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Protein

Importin subunit beta-1

Gene

KPNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.5 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • nuclear localization sequence binding Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • protein transporter activity Source: GO_Central
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • apoptotic DNA fragmentation Source: Reactome
  • astral microtubule organization Source: UniProtKB
  • establishment of mitotic spindle localization Source: UniProtKB
  • establishment of protein localization Source: UniProtKB
  • intracellular transport of virus Source: Reactome
  • mitotic chromosome movement towards spindle pole Source: UniProtKB
  • mitotic metaphase plate congression Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • modulation by virus of host process Source: Reactome
  • NLS-bearing protein import into nucleus Source: ProtInc
  • protein import into nucleus Source: MGI
  • protein import into nucleus, docking Source: GO_Central
  • protein import into nucleus, translocation Source: ProtInc
  • Ran protein signal transduction Source: UniProtKB
  • ribosomal protein import into nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108424-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-211227. Activation of DNA fragmentation factor.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ14974.
SIGNORiQ14974.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit beta-1
Alternative name(s):
Importin-90
Karyopherin subunit beta-1
Nuclear factor p97
Pore targeting complex 97 kDa subunit
Short name:
PTAC97
Gene namesi
Name:KPNB1
Synonyms:NTF97
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6400. KPNB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • endoplasmic reticulum tubular network Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nuclear membrane Source: HPA
  • nuclear periphery Source: GO_Central
  • nuclear pore Source: ProtInc
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi178I → A: Largely reduced binding to FxFG repeats and reduced nuclear import. 1 Publication1
Mutagenesisi178I → F or D: Loss of binding to FxFG repeats and reduced nuclear import. 1 Publication1

Organism-specific databases

DisGeNETi3837.
OpenTargetsiENSG00000108424.
PharmGKBiPA30191.

Polymorphism and mutation databases

DMDMi20981701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207451 – 876Importin subunit beta-1Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei12PhosphoserineCombined sources1
Modified residuei211N6-acetyllysineCombined sources1
Modified residuei835N6-acetyllysineCombined sources1
Modified residuei867N6-acetyllysineCombined sources1

Post-translational modificationi

Mono-ADP-ribosylated by PARP16.

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiQ14974.
MaxQBiQ14974.
PaxDbiQ14974.
PeptideAtlasiQ14974.
PRIDEiQ14974.
TopDownProteomicsiQ14974-1. [Q14974-1]

PTM databases

iPTMnetiQ14974.
PhosphoSitePlusiQ14974.
SwissPalmiQ14974.

Expressioni

Gene expression databases

BgeeiENSG00000108424.
CleanExiHS_KPNB1.
ExpressionAtlasiQ14974. baseline and differential.
GenevisibleiQ14974. HS.

Organism-specific databases

HPAiCAB034449.
HPA029878.
HPA050302.

Interactioni

Subunit structurei

Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Binds to HIV-1 Rev and Tat. Interacts with HTLV-1 Rex. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with human respiratory syncytial virus (HRSV) protein M. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN (By similarity).By similarity22 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-286758,EBI-710918From a different organism.
ERBB2P0462614EBI-286758,EBI-641062
L1P031012EBI-286758,EBI-7362698From a different organism.
L2P031072EBI-286758,EBI-7362531From a different organism.
Mkl1Q8K4J65EBI-286758,EBI-8291665From a different organism.
NSP1P149072EBI-286758,EBI-12265From a different organism.
NUP153P497903EBI-286758,EBI-286779
revP046203EBI-286758,EBI-10687101From a different organism.
SMN2Q16637-35EBI-286758,EBI-395447
SMNDC1O759402EBI-286758,EBI-1052641

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110035. 242 interactors.
DIPiDIP-6204N.
IntActiQ14974. 146 interactors.
MINTiMINT-94095.
STRINGi9606.ENSP00000290158.

Structurei

Secondary structure

1876
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 9Combined sources7
Helixi15 – 45Combined sources31
Helixi51 – 65Combined sources15
Helixi70 – 81Combined sources12
Helixi85 – 98Combined sources14
Turni99 – 101Combined sources3
Beta strandi104 – 106Combined sources3
Helixi109 – 120Combined sources12
Helixi121 – 123Combined sources3
Helixi129 – 138Combined sources10
Helixi144 – 160Combined sources17
Helixi163 – 165Combined sources3
Helixi167 – 169Combined sources3
Helixi170 – 181Combined sources12
Helixi188 – 201Combined sources14
Turni202 – 205Combined sources4
Helixi206 – 209Combined sources4
Helixi212 – 225Combined sources14
Beta strandi228 – 230Combined sources3
Helixi231 – 247Combined sources17
Helixi249 – 251Combined sources3
Turni253 – 259Combined sources7
Helixi260 – 269Combined sources10
Helixi273 – 297Combined sources25
Beta strandi303 – 305Combined sources3
Helixi314 – 329Combined sources16
Helixi330 – 332Combined sources3
Beta strandi335 – 337Combined sources3
Helixi344 – 358Combined sources15
Turni359 – 362Combined sources4
Helixi363 – 374Combined sources12
Helixi380 – 392Combined sources13
Beta strandi394 – 397Combined sources4
Turni399 – 402Combined sources4
Turni404 – 408Combined sources5
Helixi409 – 415Combined sources7
Helixi416 – 418Combined sources3
Helixi422 – 438Combined sources17
Helixi439 – 442Combined sources4
Turni446 – 448Combined sources3
Helixi449 – 457Combined sources9
Helixi464 – 483Combined sources20
Beta strandi487 – 493Combined sources7
Turni500 – 502Combined sources3
Helixi503 – 513Combined sources11
Turni517 – 520Combined sources4
Helixi521 – 523Combined sources3
Helixi524 – 537Combined sources14
Helixi541 – 543Combined sources3
Helixi544 – 562Combined sources19
Turni563 – 566Combined sources4
Helixi573 – 592Combined sources20
Beta strandi593 – 595Combined sources3
Helixi597 – 601Combined sources5
Helixi604 – 614Combined sources11
Beta strandi619 – 622Combined sources4
Helixi623 – 639Combined sources17
Helixi640 – 646Combined sources7
Helixi647 – 660Combined sources14
Helixi664 – 681Combined sources18
Helixi682 – 685Combined sources4
Helixi686 – 700Combined sources15
Beta strandi703 – 705Combined sources3
Helixi707 – 709Combined sources3
Helixi710 – 724Combined sources15
Helixi725 – 731Combined sources7
Helixi732 – 743Combined sources12
Helixi752 – 777Combined sources26
Beta strandi779 – 782Combined sources4
Helixi785 – 789Combined sources5
Helixi791 – 793Combined sources3
Helixi794 – 805Combined sources12
Helixi812 – 829Combined sources18
Helixi832 – 838Combined sources7
Helixi841 – 852Combined sources12
Helixi856 – 873Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F59X-ray2.80A/B1-442[»]
1IBRX-ray2.30B/D1-462[»]
1M5NX-ray2.90S1-485[»]
1O6OX-ray2.80A/B/C1-442[»]
1O6PX-ray2.80A/B1-442[»]
1QGKX-ray2.50A1-876[»]
1QGRX-ray2.30A1-876[»]
2P8QX-ray2.35A1-876[»]
2Q5DX-ray3.20A/B1-876[»]
2QNAX-ray2.84A127-875[»]
3LWWX-ray3.15A/C1-876[»]
3W5KX-ray2.60A1-876[»]
ProteinModelPortaliQ14974.
SMRiQ14974.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14974.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 31HEAT 12 PublicationsAdd BLAST30
Domaini21 – 101Importin N-terminalPROSITE-ProRule annotationAdd BLAST81
Repeati33 – 65HEAT 22 PublicationsAdd BLAST33
Repeati85 – 123HEAT 32 PublicationsAdd BLAST39
Repeati129 – 160HEAT 42 PublicationsAdd BLAST32
Repeati170 – 202HEAT 52 PublicationsAdd BLAST33
Repeati212 – 247HEAT 62 PublicationsAdd BLAST36
Repeati253 – 302HEAT 72 PublicationsAdd BLAST50
Repeati314 – 360HEAT 82 PublicationsAdd BLAST47
Repeati364 – 394HEAT 92 PublicationsAdd BLAST31
Repeati402 – 438HEAT 102 PublicationsAdd BLAST37
Repeati449 – 485HEAT 111 PublicationAdd BLAST37
Repeati500 – 537HEAT 121 PublicationAdd BLAST38
Repeati544 – 592HEAT 131 PublicationAdd BLAST49
Repeati600 – 639HEAT 141 PublicationAdd BLAST40
Repeati644 – 681HEAT 151 PublicationAdd BLAST38
Repeati686 – 724HEAT 161 PublicationAdd BLAST39
Repeati732 – 776HEAT 171 PublicationAdd BLAST45
Repeati786 – 829HEAT 181 PublicationAdd BLAST44
Repeati831 – 873HEAT 191 PublicationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni329 – 342IAB-bindingAdd BLAST14
Regioni334 – 419Ran-GTP bindingAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi337 – 341Poly-Asp5

