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Protein

Sodium/bile acid cotransporter

Gene

SLC10A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: ProtInc

GO - Biological processi

  1. bile acid and bile salt transport Source: GO_Central
  2. bile acid metabolic process Source: Reactome
  3. small molecule metabolic process Source: Reactome
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_11042. Recycling of bile acids and salts.

Protein family/group databases

TCDBi2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Cell growth-inhibiting gene 29 protein
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:SLC10A1
Synonyms:NTCP
ORF Names:GIG29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:10905. SLC10A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Sodium/bile acid cotransporterPRO_0000052335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14973.
PRIDEiQ14973.

PTM databases

PhosphoSiteiQ14973.

Expressioni

Gene expression databases

BgeeiQ14973.
CleanExiHS_SLC10A1.
ExpressionAtlasiQ14973. baseline and differential.
GenevestigatoriQ14973.

Organism-specific databases

HPAiHPA042727.

Interactioni

Protein-protein interaction databases

BioGridi112443. 1 interaction.
IntActiQ14973. 1 interaction.
STRINGi9606.ENSP00000216540.

Structurei

3D structure databases

ProteinModelPortaliQ14973.
SMRiQ14973. Positions 34-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiQ14973.
KOiK14341.
OMAiVGKSIMF.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ14973.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF18. PTHR10361:SF18. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK
60 70 80 90 100
IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP
110 120 130 140 150
GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL
160 170 180 190 200
KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV
210 220 230 240 250
AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC
260 270 280 290 300
RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL
310 320 330 340
IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA
Length:349
Mass (Da):38,119
Last modified:November 1, 1996 - v1
Checksum:iF3AB2CC2FBD925E3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671S → F.
Corresponds to variant rs2296651 [ dbSNP | Ensembl ].
VAR_022113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21893 mRNA. Translation: AAA36381.1.
AY544127 mRNA. Translation: AAT11158.1.
CH471061 Genomic DNA. Translation: EAW81011.1.
BC069799 mRNA. Translation: AAH69799.1.
BC069822 mRNA. Translation: AAH69822.1.
BC074724 mRNA. Translation: AAH74724.1.
BC126298 mRNA. Translation: AAI26299.1.
BC136355 mRNA. Translation: AAI36356.1.
CCDSiCCDS9797.1.
PIRiI55601.
RefSeqiNP_003040.1. NM_003049.3.
UniGeneiHs.952.

Genome annotation databases

EnsembliENST00000216540; ENSP00000216540; ENSG00000100652.
GeneIDi6554.
KEGGihsa:6554.
UCSCiuc001xlr.2. human.

Polymorphism databases

DMDMi2498046.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21893 mRNA. Translation: AAA36381.1.
AY544127 mRNA. Translation: AAT11158.1.
CH471061 Genomic DNA. Translation: EAW81011.1.
BC069799 mRNA. Translation: AAH69799.1.
BC069822 mRNA. Translation: AAH69822.1.
BC074724 mRNA. Translation: AAH74724.1.
BC126298 mRNA. Translation: AAI26299.1.
BC136355 mRNA. Translation: AAI36356.1.
CCDSiCCDS9797.1.
PIRiI55601.
RefSeqiNP_003040.1. NM_003049.3.
UniGeneiHs.952.

3D structure databases

ProteinModelPortaliQ14973.
SMRiQ14973. Positions 34-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112443. 1 interaction.
IntActiQ14973. 1 interaction.
STRINGi9606.ENSP00000216540.

Chemistry

BindingDBiQ14973.
ChEMBLiCHEMBL5287.
DrugBankiDB00887. Bumetanide.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00977. Ethinyl Estradiol.
DB00328. Indomethacin.
DB00279. Liothyronine.
DB01583. Liotrix.
DB08860. Pitavastatin.
DB01032. Probenecid.
DB00396. Progesterone.
DB00624. Testosterone.
DB01586. Ursodeoxycholic acid.
GuidetoPHARMACOLOGYi959.

Protein family/group databases

TCDBi2.A.28.1.9. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteiQ14973.

Polymorphism databases

DMDMi2498046.

Proteomic databases

PaxDbiQ14973.
PRIDEiQ14973.

Protocols and materials databases

DNASUi6554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216540; ENSP00000216540; ENSG00000100652.
GeneIDi6554.
KEGGihsa:6554.
UCSCiuc001xlr.2. human.

Organism-specific databases

CTDi6554.
GeneCardsiGC14M070242.
HGNCiHGNC:10905. SLC10A1.
HPAiHPA042727.
MIMi182396. gene.
neXtProtiNX_Q14973.
PharmGKBiPA317.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiQ14973.
KOiK14341.
OMAiVGKSIMF.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ14973.
TreeFamiTF315811.

Enzyme and pathway databases

ReactomeiREACT_11042. Recycling of bile acids and salts.

Miscellaneous databases

GeneWikiiSLC10A1.
GenomeRNAii6554.
NextBioi25503.
PROiQ14973.
SOURCEiSearch...

Gene expression databases

BgeeiQ14973.
CleanExiHS_SLC10A1.
ExpressionAtlasiQ14973. baseline and differential.
GenevestigatoriQ14973.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF18. PTHR10361:SF18. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter."
    Hagenbuch B., Meier P.J.
    J. Clin. Invest. 93:1326-1331(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Identification of a human cell growth inhibition gene."
    Kim J.W.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiNTCP_HUMAN
AccessioniPrimary (citable) accession number: Q14973
Secondary accession number(s): B9EGB6, Q2TU29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.