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Protein

Ras-related protein Rab-39A

Gene

RAB39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • phagosome acidification Source: UniProtKB
  • phagosome-lysosome fusion Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-39A
Short name:
Rab-39
Gene namesi
Name:RAB39A
Synonyms:RAB39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000179331.2
HGNCiHGNC:16521 RAB39A
neXtProtiNX_Q14964

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34 – 41PGLRSPAC → AQVS: Disrupts interaction with BECN1. 1 Publication8

Organism-specific databases

DisGeNETi54734
OpenTargetsiENSG00000179331
PharmGKBiPA34130

Polymorphism and mutation databases

BioMutaiRAB39A
DMDMi46577701

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212531 – 217Ras-related protein Rab-39AAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi215S-geranylgeranyl cysteineBy similarity1
Modified residuei217Cysteine methyl esterBy similarity1
Lipidationi217S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ14964
MaxQBiQ14964
PaxDbiQ14964
PeptideAtlasiQ14964
PRIDEiQ14964

PTM databases

iPTMnetiQ14964
PhosphoSitePlusiQ14964

Expressioni

Gene expression databases

BgeeiENSG00000179331
CleanExiHS_RAB39
GenevisibleiQ14964 HS

Organism-specific databases

HPAiHPA042505

Interactioni

Subunit structurei

Interacts with BECN1. Probably associates with the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (PubMed:24349490). Interacts with UACA (By similarity).By similarityCurated1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120117, 8 interactors
DIPiDIP-60521N
IntActiQ14964, 12 interactors
STRINGi9606.ENSP00000322594

Structurei

3D structure databases

ProteinModelPortaliQ14964
SMRiQ14964
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0091 Eukaryota
ENOG410ZQFG LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ14964
KOiK07924
OMAiKIQDGWE
OrthoDBiEOG091G0RUB
PhylomeDBiQ14964
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q14964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLRSPA CDPTVGVDFF
60 70 80 90 100
SRLLEIEPGK RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS
110 120 130 140 150
FEHVKDWLEE AKMYVQPFRI VFLLVGHKCD LASQRQVTRE EAEKLSADCG
160 170 180 190 200
MKYIETSAKD ATNVEESFTI LTRDIYELIK KGEICIQDGW EGVKSGFVPN
210
TVHSSEEAVK PRKECFC
Length:217
Mass (Da):25,007
Last modified:April 26, 2004 - v2
Checksum:iABD121649354D7F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152K → M in CAA68227 (PubMed:9119394).Curated1
Sequence conflicti168F → S in CAA68227 (PubMed:9119394).Curated1
Sequence conflicti176 – 177YE → FD in CAA68227 (PubMed:9119394).Curated2
Sequence conflicti204S → P in CAA68227 (PubMed:9119394).Curated1
Sequence conflicti216F → S in CAA68227 (PubMed:9119394).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99962 mRNA Translation: CAA68227.1
AK292969 mRNA Translation: BAF85658.1
CH471065 Genomic DNA Translation: EAW67100.1
BC028064 mRNA Translation: AAH28064.1
CCDSiCCDS8338.1
RefSeqiNP_059986.1, NM_017516.2
UniGeneiHs.354906

Genome annotation databases

EnsembliENST00000320578; ENSP00000322594; ENSG00000179331
GeneIDi54734
KEGGihsa:54734
UCSCiuc001pjt.4 human

Similar proteinsi

Entry informationi

Entry nameiRB39A_HUMAN
AccessioniPrimary (citable) accession number: Q14964
Secondary accession number(s): A8KAA4, Q8N6W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 26, 2004
Last modified: May 23, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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