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Protein

Importin subunit beta-1

Gene

KPNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.4 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • nuclear localization sequence binding Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • protein transporter activity Source: GO_Central
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • apoptotic DNA fragmentation Source: Reactome
  • astral microtubule organization Source: UniProtKB
  • establishment of mitotic spindle localization Source: UniProtKB
  • establishment of protein localization Source: UniProtKB
  • intracellular transport of virus Source: Reactome
  • mitotic chromosome movement towards spindle pole Source: UniProtKB
  • mitotic metaphase plate congression Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • modulation by virus of host process Source: Reactome
  • NLS-bearing protein import into nucleus Source: ProtInc
  • protein import into nucleus Source: MGI
  • protein import into nucleus, docking Source: GO_Central
  • protein import into nucleus, translocation Source: ProtInc
  • Ran protein signal transduction Source: UniProtKB
  • ribosomal protein import into nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-211227. Activation of DNA fragmentation factor.
SignaLinkiQ14974.
SIGNORiQ14974.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit beta-1
Alternative name(s):
Importin-90
Karyopherin subunit beta-1
Nuclear factor p97
Pore targeting complex 97 kDa subunit
Short name:
PTAC97
Gene namesi
Name:KPNB1
Synonyms:NTF97
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6400. KPNB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • endoplasmic reticulum tubular network Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nuclear membrane Source: HPA
  • nuclear periphery Source: GO_Central
  • nuclear pore Source: ProtInc
  • nucleoplasm Source: HPA
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi178 – 1781I → A: Largely reduced binding to FxFG repeats and reduced nuclear import. 1 Publication
Mutagenesisi178 – 1781I → F or D: Loss of binding to FxFG repeats and reduced nuclear import. 1 Publication

Organism-specific databases

PharmGKBiPA30191.

Polymorphism and mutation databases

DMDMi20981701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Importin subunit beta-1PRO_0000120745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication
Modified residuei12 – 121PhosphoserineCombined sources
Cross-linki206 – 206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei211 – 2111N6-acetyllysine; alternateCombined sources
Cross-linki211 – 211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei835 – 8351N6-acetyllysineCombined sources
Modified residuei867 – 8671N6-acetyllysineCombined sources

Post-translational modificationi

Mono-ADP-ribosylated by PARP16.

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14974.
MaxQBiQ14974.
PaxDbiQ14974.
PeptideAtlasiQ14974.
PRIDEiQ14974.
TopDownProteomicsiQ14974-1. [Q14974-1]

PTM databases

iPTMnetiQ14974.
PhosphoSiteiQ14974.
SwissPalmiQ14974.

Expressioni

Gene expression databases

BgeeiENSG00000108424.
CleanExiHS_KPNB1.
ExpressionAtlasiQ14974. baseline and differential.
GenevisibleiQ14974. HS.

Organism-specific databases

HPAiCAB034449.
HPA029878.
HPA050302.

Interactioni

Subunit structurei

Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Binds to HIV-1 Rev and Tat. Interacts with HTLV-1 Rex. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with human respiratory syncytial virus (HRSV) protein M. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN (By similarity).By similarity21 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-286758,EBI-710918From a different organism.
ERBB2P0462614EBI-286758,EBI-641062
L1P031012EBI-286758,EBI-7362698From a different organism.
L2P031072EBI-286758,EBI-7362531From a different organism.
Mkl1Q8K4J65EBI-286758,EBI-8291665From a different organism.
NSP1P149072EBI-286758,EBI-12265From a different organism.
NUP153P497903EBI-286758,EBI-286779
revP046203EBI-286758,EBI-10687101From a different organism.
SMN2Q16637-35EBI-286758,EBI-395447
SMNDC1O759402EBI-286758,EBI-1052641

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110035. 241 interactions.
DIPiDIP-6204N.
IntActiQ14974. 144 interactions.
MINTiMINT-94095.
STRINGi9606.ENSP00000290158.

Structurei

Secondary structure

1
876
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Helixi15 – 4531Combined sources
Helixi51 – 6515Combined sources
Helixi70 – 8112Combined sources
Helixi85 – 9814Combined sources
Turni99 – 1013Combined sources
Beta strandi104 – 1063Combined sources
Helixi109 – 12012Combined sources
Helixi121 – 1233Combined sources
Helixi129 – 13810Combined sources
Helixi144 – 16017Combined sources
Helixi163 – 1653Combined sources
Helixi167 – 1693Combined sources
Helixi170 – 18112Combined sources
Helixi188 – 20114Combined sources
Turni202 – 2054Combined sources
Helixi206 – 2094Combined sources
Helixi212 – 22514Combined sources
Beta strandi228 – 2303Combined sources
Helixi231 – 24717Combined sources
Helixi249 – 2513Combined sources
Turni253 – 2597Combined sources
Helixi260 – 26910Combined sources
Helixi273 – 29725Combined sources
Beta strandi303 – 3053Combined sources
Helixi314 – 32916Combined sources
Helixi330 – 3323Combined sources
Beta strandi335 – 3373Combined sources
Helixi344 – 35815Combined sources
Turni359 – 3624Combined sources
Helixi363 – 37412Combined sources
Helixi380 – 39213Combined sources
Beta strandi394 – 3974Combined sources
Turni399 – 4024Combined sources
Turni404 – 4085Combined sources
Helixi409 – 4157Combined sources
Helixi416 – 4183Combined sources
Helixi422 – 43817Combined sources
Helixi439 – 4424Combined sources
Turni446 – 4483Combined sources
Helixi449 – 4579Combined sources
Helixi464 – 48320Combined sources
Beta strandi487 – 4937Combined sources
Turni500 – 5023Combined sources
Helixi503 – 51311Combined sources
Turni517 – 5204Combined sources
Helixi521 – 5233Combined sources
Helixi524 – 53714Combined sources
Helixi541 – 5433Combined sources
Helixi544 – 56219Combined sources
Turni563 – 5664Combined sources
Helixi573 – 59220Combined sources
Beta strandi593 – 5953Combined sources
Helixi597 – 6015Combined sources
Helixi604 – 61411Combined sources
Beta strandi619 – 6224Combined sources
Helixi623 – 63917Combined sources
Helixi640 – 6467Combined sources
Helixi647 – 66014Combined sources
Helixi664 – 68118Combined sources
Helixi682 – 6854Combined sources
Helixi686 – 70015Combined sources
Beta strandi703 – 7053Combined sources
Helixi707 – 7093Combined sources
Helixi710 – 72415Combined sources
Helixi725 – 7317Combined sources
Helixi732 – 74312Combined sources
Helixi752 – 77726Combined sources
Beta strandi779 – 7824Combined sources
Helixi785 – 7895Combined sources
Helixi791 – 7933Combined sources
Helixi794 – 80512Combined sources
Helixi812 – 82918Combined sources
Helixi832 – 8387Combined sources
Helixi841 – 85212Combined sources
Helixi856 – 87318Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F59X-ray2.80A/B1-442[»]
1IBRX-ray2.30B/D1-462[»]
1M5NX-ray2.90S1-485[»]
1O6OX-ray2.80A/B/C1-442[»]
1O6PX-ray2.80A/B1-442[»]
1QGKX-ray2.50A1-876[»]
1QGRX-ray2.30A1-876[»]
2P8QX-ray2.35A1-876[»]
2Q5DX-ray3.20A/B1-876[»]
2QNAX-ray2.84A127-875[»]
3LWWX-ray3.15A/C1-876[»]
3W5KX-ray2.60A1-876[»]
ProteinModelPortaliQ14974.
SMRiQ14974. Positions 1-873.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14974.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3130HEAT 12 PublicationsAdd
BLAST
Domaini21 – 10181Importin N-terminalPROSITE-ProRule annotationAdd
BLAST
Repeati33 – 6533HEAT 22 PublicationsAdd
BLAST
Repeati85 – 12339HEAT 32 PublicationsAdd
BLAST
Repeati129 – 16032HEAT 42 PublicationsAdd
BLAST
Repeati170 – 20233HEAT 52 PublicationsAdd
BLAST
Repeati212 – 24736HEAT 62 PublicationsAdd
BLAST
Repeati253 – 30250HEAT 72 PublicationsAdd
BLAST
Repeati314 – 36047HEAT 82 PublicationsAdd
BLAST
Repeati364 – 39431HEAT 92 PublicationsAdd
BLAST
Repeati402 – 43837HEAT 102 PublicationsAdd
BLAST
Repeati449 – 48537HEAT 111 PublicationAdd
BLAST
Repeati500 – 53738HEAT 121 PublicationAdd
BLAST
Repeati544 – 59249HEAT 131 PublicationAdd
BLAST
Repeati600 – 63940HEAT 141 PublicationAdd
BLAST
Repeati644 – 68138HEAT 151 PublicationAdd
BLAST
Repeati686 – 72439HEAT 161 PublicationAdd
BLAST
Repeati732 – 77645HEAT 171 PublicationAdd
BLAST
Repeati786 – 82944HEAT 181 PublicationAdd
BLAST
Repeati831 – 87343HEAT 191 PublicationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni329 – 34214IAB-bindingAdd
BLAST
Regioni334 – 41986Ran-GTP bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi337 – 3415Poly-Asp

Sequence similaritiesi

Contains 19 HEAT repeats.1 Publication
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1241. Eukaryota.
COG5215. LUCA.
GeneTreeiENSGT00550000074898.
HOGENOMiHOG000204108.
HOVERGENiHBG002369.
InParanoidiQ14974.
KOiK14293.
OMAiMSNILPY.
OrthoDBiEOG091G01XQ.
PhylomeDBiQ14974.
TreeFamiTF105655.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14974-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS
60 70 80 90 100
QVARVAAGLQ IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG
110 120 130 140 150
TETYRPSSAS QCVAGIACAE IPVNQWPELI PQLVANVTNP NSTEHMKEST
160 170 180 190 200
LEAIGYICQD IDPEQLQDKS NEILTAIIQG MRKEEPSNNV KLAATNALLN
210 220 230 240 250
SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN LVKIMSLYYQ
260 270 280 290 300
YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
310 320 330 340 350
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV
360 370 380 390 400
CLMLLATCCE DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS
410 420 430 440 450
QLKPLVIQAM PTLIELMKDP SVVVRDTAAW TVGRICELLP EAAINDVYLA
460 470 480 490 500
PLLQCLIEGL SAEPRVASNV CWAFSSLAEA AYEAADVADD QEEPATYCLS
510 520 530 540 550
SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA KDCYPAVQKT
560 570 580 590 600
TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
610 620 630 640 650
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF
660 670 680 690 700
KPFLGIGLKN YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL
710 720 730 740 750
GNENVHRSVK PQILSVFGDI ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS
760 770 780 790 800
DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ ENVHPDVMLV QPRVEFILSF
810 820 830 840 850
IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR PMIHELLTEG
860 870
RRSKTNKAKT LATWATKELR KLKNQA
Length:876
Mass (Da):97,170
Last modified:May 15, 2002 - v2
Checksum:iF3BB8B73E7E51639
GO
Isoform 2 (identifier: Q14974-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:731
Mass (Da):81,179
Checksum:i03F6C311DF096541
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971Q → H in AAA82869 (PubMed:7615630).Curated
Sequence conflicti200 – 2001N → NA AA sequence (PubMed:8617227).Curated
Sequence conflicti863 – 8631T → R in AAA82869 (PubMed:7615630).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 145145Missing in isoform 2. 1 PublicationVSP_054612Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39793 Genomic DNA. Translation: AAA82869.1.
L38951 mRNA. Translation: AAC41763.1.
BT009797 mRNA. Translation: AAP88799.1.
AK316421 mRNA. Translation: BAH14792.1.
AC015674 Genomic DNA. No translation available.
AC025682 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94807.1.
CH471109 Genomic DNA. Translation: EAW94808.1.
CH471109 Genomic DNA. Translation: EAW94810.1.
BC003572 mRNA. Translation: AAH03572.1.
BC024045 mRNA. Translation: AAH24045.1.
BC036703 mRNA. Translation: AAH36703.1.
CCDSiCCDS11513.1. [Q14974-1]
CCDS62228.1. [Q14974-2]
PIRiI52907.
RefSeqiNP_001263382.1. NM_001276453.1. [Q14974-2]
NP_002256.2. NM_002265.5. [Q14974-1]
UniGeneiHs.532793.

Genome annotation databases

EnsembliENST00000290158; ENSP00000290158; ENSG00000108424. [Q14974-1]
ENST00000535458; ENSP00000438253; ENSG00000108424. [Q14974-2]
ENST00000540627; ENSP00000438964; ENSG00000108424. [Q14974-2]
GeneIDi3837.
KEGGihsa:3837.
UCSCiuc002ilt.3. human. [Q14974-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39793 Genomic DNA. Translation: AAA82869.1.
L38951 mRNA. Translation: AAC41763.1.
BT009797 mRNA. Translation: AAP88799.1.
AK316421 mRNA. Translation: BAH14792.1.
AC015674 Genomic DNA. No translation available.
AC025682 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94807.1.
CH471109 Genomic DNA. Translation: EAW94808.1.
CH471109 Genomic DNA. Translation: EAW94810.1.
BC003572 mRNA. Translation: AAH03572.1.
BC024045 mRNA. Translation: AAH24045.1.
BC036703 mRNA. Translation: AAH36703.1.
CCDSiCCDS11513.1. [Q14974-1]
CCDS62228.1. [Q14974-2]
PIRiI52907.
RefSeqiNP_001263382.1. NM_001276453.1. [Q14974-2]
NP_002256.2. NM_002265.5. [Q14974-1]
UniGeneiHs.532793.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F59X-ray2.80A/B1-442[»]
1IBRX-ray2.30B/D1-462[»]
1M5NX-ray2.90S1-485[»]
1O6OX-ray2.80A/B/C1-442[»]
1O6PX-ray2.80A/B1-442[»]
1QGKX-ray2.50A1-876[»]
1QGRX-ray2.30A1-876[»]
2P8QX-ray2.35A1-876[»]
2Q5DX-ray3.20A/B1-876[»]
2QNAX-ray2.84A127-875[»]
3LWWX-ray3.15A/C1-876[»]
3W5KX-ray2.60A1-876[»]
ProteinModelPortaliQ14974.
SMRiQ14974. Positions 1-873.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110035. 241 interactions.
DIPiDIP-6204N.
IntActiQ14974. 144 interactions.
MINTiMINT-94095.
STRINGi9606.ENSP00000290158.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ14974.
PhosphoSiteiQ14974.
SwissPalmiQ14974.

Polymorphism and mutation databases

DMDMi20981701.

Proteomic databases

EPDiQ14974.
MaxQBiQ14974.
PaxDbiQ14974.
PeptideAtlasiQ14974.
PRIDEiQ14974.
TopDownProteomicsiQ14974-1. [Q14974-1]

Protocols and materials databases

DNASUi3837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290158; ENSP00000290158; ENSG00000108424. [Q14974-1]
ENST00000535458; ENSP00000438253; ENSG00000108424. [Q14974-2]
ENST00000540627; ENSP00000438964; ENSG00000108424. [Q14974-2]
GeneIDi3837.
KEGGihsa:3837.
UCSCiuc002ilt.3. human. [Q14974-1]

Organism-specific databases

CTDi3837.
GeneCardsiKPNB1.
HGNCiHGNC:6400. KPNB1.
HPAiCAB034449.
HPA029878.
HPA050302.
MIMi602738. gene.
neXtProtiNX_Q14974.
PharmGKBiPA30191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1241. Eukaryota.
COG5215. LUCA.
GeneTreeiENSGT00550000074898.
HOGENOMiHOG000204108.
HOVERGENiHBG002369.
InParanoidiQ14974.
KOiK14293.
OMAiMSNILPY.
OrthoDBiEOG091G01XQ.
PhylomeDBiQ14974.
TreeFamiTF105655.

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-211227. Activation of DNA fragmentation factor.
SignaLinkiQ14974.
SIGNORiQ14974.

Miscellaneous databases

ChiTaRSiKPNB1. human.
EvolutionaryTraceiQ14974.
GeneWikiiKPNB1.
GenomeRNAii3837.
PROiQ14974.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108424.
CleanExiHS_KPNB1.
ExpressionAtlasiQ14974. baseline and differential.
GenevisibleiQ14974. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR021133. HEAT_type_2.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMB1_HUMAN
AccessioniPrimary (citable) accession number: Q14974
Secondary accession number(s): B7ZAV6
, D3DTT3, Q14637, Q53XN2, Q96J27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 15, 2002
Last modified: September 7, 2016
This is version 184 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.