Sequence similaritiesi

Contains 19 HEAT repeats.1 Publication
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1241. Eukaryota.
COG5215. LUCA.
GeneTreeiENSGT00550000074898.
HOGENOMiHOG000204108.
HOVERGENiHBG002369.
InParanoidiQ14974.
KOiK14293.
OMAiMSNILPY.
OrthoDBiEOG091G01XQ.
PhylomeDBiQ14974.
TreeFamiTF105655.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14974-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS
60 70 80 90 100
QVARVAAGLQ IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG
110 120 130 140 150
TETYRPSSAS QCVAGIACAE IPVNQWPELI PQLVANVTNP NSTEHMKEST
160 170 180 190 200
LEAIGYICQD IDPEQLQDKS NEILTAIIQG MRKEEPSNNV KLAATNALLN
210 220 230 240 250
SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN LVKIMSLYYQ
260 270 280 290 300
YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
310 320 330 340 350
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV
360 370 380 390 400
CLMLLATCCE DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS
410 420 430 440 450
QLKPLVIQAM PTLIELMKDP SVVVRDTAAW TVGRICELLP EAAINDVYLA
460 470 480 490 500
PLLQCLIEGL SAEPRVASNV CWAFSSLAEA AYEAADVADD QEEPATYCLS
510 520 530 540 550
SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA KDCYPAVQKT
560 570 580 590 600
TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
610 620 630 640 650
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF
660 670 680 690 700
KPFLGIGLKN YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL
710 720 730 740 750
GNENVHRSVK PQILSVFGDI ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS
760 770 780 790 800
DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ ENVHPDVMLV QPRVEFILSF
810 820 830 840 850
IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR PMIHELLTEG
860 870
RRSKTNKAKT LATWATKELR KLKNQA
Length:876
Mass (Da):97,170
Last modified:May 15, 2002 - v2
Checksum:iF3BB8B73E7E51639
GO
Isoform 2 (identifier: Q14974-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:731
Mass (Da):81,179
Checksum:i03F6C311DF096541
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97Q → H in AAA82869 (PubMed:7615630).Curated1
Sequence conflicti200N → NA AA sequence (PubMed:8617227).Curated1
Sequence conflicti863T → R in AAA82869 (PubMed:7615630).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0546121 – 145Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39793 Genomic DNA. Translation: AAA82869.1.
L38951 mRNA. Translation: AAC41763.1.
BT009797 mRNA. Translation: AAP88799.1.
AK316421 mRNA. Translation: BAH14792.1.
AC015674 Genomic DNA. No translation available.
AC025682 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94807.1.
CH471109 Genomic DNA. Translation: EAW94808.1.
CH471109 Genomic DNA. Translation: EAW94810.1.
BC003572 mRNA. Translation: AAH03572.1.
BC024045 mRNA. Translation: AAH24045.1.
BC036703 mRNA. Translation: AAH36703.1.
CCDSiCCDS11513.1. [Q14974-1]
CCDS62228.1. [Q14974-2]
PIRiI52907.
RefSeqiNP_001263382.1. NM_001276453.1. [Q14974-2]
NP_002256.2. NM_002265.5. [Q14974-1]
UniGeneiHs.532793.

