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Protein

RNA pseudouridylate synthase domain-containing protein 2

Gene

Rpusd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pseudouridylate synthase domain-containing protein 2
Gene namesi
Name:Rpusd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918066. Rpusd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553RNA pseudouridylate synthase domain-containing protein 2PRO_0000300820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei490 – 4901PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ149F1.
MaxQBiQ149F1.
PaxDbiQ149F1.
PRIDEiQ149F1.

PTM databases

PhosphoSiteiQ149F1.

Expressioni

Gene expression databases

BgeeiQ149F1.
CleanExiMM_RPUSD2.
GenevisibleiQ149F1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028796.

Structurei

3D structure databases

ProteinModelPortaliQ149F1.
SMRiQ149F1. Positions 238-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated

Phylogenomic databases

eggNOGiKOG1919. Eukaryota.
COG0564. LUCA.
GeneTreeiENSGT00420000029802.
HOGENOMiHOG000167783.
HOVERGENiHBG103625.
InParanoidiQ149F1.
OMAiHLNEEPV.
OrthoDBiEOG7JDQX4.
PhylomeDBiQ149F1.
TreeFamiTF323255.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q149F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGVPGCLR DIVQWQVALW SHSFVRTWGS CGKAMTEALS AQAEAAGGLK
60 70 80 90 100
ALVQPNGDAG SNTSGEPLLE RLEPAAVGKQ VPESGDQAQG GEGQLPSNGE
110 120 130 140 150
QTPAPVADSG KRKKRRGATG ERVVPPPKKR RTGVSFSDEH FAETTYYFEG
160 170 180 190 200
GLRKVRPYYF DFQTYCKGRW VGRSLLHVFS TEFRSQPLSY YEAAVRAGRL
210 220 230 240 250
HLNEEPVQDL SIVLKDNDFL RNTVHRHEPP VTAEPIHLLA ENNDVVVIDK
260 270 280 290 300
PSSIPVHPCG RFRHNTVIFI LGKEHQLKEL HPLHRLDRLT SGVLMFAKTA
310 320 330 340 350
AVSEKIHEQV RDRQLEKEYV CRVAGEFPDK EVICKEPILV VSYKVGVCRV
360 370 380 390 400
DPRGKPCETV FQRLSYNGRS SVVQCRPLTG RTHQIRVHLQ FLGHPILNDP
410 420 430 440 450
IYNSTAWGPS RGQGGHIPKT DEELLRDLVA EHQAKESLSM LDLCESDLTP
460 470 480 490 500
GLIDSTAPSS ELAKDSLEGL ATAAQKIDGI AEAAPQHLDT PEKAAKADVT
510 520 530 540 550
QETDPLCAEC RVLRQDPLPQ DLVMFLHALR YKGPDFEYVS PIPAWARDDW

QED
Length:553
Mass (Da):61,535
Last modified:September 11, 2007 - v2
Checksum:i995678B1C9FC4EC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371H → R in AAI17828 (PubMed:15489334).Curated
Sequence conflicti237 – 2371H → R in AAI17829 (PubMed:15489334).Curated
Sequence conflicti360 – 3601V → M in AAI17828 (PubMed:15489334).Curated
Sequence conflicti360 – 3601V → M in AAI17829 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044767 mRNA. Translation: BAC32077.1.
AL772264 Genomic DNA. Translation: CAM45958.1.
BC117827 mRNA. Translation: AAI17828.1.
BC117828 mRNA. Translation: AAI17829.1.
CCDSiCCDS16588.1.
RefSeqiNP_775626.1. NM_173450.3.
UniGeneiMm.33617.

Genome annotation databases

EnsembliENSMUST00000028796; ENSMUSP00000028796; ENSMUSG00000027324.
GeneIDi271842.
KEGGimmu:271842.
UCSCiuc008lsz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044767 mRNA. Translation: BAC32077.1.
AL772264 Genomic DNA. Translation: CAM45958.1.
BC117827 mRNA. Translation: AAI17828.1.
BC117828 mRNA. Translation: AAI17829.1.
CCDSiCCDS16588.1.
RefSeqiNP_775626.1. NM_173450.3.
UniGeneiMm.33617.

3D structure databases

ProteinModelPortaliQ149F1.
SMRiQ149F1. Positions 238-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028796.

PTM databases

PhosphoSiteiQ149F1.

Proteomic databases

EPDiQ149F1.
MaxQBiQ149F1.
PaxDbiQ149F1.
PRIDEiQ149F1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028796; ENSMUSP00000028796; ENSMUSG00000027324.
GeneIDi271842.
KEGGimmu:271842.
UCSCiuc008lsz.2. mouse.

Organism-specific databases

CTDi27079.
MGIiMGI:1918066. Rpusd2.

Phylogenomic databases

eggNOGiKOG1919. Eukaryota.
COG0564. LUCA.
GeneTreeiENSGT00420000029802.
HOGENOMiHOG000167783.
HOVERGENiHBG103625.
InParanoidiQ149F1.
OMAiHLNEEPV.
OrthoDBiEOG7JDQX4.
PhylomeDBiQ149F1.
TreeFamiTF323255.

Miscellaneous databases

NextBioi393510.
PROiQ149F1.
SOURCEiSearch...

Gene expression databases

BgeeiQ149F1.
CleanExiMM_RPUSD2.
GenevisibleiQ149F1. MM.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiRUSD2_MOUSE
AccessioniPrimary (citable) accession number: Q149F1
Secondary accession number(s): Q8BXL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 11, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.