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Q14966

- ZN638_HUMAN

UniProt

Q14966 - ZN638_HUMAN

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Protein

Zinc finger protein 638

Gene

ZNF638

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 By similarity. Binds to cytidine clusters in double-stranded DNA.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1353 – 1477125Add
BLAST
Zinc fingeri1928 – 195831Matrin-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: ProtInc
  2. nucleotide binding Source: InterPro
  3. poly(A) RNA binding Source: UniProtKB
  4. RNA binding Source: ProtInc
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. RNA splicing Source: ProtInc
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 638
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se33-1
Short name:
CTCL-associated antigen se33-1
Nuclear protein 220
Zinc finger matrin-like protein
Gene namesi
Name:ZNF638
Synonyms:NP220, ZFML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17894. ZNF638.

Subcellular locationi

Nucleus speckle 2 PublicationsPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. intracellular membrane-bounded organelle Source: HPA
  3. nucleoplasm Source: ProtInc
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19781978Zinc finger protein 638PRO_0000082011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine5 Publications
Modified residuei383 – 3831Phosphoserine2 Publications
Modified residuei420 – 4201Phosphoserine1 Publication
Modified residuei552 – 5521Phosphoserine2 Publications
Modified residuei605 – 6051Phosphoserine1 Publication
Modified residuei614 – 6141Phosphoserine1 Publication
Modified residuei1100 – 11001Phosphoserine1 Publication
Modified residuei1401 – 14011Phosphoserine2 Publications
Modified residuei1667 – 16671Phosphoserine1 Publication
Modified residuei1882 – 18821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14966.
PaxDbiQ14966.
PRIDEiQ14966.

PTM databases

PhosphoSiteiQ14966.

Expressioni

Gene expression databases

BgeeiQ14966.
CleanExiHS_ZNF638.
ExpressionAtlasiQ14966. baseline and differential.
GenevestigatoriQ14966.

Organism-specific databases

HPAiHPA036784.

Interactioni

Subunit structurei

Interacts with FHL2. Interacts with CEBPA, CEBPD and CEBPG By similarity.By similarity

Protein-protein interaction databases

BioGridi118145. 36 interactions.
DIPiDIP-42386N.
IntActiQ14966. 21 interactions.
MINTiMINT-1439144.

Structurei

3D structure databases

ProteinModelPortaliQ14966.
SMRiQ14966. Positions 676-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini676 – 75176RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini905 – 97975RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi472 – 574103Arg-richAdd
BLAST
Compositional biasi1087 – 1355269Glu-richAdd
BLAST
Compositional biasi1580 – 15856Poly-Lys

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1928 – 195831Matrin-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG45231.
GeneTreeiENSGT00760000119324.
HOVERGENiHBG094186.
InParanoidiQ14966.
OMAiCNSMFPV.
PhylomeDBiQ14966.
TreeFamiTF333921.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q14966-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPRFNPRG DFPLQRPRAP NPSGMRPPGP FMRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFAGHES YQNMGPQRMN VQVTQHRTDP RLTKEKLDFH EAQQKKGKPH
110 120 130 140 150
GSRWDDEPHI SASVAVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMGRRLPNLP SQSRNKETLG
210 220 230 240 250
SEAVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVEN EFQSQQNISA
260 270 280 290 300
SVPNPNVICN SMFPVEDVFR QMDFPGESSN NRSFFSVESG TKMSGLHISG
310 320 330 340 350
GQSVLEPIKS VNQSINQTVS QTMSQSLIPP SMNQQPFSSE LISSVSQQER
360 370 380 390 400
IPHEPVINSS NVHVGSRGSK KNYQSQADIP IRSPFGIVKA SWLPKFSHAD
410 420 430 440 450
AQKMKRLPTP SMMNDYYAAS PRIFPHLCSL CNVECSHLKD WIQHQNTSTH
460 470 480 490 500
IESCRQLRQQ YPDWNPEILP SRRNEGNRKE NETPRRRSHS PSPRRSRRSS
510 520 530 540 550
SSHRFRRSRS PMHYMYRPRS RSPRICHRFI SRYRSRSRSR SPYRIRNPFR
560 570 580 590 600
GSPKCFRSVS PERMSRRSVR SSDRKKALED VVQRSGHGTE FNKQKHLEAA
610 620 630 640 650
DKGHSPAQKP KTSSGTKPSV KPTSATKSDS NLGGHSIRCK SKNLEDDTLS
660 670 680 690 700
ECKQVSDKAV SLQRKLRKEQ SLHYGSVLLI TELPEDGCTE EDVRKLFQPF
710 720 730 740 750
GKVNDVLIVP YRKEAYLEME FKEAITAIMK YIETTPLTIK GKSVKICVPG
760 770 780 790 800
KKKAQNKEVK KKTLESKKVS ASTLKRDADA SKAVEIVTST SAAKTGQAKA
810 820 830 840 850
SVAKVNKSTG KSASSVKSVV TVAVKGNKAS IKTAKSGGKK SLEAKKTGNV
860 870 880 890 900
KNKDSNKPVT IPENSEIKTS IEVKATENCA KEAISDAALE ATENEPLNKE
910 920 930 940 950
TEEMCVMLVS NLPNKGYSVE EVYDLAKPFG GLKDILILSS HKKAYIEINR
960 970 980 990 1000
KAAESMVKFY TCFPVLMDGN QLSISMAPEN MNIKDEEAIF ITLVKENDPE
1010 1020 1030 1040 1050
ANIDTIYDRF VHLDNLPEDG LQCVLCVGLQ FGKVDHHVFI SNRNKAILQL
1060 1070 1080 1090 1100
DSPESAQSMY SFLKQNPQNI GDHMLTCSLS PKIDLPEVQI EHDPELEKES
1110 1120 1130 1140 1150
PGLKNSPIDE SEVQTATDSP SVKPNELEEE STPSIQTETL VQQEEPCEEE
1160 1170 1180 1190 1200
AEKATCDSDF AVETLELETQ GEEVKEEIPL VASASVSIEQ FTENAEECAL
1210 1220 1230 1240 1250
NQQMFNSDLE KKGAEIINPK TALLPSDSVF AEERNLKGIL EESPSEAEDF
1260 1270 1280 1290 1300
ISGITQTMVE AVAEVEKNET VSEILPSTCI VTLVPGIPTG DEKTVDKKNI
1310 1320 1330 1340 1350
SEKKGNMDEK EEKEFNTKET RMDLQIGTEK AEKNEGRMDA EKVEKMAAMK
1360 1370 1380 1390 1400
EKPAENTLFK AYPNKGVGQA NKPDETSKTS ILAVSDVSSS KPSIKAVIVS
1410 1420 1430 1440 1450
SPKAKATVSK TENQKSFPKS VPRDQINAEK KLSAKEFGLL KPTSARSGLA
1460 1470 1480 1490 1500
ESSSKFKPTQ SSLTRGGSGR ISALQGKLSK LDYRDITKQS QETEARPSIM
1510 1520 1530 1540 1550
KRDDSNNKTL AEQNTKNPKS TTGRSSKSKE EPLFPFNLDE FVTVDEVIEE
1560 1570 1580 1590 1600
VNPSQAKQNP LKGKRKETLK NVPFSELNLK KKKGKTSTPR GVEGELSFVT
1610 1620 1630 1640 1650
LDEIGEEEDA AAHLAQALVT VDEVIDEEEL NMEEMVKNSN SLFTLDELID
1660 1670 1680 1690 1700
QDDCISHSEP KDVTVLSVAE EQDLLKQERL VTVDEIGEVE ELPLNESADI
1710 1720 1730 1740 1750
TFATLNTKGN EGDTVRDSIG FISSQVPEDP STLVTVDEIQ DDSSDLHLVT
1760 1770 1780 1790 1800
LDEVTEEDED SLADFNNLKE ELNFVTVDEV GEEEDGDNDL KVELAQSKND
1810 1820 1830 1840 1850
HPTDKKGNRK KRAVDTKKTK LESLSQVGPV NENVMEEDLK TMIERHLTAK
1860 1870 1880 1890 1900
TPTKRVRIGK TLPSEKAVVT EPAKGEEAFQ MSEVDEESGL KDSEPERKRK
1910 1920 1930 1940 1950
KTEDSSSGKS VASDVPEELD FLVPKAGFFC PICSLFYSGE KAMTNHCKST
1960 1970
RHKQNTEKFM AKQRKEKEQN EAEERSSR
Length:1,978
Mass (Da):220,625
Last modified:July 19, 2005 - v2
Checksum:iFC006A4BA4885455
GO
Isoform 2 (identifier: Q14966-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-814: AKTGQAKASVAKVNKSTGKSAS → GLLPTGGGNNYPQIVLAPGLCH
     815-1978: Missing.

Note: No experimental confirmation available.

Show »
Length:814
Mass (Da):92,052
Checksum:iD3DEC862617E65FF
GO
Isoform 3 (identifier: Q14966-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1918-1938: Missing.

Note: No experimental confirmation available.

Show »
Length:1,957
Mass (Da):218,246
Checksum:i7BFD62828B7911B8
GO
Isoform 4 (identifier: Q14966-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1139: SPGLKNSPID...ESTPSIQTET → RLWLSKTLRI...WMNLLLWMRL
     1140-1978: Missing.

Show »
Length:1,139
Mass (Da):128,489
Checksum:iBD7EAA34D634A34D
GO
Isoform 5 (identifier: Q14966-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-903: Missing.

Note: Broadly expressed.

Show »
Length:1,075
Mass (Da):119,295
Checksum:i8927B07C562F396B
GO

Sequence cautioni

The sequence AAH64530.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581H → L in BAA11748. (PubMed:8647861)Curated
Sequence conflicti209 – 2091I → V in AAM97681. 1 PublicationCurated
Sequence conflicti262 – 2621M → I in CAD97667. (PubMed:17974005)Curated
Sequence conflicti599 – 5991A → V in CAH18177. (PubMed:17974005)Curated
Sequence conflicti801 – 8011S → C in BAA11748. (PubMed:8647861)Curated
Sequence conflicti977 – 9771A → D in CAD97667. (PubMed:17974005)Curated
Sequence conflicti1205 – 12051F → L in CAD97667. (PubMed:17974005)Curated
Sequence conflicti1243 – 12431S → P in CAD97667. (PubMed:17974005)Curated
Sequence conflicti1336 – 13361G → S in CAH18177. (PubMed:17974005)Curated
Sequence conflicti1404 – 14041A → T in CAD97667. (PubMed:17974005)Curated
Sequence conflicti1714 – 17141T → I(PubMed:8647861)Curated
Sequence conflicti1714 – 17141T → I(PubMed:11149944)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101I → V.1 Publication
Corresponds to variant rs12612365 [ dbSNP | Ensembl ].
VAR_023069
Natural varianti980 – 9801N → S.1 Publication
Corresponds to variant rs3732235 [ dbSNP | Ensembl ].
VAR_023070
Natural varianti1462 – 14621S → N.
Corresponds to variant rs10427371 [ dbSNP | Ensembl ].
VAR_052238
Natural varianti1726 – 17261V → M.1 Publication
Corresponds to variant rs1804020 [ dbSNP | Ensembl ].
VAR_023071
Natural varianti1912 – 19121A → V.1 Publication
Corresponds to variant rs11542286 [ dbSNP | Ensembl ].
VAR_023072

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 903903Missing in isoform 5. 1 PublicationVSP_014801Add
BLAST
Alternative sequencei793 – 81422AKTGQ…GKSAS → GLLPTGGGNNYPQIVLAPGL CH in isoform 2. 1 PublicationVSP_014802Add
BLAST
Alternative sequencei815 – 19781164Missing in isoform 2. 1 PublicationVSP_014803Add
BLAST
Alternative sequencei1100 – 113940SPGLK…IQTET → RLWLSKTLRILKALLVEVPN LKRSHYFHLIWMNLLLWMRL in isoform 4. 1 PublicationVSP_014804Add
BLAST
Alternative sequencei1140 – 1978839Missing in isoform 4. 1 PublicationVSP_014805Add
BLAST
Alternative sequencei1918 – 193821Missing in isoform 3. 1 PublicationVSP_014806Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83032 mRNA. Translation: BAA11748.1.
AF273049 mRNA. Translation: AAG34909.1.
AF534078 mRNA. Translation: AAM97681.1.
BX537425 mRNA. Translation: CAD97667.1.
CR749322 mRNA. Translation: CAH18177.1.
AC007878 Genomic DNA. Translation: AAF66079.1.
AC096569 Genomic DNA. Translation: AAY14979.1.
AC104084 Genomic DNA. No translation available.
AC109343 Genomic DNA. No translation available.
BC024000 mRNA. Translation: AAH24000.1.
BC064530 mRNA. Translation: AAH64530.1. Sequence problems.
BC083513 mRNA. Translation: AAH83513.1.
BC143728 mRNA. Translation: AAI43729.1.
CCDSiCCDS1917.1. [Q14966-1]
PIRiJU0239.
JU0240.
RefSeqiNP_001014972.1. NM_001014972.2. [Q14966-1]
NP_001239541.1. NM_001252612.1. [Q14966-1]
NP_001239542.1. NM_001252613.1. [Q14966-3]
NP_055312.2. NM_014497.4. [Q14966-1]
UniGeneiHs.434401.
Hs.732823.

Genome annotation databases

EnsembliENST00000264447; ENSP00000264447; ENSG00000075292. [Q14966-1]
ENST00000409544; ENSP00000386433; ENSG00000075292. [Q14966-1]
GeneIDi27332.
KEGGihsa:27332.
UCSCiuc002shw.3. human. [Q14966-2]
uc002shx.3. human. [Q14966-1]
uc002shz.3. human. [Q14966-3]
uc002sib.1. human. [Q14966-4]

Polymorphism databases

DMDMi71153483.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83032 mRNA. Translation: BAA11748.1 .
AF273049 mRNA. Translation: AAG34909.1 .
AF534078 mRNA. Translation: AAM97681.1 .
BX537425 mRNA. Translation: CAD97667.1 .
CR749322 mRNA. Translation: CAH18177.1 .
AC007878 Genomic DNA. Translation: AAF66079.1 .
AC096569 Genomic DNA. Translation: AAY14979.1 .
AC104084 Genomic DNA. No translation available.
AC109343 Genomic DNA. No translation available.
BC024000 mRNA. Translation: AAH24000.1 .
BC064530 mRNA. Translation: AAH64530.1 . Sequence problems.
BC083513 mRNA. Translation: AAH83513.1 .
BC143728 mRNA. Translation: AAI43729.1 .
CCDSi CCDS1917.1. [Q14966-1 ]
PIRi JU0239.
JU0240.
RefSeqi NP_001014972.1. NM_001014972.2. [Q14966-1 ]
NP_001239541.1. NM_001252612.1. [Q14966-1 ]
NP_001239542.1. NM_001252613.1. [Q14966-3 ]
NP_055312.2. NM_014497.4. [Q14966-1 ]
UniGenei Hs.434401.
Hs.732823.

3D structure databases

ProteinModelPortali Q14966.
SMRi Q14966. Positions 676-748.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118145. 36 interactions.
DIPi DIP-42386N.
IntActi Q14966. 21 interactions.
MINTi MINT-1439144.

PTM databases

PhosphoSitei Q14966.

Polymorphism databases

DMDMi 71153483.

Proteomic databases

MaxQBi Q14966.
PaxDbi Q14966.
PRIDEi Q14966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264447 ; ENSP00000264447 ; ENSG00000075292 . [Q14966-1 ]
ENST00000409544 ; ENSP00000386433 ; ENSG00000075292 . [Q14966-1 ]
GeneIDi 27332.
KEGGi hsa:27332.
UCSCi uc002shw.3. human. [Q14966-2 ]
uc002shx.3. human. [Q14966-1 ]
uc002shz.3. human. [Q14966-3 ]
uc002sib.1. human. [Q14966-4 ]

Organism-specific databases

CTDi 27332.
GeneCardsi GC02P071412.
HGNCi HGNC:17894. ZNF638.
HPAi HPA036784.
MIMi 614349. gene.
neXtProti NX_Q14966.
PharmGKBi PA134983478.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45231.
GeneTreei ENSGT00760000119324.
HOVERGENi HBG094186.
InParanoidi Q14966.
OMAi CNSMFPV.
PhylomeDBi Q14966.
TreeFami TF333921.

Miscellaneous databases

ChiTaRSi ZNF638. human.
GeneWikii ZNF638.
GenomeRNAii 27332.
NextBioi 50376.
PROi Q14966.
SOURCEi Search...

Gene expression databases

Bgeei Q14966.
CleanExi HS_ZNF638.
ExpressionAtlasi Q14966. baseline and differential.
Genevestigatori Q14966.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain."
    Inagaki H., Matsushima Y., Nakamura K., Ohshima M., Kadowaki T., Kitagawa Y.
    J. Biol. Chem. 271:12525-12531(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DNA-BINDING, SUBCELLULAR LOCATION, FUNCTION.
    Tissue: Epithelium.
  2. "Serological detection of cutaneous T-cell lymphoma-associated antigens."
    Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.
    Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), IDENTIFICATION AS TUMOR-ASSOCIATED ANTIGEN, VARIANTS SER-980 AND VAL-1912.
    Tissue: Testis.
  3. "Identification of a variant splice form of human nuclear protein NP220 mRNA encoding an isoform with truncated carboxyl-terminal."
    Chan C.W., Tsui S.K.W., Fung K.P., Lee C.Y., Waye M.M.Y.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-110 AND MET-1726.
    Tissue: Cervix and Testis.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Cerebellum, Skin and Testis.
  7. "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220."
    Ng E.K.O., Chan K.K., Wong C.H., Tsui S.K.W., Ngai S.M., Lee S.M.Y., Kotaka M., Lee C.Y., Waye M.M.Y., Fung K.P.
    J. Cell. Biochem. 84:556-566(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH FHL2.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-605, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-383; SER-420; SER-614; SER-1401 AND SER-1882, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128 AND SER-1100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-383; SER-552 AND SER-1667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1401, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN638_HUMAN
AccessioniPrimary (citable) accession number: Q14966
Secondary accession number(s): B5MDV1
, B7ZLD1, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3