Genome annotation databases

EnsembliENST00000290158; ENSP00000290158; ENSG00000108424. [Q14974-1]
ENST00000535458; ENSP00000438253; ENSG00000108424. [Q14974-2]
ENST00000540627; ENSP00000438964; ENSG00000108424. [Q14974-2]
GeneIDi3837.
KEGGihsa:3837.
UCSCiuc002ilt.3. human. [Q14974-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39793 Genomic DNA. Translation: AAA82869.1.
L38951 mRNA. Translation: AAC41763.1.
BT009797 mRNA. Translation: AAP88799.1.
AK316421 mRNA. Translation: BAH14792.1.
AC015674 Genomic DNA. No translation available.
AC025682 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94807.1.
CH471109 Genomic DNA. Translation: EAW94808.1.
CH471109 Genomic DNA. Translation: EAW94810.1.
BC003572 mRNA. Translation: AAH03572.1.
BC024045 mRNA. Translation: AAH24045.1.
BC036703 mRNA. Translation: AAH36703.1.
CCDSiCCDS11513.1. [Q14974-1]
CCDS62228.1. [Q14974-2]
PIRiI52907.
RefSeqiNP_001263382.1. NM_001276453.1. [Q14974-2]
NP_002256.2. NM_002265.5. [Q14974-1]
UniGeneiHs.532793.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F59X-ray2.80A/B1-442[»]
1IBRX-ray2.30B/D1-462[»]
1M5NX-ray2.90S1-485[»]
1O6OX-ray2.80A/B/C1-442[»]
1O6PX-ray2.80A/B1-442[»]
1QGKX-ray2.50A1-876[»]
1QGRX-ray2.30A1-876[»]
2P8QX-ray2.35A1-876[»]
2Q5DX-ray3.20A/B1-876[»]
2QNAX-ray2.84A127-875[»]
3LWWX-ray3.15A/C1-876[»]
3W5KX-ray2.60A1-876[»]
ProteinModelPortaliQ14974.
SMRiQ14974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110035. 242 interactors.
DIPiDIP-6204N.
IntActiQ14974. 146 interactors.
MINTiMINT-94095.
STRINGi9606.ENSP00000290158.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ14974.
PhosphoSitePlusiQ14974.
SwissPalmiQ14974.

Polymorphism and mutation databases

DMDMi20981701.

Proteomic databases

EPDiQ14974.
MaxQBiQ14974.
PaxDbiQ14974.
PeptideAtlasiQ14974.
PRIDEiQ14974.
TopDownProteomicsiQ14974-1. [Q14974-1]

Protocols and materials databases

DNASUi3837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290158; ENSP00000290158; ENSG00000108424. [Q14974-1]
ENST00000535458; ENSP00000438253; ENSG00000108424. [Q14974-2]
ENST00000540627; ENSP00000438964; ENSG00000108424. [Q14974-2]
GeneIDi3837.
KEGGihsa:3837.
UCSCiuc002ilt.3. human. [Q14974-1]

Organism-specific databases

CTDi3837.
DisGeNETi3837.
GeneCardsiKPNB1.
HGNCiHGNC:6400. KPNB1.
HPAiCAB034449.
HPA029878.
HPA050302.
MIMi602738. gene.
neXtProtiNX_Q14974.
OpenTargetsiENSG00000108424.
PharmGKBiPA30191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1241. Eukaryota.
COG5215. LUCA.
GeneTreeiENSGT00550000074898.
HOGENOMiHOG000204108.
HOVERGENiHBG002369.
InParanoidiQ14974.
KOiK14293.
OMAiMSNILPY.
OrthoDBiEOG091G01XQ.
PhylomeDBiQ14974.
TreeFamiTF105655.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108424-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-211227. Activation of DNA fragmentation factor.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ14974.
SIGNORiQ14974.

Miscellaneous databases

ChiTaRSiKPNB1. human.
EvolutionaryTraceiQ14974.
GeneWikiiKPNB1.
GenomeRNAii3837.
PROiQ14974.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108424.
CleanExiHS_KPNB1.
ExpressionAtlasiQ14974. baseline and differential.
GenevisibleiQ14974. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMB1_HUMAN
AccessioniPrimary (citable) accession number: Q14974
Secondary accession number(s): B7ZAV6
, D3DTT3, Q14637, Q53XN2, Q96J27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 15, 2002
Last modified: November 30, 2016
This is version 187 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.