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Q14964

- RB39A_HUMAN

UniProt

Q14964 - RB39A_HUMAN

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Protein

Ras-related protein Rab-39A

Gene

RAB39A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi127 – 1304GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB

GO - Biological processi

  1. phagosome acidification Source: UniProtKB
  2. phagosome-lysosome fusion Source: UniProtKB
  3. protein transport Source: UniProtKB-KW
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-39A
Short name:
Rab-39
Gene namesi
Name:RAB39A
Synonyms:RAB39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16521. RAB39A.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasmic vesiclephagosome 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.

GO - Cellular componenti

  1. phagocytic vesicle Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Ras-related protein Rab-39APRO_0000121253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
Modified residuei217 – 2171Cysteine methyl esterBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ14964.
PaxDbiQ14964.
PRIDEiQ14964.

PTM databases

PhosphoSiteiQ14964.

Expressioni

Gene expression databases

BgeeiQ14964.
CleanExiHS_RAB39.
GenevestigatoriQ14964.

Organism-specific databases

HPAiHPA042505.
HPA042715.

Interactioni

Protein-protein interaction databases

BioGridi120117. 5 interactions.
DIPiDIP-60521N.
IntActiQ14964. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14964.
SMRiQ14964. Positions 5-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ14964.
KOiK07924.
OMAiYKVEDGW.
OrthoDBiEOG7JHM6Q.
PhylomeDBiQ14964.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14964-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLRSPA CDPTVGVDFF
60 70 80 90 100
SRLLEIEPGK RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS
110 120 130 140 150
FEHVKDWLEE AKMYVQPFRI VFLLVGHKCD LASQRQVTRE EAEKLSADCG
160 170 180 190 200
MKYIETSAKD ATNVEESFTI LTRDIYELIK KGEICIQDGW EGVKSGFVPN
210
TVHSSEEAVK PRKECFC
Length:217
Mass (Da):25,007
Last modified:April 26, 2004 - v2
Checksum:iABD121649354D7F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521K → M in CAA68227. (PubMed:9119394)Curated
Sequence conflicti168 – 1681F → S in CAA68227. (PubMed:9119394)Curated
Sequence conflicti176 – 1772YE → FD in CAA68227. (PubMed:9119394)Curated
Sequence conflicti204 – 2041S → P in CAA68227. (PubMed:9119394)Curated
Sequence conflicti216 – 2161F → S in CAA68227. (PubMed:9119394)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99962 mRNA. Translation: CAA68227.1.
AK292969 mRNA. Translation: BAF85658.1.
CH471065 Genomic DNA. Translation: EAW67100.1.
BC028064 mRNA. Translation: AAH28064.1.
CCDSiCCDS8338.1.
RefSeqiNP_059986.1. NM_017516.1.
UniGeneiHs.354906.

Genome annotation databases

EnsembliENST00000320578; ENSP00000322594; ENSG00000179331.
GeneIDi54734.
KEGGihsa:54734.
UCSCiuc001pjt.3. human.

Polymorphism databases

DMDMi46577701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99962 mRNA. Translation: CAA68227.1 .
AK292969 mRNA. Translation: BAF85658.1 .
CH471065 Genomic DNA. Translation: EAW67100.1 .
BC028064 mRNA. Translation: AAH28064.1 .
CCDSi CCDS8338.1.
RefSeqi NP_059986.1. NM_017516.1.
UniGenei Hs.354906.

3D structure databases

ProteinModelPortali Q14964.
SMRi Q14964. Positions 5-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120117. 5 interactions.
DIPi DIP-60521N.
IntActi Q14964. 1 interaction.

PTM databases

PhosphoSitei Q14964.

Polymorphism databases

DMDMi 46577701.

Proteomic databases

MaxQBi Q14964.
PaxDbi Q14964.
PRIDEi Q14964.

Protocols and materials databases

DNASUi 54734.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320578 ; ENSP00000322594 ; ENSG00000179331 .
GeneIDi 54734.
KEGGi hsa:54734.
UCSCi uc001pjt.3. human.

Organism-specific databases

CTDi 54734.
GeneCardsi GC11P107799.
HGNCi HGNC:16521. RAB39A.
HPAi HPA042505.
HPA042715.
neXtProti NX_Q14964.
PharmGKBi PA34130.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118841.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q14964.
KOi K07924.
OMAi YKVEDGW.
OrthoDBi EOG7JHM6Q.
PhylomeDBi Q14964.
TreeFami TF300032.

Miscellaneous databases

GenomeRNAii 54734.
NextBioi 57320.
PROi Q14964.

Gene expression databases

Bgeei Q14964.
CleanExi HS_RAB39.
Genevestigatori Q14964.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes."
    Stankovic T., Byrd P.J., Cooper P.R., McConville C.M., Munroe D.J., Riley J.H., Watts G.D.J., Ambrose H., McGuire G., Smith A.D., Sutcliffe A., Mills T., Taylor A.M.R.
    Genomics 40:267-276(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
    Seto S., Tsujimura K., Koide Y.
    Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRB39A_HUMAN
AccessioniPrimary (citable) accession number: Q14964
Secondary accession number(s): A8KAA4, Q8N6W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 26, 2004
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3