##gff-version 3 Q14957 UniProtKB Signal peptide 1 19 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Chain 20 1233 . . . ID=PRO_0000011580;Note=Glutamate receptor ionotropic%2C NMDA 2C Q14957 UniProtKB Topological domain 20 554 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Transmembrane 555 573 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Topological domain 574 600 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Intramembrane 601 620 . . . Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Topological domain 621 627 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Transmembrane 628 643 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Topological domain 644 814 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Transmembrane 815 834 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Topological domain 835 1233 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Region 601 620 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Region 920 995 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14957 UniProtKB Motif 1231 1233 . . . Note=PDZ-binding Q14957 UniProtKB Compositional bias 929 960 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14957 UniProtKB Binding site 509 511 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Binding site 511 511 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Binding site 516 516 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Binding site 687 688 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Binding site 729 729 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00960 Q14957 UniProtKB Site 612 612 . . . Note=Functional determinant of NMDA receptors;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14957 UniProtKB Modified residue 875 875 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01098 Q14957 UniProtKB Modified residue 881 881 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01098 Q14957 UniProtKB Modified residue 912 912 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00961 Q14957 UniProtKB Glycosylation 70 70 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Glycosylation 73 73 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Glycosylation 337 337 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Glycosylation 438 438 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Glycosylation 539 539 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Glycosylation 685 685 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14957 UniProtKB Disulfide bond 82 317 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Disulfide bond 426 453 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Disulfide bond 433 454 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Disulfide bond 743 798 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q14957 UniProtKB Natural variant 18 1233 . . . ID=VAR_079958;Note=Found in a patient with autism spectrum disorder%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=PMID:22833210 Q14957 UniProtKB Natural variant 90 90 . . . ID=VAR_079959;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs192960268,PMID:22833210 Q14957 UniProtKB Natural variant 166 166 . . . ID=VAR_079960;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs201199917,PMID:22833210 Q14957 UniProtKB Natural variant 573 573 . . . ID=VAR_079961;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=PMID:22833210 Q14957 UniProtKB Natural variant 641 641 . . . ID=VAR_079962;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs746610735,PMID:22833210 Q14957 UniProtKB Natural variant 679 679 . . . ID=VAR_079963;Note=Found in a patient with schizophrenia%3B uncertain significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs1381530257,PMID:22833210 Q14957 UniProtKB Natural variant 863 863 . . . ID=VAR_079964;Note=Found in a patient with autism spectrum disorder%3B uncertain significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs1308468356,PMID:22833210 Q14957 UniProtKB Natural variant 871 871 . . . ID=VAR_079965;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs765016248,PMID:22833210 Q14957 UniProtKB Natural variant 877 877 . . . ID=VAR_079966;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs139011774,PMID:22833210 Q14957 UniProtKB Natural variant 911 911 . . . ID=VAR_079967;Note=S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs370546831,PMID:22833210 Q14957 UniProtKB Natural variant 982 982 . . . ID=VAR_079968;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs960726960,PMID:22833210 Q14957 UniProtKB Natural variant 989 989 . . . ID=VAR_079969;Note=Found in a patient with schizophrenia%3B uncertain significance. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs552196496,PMID:22833210 Q14957 UniProtKB Natural variant 995 995 . . . ID=VAR_079970;Note=Found in a patient with schizophrenia%3B uncertain significance. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=PMID:22833210 Q14957 UniProtKB Natural variant 1079 1079 . . . ID=VAR_079971;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs889196426,PMID:22833210 Q14957 UniProtKB Natural variant 1141 1141 . . . ID=VAR_079972;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs751640851,PMID:22833210 Q14957 UniProtKB Natural variant 1180 1180 . . . ID=VAR_079973;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs115230539,PMID:22833210 Q14957 UniProtKB Natural variant 1196 1196 . . . ID=VAR_079974;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs143282101,PMID:22833210 Q14957 UniProtKB Natural variant 1209 1209 . . . ID=VAR_037634;Note=R->S;Dbxref=dbSNP:rs3744215 Q14957 UniProtKB Mutagenesis 550 550 . . . Note=Changed glutamate-gated calcium ion channel activity characterized by increased glutamate and glycine potency. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q14957 UniProtKB Sequence conflict 1048 1048 . . . Note=E->EPPE;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14957 UniProtKB Sequence conflict 1057 1057 . . . Note=P->K;Ontology_term=ECO:0000305;evidence=ECO:0000305