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Protein

Opioid-binding protein/cell adhesion molecule

Gene

OPCML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

GO - Biological processi

  • cell adhesion Source: ProtInc
  • neuron recognition Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid-binding protein/cell adhesion molecule
Short name:
OBCAM
Short name:
OPCML
Short name:
Opioid-binding cell adhesion molecule
Alternative name(s):
IgLON family member 1
Gene namesi
Name:OPCML
Synonyms:IGLON1, OBCAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8143. OPCML.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Ovarian cancer (OC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
See also OMIM:167000

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiOPCML.
MIMi167000. phenotype.
PharmGKBiPA31930.

Polymorphism and mutation databases

BioMutaiOPCML.
DMDMi2497326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 322295Opioid-binding protein/cell adhesion moleculePRO_0000015118Add
BLAST
Propeptidei323 – 34523Removed in mature formSequence analysisPRO_0000015119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 202PROSITE-ProRule annotation
Disulfide bondi244 ↔ 296PROSITE-ProRule annotation
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence analysis
Lipidationi322 – 3221GPI-anchor amidated asparagineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ14982.
PRIDEiQ14982.

PTM databases

iPTMnetiQ14982.
PhosphoSiteiQ14982.

Expressioni

Gene expression databases

BgeeiQ14982.
CleanExiHS_OPCML.
ExpressionAtlasiQ14982. baseline and differential.
GenevisibleiQ14982. HS.

Interactioni

Protein-protein interaction databases

BioGridi111026. 12 interactions.
IntActiQ14982. 2 interactions.
STRINGi9606.ENSP00000330862.

Structurei

3D structure databases

ProteinModelPortaliQ14982.
SMRiQ14982. Positions 37-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 12688Ig-like C2-type 1Add
BLAST
Domaini136 – 21984Ig-like C2-type 2Add
BLAST
Domaini223 – 31088Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJH. Eukaryota.
ENOG410XT1Y. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ14982.
KOiK06773.
OMAiWSIDNRV.
OrthoDBiEOG783MVP.
PhylomeDBiQ14982.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14982-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI
110 120 130 140 150
MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEG
160 170 180 190 200
SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY
210 220 230 240 250
ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP
260 270 280 290 300
MAEFQWFKEE TRLATGLDGM RIENKGRMST LTFFNVSEKD YGNYTCVATN
310 320 330 340
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH FFIKF
Length:345
Mass (Da):38,008
Last modified:November 1, 1996 - v1
Checksum:iE7AD17BEA1AA3FF4
GO
Isoform 2 (identifier: Q14982-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MYHPAYWVVFSATTALLFIP

Show »
Length:338
Mass (Da):37,267
Checksum:iEDD86EE2C57B09E3
GO
Isoform 3 (identifier: Q14982-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:304
Mass (Da):33,574
Checksum:i697F8D7D53994A82
GO
Isoform 4 (identifier: Q14982-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: Y → YEISPSSAVA

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,849
Checksum:i185C69C6FBA2839C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951P → R in ovarian cancer; somatic mutation. 1 Publication
VAR_055421

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 3. 2 PublicationsVSP_047730Add
BLAST
Alternative sequencei1 – 2727MGVCG…FLVPT → MYHPAYWVVFSATTALLFIP in isoform 2. 3 PublicationsVSP_043440Add
BLAST
Alternative sequencei312 – 3121Y → YEISPSSAVA in isoform 4. 1 PublicationVSP_054155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34774 mRNA. Translation: AAA36387.1.
EU562296 mRNA. Translation: ACB56656.1.
EU562297 mRNA. Translation: ACB56657.1.
EU562299 mRNA. Translation: ACB56659.1.
AK299908 mRNA. Translation: BAG61748.1.
AK316491 mRNA. Translation: BAH14862.1.
BX537377 mRNA. Translation: CAD97619.1.
AP000843 Genomic DNA. No translation available.
AP000863 Genomic DNA. No translation available.
AP000903 Genomic DNA. No translation available.
AP003029 Genomic DNA. No translation available.
AP003784 Genomic DNA. No translation available.
AP003972 Genomic DNA. No translation available.
AP004606 Genomic DNA. No translation available.
AP004782 Genomic DNA. No translation available.
AP005122 Genomic DNA. No translation available.
AP005133 Genomic DNA. No translation available.
AP005638 Genomic DNA. No translation available.
BC074773 mRNA. Translation: AAH74773.1.
BC117254 mRNA. Translation: AAI17255.1.
BC126251 mRNA. Translation: AAI26252.1.
BC143946 mRNA. Translation: AAI43947.1.
CCDSiCCDS31722.1. [Q14982-2]
CCDS8492.1. [Q14982-1]
PIRiJC4025.
RefSeqiNP_001012393.1. NM_001012393.2. [Q14982-2]
NP_001306032.1. NM_001319103.1. [Q14982-4]
NP_001306033.1. NM_001319104.1.
NP_001306034.1. NM_001319105.1. [Q14982-3]
NP_001306035.1. NM_001319106.1.
NP_002536.1. NM_002545.4. [Q14982-1]
XP_011541158.1. XM_011542856.1. [Q14982-3]
UniGeneiHs.4817.

Genome annotation databases

EnsembliENST00000331898; ENSP00000330862; ENSG00000183715. [Q14982-1]
ENST00000374778; ENSP00000363910; ENSG00000183715. [Q14982-3]
ENST00000524381; ENSP00000434750; ENSG00000183715. [Q14982-2]
ENST00000541867; ENSP00000445496; ENSG00000183715. [Q14982-4]
ENST00000612177; ENSP00000482061; ENSG00000183715. [Q14982-1]
GeneIDi4978.
KEGGihsa:4978.
UCSCiuc001qgs.4. human. [Q14982-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34774 mRNA. Translation: AAA36387.1.
EU562296 mRNA. Translation: ACB56656.1.
EU562297 mRNA. Translation: ACB56657.1.
EU562299 mRNA. Translation: ACB56659.1.
AK299908 mRNA. Translation: BAG61748.1.
AK316491 mRNA. Translation: BAH14862.1.
BX537377 mRNA. Translation: CAD97619.1.
AP000843 Genomic DNA. No translation available.
AP000863 Genomic DNA. No translation available.
AP000903 Genomic DNA. No translation available.
AP003029 Genomic DNA. No translation available.
AP003784 Genomic DNA. No translation available.
AP003972 Genomic DNA. No translation available.
AP004606 Genomic DNA. No translation available.
AP004782 Genomic DNA. No translation available.
AP005122 Genomic DNA. No translation available.
AP005133 Genomic DNA. No translation available.
AP005638 Genomic DNA. No translation available.
BC074773 mRNA. Translation: AAH74773.1.
BC117254 mRNA. Translation: AAI17255.1.
BC126251 mRNA. Translation: AAI26252.1.
BC143946 mRNA. Translation: AAI43947.1.
CCDSiCCDS31722.1. [Q14982-2]
CCDS8492.1. [Q14982-1]
PIRiJC4025.
RefSeqiNP_001012393.1. NM_001012393.2. [Q14982-2]
NP_001306032.1. NM_001319103.1. [Q14982-4]
NP_001306033.1. NM_001319104.1.
NP_001306034.1. NM_001319105.1. [Q14982-3]
NP_001306035.1. NM_001319106.1.
NP_002536.1. NM_002545.4. [Q14982-1]
XP_011541158.1. XM_011542856.1. [Q14982-3]
UniGeneiHs.4817.

3D structure databases

ProteinModelPortaliQ14982.
SMRiQ14982. Positions 37-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111026. 12 interactions.
IntActiQ14982. 2 interactions.
STRINGi9606.ENSP00000330862.

PTM databases

iPTMnetiQ14982.
PhosphoSiteiQ14982.

Polymorphism and mutation databases

BioMutaiOPCML.
DMDMi2497326.

Proteomic databases

PaxDbiQ14982.
PRIDEiQ14982.

Protocols and materials databases

DNASUi4978.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331898; ENSP00000330862; ENSG00000183715. [Q14982-1]
ENST00000374778; ENSP00000363910; ENSG00000183715. [Q14982-3]
ENST00000524381; ENSP00000434750; ENSG00000183715. [Q14982-2]
ENST00000541867; ENSP00000445496; ENSG00000183715. [Q14982-4]
ENST00000612177; ENSP00000482061; ENSG00000183715. [Q14982-1]
GeneIDi4978.
KEGGihsa:4978.
UCSCiuc001qgs.4. human. [Q14982-1]

Organism-specific databases

CTDi4978.
GeneCardsiOPCML.
HGNCiHGNC:8143. OPCML.
MalaCardsiOPCML.
MIMi167000. phenotype.
600632. gene.
neXtProtiNX_Q14982.
PharmGKBiPA31930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJH. Eukaryota.
ENOG410XT1Y. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ14982.
KOiK06773.
OMAiWSIDNRV.
OrthoDBiEOG783MVP.
PhylomeDBiQ14982.
TreeFamiTF325565.

Miscellaneous databases

ChiTaRSiOPCML. human.
GeneWikiiOPCML.
GenomeRNAii4978.
NextBioi19174.
PROiQ14982.
SOURCEiSearch...

Gene expression databases

BgeeiQ14982.
CleanExiHS_OPCML.
ExpressionAtlasiQ14982. baseline and differential.
GenevisibleiQ14982. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM)."
    Shark K.B., Lee N.M.
    Gene 155:213-217(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Occipital cortex.
  2. "Multiple promoters and alternative splicing of OPCML."
    Cui Y., Tao Q.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain and Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Brain and Fetal brain.
  7. "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer."
    Sellar G.C., Watt K.P., Rabiasz G.J., Stronach E.A., Li L., Miller E.P., Massie C.E., Miller J., Contreras-Moreira B., Scott D., Brown I., Williams A.R., Bates P.A., Smyth J.F., Gabra H.
    Nat. Genet. 34:337-343(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT OVARIAN CANCER ARG-95.

Entry informationi

Entry nameiOPCM_HUMAN
AccessioniPrimary (citable) accession number: Q14982
Secondary accession number(s): B2CZX2
, B7ZLQ1, Q17RN7, Q7Z3W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.