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Protein

Outer dense fiber protein 1

Gene

ODF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 1
Alternative name(s):
Heat shock protein beta-10
Short name:
HspB10
Gene namesi
Name:ODF1
Synonyms:HSPB10, ODFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:8113. ODF1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31901.

Polymorphism and mutation databases

BioMutaiODF1.
DMDMi145559511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Outer dense fiber protein 1PRO_0000058024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphoserineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei64 – 641PhosphoserineBy similarity
Modified residuei86 – 861PhosphoserineBy similarity
Modified residuei122 – 1221PhosphoserineBy similarity
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei189 – 1891PhosphoserineBy similarity
Modified residuei194 – 1941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ14990.
PeptideAtlasiQ14990.
PRIDEiQ14990.

PTM databases

iPTMnetiQ14990.
PhosphoSiteiQ14990.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiQ14990.
CleanExiHS_ODF1.
ExpressionAtlasiQ14990. baseline and differential.
GenevisibleiQ14990. HS.

Organism-specific databases

HPAiHPA064295.

Interactioni

Subunit structurei

Interacts with SPAG4 and KLC3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP12-2P599913EBI-10234557,EBI-10176379
MTUS2Q5JR593EBI-10234557,EBI-742948

Protein-protein interaction databases

BioGridi111009. 20 interactions.
IntActiQ14990. 2 interactions.
STRINGi9606.ENSP00000285402.

Structurei

3D structure databases

ProteinModelPortaliQ14990.
SMRiQ14990. Positions 124-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 3851
Repeati73 – 7752

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 77442 X 5 AA repeats of [RC]-C-L-C-DAdd
BLAST
Regioni209 – 23830C-X-P repeat regionAdd
BLAST

Domaini

The C-terminal contains many C-X-P repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHKT. Eukaryota.
ENOG4111C5F. LUCA.
GeneTreeiENSGT00440000038909.
HOGENOMiHOG000290650.
HOVERGENiHBG007863.
InParanoidiQ14990.
OMAiCYPCASP.
OrthoDBiEOG7MD4RJ.
PhylomeDBiQ14990.
TreeFamiTF337986.

Family and domain databases

InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALSCLLDS VRRDIKKVDR ELRQLRCIDE FSTRCLCDLY MHPYCCCDLH
60 70 80 90 100
PYPYCLCYSK RSRSCGLCDL YPCCLCDYKL YCLRPSLRSL ERKAIRAIED
110 120 130 140 150
EKRELAKLRR TTNRILASSC CSSNILGSVN VCGFEPDQVK VRVKDGKVCV
160 170 180 190 200
SAERENRYDC LGSKKYSYMN ICKEFSLPPC VDEKDVTYSY GLGSCVKIES
210 220 230 240 250
PCYPCTSPCS PCSPCSPCNP CSPCNPCSPY DPCNPCYPCG SRFSCRKMIL
Length:250
Mass (Da):28,366
Last modified:April 17, 2007 - v2
Checksum:i48E7FD05C2FB952B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431V → L in M93131 (PubMed:8305202).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161S → N.2 Publications
Corresponds to variant rs2916569 [ dbSNP | Ensembl ].
VAR_031684
Natural varianti219 – 2279Missing .1 Publication
VAR_005523
Natural varianti243 – 2431F → L.
Corresponds to variant rs11995900 [ dbSNP | Ensembl ].
VAR_051251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93131 Genomic DNA. No translation available.
X74614 Genomic DNA. Translation: CAA52685.1.
BC104456 mRNA. Translation: AAI04457.1.
BC104457 mRNA. Translation: AAI04458.1.
CCDSiCCDS6293.1.
PIRiS71522.
RefSeqiNP_077721.2. NM_024410.3.
UniGeneiHs.159274.

Genome annotation databases

EnsembliENST00000285402; ENSP00000285402; ENSG00000155087.
GeneIDi4956.
KEGGihsa:4956.
UCSCiuc003ykt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93131 Genomic DNA. No translation available.
X74614 Genomic DNA. Translation: CAA52685.1.
BC104456 mRNA. Translation: AAI04457.1.
BC104457 mRNA. Translation: AAI04458.1.
CCDSiCCDS6293.1.
PIRiS71522.
RefSeqiNP_077721.2. NM_024410.3.
UniGeneiHs.159274.

3D structure databases

ProteinModelPortaliQ14990.
SMRiQ14990. Positions 124-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111009. 20 interactions.
IntActiQ14990. 2 interactions.
STRINGi9606.ENSP00000285402.

PTM databases

iPTMnetiQ14990.
PhosphoSiteiQ14990.

Polymorphism and mutation databases

BioMutaiODF1.
DMDMi145559511.

Proteomic databases

PaxDbiQ14990.
PeptideAtlasiQ14990.
PRIDEiQ14990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285402; ENSP00000285402; ENSG00000155087.
GeneIDi4956.
KEGGihsa:4956.
UCSCiuc003ykt.3. human.

Organism-specific databases

CTDi4956.
GeneCardsiODF1.
H-InvDBHIX0034374.
HGNCiHGNC:8113. ODF1.
HPAiHPA064295.
MIMi182878. gene.
neXtProtiNX_Q14990.
PharmGKBiPA31901.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHKT. Eukaryota.
ENOG4111C5F. LUCA.
GeneTreeiENSGT00440000038909.
HOGENOMiHOG000290650.
HOVERGENiHBG007863.
InParanoidiQ14990.
OMAiCYPCASP.
OrthoDBiEOG7MD4RJ.
PhylomeDBiQ14990.
TreeFamiTF337986.

Miscellaneous databases

GeneWikiiODF1.
GenomeRNAii4956.
PROiQ14990.
SOURCEiSearch...

Gene expression databases

BgeeiQ14990.
CleanExiHS_ODF1.
ExpressionAtlasiQ14990. baseline and differential.
GenevisibleiQ14990. HS.

Family and domain databases

InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene."
    Gastmann O., Burfeind P., Gunther E., Hameister H., Szpirer C., Hoyer-Fender S.
    Mol. Reprod. Dev. 36:407-418(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Sperm.
  2. "A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype."
    Hofferbert S., Burfeind P., Hoyer-Fender S., Lange R., Haidl G., Engel W.
    Hum. Mol. Genet. 2:2167-2170(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-216 AND 219-ASN--CYS-227 DEL.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-216.

Entry informationi

Entry nameiODFP1_HUMAN
AccessioniPrimary (citable) accession number: Q14990
Secondary accession number(s): Q3SX72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 17, 2007
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.