Q14994 (NR1I3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear receptor subfamily 1 group I member 3

Alternative name(s):
Constitutive activator of retinoid response
Short name=Constitutive active response
Constitutive androstane receptor
Short name=CAR
Orphan nuclear receptor MB67

Gene names

Name:	NR1I3
Synonyms:	CAR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Subunit structure	Interacts with ECT2 By similarity. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 By similarity. Ref.8 Ref.9
Subcellular location	Nucleus. Cytoplasm. Cytoplasm › cytoskeleton. Note: Recruited to the cytoplasm by DNAJC7 By similarity. Ref.9 Ref.10
Tissue specificity	Predominantly expressed in liver.
Induction	By dexamethasone.
Domain	Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
Post-translational modification	Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. Ref.10
Sequence similarities	Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Receptor
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	DNA binding Traceable author statement PubMed 9783588. Source: ProtInc androgen receptor activity Traceable author statement PubMed 9783588. Source: ProtInc sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro thyroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription coactivator activity Traceable author statement PubMed 9783588. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14994-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14994-2)

The sequence of this isoform differs from the canonical sequence as follows:
     233-236: Missing.

Isoform 3 (identifier: Q14994-3)

The sequence of this isoform differs from the canonical sequence as follows:
     232-274: VSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSP → APYLT

Isoform 4 (identifier: Q14994-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
     232-274: Missing.

Isoform 5 (identifier: Q14994-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
     233-236: Missing.

Isoform 6 (identifier: Q14994-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
     233-236: Missing.
     274-274: P → PAPYLT

Isoform 7 (identifier: Q14994-7)

The sequence of this isoform differs from the canonical sequence as follows:
     232-274: Missing.

Isoform 8 (identifier: Q14994-8)

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: P → PAPYLT

Isoform 9 (identifier: Q14994-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
     233-236: Missing.
     311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ

Isoform 10 (identifier: Q14994-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
     233-236: Missing.
     274-274: P → PAPYLT
     311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ

Isoform 11 (identifier: Q14994-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
     274-274: P → PAPYLT
     311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 352

352

Nuclear receptor subfamily 1 group I member 3

PRO_0000053552

Regions

DNA binding

8 – 83

76

Nuclear receptor

Zinc finger

11 – 31

21

NR C4-type

Zinc finger

47 – 71

25

NR C4-type

Amino acid modifications

Modified residue

38

1

Phosphothreonine; by PKC Ref.10

Natural variations

Alternative sequence

1 – 35

35

MASRE…CKGFF → MLPKRS in isoform 4, isoform 5, isoform 6, isoform 9, isoform 10 and isoform 11.

VSP_043730

Alternative sequence

232 – 274

43

VSPTV…ALFSP → APYLT in isoform 3.

VSP_043144

Alternative sequence

232 – 274

43

Missing in isoform 4 and isoform 7.

VSP_043731

Alternative sequence

233 – 236

4

Missing in isoform 2, isoform 5, isoform 6, isoform 9 and isoform 10.

VSP_010634

Alternative sequence

274

1

P → PAPYLT in isoform 6, isoform 8, isoform 10 and isoform 11.

VSP_043732

Alternative sequence

311 – 352

42

FLYAK…QEICS → SPGTPWIHWSGKMLGPKIGP GSKGAQWLQ in isoform 9, isoform 10 and isoform 11.

VSP_046144

Natural variant

133

1

V → G. Ref.12

VAR_018344

Secondary structure

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352

Helix Strand Turn

Details...

Helix

108 – 122

15

Beta strand

125 – 127

3

Helix

128 – 135

8

Helix

139 – 141

3

Helix

155 – 176

22

Helix

180 – 184

5

Helix

187 – 206

20

Helix

207 – 209

3

Turn

212 – 215

4

Beta strand

216 – 218

3

Beta strand

222 – 224

3

Helix

226 – 231

6

Helix

240 – 255

16

Helix

260 – 271

12

Beta strand

274 – 276

3

Helix

282 – 301

20

Helix

312 – 336

25

Helix

340 – 343

4

Helix

345 – 350

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 21, 2004. Version 2. Checksum: 73B060FE4950D519	FASTA	352	39,942
	10 20 30 40 50 60 MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 70 80 90 100 110 120 RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 130 140 150 160 170 180 HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 190 200 210 220 230 240 VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVSPTVGFQV 250 260 270 280 290 300 EFLELLFHFH GTLRKLQLQE PEYVLLAAMA LFSPDRPGVT QRDEIDQLQE EMALTLQSYI 310 320 330 340 350 KGQQRRPRDR FLYAKLLGLL AELRSINEAY GYQIQHIQGL SAMMPLLQEI CS
	Isoform 2 [UniParc]. Checksum: 92EAAD07D7DCB9DA	FASTA	348	39,558
	10 20 30 40 50 60 MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 70 80 90 100 110 120 RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 130 140 150 160 170 180 HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 190 200 210 220 230 240 VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVGFQVEFLE 250 260 270 280 290 300 LLFHFHGTLR KLQLQEPEYV LLAAMALFSP DRPGVTQRDE IDQLQEEMAL TLQSYIKGQQ 310 320 330 340 RRPRDRFLYA KLLGLLAELR SINEAYGYQI QHIQGLSAMM PLLQEICS
	Isoform 3 [UniParc]. Checksum: EE9F842EF2B19A2E	FASTA	314	35,588
	10 20 30 40 50 60 MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 70 80 90 100 110 120 RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 130 140 150 160 170 180 HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 190 200 210 220 230 240 VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RAPYLTDRPG 250 260 270 280 290 300 VTQRDEIDQL QEEMALTLQS YIKGQQRRPR DRFLYAKLLG LLAELRSINE AYGYQIQHIQ 310 GLSAMMPLLQ EICS
	Isoform 4 [UniParc]. Checksum: 7F3BFA4F60A16FB1	FASTA	280	31,900
	10 20 30 40 50 60 MLPKRSRRTV SKSIGPTCPF AGSCEVSKTQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL 70 80 90 100 110 120 RRAKQAQRRA QQTPVQLSKE QEELIRTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP 130 140 150 160 170 180 TLAPVLPLVT HFADINTFMV LQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT 190 200 210 220 230 240 FCLQTQNFLC GPLRYTIEDG ARDRPGVTQR DEIDQLQEEM ALTLQSYIKG QQRRPRDRFL 250 260 270 280 YAKLLGLLAE LRSINEAYGY QIQHIQGLSA MMPLLQEICS
	Isoform 5 [UniParc]. Checksum: C41CFFC814E96E46	FASTA	319	36,416
	10 20 30 40 50 60 MLPKRSRRTV SKSIGPTCPF AGSCEVSKTQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL 70 80 90 100 110 120 RRAKQAQRRA QQTPVQLSKE QEELIRTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP 130 140 150 160 170 180 TLAPVLPLVT HFADINTFMV LQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT 190 200 210 220 230 240 FCLQTQNFLC GPLRYTIEDG ARVGFQVEFL ELLFHFHGTL RKLQLQEPEY VLLAAMALFS 250 260 270 280 290 300 PDRPGVTQRD EIDQLQEEMA LTLQSYIKGQ QRRPRDRFLY AKLLGLLAEL RSINEAYGYQ 310 IQHIQGLSAM MPLLQEICS
	Isoform 6 [UniParc]. Checksum: 32245F1A8C523B1E	FASTA	324	36,961
	10 20 30 40 50 60 MLPKRSRRTV SKSIGPTCPF AGSCEVSKTQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL 70 80 90 100 110 120 RRAKQAQRRA QQTPVQLSKE QEELIRTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP 130 140 150 160 170 180 TLAPVLPLVT HFADINTFMV LQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT 190 200 210 220 230 240 FCLQTQNFLC GPLRYTIEDG ARVGFQVEFL ELLFHFHGTL RKLQLQEPEY VLLAAMALFS 250 260 270 280 290 300 PAPYLTDRPG VTQRDEIDQL QEEMALTLQS YIKGQQRRPR DRFLYAKLLG LLAELRSINE 310 320 AYGYQIQHIQ GLSAMMPLLQ EICS
	Isoform 7 [UniParc]. Checksum: 47BDCF4FC3777574	FASTA	309	35,043
	10 20 30 40 50 60 MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 70 80 90 100 110 120 RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 130 140 150 160 170 180 HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 190 200 210 220 230 240 VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RDRPGVTQRD 250 260 270 280 290 300 EIDQLQEEMA LTLQSYIKGQ QRRPRDRFLY AKLLGLLAEL RSINEAYGYQ IQHIQGLSAM MPLLQEICS
	Isoform 8 [UniParc]. Checksum: 1AF956D0A2759781	FASTA	357	40,488
	10 20 30 40 50 60 MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR 70 80 90 100 110 120 RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA 130 140 150 160 170 180 HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP 190 200 210 220 230 240 VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVSPTVGFQV 250 260 270 280 290 300 EFLELLFHFH GTLRKLQLQE PEYVLLAAMA LFSPAPYLTD RPGVTQRDEI DQLQEEMALT 310 320 330 340 350 LQSYIKGQQR RPRDRFLYAK LLGLLAELRS INEAYGYQIQ HIQGLSAMMP LLQEICS
	Isoform 9 [UniParc]. Checksum: EA8397560E3A2AC1	FASTA	306	34,778
	10 20 30 40 50 60 MLPKRSRRTV SKSIGPTCPF AGSCEVSKTQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL 70 80 90 100 110 120 RRAKQAQRRA QQTPVQLSKE QEELIRTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP 130 140 150 160 170 180 TLAPVLPLVT HFADINTFMV LQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT 190 200 210 220 230 240 FCLQTQNFLC GPLRYTIEDG ARVGFQVEFL ELLFHFHGTL RKLQLQEPEY VLLAAMALFS 250 260 270 280 290 300 PDRPGVTQRD EIDQLQEEMA LTLQSYIKGQ QRRPRDRSPG TPWIHWSGKM LGPKIGPGSK GAQWLQ
	Isoform 10 [UniParc]. Checksum: 88A1BD387DDFFF8B	FASTA	311	35,323
	10 20 30 40 50 60 MLPKRSRRTV SKSIGPTCPF AGSCEVSKTQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL 70 80 90 100 110 120 RRAKQAQRRA QQTPVQLSKE QEELIRTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP 130 140 150 160 170 180 TLAPVLPLVT HFADINTFMV LQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT 190 200 210 220 230 240 FCLQTQNFLC GPLRYTIEDG ARVGFQVEFL ELLFHFHGTL RKLQLQEPEY VLLAAMALFS 250 260 270 280 290 300 PAPYLTDRPG VTQRDEIDQL QEEMALTLQS YIKGQQRRPR DRSPGTPWIH WSGKMLGPKI 310 GPGSKGAQWL Q
	Isoform 11 [UniParc]. Checksum: A90FF3A0E39D1305	FASTA	315	35,708
	10 20 30 40 50 60 MLPKRSRRTV SKSIGPTCPF AGSCEVSKTQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL 70 80 90 100 110 120 RRAKQAQRRA QQTPVQLSKE QEELIRTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP 130 140 150 160 170 180 TLAPVLPLVT HFADINTFMV LQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT 190 200 210 220 230 240 FCLQTQNFLC GPLRYTIEDG ARVSPTVGFQ VEFLELLFHF HGTLRKLQLQ EPEYVLLAAM 250 260 270 280 290 300 ALFSPAPYLT DRPGVTQRDE IDQLQEEMAL TLQSYIKGQQ RRPRDRSPGT PWIHWSGKML 310 GPKIGPGSKG AQWLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements." Baes M., Gulick T., Choi H.S., Martinoli M.G., Simha D., Moore D.D. Mol. Cell. Biol. 14:1544-1552(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Liver.
[2]	"Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences." Lamba J.K., Lamba V., Yasuda K., Lin Y.S., Assem M., Thompson E., Strom S., Schuetz E.G. J. Pharmacol. Exp. Ther. 311:811-821(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7), NUCLEOTIDE SEQUENCE [MRNA] OF 1-288 (ISOFORM 9), NUCLEOTIDE SEQUENCE [MRNA] OF 1-293 (ISOFORM 10), NUCLEOTIDE SEQUENCE [MRNA] OF 1-297 (ISOFORM 11), ALTERNATIVE SPLICING.
[3]	Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
[4]	"Isolation of cDNA coding for multiple human nuclear receptor clones." Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 7). Tissue: Eye and Small intestine.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 7).
[8]	"A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily." Choi H.S., Seol W., Moore D.D. J. Steroid Biochem. Mol. Biol. 56:23-30(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PSMC4.
[9]	"Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells." Kobayashi K., Sueyoshi T., Inoue K., Moore R., Negishi M. Mol. Pharmacol. 64:1069-1075(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DNAJC7, SUBCELLULAR LOCATION.
[10]	"Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3)." Mutoh S., Osabe M., Inoue K., Moore R., Pedersen L., Perera L., Rebolloso Y., Sueyoshi T., Negishi M. J. Biol. Chem. 284:34785-34792(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT THR-38, SUBCELLULAR LOCATION.
[11]	"A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer." Xu R.X., Lambert M.H., Wisely B.B., Warren E.N., Weinert E.E., Waitt G.M., Williams J.D., Collins J.L., Moore L.B., Willson T.M., Moore J.T. Mol. Cell 16:919-928(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 103-352.
[12]	"Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population." Ikeda S., Kurose K., Ozawa S., Sai K., Hasegawa R., Komamura K., Ueno K., Kamakura S., Kitakaze M., Tomoike H., Nakajima T., Matsumoto K., Saito H., Goto Y., Kimura H., Katoh M., Sugai K., Minami N. , Shirao K., Tamura T., Yamamoto N., Minami H., Ohtsu A., Yoshida T., Saijo N., Saito Y., Sawada J. Drug Metab. Pharmacokinet. 18:413-418(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLY-133.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z30425 mRNA. Translation: CAA83016.1.
AY572808 mRNA. Translation: AAT47161.1.
AY572810 mRNA. Translation: AAT47163.1.
AY572811 mRNA. Translation: AAT47164.1.
AY572812 mRNA. Translation: AAT47165.1.
AY572817 mRNA. Translation: AAT47170.1.
AY572818 mRNA. Translation: AAT47171.1.
AY572827 mRNA. Translation: AAT47180.1.
DQ022681 mRNA. Translation: AAY56401.1.
HQ692838 mRNA. Translation: ADZ17349.1.
HQ692839 mRNA. Translation: ADZ17350.1.
HQ692840 mRNA. Translation: ADZ17351.1.
HQ692841 mRNA. Translation: ADZ17352.1.
AL590714 Genomic DNA. Translation: CAH72153.1.
AL590714 Genomic DNA. Translation: CAH72154.1.
CH471121 Genomic DNA. Translation: EAW52608.1.
CH471121 Genomic DNA. Translation: EAW52609.1.
BC069626 mRNA. Translation: AAH69626.1.
BC121120 mRNA. Translation: AAI21121.1.
BC121121 mRNA. Translation: AAI21122.1.

