Q149T7 (PPM1J_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 56.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein phosphatase 1J EC=3.1.3.16 Alternative name(s): Protein phosphatase 2C isoform zeta Short name=PP2C-zeta | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 507 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | A phosphoprotein + H2O = a protein + phosphate. |
| Subunit structure | Interacts with UBE2I/UBC9. Ref.1 |
| Tissue specificity | Specifically expressed in the testicular germ cells. Ref.1 |
| Sequence similarities | Belongs to the PP2C family. Contains 1 PP2C-like domain. |
| Sequence caution | The sequence BAB26156.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Hydrolase Protein phosphatase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | protein dephosphorylation Inferred from direct assay Ref.1. Source: MGI |
| Molecular_function | protein serine/threonine phosphatase activity Inferred from direct assay Ref.1. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 507 | 507 | Protein phosphatase 1J | PRO_0000289059 | |||||
Regions | |||||||||
| Domain | 119 – 499 | 381 | PP2C-like | ||||||
Amino acid modifications | |||||||||
| Modified residue | 75 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 5 | 1 | V → A in AAO72079. Ref.1 | ||||||
| Sequence conflict | 61 – 62 | 2 | Missing in AAO72079. Ref.1 | ||||||
| Sequence conflict | 78 | 1 | G → GET in AAO72079. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9." Kashiwaba M., Katsura K., Ohnishi M., Sasaki M., Tanaka H., Nishimune Y., Kobayashi T., Tamura S. FEBS Lett. 538:197-202(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH UBE2I, TISSUE SPECIFICITY. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.  Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-507. Strain: C57BL/6J. Tissue: Tongue. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY184802 mRNA. Translation: AAO72079.1. BC117498 mRNA. Translation: AAI17499.1. BC121788 mRNA. Translation: AAI21789.1. AK009235 mRNA. Translation: BAB26156.1. Different initiation. |
| IPI | IPI00329932. |
| RefSeq | NP_082258.2. NM_027982.2. |
| UniGene | Mm.379204. |
3D structure databases | |
| ProteinModelPortal | Q149T7. |
| SMR | Q149T7. Positions 258-311, 372-501. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q149T7. |
Proteomic databases | |
| PaxDb | Q149T7. |
| PRIDE | Q149T7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000002298; ENSMUSP00000002298; ENSMUSG00000002228. |
| GeneID | 71887. |
| KEGG | mmu:71887. |
| UCSC | uc008quk.1. mouse. |
Organism-specific databases | |
| CTD | 333926. |
| MGI | MGI:1919137. Ppm1j. |
Phylogenomic databases | |
| eggNOG | NOG314780. |
| GeneTree | ENSGT00530000063231. |
| HOGENOM | HOG000251606. |
| HOVERGEN | HBG105802. |
| InParanoid | Q149T7. |
| OMA | RMLYRDQ. |
| OrthoDB | EOG42JNRC. |
Gene expression databases | |
| Bgee | Q149T7. |
| CleanEx | MM_PPM1J. |
| Genevestigator | Q149T7. |
Family and domain databases | |
| Gene3D | 3.60.40.10. 3 hits. |
| InterPro | IPR001932. PP2C-like. IPR015655. Protein_Pase_2C. [Graphical view] |
| PANTHER | PTHR13832. PTHR13832. 1 hit. |
| Pfam | PF00481. PP2C. 2 hits. [Graphical view] |
| SMART | SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view] |
| SUPFAM | SSF81606. PP2C-related. 1 hit. |
| PROSITE | PS01032. PP2C. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | Q149T7. |
| ChEMBL | CHEMBL2776. |
| NextBio | 334852. |
| SOURCE | Search... |
Entry information
| Entry name | PPM1J_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q149T7 Secondary accession number(s): Q810X6, Q9D7H6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |