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Q14964

- RB39A_HUMAN

UniProt

Q14964 - RB39A_HUMAN

Protein

Ras-related protein Rab-39A

Gene

RAB39A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi127 – 1304GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB

    GO - Biological processi

    1. phagosome acidification Source: UniProtKB
    2. phagosome-lysosome fusion Source: UniProtKB
    3. protein transport Source: UniProtKB-KW
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-39A
    Short name:
    Rab-39
    Gene namesi
    Name:RAB39A
    Synonyms:RAB39
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16521. RAB39A.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmic vesiclephagosome 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.

    GO - Cellular componenti

    1. phagocytic vesicle Source: UniProtKB
    2. phagocytic vesicle membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34130.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Ras-related protein Rab-39APRO_0000121253Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
    Modified residuei217 – 2171Cysteine methyl esterBy similarity
    Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ14964.
    PaxDbiQ14964.
    PRIDEiQ14964.

    PTM databases

    PhosphoSiteiQ14964.

    Expressioni

    Gene expression databases

    BgeeiQ14964.
    CleanExiHS_RAB39.
    GenevestigatoriQ14964.

    Organism-specific databases

    HPAiHPA042505.
    HPA042715.

    Interactioni

    Protein-protein interaction databases

    BioGridi120117. 4 interactions.
    DIPiDIP-60521N.
    IntActiQ14964. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14964.
    SMRiQ14964. Positions 5-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ14964.
    KOiK07924.
    OMAiYKVEDGW.
    OrthoDBiEOG7JHM6Q.
    PhylomeDBiQ14964.
    TreeFamiTF300032.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14964-1 [UniParc]FASTAAdd to Basket

    « Hide

    METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLRSPA CDPTVGVDFF    50
    SRLLEIEPGK RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS 100
    FEHVKDWLEE AKMYVQPFRI VFLLVGHKCD LASQRQVTRE EAEKLSADCG 150
    MKYIETSAKD ATNVEESFTI LTRDIYELIK KGEICIQDGW EGVKSGFVPN 200
    TVHSSEEAVK PRKECFC 217
    Length:217
    Mass (Da):25,007
    Last modified:April 26, 2004 - v2
    Checksum:iABD121649354D7F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521K → M in CAA68227. (PubMed:9119394)Curated
    Sequence conflicti168 – 1681F → S in CAA68227. (PubMed:9119394)Curated
    Sequence conflicti176 – 1772YE → FD in CAA68227. (PubMed:9119394)Curated
    Sequence conflicti204 – 2041S → P in CAA68227. (PubMed:9119394)Curated
    Sequence conflicti216 – 2161F → S in CAA68227. (PubMed:9119394)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99962 mRNA. Translation: CAA68227.1.
    AK292969 mRNA. Translation: BAF85658.1.
    CH471065 Genomic DNA. Translation: EAW67100.1.
    BC028064 mRNA. Translation: AAH28064.1.
    CCDSiCCDS8338.1.
    RefSeqiNP_059986.1. NM_017516.1.
    UniGeneiHs.354906.

    Genome annotation databases

    EnsembliENST00000320578; ENSP00000322594; ENSG00000179331.
    GeneIDi54734.
    KEGGihsa:54734.
    UCSCiuc001pjt.3. human.

    Polymorphism databases

    DMDMi46577701.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99962 mRNA. Translation: CAA68227.1 .
    AK292969 mRNA. Translation: BAF85658.1 .
    CH471065 Genomic DNA. Translation: EAW67100.1 .
    BC028064 mRNA. Translation: AAH28064.1 .
    CCDSi CCDS8338.1.
    RefSeqi NP_059986.1. NM_017516.1.
    UniGenei Hs.354906.

    3D structure databases

    ProteinModelPortali Q14964.
    SMRi Q14964. Positions 5-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120117. 4 interactions.
    DIPi DIP-60521N.
    IntActi Q14964. 1 interaction.

    PTM databases

    PhosphoSitei Q14964.

    Polymorphism databases

    DMDMi 46577701.

    Proteomic databases

    MaxQBi Q14964.
    PaxDbi Q14964.
    PRIDEi Q14964.

    Protocols and materials databases

    DNASUi 54734.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320578 ; ENSP00000322594 ; ENSG00000179331 .
    GeneIDi 54734.
    KEGGi hsa:54734.
    UCSCi uc001pjt.3. human.

    Organism-specific databases

    CTDi 54734.
    GeneCardsi GC11P107799.
    HGNCi HGNC:16521. RAB39A.
    HPAi HPA042505.
    HPA042715.
    neXtProti NX_Q14964.
    PharmGKBi PA34130.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q14964.
    KOi K07924.
    OMAi YKVEDGW.
    OrthoDBi EOG7JHM6Q.
    PhylomeDBi Q14964.
    TreeFami TF300032.

    Miscellaneous databases

    GenomeRNAii 54734.
    NextBioi 57320.
    PROi Q14964.

    Gene expression databases

    Bgeei Q14964.
    CleanExi HS_RAB39.
    Genevestigatori Q14964.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes."
      Stankovic T., Byrd P.J., Cooper P.R., McConville C.M., Munroe D.J., Riley J.H., Watts G.D.J., Ambrose H., McGuire G., Smith A.D., Sutcliffe A., Mills T., Taylor A.M.R.
      Genomics 40:267-276(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
      Seto S., Tsujimura K., Koide Y.
      Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRB39A_HUMAN
    AccessioniPrimary (citable) accession number: Q14964
    Secondary accession number(s): A8KAA4, Q8N6W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3