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Q14973

- NTCP_HUMAN

UniProt

Q14973 - NTCP_HUMAN

Protein

Sodium/bile acid cotransporter

Gene

SLC10A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: ProtInc

    GO - Biological processi

    1. bile acid and bile salt transport Source: Reactome
    2. bile acid metabolic process Source: Reactome
    3. small molecule metabolic process Source: Reactome
    4. transport Source: ProtInc

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_11042. Recycling of bile acids and salts.

    Protein family/group databases

    TCDBi2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/bile acid cotransporter
    Alternative name(s):
    Cell growth-inhibiting gene 29 protein
    Na(+)/bile acid cotransporter
    Na(+)/taurocholate transport protein
    Sodium/taurocholate cotransporting polypeptide
    Solute carrier family 10 member 1
    Gene namesi
    Name:SLC10A1
    Synonyms:NTCP
    ORF Names:GIG29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:10905. SLC10A1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA317.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Sodium/bile acid cotransporterPRO_0000052335Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ14973.
    PRIDEiQ14973.

    PTM databases

    PhosphoSiteiQ14973.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14973.
    BgeeiQ14973.
    CleanExiHS_SLC10A1.
    GenevestigatoriQ14973.

    Organism-specific databases

    HPAiHPA042727.

    Interactioni

    Protein-protein interaction databases

    BioGridi112443. 1 interaction.
    IntActiQ14973. 1 interaction.
    STRINGi9606.ENSP00000216540.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14973.
    SMRiQ14973. Positions 34-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    HOGENOMiHOG000234524.
    HOVERGENiHBG101123.
    InParanoidiQ14973.
    KOiK14341.
    OMAiVGKSIMF.
    OrthoDBiEOG7XWPNW.
    PhylomeDBiQ14973.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00841. bass. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q14973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK    50
    IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP 100
    GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL 150
    KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV 200
    AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC 250
    RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL 300
    IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA 349
    Length:349
    Mass (Da):38,119
    Last modified:November 1, 1996 - v1
    Checksum:iF3AB2CC2FBD925E3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671S → F.
    Corresponds to variant rs2296651 [ dbSNP | Ensembl ].
    VAR_022113

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21893 mRNA. Translation: AAA36381.1.
    AY544127 mRNA. Translation: AAT11158.1.
    CH471061 Genomic DNA. Translation: EAW81011.1.
    BC069799 mRNA. Translation: AAH69799.1.
    BC069822 mRNA. Translation: AAH69822.1.
    BC074724 mRNA. Translation: AAH74724.1.
    BC126298 mRNA. Translation: AAI26299.1.
    BC136355 mRNA. Translation: AAI36356.1.
    CCDSiCCDS9797.1.
    PIRiI55601.
    RefSeqiNP_003040.1. NM_003049.3.
    UniGeneiHs.952.

    Genome annotation databases

    EnsembliENST00000216540; ENSP00000216540; ENSG00000100652.
    GeneIDi6554.
    KEGGihsa:6554.
    UCSCiuc001xlr.2. human.

    Polymorphism databases

    DMDMi2498046.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21893 mRNA. Translation: AAA36381.1 .
    AY544127 mRNA. Translation: AAT11158.1 .
    CH471061 Genomic DNA. Translation: EAW81011.1 .
    BC069799 mRNA. Translation: AAH69799.1 .
    BC069822 mRNA. Translation: AAH69822.1 .
    BC074724 mRNA. Translation: AAH74724.1 .
    BC126298 mRNA. Translation: AAI26299.1 .
    BC136355 mRNA. Translation: AAI36356.1 .
    CCDSi CCDS9797.1.
    PIRi I55601.
    RefSeqi NP_003040.1. NM_003049.3.
    UniGenei Hs.952.

    3D structure databases

    ProteinModelPortali Q14973.
    SMRi Q14973. Positions 34-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112443. 1 interaction.
    IntActi Q14973. 1 interaction.
    STRINGi 9606.ENSP00000216540.

    Chemistry

    BindingDBi Q14973.
    ChEMBLi CHEMBL5287.
    GuidetoPHARMACOLOGYi 959.

    Protein family/group databases

    TCDBi 2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

    PTM databases

    PhosphoSitei Q14973.

    Polymorphism databases

    DMDMi 2498046.

    Proteomic databases

    PaxDbi Q14973.
    PRIDEi Q14973.

    Protocols and materials databases

    DNASUi 6554.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216540 ; ENSP00000216540 ; ENSG00000100652 .
    GeneIDi 6554.
    KEGGi hsa:6554.
    UCSCi uc001xlr.2. human.

    Organism-specific databases

    CTDi 6554.
    GeneCardsi GC14M070242.
    HGNCi HGNC:10905. SLC10A1.
    HPAi HPA042727.
    MIMi 182396. gene.
    neXtProti NX_Q14973.
    PharmGKBi PA317.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0385.
    HOGENOMi HOG000234524.
    HOVERGENi HBG101123.
    InParanoidi Q14973.
    KOi K14341.
    OMAi VGKSIMF.
    OrthoDBi EOG7XWPNW.
    PhylomeDBi Q14973.
    TreeFami TF315811.

    Enzyme and pathway databases

    Reactomei REACT_11042. Recycling of bile acids and salts.

    Miscellaneous databases

    GeneWikii SLC10A1.
    GenomeRNAii 6554.
    NextBioi 25503.
    PROi Q14973.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14973.
    Bgeei Q14973.
    CleanExi HS_SLC10A1.
    Genevestigatori Q14973.

    Family and domain databases

    InterProi IPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00841. bass. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter."
      Hagenbuch B., Meier P.J.
      J. Clin. Invest. 93:1326-1331(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Identification of a human cell growth inhibition gene."
      Kim J.W.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.

    Entry informationi

    Entry nameiNTCP_HUMAN
    AccessioniPrimary (citable) accession number: Q14973
    Secondary accession number(s): B9EGB6, Q2TU29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3