Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q149C3 (LIGO4_MOUSE)

Last modified November 25, 2008. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4
Alternative name(s):
    Leucine-rich repeat neuronal protein 6D
Gene names
Name: Lingo4
Synonyms: Lrrn6d
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane proteinPotential.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 13 LRR (leucine-rich) repeats.

Sequence caution

The sequence BAC31214.1 differs from that shown. Reason: Frameshift at position 7.

Hide | Top

Ontologies

Keywords

   Cellular componentMembrane
   DomainImmunoglobulin domain
Leucine-rich repeat
Repeat
Signal
Transmembrane
   PTMGlycoprotein

Gene Ontology (GO)

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 593564Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4
PRO_0000324185

Regions

Topological domain30 – 533504Extracellular Potential
Transmembrane534 – 55421 Potential
Topological domain555 – 59339Cytoplasmic Potential
Repeat38 – 5922LRR 1
Repeat60 – 8223LRR 2
Repeat83 – 10624LRR 3
Repeat108 – 13023LRR 4
Repeat132 – 15423LRR 5
Repeat155 – 17824LRR 6
Repeat180 – 20223LRR 7
Repeat203 – 22624LRR 8
Repeat251 – 27424LRR 9
Repeat275 – 29824LRR 10
Repeat300 – 32223LRR 11
Repeat323 – 34624LRR 12
Repeat348 – 37023LRR 13
Domain412 – 50291Ig-like C2-type

Amino acid modifications

Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential
Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential
Glycosylation5081N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Disulfide bond435 ↔ 484 By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q149C3-1 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: CCF153432BE07A5B

FASTA59364,189
        10         20         30         40         50         60 
MDAATAPKQA WLPWSPLLFL LLLPGGSISS CPTVCDCTSQ TRAVFCAHRR LDTIPGGLPL 

        70         80         90        100        110        120 
DTELLDLSGN RLWGLQRGML SRLGQLQELD LSYNQLSTLE PGAFHGLQSL LTLRLQGNRL 

       130        140        150        160        170        180 
RIVGPGIFSG LTALTLLDLR LNQIVLFLDG AFSELGSLQQ LEVGDNHLVF VAPGAFAGLA 

       190        200        210        220        230        240 
KLSTITLERC NLSTVPGLAL AQLPALVALR LRELDIERLP AGALRGLGQL KELEIHHWPS 

       250        260        270        280        290        300 
LEALDPGSLV GLNLSSLAIT RCNLSSVPFQ ALHHLSFLRI LDLSQNPISA IPARRLSPLV 

       310        320        330        340        350        360 
RLQELRLSGA CLTSIAAHAF HGLTAFHLLD VADNALQTLE ETAFPSPDKL VTLRLSGNPL 

       370        380        390        400        410        420 
TCDCRLLWLL RLRRRLDFGT SPPACAGPQH VQGKSLREFS DILPPGHFTC KPALIRKSGP 

       430        440        450        460        470        480 
RWVIAEEGGH AVFSCSGDGD PAPTVSWMRP QGAWLGRVGR VRVLEDGTLE IRSVQLRDRG 

       490        500        510        520        530        540 
AYVCVVSNVA GNDSLRTWLE VIQVEPPNGT LSDPNITMPG IPGPFFLDSR GVAMVLAVGF 

       550        560        570        580        590 
LPFLTSVTLC FGLIALWSKG KGRVKHHMTF DFVAPRPSGD KNSGGNRVTA KLF

« Hide

Hide | Top

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-401.
Strain: C57BL/6J.
Tissue: Thymus.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

BC117866 mRNA. Translation: AAI17867.1. Different initiation.
BC117867 mRNA. Translation: AAI17868.1. Different initiation.
AK042286 mRNA. Translation: BAC31214.1. Frameshift.
UniGeneMm.213001

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000044505. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:2444651. Lingo4.

Phylogenomic databases

HOVERGENQ149C3.

Gene expression databases

ArrayExpressQ149C3.
CleanExMM_LINGO4.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. LRR.
IPR000483. LRR_C.
IPR000372. LRR_cys_N.
IPR003591. LRR_sub-typ.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07679. I-set. 1 hit.
PF00560. LRR_1. 9 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSPR00019. LEURICHRPT.
SMARTSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Hide | Top

Entry information

Entry nameLIGO4_MOUSE
AccessionPrimary (citable) accession number: Q149C3
Secondary accession number(s): A0A4X2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 25, 2008
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents