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Protein

Sodium/bile acid cotransporter

Gene

SLC10A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
(Microbial infection) Acts as a receptor for hepatitis B virus.1 Publication

GO - Molecular functioni

GO - Biological processi

  • bile acid and bile salt transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100652-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.

Protein family/group databases

TCDBi2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Cell growth-inhibiting gene 29 protein
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:SLC10A1
Synonyms:NTCP
ORF Names:GIG29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:10905. SLC10A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6554.
OpenTargetsiENSG00000100652.
PharmGKBiPA317.

Chemistry databases

ChEMBLiCHEMBL5287.
DrugBankiDB00887. Bumetanide.
DB02659. Cholic Acid.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB03619. Deoxycholic Acid.
DB00977. Ethinyl Estradiol.
DB00328. Indomethacin.
DB00279. Liothyronine.
DB01583. Liotrix.
DB08860. Pitavastatin.
DB01032. Probenecid.
DB00396. Progesterone.
DB00624. Testosterone.
DB01586. Ursodeoxycholic acid.
GuidetoPHARMACOLOGYi959.

Polymorphism and mutation databases

BioMutaiSLC10A1.
DMDMi2498046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523351 – 349Sodium/bile acid cotransporterAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi336N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14973.
PRIDEiQ14973.

PTM databases

iPTMnetiQ14973.
PhosphoSitePlusiQ14973.

Expressioni

Gene expression databases

BgeeiENSG00000100652.
CleanExiHS_SLC10A1.
GenevisibleiQ14973. HS.

Organism-specific databases

HPAiHPA042727.

Interactioni

Subunit structurei

(Microbial infection) Interacts with hepatitis B virus large envelope protein.1 Publication

Protein-protein interaction databases

BioGridi112443. 1 interactor.
IntActiQ14973. 1 interactor.
STRINGi9606.ENSP00000216540.

Chemistry databases

BindingDBiQ14973.

Structurei

3D structure databases

ProteinModelPortaliQ14973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiQ14973.
KOiK14341.
OMAiKIKAHFW.
OrthoDBiEOG091G0GT5.
PhylomeDBiQ14973.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF40. PTHR10361:SF40. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK
60 70 80 90 100
IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP
110 120 130 140 150
GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL
160 170 180 190 200
KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV
210 220 230 240 250
AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC
260 270 280 290 300
RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL
310 320 330 340
IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA
Length:349
Mass (Da):38,119
Last modified:November 1, 1996 - v1
Checksum:iF3AB2CC2FBD925E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022113267S → F.Corresponds to variant rs2296651dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21893 mRNA. Translation: AAA36381.1.
AY544127 mRNA. Translation: AAT11158.1.
CH471061 Genomic DNA. Translation: EAW81011.1.
BC069799 mRNA. Translation: AAH69799.1.
BC069822 mRNA. Translation: AAH69822.1.
BC074724 mRNA. Translation: AAH74724.1.
BC126298 mRNA. Translation: AAI26299.1.
BC136355 mRNA. Translation: AAI36356.1.
CCDSiCCDS9797.1.
PIRiI55601.
RefSeqiNP_003040.1. NM_003049.3.
UniGeneiHs.952.

Genome annotation databases

EnsembliENST00000216540; ENSP00000216540; ENSG00000100652.
GeneIDi6554.
KEGGihsa:6554.
UCSCiuc001xlr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21893 mRNA. Translation: AAA36381.1.
AY544127 mRNA. Translation: AAT11158.1.
CH471061 Genomic DNA. Translation: EAW81011.1.
BC069799 mRNA. Translation: AAH69799.1.
BC069822 mRNA. Translation: AAH69822.1.
BC074724 mRNA. Translation: AAH74724.1.
BC126298 mRNA. Translation: AAI26299.1.
BC136355 mRNA. Translation: AAI36356.1.
CCDSiCCDS9797.1.
PIRiI55601.
RefSeqiNP_003040.1. NM_003049.3.
UniGeneiHs.952.

3D structure databases

ProteinModelPortaliQ14973.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112443. 1 interactor.
IntActiQ14973. 1 interactor.
STRINGi9606.ENSP00000216540.

Chemistry databases

BindingDBiQ14973.
ChEMBLiCHEMBL5287.
DrugBankiDB00887. Bumetanide.
DB02659. Cholic Acid.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB03619. Deoxycholic Acid.
DB00977. Ethinyl Estradiol.
DB00328. Indomethacin.
DB00279. Liothyronine.
DB01583. Liotrix.
DB08860. Pitavastatin.
DB01032. Probenecid.
DB00396. Progesterone.
DB00624. Testosterone.
DB01586. Ursodeoxycholic acid.
GuidetoPHARMACOLOGYi959.

Protein family/group databases

TCDBi2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

PTM databases

iPTMnetiQ14973.
PhosphoSitePlusiQ14973.

Polymorphism and mutation databases

BioMutaiSLC10A1.
DMDMi2498046.

Proteomic databases

PaxDbiQ14973.
PRIDEiQ14973.

Protocols and materials databases

DNASUi6554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216540; ENSP00000216540; ENSG00000100652.
GeneIDi6554.
KEGGihsa:6554.
UCSCiuc001xlr.3. human.

Organism-specific databases

CTDi6554.
DisGeNETi6554.
GeneCardsiSLC10A1.
HGNCiHGNC:10905. SLC10A1.
HPAiHPA042727.
MIMi182396. gene.
neXtProtiNX_Q14973.
OpenTargetsiENSG00000100652.
PharmGKBiPA317.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiQ14973.
KOiK14341.
OMAiKIKAHFW.
OrthoDBiEOG091G0GT5.
PhylomeDBiQ14973.
TreeFamiTF315811.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100652-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.

Miscellaneous databases

GeneWikiiSLC10A1.
GenomeRNAii6554.
PROiQ14973.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100652.
CleanExiHS_SLC10A1.
GenevisibleiQ14973. HS.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF40. PTHR10361:SF40. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP_HUMAN
AccessioniPrimary (citable) accession number: Q14973
Secondary accession number(s): B9EGB6, Q2TU29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.