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Protein
Submitted name:

Frizzled homolog 10 (Drosophila)

Gene

Fzd10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation, G-protein coupled receptorSAAS annotation, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Frizzled homolog 10 (Drosophila)Imported
Submitted name:
MCG51280Imported
Gene namesi
Name:Fzd10Imported
ORF Names:mCG_51280Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2136761. Fzd10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei228 – 252HelicalSequence analysisAdd BLAST25
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei312 – 337HelicalSequence analysisAdd BLAST26
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei397 – 424HelicalSequence analysisAdd BLAST28
Transmembranei445 – 466HelicalSequence analysisAdd BLAST22
Transmembranei505 – 524HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500877954822 – 582Sequence analysisAdd BLAST561

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000081683.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114114.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 151FZ (frizzled)InterPro annotationAdd BLAST122
Domaini228 – 531G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG006977.
KOiK02842.
OMAiEYGCHGH.
OrthoDBiEOG091G0N5M.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q149J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHPGPRLWL VLQVMIGSCT AISSMDLERP GDGKCQPVEI PMCKDIGYNT
60 70 80 90 100
TRMPNLMGHE NQREAAIQLH EFAPLVEYGC HSHLRFFLCS LYAPMCTEQV
110 120 130 140 150
STPIPACRVM CEQARLKCSP IMEQFKFRWP DSLDCSKLPN KNDPNYLCME
160 170 180 190 200
APNNGSDEPS RGSGMFPPLF RPQRPHSAQE HPLKDGGPGR AGCDNPGKFH
210 220 230 240 250
HVEKSESCAP LCTPGVDVYW SRDDKRFAVV WLAIWSVLCF FSSAFTVLTF
260 270 280 290 300
LIDPSRFRYP ERPIIFLSMC YCVYSVGYII RLFAGAESIA CDRDSGQLYV
310 320 330 340 350
IQEGLESTGC TLVFLVLYYF GMASSLWWVV LTLTWFLAAG KKWGHEAIEA
360 370 380 390 400
NSSYFHLAAW AIPAVKTILI LVMRRVAGDE LTGVCYVGSM DVNALTGFVL
410 420 430 440 450
VPLACYLVIG TSFILSGFVA LFHIRRVMKT GGENTDKLEK LMVRIGVFSL
460 470 480 490 500
LYTVPATCVI ACYFYERLNM DYWKMLATQH KCKMNNQTKT PDCLMTTSIP
510 520 530 540 550
AVEVFMVKVS MLLVVGITSG VWVWTSKTLQ SWQHVCSRGL KRKSRRKPAS
560 570 580
VVTSAGIYKK AQHPQKPHLG KYELPAQPSA CV
Length:582
Mass (Da):65,318
Last modified:August 22, 2006 - v1
Checksum:i3ED4F5340B1505E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117759 mRNA. Translation: AAI17760.1.
CH466529 Genomic DNA. Translation: EDL19534.1.
RefSeqiNP_780493.1. NM_175284.3.
UniGeneiMm.197628.

Genome annotation databases

GeneIDi93897.
KEGGimmu:93897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117759 mRNA. Translation: AAI17760.1.
CH466529 Genomic DNA. Translation: EDL19534.1.
RefSeqiNP_780493.1. NM_175284.3.
UniGeneiMm.197628.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114114.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi93897.
KEGGimmu:93897.

Organism-specific databases

CTDi11211.
MGIiMGI:2136761. Fzd10.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG006977.
KOiK02842.
OMAiEYGCHGH.
OrthoDBiEOG091G0N5M.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000081683.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ149J3_MOUSE
AccessioniPrimary (citable) accession number: Q149J3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.