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Q14973 (NTCP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Cell growth-inhibiting gene 29 protein
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene names
Name:SLC10A1
Synonyms:NTCP
ORF Names:GIG29
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Sodium/bile acid cotransporter
PRO_0000052335

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane91 – 11121Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane283 – 30321Helical; Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation3361N-linked (GlcNAc...) Potential

Natural variations

Natural variant2671S → F.
Corresponds to variant rs2296651 [ dbSNP | Ensembl ].
VAR_022113

Sequences

Sequence LengthMass (Da)Tools
Q14973 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F3AB2CC2FBD925E3

FASTA34938,119
        10         20         30         40         50         60 
MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK IKAHLWKPKG 

        70         80         90        100        110        120 
LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP GGNLSNVFSL AMKGDMNLSI 

       130        140        150        160        170        180 
VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR 

       190        200        210        220        230        240 
PQYMRYVIKG GMIIILLCSV AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL 

       250        260        270        280        290        300 
SALFCLNGRC RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL 

       310        320        330        340 
IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter."
Hagenbuch B., Meier P.J.
J. Clin. Invest. 93:1326-1331(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Identification of a human cell growth inhibition gene."
Kim J.W.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L21893 mRNA. Translation: AAA36381.1.
AY544127 mRNA. Translation: AAT11158.1.
CH471061 Genomic DNA. Translation: EAW81011.1.
BC069799 mRNA. Translation: AAH69799.1.
BC069822 mRNA. Translation: AAH69822.1.
BC074724 mRNA. Translation: AAH74724.1.
BC126298 mRNA. Translation: AAI26299.1.
BC136355 mRNA. Translation: AAI36356.1.
CCDSCCDS9797.1.
PIRI55601.
RefSeqNP_003040.1. NM_003049.3.
UniGeneHs.952.

3D structure databases

ProteinModelPortalQ14973.
SMRQ14973. Positions 34-289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112443. 1 interaction.
IntActQ14973. 1 interaction.
STRING9606.ENSP00000216540.

Chemistry

BindingDBQ14973.
ChEMBLCHEMBL5287.
GuidetoPHARMACOLOGY959.

Protein family/group databases

TCDB2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteQ14973.

Polymorphism databases

DMDM2498046.

Proteomic databases

PaxDbQ14973.
PRIDEQ14973.

Protocols and materials databases

DNASU6554.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216540; ENSP00000216540; ENSG00000100652.
GeneID6554.
KEGGhsa:6554.
UCSCuc001xlr.2. human.

Organism-specific databases

CTD6554.
GeneCardsGC14M070242.
HGNCHGNC:10905. SLC10A1.
HPAHPA042727.
MIM182396. gene.
neXtProtNX_Q14973.
PharmGKBPA317.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0385.
HOGENOMHOG000234524.
HOVERGENHBG101123.
InParanoidQ14973.
KOK14341.
OMAVGKSIMF.
OrthoDBEOG7XWPNW.
PhylomeDBQ14973.
TreeFamTF315811.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ14973.
BgeeQ14973.
CleanExHS_SLC10A1.
GenevestigatorQ14973.

Family and domain databases

InterProIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00841. bass. 1 hit.
ProtoNetSearch...

Other

GeneWikiSLC10A1.
GenomeRNAi6554.
NextBio25503.
PROQ14973.
SOURCESearch...

Entry information

Entry nameNTCP_HUMAN
AccessionPrimary (citable) accession number: Q14973
Secondary accession number(s): B9EGB6, Q2TU29
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM