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Q149T7

- PPM1J_MOUSE

UniProt

Q149T7 - PPM1J_MOUSE

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Protein

Protein phosphatase 1J

Gene

Ppm1j

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1J (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform zeta
Short name:
PP2C-zeta
Gene namesi
Name:Ppm1j
Synonyms:Ppp2cz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1919137. Ppm1j.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Protein phosphatase 1JPRO_0000289059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ149T7.
PaxDbiQ149T7.
PRIDEiQ149T7.

PTM databases

PhosphoSiteiQ149T7.

Expressioni

Tissue specificityi

Specifically expressed in the testicular germ cells.1 Publication

Gene expression databases

BgeeiQ149T7.
CleanExiMM_PPM1J.
GenevestigatoriQ149T7.

Interactioni

Subunit structurei

Interacts with UBE2I/UBC9.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ149T7.
SMRiQ149T7. Positions 258-311, 372-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 499381PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiNOG314780.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ149T7.
KOiK17504.
OMAiDHNLKVC.
OrthoDBiEOG7F511J.
PhylomeDBiQ149T7.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.

Sequencei

Sequence statusi: Complete.

Q149T7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNRVRSAVA HLVSSGGTSS QRSKSPDLPN ATSAPPAAQE TPKSSREKPG
60 70 80 90 100
NQVGAPQKTA ETTVSFSRPT FLQLSPGGLR RADDHAGRAV QSPPDTGRRL
110 120 130 140 150
PWSTGYAEVI NAGKSRHNED QACCEVVYVE SRRSRSVTGV SREPSHNQGF
160 170 180 190 200
CFYYWGLFDG HAGGGAAEMA SRLLHRHIRE QLKDLVEILK DPLPPPLCLP
210 220 230 240 250
STPGTPGAPS PSQLVSPQSC WSPQKEVTHD SLIVGAIENA FHLMDEQMAR
260 270 280 290 300
ERRGHQVEGG CCALVVLYLL GKMYVANAGD SRAIIVRNGE IIPMSREFTP
310 320 330 340 350
ETERQRLQLL GFLKPELLGS EFTHLEFPRR VQPKELGQRM LYRDQNMTGW
360 370 380 390 400
AYKKIEVEDL RFPLVCGEGK KARVMATIGV TRGLGDHNLK VCSSTLSIKP
410 420 430 440 450
FLSCFPEVRV YDLTQYEHCP DDVLVLGTDG LWDVTNDSEV AATVDRVLSS
460 470 480 490 500
YEPNDPSRYT ALAQALVLGA RGIPRDRGWR LPNNKLGSGD DISVFVIPLG

GPGSSYS
Length:507
Mass (Da):55,550
Last modified:August 22, 2006 - v1
Checksum:i4754E503AA8A7FE2
GO

Sequence cautioni

The sequence BAB26156.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → A in AAO72079. (PubMed:12633878)Curated
Sequence conflicti61 – 622Missing in AAO72079. (PubMed:12633878)Curated
Sequence conflicti78 – 781G → GET in AAO72079. (PubMed:12633878)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184802 mRNA. Translation: AAO72079.1.
BC117498 mRNA. Translation: AAI17499.1.
BC121788 mRNA. Translation: AAI21789.1.
AK009235 mRNA. Translation: BAB26156.1. Different initiation.
CCDSiCCDS17703.1.
RefSeqiNP_082258.2. NM_027982.2.
UniGeneiMm.379204.

Genome annotation databases

EnsembliENSMUST00000002298; ENSMUSP00000002298; ENSMUSG00000002228.
GeneIDi71887.
KEGGimmu:71887.
UCSCiuc008quk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184802 mRNA. Translation: AAO72079.1 .
BC117498 mRNA. Translation: AAI17499.1 .
BC121788 mRNA. Translation: AAI21789.1 .
AK009235 mRNA. Translation: BAB26156.1 . Different initiation.
CCDSi CCDS17703.1.
RefSeqi NP_082258.2. NM_027982.2.
UniGenei Mm.379204.

3D structure databases

ProteinModelPortali Q149T7.
SMRi Q149T7. Positions 258-311, 372-501.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q149T7.

PTM databases

PhosphoSitei Q149T7.

Proteomic databases

MaxQBi Q149T7.
PaxDbi Q149T7.
PRIDEi Q149T7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002298 ; ENSMUSP00000002298 ; ENSMUSG00000002228 .
GeneIDi 71887.
KEGGi mmu:71887.
UCSCi uc008quk.1. mouse.

Organism-specific databases

CTDi 333926.
MGIi MGI:1919137. Ppm1j.

Phylogenomic databases

eggNOGi NOG314780.
GeneTreei ENSGT00530000063231.
HOGENOMi HOG000251606.
HOVERGENi HBG105802.
InParanoidi Q149T7.
KOi K17504.
OMAi DHNLKVC.
OrthoDBi EOG7F511J.
PhylomeDBi Q149T7.
TreeFami TF314700.

Miscellaneous databases

NextBioi 334852.
PROi Q149T7.
SOURCEi Search...

Gene expression databases

Bgeei Q149T7.
CleanExi MM_PPM1J.
Genevestigatori Q149T7.

Family and domain databases

Gene3Di 3.60.40.10. 3 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9."
    Kashiwaba M., Katsura K., Ohnishi M., Sasaki M., Tanaka H., Nishimune Y., Kobayashi T., Tamura S.
    FEBS Lett. 538:197-202(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH UBE2I, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-507.
    Strain: C57BL/6J.
    Tissue: Tongue.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPM1J_MOUSE
AccessioniPrimary (citable) accession number: Q149T7
Secondary accession number(s): Q810X6, Q9D7H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3