue751Phosphoserine By similarity

Experimental info

Sequence conflict51V → A in AAO72079. Ref.1
Sequence conflict61 – 622Missing in AAO72079. Ref.1
Sequence conflict781G → GET in AAO72079. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q149T7 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 4754E503AA8A7FE2

FASTA50755,550
        10         20         30         40         50         60 
MLNRVRSAVA HLVSSGGTSS QRSKSPDLPN ATSAPPAAQE TPKSSREKPG NQVGAPQKTA 

        70         80         90        100        110        120 
ETTVSFSRPT FLQLSPGGLR RADDHAGRAV QSPPDTGRRL PWSTGYAEVI NAGKSRHNED 

       130        140        150        160        170        180 
QACCEVVYVE SRRSRSVTGV SREPSHNQGF CFYYWGLFDG HAGGGAAEMA SRLLHRHIRE 

       190        200        210        220        230        240 
QLKDLVEILK DPLPPPLCLP STPGTPGAPS PSQLVSPQSC WSPQKEVTHD SLIVGAIENA 

       250        260        270        280        290        300 
FHLMDEQMAR ERRGHQVEGG CCALVVLYLL GKMYVANAGD SRAIIVRNGE IIPMSREFTP 

       310        320        330        340        350        360 
ETERQRLQLL GFLKPELLGS EFTHLEFPRR VQPKELGQRM LYRDQNMTGW AYKKIEVEDL 

       370        380        390        400        410        420 
RFPLVCGEGK KARVMATIGV TRGLGDHNLK VCSSTLSIKP FLSCFPEVRV YDLTQYEHCP 

       430        440        450        460        470        480 
DDVLVLGTDG LWDVTNDSEV AATVDRVLSS YEPNDPSRYT ALAQALVLGA RGIPRDRGWR 

       490        500 
LPNNKLGSGD DISVFVIPLG GPGSSYS 

« Hide

References

« Hide 'large scale' references
[1]"A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9."
Kashiwaba M., Katsura K., Ohnishi M., Sasaki M., Tanaka H., Nishimune Y., Kobayashi T., Tamura S.
FEBS Lett. 538:197-202(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH UBE2I, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-507.
Strain: C57BL/6J.
Tissue: Tongue.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY184802 mRNA. Translation: AAO72079.1.
BC117498 mRNA. Translation: AAI17499.1.
BC121788 mRNA. Translation: AAI21789.1.
AK009235 mRNA. Translation: BAB26156.1. Different initiation.
CCDSCCDS17703.1.
RefSeqNP_082258.2. NM_027982.2.
UniGeneMm.379204.

3D structure databases

ProteinModelPortalQ149T7.
SMRQ149T7. Positions 258-311, 372-501.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ149T7.

PTM databases

PhosphoSiteQ149T7.

Proteomic databases

PaxDbQ149T7.
PRIDEQ149T7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002298; ENSMUSP00000002298; ENSMUSG00000002228.
GeneID71887.
KEGGmmu:71887.
UCSCuc008quk.1. mouse.

Organism-specific databases

CTD333926.
MGIMGI:1919137. Ppm1j.

Phylogenomic databases

eggNOGNOG314780.
GeneTreeENSGT00530000063231.
HOGENOMHOG000251606.
HOVERGENHBG105802.
InParanoidQ149T7.
KOK17504.
OMADHNLKVC.
OrthoDBEOG7F511J.
PhylomeDBQ149T7.
TreeFamTF314700.

Gene expression databases

BgeeQ149T7.
CleanExMM_PPM1J.
GenevestigatorQ149T7.

Family and domain databases

Gene3D3.60.40.10. 3 hits.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 2 hits.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 3 hits.
ProtoNetSearch...

Other

NextBio334852.
PROQ149T7.
SOURCESearch...

Entry information

Entry namePPM1J_MOUSE
AccessionPrimary (citable) accession number: Q149T7
Secondary accession number(s): Q810X6, Q9D7H6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot