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Q14966

- ZN638_HUMAN

UniProt

Q14966 - ZN638_HUMAN

Protein

Zinc finger protein 638

Gene

ZNF638

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 By similarity. Binds to cytidine clusters in double-stranded DNA.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi1353 – 1477125Add
    BLAST
    Zinc fingeri1928 – 195831Matrin-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. double-stranded DNA binding Source: ProtInc
    2. nucleotide binding Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB
    4. RNA binding Source: ProtInc
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. RNA splicing Source: ProtInc
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 638
    Alternative name(s):
    Cutaneous T-cell lymphoma-associated antigen se33-1
    Short name:
    CTCL-associated antigen se33-1
    Nuclear protein 220
    Zinc finger matrin-like protein
    Gene namesi
    Name:ZNF638
    Synonyms:NP220, ZFML
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17894. ZNF638.

    Subcellular locationi

    Nucleus speckle 2 PublicationsPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. intracellular membrane-bounded organelle Source: HPA
    3. nuclear speck Source: UniProtKB-SubCell
    4. nucleoplasm Source: ProtInc
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134983478.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19781978Zinc finger protein 638PRO_0000082011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281Phosphoserine5 Publications
    Modified residuei383 – 3831Phosphoserine2 Publications
    Modified residuei420 – 4201Phosphoserine1 Publication
    Modified residuei552 – 5521Phosphoserine2 Publications
    Modified residuei605 – 6051Phosphoserine1 Publication
    Modified residuei614 – 6141Phosphoserine1 Publication
    Modified residuei1100 – 11001Phosphoserine1 Publication
    Modified residuei1401 – 14011Phosphoserine2 Publications
    Modified residuei1667 – 16671Phosphoserine1 Publication
    Modified residuei1882 – 18821Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14966.
    PaxDbiQ14966.
    PRIDEiQ14966.

    PTM databases

    PhosphoSiteiQ14966.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14966.
    BgeeiQ14966.
    CleanExiHS_ZNF638.
    GenevestigatoriQ14966.

    Organism-specific databases

    HPAiHPA036784.

    Interactioni

    Subunit structurei

    Interacts with FHL2. Interacts with CEBPA, CEBPD and CEBPG By similarity.By similarity

    Protein-protein interaction databases

    BioGridi118145. 35 interactions.
    DIPiDIP-42386N.
    IntActiQ14966. 21 interactions.
    MINTiMINT-1439144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14966.
    SMRiQ14966. Positions 674-749.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini676 – 75176RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini905 – 97975RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi472 – 574103Arg-richAdd
    BLAST
    Compositional biasi1087 – 1355269Glu-richAdd
    BLAST
    Compositional biasi1580 – 15856Poly-Lys

    Sequence similaritiesi

    Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1928 – 195831Matrin-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG45231.
    HOVERGENiHBG094186.
    InParanoidiQ14966.
    OMAiCNSMFPV.
    PhylomeDBiQ14966.
    TreeFamiTF333921.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR000690. Znf_C2H2_matrin.
    IPR003604. Znf_U1.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    SM00355. ZnF_C2H2. 2 hits.
    SM00451. ZnF_U1. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    PS50171. ZF_MATRIN. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q14966-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRPRFNPRG DFPLQRPRAP NPSGMRPPGP FMRPGSMGLP RFYPAGRARG     50
    IPHRFAGHES YQNMGPQRMN VQVTQHRTDP RLTKEKLDFH EAQQKKGKPH 100
    GSRWDDEPHI SASVAVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS 150
    NEDLEELSRY PDEQLTPENM PLILRDIRMR KMGRRLPNLP SQSRNKETLG 200
    SEAVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVEN EFQSQQNISA 250
    SVPNPNVICN SMFPVEDVFR QMDFPGESSN NRSFFSVESG TKMSGLHISG 300
    GQSVLEPIKS VNQSINQTVS QTMSQSLIPP SMNQQPFSSE LISSVSQQER 350
    IPHEPVINSS NVHVGSRGSK KNYQSQADIP IRSPFGIVKA SWLPKFSHAD 400
    AQKMKRLPTP SMMNDYYAAS PRIFPHLCSL CNVECSHLKD WIQHQNTSTH 450
    IESCRQLRQQ YPDWNPEILP SRRNEGNRKE NETPRRRSHS PSPRRSRRSS 500
    SSHRFRRSRS PMHYMYRPRS RSPRICHRFI SRYRSRSRSR SPYRIRNPFR 550
    GSPKCFRSVS PERMSRRSVR SSDRKKALED VVQRSGHGTE FNKQKHLEAA 600
    DKGHSPAQKP KTSSGTKPSV KPTSATKSDS NLGGHSIRCK SKNLEDDTLS 650
    ECKQVSDKAV SLQRKLRKEQ SLHYGSVLLI TELPEDGCTE EDVRKLFQPF 700
    GKVNDVLIVP YRKEAYLEME FKEAITAIMK YIETTPLTIK GKSVKICVPG 750
    KKKAQNKEVK KKTLESKKVS ASTLKRDADA SKAVEIVTST SAAKTGQAKA 800
    SVAKVNKSTG KSASSVKSVV TVAVKGNKAS IKTAKSGGKK SLEAKKTGNV 850
    KNKDSNKPVT IPENSEIKTS IEVKATENCA KEAISDAALE ATENEPLNKE 900
    TEEMCVMLVS NLPNKGYSVE EVYDLAKPFG GLKDILILSS HKKAYIEINR 950
    KAAESMVKFY TCFPVLMDGN QLSISMAPEN MNIKDEEAIF ITLVKENDPE 1000
    ANIDTIYDRF VHLDNLPEDG LQCVLCVGLQ FGKVDHHVFI SNRNKAILQL 1050
    DSPESAQSMY SFLKQNPQNI GDHMLTCSLS PKIDLPEVQI EHDPELEKES 1100
    PGLKNSPIDE SEVQTATDSP SVKPNELEEE STPSIQTETL VQQEEPCEEE 1150
    AEKATCDSDF AVETLELETQ GEEVKEEIPL VASASVSIEQ FTENAEECAL 1200
    NQQMFNSDLE KKGAEIINPK TALLPSDSVF AEERNLKGIL EESPSEAEDF 1250
    ISGITQTMVE AVAEVEKNET VSEILPSTCI VTLVPGIPTG DEKTVDKKNI 1300
    SEKKGNMDEK EEKEFNTKET RMDLQIGTEK AEKNEGRMDA EKVEKMAAMK 1350
    EKPAENTLFK AYPNKGVGQA NKPDETSKTS ILAVSDVSSS KPSIKAVIVS 1400
    SPKAKATVSK TENQKSFPKS VPRDQINAEK KLSAKEFGLL KPTSARSGLA 1450
    ESSSKFKPTQ SSLTRGGSGR ISALQGKLSK LDYRDITKQS QETEARPSIM 1500
    KRDDSNNKTL AEQNTKNPKS TTGRSSKSKE EPLFPFNLDE FVTVDEVIEE 1550
    VNPSQAKQNP LKGKRKETLK NVPFSELNLK KKKGKTSTPR GVEGELSFVT 1600
    LDEIGEEEDA AAHLAQALVT VDEVIDEEEL NMEEMVKNSN SLFTLDELID 1650
    QDDCISHSEP KDVTVLSVAE EQDLLKQERL VTVDEIGEVE ELPLNESADI 1700
    TFATLNTKGN EGDTVRDSIG FISSQVPEDP STLVTVDEIQ DDSSDLHLVT 1750
    LDEVTEEDED SLADFNNLKE ELNFVTVDEV GEEEDGDNDL KVELAQSKND 1800
    HPTDKKGNRK KRAVDTKKTK LESLSQVGPV NENVMEEDLK TMIERHLTAK 1850
    TPTKRVRIGK TLPSEKAVVT EPAKGEEAFQ MSEVDEESGL KDSEPERKRK 1900
    KTEDSSSGKS VASDVPEELD FLVPKAGFFC PICSLFYSGE KAMTNHCKST 1950
    RHKQNTEKFM AKQRKEKEQN EAEERSSR 1978
    Length:1,978
    Mass (Da):220,625
    Last modified:July 19, 2005 - v2
    Checksum:iFC006A4BA4885455
    GO
    Isoform 2 (identifier: Q14966-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         793-814: AKTGQAKASVAKVNKSTGKSAS → GLLPTGGGNNYPQIVLAPGLCH
         815-1978: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:814
    Mass (Da):92,052
    Checksum:iD3DEC862617E65FF
    GO
    Isoform 3 (identifier: Q14966-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1918-1938: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,957
    Mass (Da):218,246
    Checksum:i7BFD62828B7911B8
    GO
    Isoform 4 (identifier: Q14966-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1100-1139: SPGLKNSPID...ESTPSIQTET → RLWLSKTLRI...WMNLLLWMRL
         1140-1978: Missing.

    Show »
    Length:1,139
    Mass (Da):128,489
    Checksum:iBD7EAA34D634A34D
    GO
    Isoform 5 (identifier: Q14966-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-903: Missing.

    Note: Broadly expressed.

    Show »
    Length:1,075
    Mass (Da):119,295
    Checksum:i8927B07C562F396B
    GO

    Sequence cautioni

    The sequence AAH64530.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581H → L in BAA11748. (PubMed:8647861)Curated
    Sequence conflicti209 – 2091I → V in AAM97681. 1 PublicationCurated
    Sequence conflicti262 – 2621M → I in CAD97667. (PubMed:17974005)Curated
    Sequence conflicti599 – 5991A → V in CAH18177. (PubMed:17974005)Curated
    Sequence conflicti801 – 8011S → C in BAA11748. (PubMed:8647861)Curated
    Sequence conflicti977 – 9771A → D in CAD97667. (PubMed:17974005)Curated
    Sequence conflicti1205 – 12051F → L in CAD97667. (PubMed:17974005)Curated
    Sequence conflicti1243 – 12431S → P in CAD97667. (PubMed:17974005)Curated
    Sequence conflicti1336 – 13361G → S in CAH18177. (PubMed:17974005)Curated
    Sequence conflicti1404 – 14041A → T in CAD97667. (PubMed:17974005)Curated
    Sequence conflicti1714 – 17141T → I(PubMed:8647861)Curated
    Sequence conflicti1714 – 17141T → I(PubMed:11149944)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101I → V.1 Publication
    Corresponds to variant rs12612365 [ dbSNP | Ensembl ].
    VAR_023069
    Natural varianti980 – 9801N → S.1 Publication
    Corresponds to variant rs3732235 [ dbSNP | Ensembl ].
    VAR_023070
    Natural varianti1462 – 14621S → N.
    Corresponds to variant rs10427371 [ dbSNP | Ensembl ].
    VAR_052238
    Natural varianti1726 – 17261V → M.1 Publication
    Corresponds to variant rs1804020 [ dbSNP | Ensembl ].
    VAR_023071
    Natural varianti1912 – 19121A → V.1 Publication
    Corresponds to variant rs11542286 [ dbSNP | Ensembl ].
    VAR_023072

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 903903Missing in isoform 5. 1 PublicationVSP_014801Add
    BLAST
    Alternative sequencei793 – 81422AKTGQ…GKSAS → GLLPTGGGNNYPQIVLAPGL CH in isoform 2. 1 PublicationVSP_014802Add
    BLAST
    Alternative sequencei815 – 19781164Missing in isoform 2. 1 PublicationVSP_014803Add
    BLAST
    Alternative sequencei1100 – 113940SPGLK…IQTET → RLWLSKTLRILKALLVEVPN LKRSHYFHLIWMNLLLWMRL in isoform 4. 1 PublicationVSP_014804Add
    BLAST
    Alternative sequencei1140 – 1978839Missing in isoform 4. 1 PublicationVSP_014805Add
    BLAST
    Alternative sequencei1918 – 193821Missing in isoform 3. 1 PublicationVSP_014806Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83032 mRNA. Translation: BAA11748.1.
    AF273049 mRNA. Translation: AAG34909.1.
    AF534078 mRNA. Translation: AAM97681.1.
    BX537425 mRNA. Translation: CAD97667.1.
    CR749322 mRNA. Translation: CAH18177.1.
    AC007878 Genomic DNA. Translation: AAF66079.1.
    AC096569 Genomic DNA. Translation: AAY14979.1.
    AC104084 Genomic DNA. No translation available.
    AC109343 Genomic DNA. No translation available.
    BC024000 mRNA. Translation: AAH24000.1.
    BC064530 mRNA. Translation: AAH64530.1. Sequence problems.
    BC083513 mRNA. Translation: AAH83513.1.
    BC143728 mRNA. Translation: AAI43729.1.
    CCDSiCCDS1917.1. [Q14966-1]
    PIRiJU0239.
    JU0240.
    RefSeqiNP_001014972.1. NM_001014972.2. [Q14966-1]
    NP_001239541.1. NM_001252612.1. [Q14966-1]
    NP_001239542.1. NM_001252613.1. [Q14966-3]
    NP_055312.2. NM_014497.4. [Q14966-1]
    UniGeneiHs.434401.
    Hs.732823.

    Genome annotation databases

    EnsembliENST00000264447; ENSP00000264447; ENSG00000075292. [Q14966-1]
    ENST00000409544; ENSP00000386433; ENSG00000075292. [Q14966-1]
    GeneIDi27332.
    KEGGihsa:27332.
    UCSCiuc002shw.3. human. [Q14966-2]
    uc002shx.3. human. [Q14966-1]
    uc002shz.3. human. [Q14966-3]
    uc002sib.1. human. [Q14966-4]

    Polymorphism databases

    DMDMi71153483.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83032 mRNA. Translation: BAA11748.1 .
    AF273049 mRNA. Translation: AAG34909.1 .
    AF534078 mRNA. Translation: AAM97681.1 .
    BX537425 mRNA. Translation: CAD97667.1 .
    CR749322 mRNA. Translation: CAH18177.1 .
    AC007878 Genomic DNA. Translation: AAF66079.1 .
    AC096569 Genomic DNA. Translation: AAY14979.1 .
    AC104084 Genomic DNA. No translation available.
    AC109343 Genomic DNA. No translation available.
    BC024000 mRNA. Translation: AAH24000.1 .
    BC064530 mRNA. Translation: AAH64530.1 . Sequence problems.
    BC083513 mRNA. Translation: AAH83513.1 .
    BC143728 mRNA. Translation: AAI43729.1 .
    CCDSi CCDS1917.1. [Q14966-1 ]
    PIRi JU0239.
    JU0240.
    RefSeqi NP_001014972.1. NM_001014972.2. [Q14966-1 ]
    NP_001239541.1. NM_001252612.1. [Q14966-1 ]
    NP_001239542.1. NM_001252613.1. [Q14966-3 ]
    NP_055312.2. NM_014497.4. [Q14966-1 ]
    UniGenei Hs.434401.
    Hs.732823.

    3D structure databases

    ProteinModelPortali Q14966.
    SMRi Q14966. Positions 674-749.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118145. 35 interactions.
    DIPi DIP-42386N.
    IntActi Q14966. 21 interactions.
    MINTi MINT-1439144.

    PTM databases

    PhosphoSitei Q14966.

    Polymorphism databases

    DMDMi 71153483.

    Proteomic databases

    MaxQBi Q14966.
    PaxDbi Q14966.
    PRIDEi Q14966.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264447 ; ENSP00000264447 ; ENSG00000075292 . [Q14966-1 ]
    ENST00000409544 ; ENSP00000386433 ; ENSG00000075292 . [Q14966-1 ]
    GeneIDi 27332.
    KEGGi hsa:27332.
    UCSCi uc002shw.3. human. [Q14966-2 ]
    uc002shx.3. human. [Q14966-1 ]
    uc002shz.3. human. [Q14966-3 ]
    uc002sib.1. human. [Q14966-4 ]

    Organism-specific databases

    CTDi 27332.
    GeneCardsi GC02P071412.
    HGNCi HGNC:17894. ZNF638.
    HPAi HPA036784.
    MIMi 614349. gene.
    neXtProti NX_Q14966.
    PharmGKBi PA134983478.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45231.
    HOVERGENi HBG094186.
    InParanoidi Q14966.
    OMAi CNSMFPV.
    PhylomeDBi Q14966.
    TreeFami TF333921.

    Miscellaneous databases

    ChiTaRSi ZNF638. human.
    GeneWikii ZNF638.
    GenomeRNAii 27332.
    NextBioi 50376.
    PROi Q14966.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14966.
    Bgeei Q14966.
    CleanExi HS_ZNF638.
    Genevestigatori Q14966.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR000690. Znf_C2H2_matrin.
    IPR003604. Znf_U1.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    SM00355. ZnF_C2H2. 2 hits.
    SM00451. ZnF_U1. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    PS50171. ZF_MATRIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain."
      Inagaki H., Matsushima Y., Nakamura K., Ohshima M., Kadowaki T., Kitagawa Y.
      J. Biol. Chem. 271:12525-12531(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DNA-BINDING, SUBCELLULAR LOCATION, FUNCTION.
      Tissue: Epithelium.
    2. "Serological detection of cutaneous T-cell lymphoma-associated antigens."
      Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.
      Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), IDENTIFICATION AS TUMOR-ASSOCIATED ANTIGEN, VARIANTS SER-980 AND VAL-1912.
      Tissue: Testis.
    3. "Identification of a variant splice form of human nuclear protein NP220 mRNA encoding an isoform with truncated carboxyl-terminal."
      Chan C.W., Tsui S.K.W., Fung K.P., Lee C.Y., Waye M.M.Y.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-110 AND MET-1726.
      Tissue: Cervix and Testis.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Cerebellum, Skin and Testis.
    7. "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220."
      Ng E.K.O., Chan K.K., Wong C.H., Tsui S.K.W., Ngai S.M., Lee S.M.Y., Kotaka M., Lee C.Y., Waye M.M.Y., Fung K.P.
      J. Cell. Biochem. 84:556-566(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH FHL2.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-605, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-383; SER-420; SER-614; SER-1401 AND SER-1882, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128 AND SER-1100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-383; SER-552 AND SER-1667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1401, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN638_HUMAN
    AccessioniPrimary (citable) accession number: Q14966
    Secondary accession number(s): B5MDV1
    , B7ZLD1, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3