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Protein

Sodium/bile acid cotransporter

Gene

SLC10A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
(Microbial infection) Acts as a receptor for hepatitis B virus.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts

Protein family/group databases

TCDBi2.A.28.1.9 the bile acid:na(+) symporter (bass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Cell growth-inhibiting gene 29 protein
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:SLC10A1
Synonyms:NTCP
ORF Names:GIG29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100652.4
HGNCiHGNC:10905 SLC10A1
MIMi182396 gene
neXtProtiNX_Q14973

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6554
OpenTargetsiENSG00000100652
PharmGKBiPA317

Chemistry databases

ChEMBLiCHEMBL5287
DrugBankiDB00887 Bumetanide
DB02659 Cholic Acid
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB03619 Deoxycholic Acid
DB00977 Ethinyl Estradiol
DB02123 Glycochenodeoxycholic Acid
DB00328 Indomethacin
DB00279 Liothyronine
DB01583 Liotrix
DB08860 Pitavastatin
DB01032 Probenecid
DB00396 Progesterone
DB04348 Taurocholic Acid
DB00624 Testosterone
DB01586 Ursodeoxycholic acid
GuidetoPHARMACOLOGYi959

Polymorphism and mutation databases

BioMutaiSLC10A1
DMDMi2498046

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523351 – 349Sodium/bile acid cotransporterAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14973
PeptideAtlasiQ14973
PRIDEiQ14973

PTM databases

iPTMnetiQ14973
PhosphoSitePlusiQ14973

Expressioni

Gene expression databases

BgeeiENSG00000100652
CleanExiHS_SLC10A1
GenevisibleiQ14973 HS

Organism-specific databases

HPAiHPA042727

Interactioni

Subunit structurei

(Microbial infection) Interacts with hepatitis B virus large envelope protein.1 Publication

Protein-protein interaction databases

BioGridi112443, 1 interactor
IntActiQ14973, 1 interactor
STRINGi9606.ENSP00000216540

Chemistry databases

BindingDBiQ14973

Structurei

3D structure databases

ProteinModelPortaliQ14973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG101123
InParanoidiQ14973
KOiK14341
OMAiKIKAHFW
OrthoDBiEOG091G0GT5
PhylomeDBiQ14973
TreeFamiTF315811

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030208 SLC10A1
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF40 PTHR10361:SF40, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

Sequencei

Sequence statusi: Complete.

Q14973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK
60 70 80 90 100
IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP
110 120 130 140 150
GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL
160 170 180 190 200
KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV
210 220 230 240 250
AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC
260 270 280 290 300
RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL
310 320 330 340
IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA
Length:349
Mass (Da):38,119
Last modified:November 1, 1996 - v1
Checksum:iF3AB2CC2FBD925E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022113267S → F. Corresponds to variant dbSNP:rs2296651EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21893 mRNA Translation: AAA36381.1
AY544127 mRNA Translation: AAT11158.1
CH471061 Genomic DNA Translation: EAW81011.1
BC069799 mRNA Translation: AAH69799.1
BC069822 mRNA Translation: AAH69822.1
BC074724 mRNA Translation: AAH74724.1
BC126298 mRNA Translation: AAI26299.1
BC136355 mRNA Translation: AAI36356.1
CCDSiCCDS9797.1
PIRiI55601
RefSeqiNP_003040.1, NM_003049.3
UniGeneiHs.952

Genome annotation databases

EnsembliENST00000216540; ENSP00000216540; ENSG00000100652
GeneIDi6554
KEGGihsa:6554
UCSCiuc001xlr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNTCP_HUMAN
AccessioniPrimary (citable) accession number: Q14973
Secondary accession number(s): B9EGB6, Q2TU29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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