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Protein

Lysophosphatidic acid receptor 5

Gene

Lpar5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.By similarity

GO - Molecular functioni

GO - Biological processi

  • behavioral response to pain Source: MGI
  • positive regulation of CREB transcription factor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 5
Short name:
LPA receptor 5
Short name:
LPA-5
Alternative name(s):
G-protein coupled receptor 92
Gene namesi
Name:Lpar5
Synonyms:Gm1072, Gpr92
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2685918. Lpar5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 598CytoplasmicSequence analysis
Transmembranei60 – 8021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 10020ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 19130ExtracellularSequence analysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini213 – 24331CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 28016ExtracellularSequence analysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini302 – 37271CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Lysophosphatidic acid receptor 5PRO_0000303236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ149R9.
PRIDEiQ149R9.

PTM databases

iPTMnetiQ149R9.
PhosphoSiteiQ149R9.

Expressioni

Gene expression databases

BgeeiQ149R9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085630.

Structurei

3D structure databases

ProteinModelPortaliQ149R9.
SMRiQ149R9. Positions 30-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9D. Eukaryota.
ENOG410XTCM. LUCA.
HOGENOMiHOG000231307.
HOVERGENiHBG103813.
InParanoidiQ149R9.
PhylomeDBiQ149R9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q149R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFANSSANTT STNSSVLQCP DYRDTHRLHM VVYSLVLATG LPLNALALWV
60 70 80 90 100
FLRVLRVHSV VSVYMCNLAA SDLLFTLSLP LRLSYYAQHH WPFPGFLCQT
110 120 130 140 150
SGAIFQMNMY GSCLFLMLIN VDRYAAIVHP LRLRHLRRPR VARRLCLGVW
160 170 180 190 200
ALILLFAVPA ARVHSPSHCT YKNITVRLCF ESFSDELWKG RLLPLLLLAE
210 220 230 240 250
ILGFLLPLAA VVYSSGRVFW TLARPDATQS QRRRKTVRLL LANLIIFLLC
260 270 280 290 300
FVPYNSTLAV YGLLRANLVK NSIQDRDQVR GVLMIMVLLA GANCVLDPLV
310 320 330 340 350
YYFSAEGFRN TLRNLGAPLN TRPLATNGAA GVLTELPSES TQNTGQDATS
360 370
QVLLQPATLG TPPDNCSQDS AL
Length:372
Mass (Da):41,394
Last modified:September 5, 2006 - v2
Checksum:i0D3EFBD489F60446
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti186 – 1861E → K in BAE20836 (PubMed:16141072).Curated
Sequence conflicti242 – 2421A → S in BAE20836 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116702 mRNA. Translation: AAI16703.2.
BC117528 mRNA. Translation: AAI17529.2.
AK131863 mRNA. Translation: BAE20836.1.
AY255621 mRNA. Translation: AAO85133.1.
UniGeneiMm.333386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116702 mRNA. Translation: AAI16703.2.
BC117528 mRNA. Translation: AAI17529.2.
AK131863 mRNA. Translation: BAE20836.1.
AY255621 mRNA. Translation: AAO85133.1.
UniGeneiMm.333386.

3D structure databases

ProteinModelPortaliQ149R9.
SMRiQ149R9. Positions 30-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085630.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ149R9.
PhosphoSiteiQ149R9.

Proteomic databases

PaxDbiQ149R9.
PRIDEiQ149R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2685918. Lpar5.

Phylogenomic databases

eggNOGiENOG410IF9D. Eukaryota.
ENOG410XTCM. LUCA.
HOGENOMiHOG000231307.
HOVERGENiHBG103813.
InParanoidiQ149R9.
PhylomeDBiQ149R9.

Miscellaneous databases

PROiQ149R9.
SOURCEiSearch...

Gene expression databases

BgeeiQ149R9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-242.
    Strain: C57BL/6J.
    Tissue: Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-104.

Entry informationi

Entry nameiLPAR5_MOUSE
AccessioniPrimary (citable) accession number: Q149R9
Secondary accession number(s): Q3V2G2, Q80T30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.