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Q14964 (RB39A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-39A

Short name=Rab-39
Gene names
Name:RAB39A
Synonyms:RAB39
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Ref.5

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cytoplasmic vesiclephagosome. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or M.tuberculosis. Ref.5

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Ras-related protein Rab-39A
PRO_0000121253

Regions

Nucleotide binding15 – 228GTP By similarity
Nucleotide binding68 – 725GTP By similarity
Nucleotide binding127 – 1304GTP By similarity
Motif41 – 499Effector region By similarity

Amino acid modifications

Modified residue2171Cysteine methyl ester By similarity
Lipidation2151S-geranylgeranyl cysteine By similarity
Lipidation2171S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict1521K → M in CAA68227. Ref.1
Sequence conflict1681F → S in CAA68227. Ref.1
Sequence conflict176 – 1772YE → FD in CAA68227. Ref.1
Sequence conflict2041S → P in CAA68227. Ref.1
Sequence conflict2161F → S in CAA68227. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q14964 [UniParc].

Last modified April 26, 2004. Version 2.
Checksum: ABD121649354D7F5

FASTA21725,007
        10         20         30         40         50         60 
METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLRSPA CDPTVGVDFF SRLLEIEPGK 

        70         80         90        100        110        120 
RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS FEHVKDWLEE AKMYVQPFRI 

       130        140        150        160        170        180 
VFLLVGHKCD LASQRQVTRE EAEKLSADCG MKYIETSAKD ATNVEESFTI LTRDIYELIK 

       190        200        210 
KGEICIQDGW EGVKSGFVPN TVHSSEEAVK PRKECFC 

« Hide

References

« Hide 'large scale' references
[1]"Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes."
Stankovic T., Byrd P.J., Cooper P.R., McConville C.M., Munroe D.J., Riley J.H., Watts G.D.J., Ambrose H., McGuire G., Smith A.D., Sutcliffe A., Mills T., Taylor A.M.R.
Genomics 40:267-276(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
Seto S., Tsujimura K., Koide Y.
Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99962 mRNA. Translation: CAA68227.1.
AK292969 mRNA. Translation: BAF85658.1.
CH471065 Genomic DNA. Translation: EAW67100.1.
BC028064 mRNA. Translation: AAH28064.1.
RefSeqNP_059986.1. NM_017516.1.
UniGeneHs.354906.

3D structure databases

ProteinModelPortalQ14964.
SMRQ14964. Positions 5-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120117. 4 interactions.
DIPDIP-60521N.
IntActQ14964. 1 interaction.

PTM databases

PhosphoSiteQ14964.

Polymorphism databases

DMDM46577701.

Proteomic databases

PaxDbQ14964.
PRIDEQ14964.

Protocols and materials databases

DNASU54734.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320578; ENSP00000322594; ENSG00000179331.
GeneID54734.
KEGGhsa:54734.
UCSCuc001pjt.3. human.

Organism-specific databases

CTD54734.
GeneCardsGC11P107799.
HGNCHGNC:16521. RAB39A.
HPAHPA042505.
HPA042715.
neXtProtNX_Q14964.
PharmGKBPA34130.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ14964.
KOK07924.
OMAYKVEDGW.
OrthoDBEOG7JHM6Q.
PhylomeDBQ14964.
TreeFamTF300032.

Gene expression databases

BgeeQ14964.
CleanExHS_RAB39.
GenevestigatorQ14964.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54734.
NextBio57320.
PROQ14964.

Entry information

Entry nameRB39A_HUMAN
AccessionPrimary (citable) accession number: Q14964
Secondary accession number(s): A8KAA4, Q8N6W2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 26, 2004
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM