Q14990 (ODFP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer dense fiber protein 1

Gene names

Name:	ODF1
Synonyms:	ODFP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Subunit structure	Interacts with SPAG4 and KLC3 By similarity.
Tissue specificity	Testis.
Domain	The C-terminal contains many C-X-P repeats.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Coding sequence diversity	Polymorphism
Domain	Repeat
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Non-traceable author statement. Source: UniProtKB
Cellular component	outer dense fiber Non-traceable author statement. Source: UniProtKB
Molecular function	structural molecule activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Outer dense fiber protein 1		PRO_0000058024
Regions
	Repeat	34 – 38	5	1
	Repeat	73 – 77	5	2
	Region	34 – 77	44	2 X 5 AA repeats of [RC]-C-L-C-D
	Region	209 – 238	30	C-X-P repeat region
Natural variations
	Natural variant	216	1	S → N. Ref.2 Ref.3 Corresponds to variant rs2916569 [ dbSNP | Ensembl ].		VAR_031684
	Natural variant	219 – 227	9	Missing.		VAR_005523
	Natural variant	243	1	F → L. Corresponds to variant rs11995900 [ dbSNP | Ensembl ].		VAR_051251
Experimental info
	Sequence conflict	143	1	V → L in M93131. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q14990 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: 48E7FD05C2FB952B	FASTA	250	28,366
	10 20 30 40 50 60 MAALSCLLDS VRRDIKKVDR ELRQLRCIDE FSTRCLCDLY MHPYCCCDLH PYPYCLCYSK 70 80 90 100 110 120 RSRSCGLCDL YPCCLCDYKL YCLRPSLRSL ERKAIRAIED EKRELAKLRR TTNRILASSC 130 140 150 160 170 180 CSSNILGSVN VCGFEPDQVK VRVKDGKVCV SAERENRYDC LGSKKYSYMN ICKEFSLPPC 190 200 210 220 230 240 VDEKDVTYSY GLGSCVKIES PCYPCTSPCS PCSPCSPCNP CSPCNPCSPY DPCNPCYPCG 250 SRFSCRKMIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene." Gastmann O., Burfeind P., Gunther E., Hameister H., Szpirer C., Hoyer-Fender S. Mol. Reprod. Dev. 36:407-418(1993) [PubMed: 8305202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Sperm.
[2]	"A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype." Hofferbert S., Burfeind P., Hoyer-Fender S., Lange R., Haidl G., Engel W. Hum. Mol. Genet. 2:2167-2170(1993) [PubMed: 8111388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-216 AND 219-ASN--CYS-227 DEL.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-216.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M93131 Genomic DNA. No translation available. X74614 Genomic DNA. Translation: CAA52685.1. BC104456 mRNA. Translation: AAI04457.1. BC104457 mRNA. Translation: AAI04458.1.
IPI	IPI00001677.
PIR	S71522.
RefSeq	NP_077721.2. NM_024410.3.
UniGene	Hs.159274.
3D structure databases
ProteinModelPortal	Q14990.
SMR	Q14990. Positions 122-203.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14990.
PTM databases
PhosphoSite	Q14990.
Polymorphism databases
DMDM	145559511.
Proteomic databases
PRIDE	Q14990.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285402; ENSP00000285402; ENSG00000155087.
GeneID	4956.
KEGG	hsa:4956.
NMPDR	fig|9606.3.peg.30612.
UCSC	uc003ykt.1. human.
Organism-specific databases
CTD	4956.
GeneCards	GC08P103633.
H-InvDB	HIX0034374.
HGNC	HGNC:8113. ODF1.
MIM	182878. gene.
neXtProt	NX_Q14990.
PharmGKB	PA31901.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18161.
GeneTree	ENSGT00440000038909.
HOGENOM	HBG282441.
HOVERGEN	HBG007863.
InParanoid	Q14990.
OMA	SCGLCDL.
OrthoDB	EOG4SXNDJ.
PhylomeDB	Q14990.
Gene expression databases
ArrayExpress	Q14990.
Bgee	Q14990.
CleanEx	HS_ODF1.
Genevestigator	Q14990.
GermOnline	ENSG00000155087. Homo sapiens.
Family and domain databases
InterPro	IPR002068. Hsp20. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ODFP1_HUMAN

Accession

Primary (citable) accession number: Q14990
Secondary accession number(s): Q3SX72

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.