Q14964 (RB39A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-39A
Short name=Rab-39

Gene names

Name:	RAB39A
Synonyms:	RAB39

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Ref.5
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cytoplasmic vesicle › phagosome. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or M.tuberculosis. Ref.5
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phagosome acidification Inferred from mutant phenotype Ref.5. Source: UniProtKB phagosome-lysosome fusion Inferred from mutant phenotype Ref.5. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	phagocytic vesicle Inferred from direct assay Ref.5. Source: UniProtKB phagocytic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Ras-related protein Rab-39A		PRO_0000121253
Regions
	Nucleotide binding	15 – 22	8	GTP By similarity
	Nucleotide binding	68 – 72	5	GTP By similarity
	Nucleotide binding	127 – 130	4	GTP By similarity
	Motif	41 – 49	9	Effector region By similarity
Amino acid modifications
	Modified residue	217	1	Cysteine methyl ester By similarity
	Lipidation	215	1	S-geranylgeranyl cysteine By similarity
	Lipidation	217	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	152	1	K → M in CAA68227. Ref.1
	Sequence conflict	168	1	F → S in CAA68227. Ref.1
	Sequence conflict	176 – 177	2	YE → FD in CAA68227. Ref.1
	Sequence conflict	204	1	S → P in CAA68227. Ref.1
	Sequence conflict	216	1	F → S in CAA68227. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q14964 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: ABD121649354D7F5	FASTA	217	25,007
	10 20 30 40 50 60 METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLRSPA CDPTVGVDFF SRLLEIEPGK 70 80 90 100 110 120 RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS FEHVKDWLEE AKMYVQPFRI 130 140 150 160 170 180 VFLLVGHKCD LASQRQVTRE EAEKLSADCG MKYIETSAKD ATNVEESFTI LTRDIYELIK 190 200 210 KGEICIQDGW EGVKSGFVPN TVHSSEEAVK PRKECFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes." Stankovic T., Byrd P.J., Cooper P.R., McConville C.M., Munroe D.J., Riley J.H., Watts G.D.J., Ambrose H., McGuire G., Smith A.D., Sutcliffe A., Mills T., Taylor A.M.R. Genomics 40:267-276(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes." Seto S., Tsujimura K., Koide Y. Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99962 mRNA. Translation: CAA68227.1. AK292969 mRNA. Translation: BAF85658.1. CH471065 Genomic DNA. Translation: EAW67100.1. BC028064 mRNA. Translation: AAH28064.1.
IPI	IPI00001618.
RefSeq	NP_059986.1. NM_017516.1.
UniGene	Hs.354906.
3D structure databases
ProteinModelPortal	Q14964.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14964. 1 interaction.
PTM databases
PhosphoSite	Q14964.
Polymorphism databases
DMDM	46577701.
Proteomic databases
PaxDb	Q14964.
PRIDE	Q14964.
Protocols and materials databases
DNASU	54734.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320578; ENSP00000322594; ENSG00000179331.
GeneID	54734.
KEGG	hsa:54734.
UCSC	uc001pjt.3. human.
Organism-specific databases
CTD	54734.
GeneCards	GC11P107799.
HGNC	HGNC:16521. RAB39A.
HPA	HPA042505. HPA042715.
neXtProt	NX_Q14964.
PharmGKB	PA34130.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	Q14964.
KO	K07924.
OMA	VEDGWDG.
OrthoDB	EOG43JC5J.
PhylomeDB	Q14964.
Gene expression databases
Bgee	Q14964.
CleanEx	HS_RAB39.
Genevestigator	Q14964.
GermOnline	ENSG00000179331. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54734.
NextBio	57320.

Entry information

Entry name

RB39A_HUMAN

Accession

Primary (citable) accession number: Q14964
Secondary accession number(s): A8KAA4, Q8N6W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	April 26, 2004
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.