IPI

IPI00001687.
IPI00418379.
IPI00434598.
IPI00815775.
IPI00815841.
IPI00816112.
IPI00816473.
IPI00816486.
IPI00816695.
IPI00816828.

PIR

A56197.

RefSeq

NP_001070938.1. NM_001077470.2.
NP_001070939.1. NM_001077471.2.
NP_001070940.1. NM_001077472.2.
NP_001070941.1. NM_001077473.2.
NP_001070944.1. NM_001077476.2.
NP_001070945.1. NM_001077477.2.
NP_001070947.1. NM_001077479.2.
NP_001070948.1. NM_001077480.2.
NP_001070949.1. NM_001077481.2.
NP_001070950.1. NM_001077482.2.
NP_005113.1. NM_005122.4.

UniGene

Hs.349642.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XV9	X-ray	2.70	B/D	103-352	[»]
1XVP	X-ray	2.60	B/D	103-352	[»]

ProteinModelPortal

Q14994.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q14994. 7 interactions.

STRING

9606.ENSP00000356959.

PTM databases

PhosphoSite

Q14994.

Polymorphism databases

DMDM

49066046.

Proteomic databases

PaxDb

Q14994.

PRIDE

Q14994.

Protocols and materials databases

DNASU

9970.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000367979; ENSP00000356958; ENSG00000143257.
ENST00000367980; ENSP00000356959; ENSG00000143257.
ENST00000367981; ENSP00000356960; ENSG00000143257.
ENST00000367982; ENSP00000356961; ENSG00000143257.
ENST00000367983; ENSP00000356962; ENSG00000143257.
ENST00000367984; ENSP00000356963; ENSG00000143257.
ENST00000367985; ENSP00000356965; ENSG00000143257.
ENST00000412844; ENSP00000399361; ENSG00000143257.
ENST00000437437; ENSP00000407446; ENSG00000143257.
ENST00000504010; ENSP00000424345; ENSG00000143257.
ENST00000508740; ENSP00000423666; ENSG00000143257.
ENST00000511676; ENSP00000427175; ENSG00000143257.

GeneID

9970.

KEGG

hsa:9970.

UCSC

uc001fzx.3. human.

Organism-specific databases

CTD

9970.

GeneCards

GC01M161199.

HGNC

HGNC:7969. NR1I3.

HPA

HPA051365.

MIM

603881. gene.

neXtProt

NX_Q14994.

PharmGKB

PA391.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG251788.

HOGENOM

HOG000220844.

HOVERGEN

HBG108655.

KO

K08541.

OMA

PRDRFLY.

Enzyme and pathway databases

Reactome

REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

Q14994.

Bgee

Q14994.

CleanEx

HS_NR1I3.

Genevestigator

Q14994.

GermOnline

ENSG00000143257. Homo sapiens.

Family and domain databases

Gene3D

1.10.565.10. 1 hit.
3.30.50.10. 1 hit.

InterPro

IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]

Pfam

PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]

PRINTS

PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.

SMART

SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]

SUPFAM

SSF48508. Str_ncl_receptor. 1 hit.

PROSITE

PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q14994.

ChEMBL

CHEMBL5503.

EvolutionaryTrace

Q14994.

GenomeRNAi

9970.

NextBio

37626.

SOURCE

Search...

Entry information

Entry name

NR1I3_HUMAN

Accession

Primary (citable) accession number: Q14994
Secondary accession number(s): E9PGH6 , E9PH10, E9PHN4, F1D8Q0, F1D8Q1, Q0VAC9, Q4U0F0, Q5VTW5, Q5VTW6, Q6GZ68, Q6GZ77, Q6GZ78, Q6GZ83, Q6GZ84, Q6GZ85, Q6GZ87

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 21, 2004
Last modified:	May 1, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.