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Protein

Killer cell immunoglobulin-like receptor 2DS1

Gene

KIR2DS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • innate immune response Source: Reactome
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS1
Alternative name(s):
CD158 antigen-like family member H
MHC class I NK cell receptor Eb6 ActI
CD_antigen: CD158h
Gene namesi
Name:KIR2DS1
Synonyms:CD158H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:6333. KIR2DS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 304CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3806.
57292.
PharmGKBiPA30118.

Polymorphism and mutation databases

DMDMi13124324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508222 – 304Killer cell immunoglobulin-like receptor 2DS1Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100By similarity
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ14954.
PRIDEiQ14954.

PTM databases

iPTMnetiQ14954.

Interactioni

Protein-protein interaction databases

BioGridi110007. 2 interactors.
IntActiQ14954. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ14954.
SMRiQ14954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ14954.
KOiK07982.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM RQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGTKVNGT FQANFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,646
Last modified:November 1, 1996 - v1
Checksum:i4193A5421510AE06
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01031891R → K.2 PublicationsCorresponds to variant rs687485dbSNPEnsembl.1
Natural variantiVAR_059419111L → V.Corresponds to variant rs687885dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89892 mRNA. Translation: CAA61982.1.
AF022046 mRNA. Translation: AAB95319.1.
AL133414 Genomic DNA. Translation: CAC40716.1.
RefSeqiNP_055327.1. NM_014512.1.
UniGeneiHs.744319.

Genome annotation databases

GeneIDi3806.
KEGGihsa:3806.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89892 mRNA. Translation: CAA61982.1.
AF022046 mRNA. Translation: AAB95319.1.
AL133414 Genomic DNA. Translation: CAC40716.1.
RefSeqiNP_055327.1. NM_014512.1.
UniGeneiHs.744319.

3D structure databases

ProteinModelPortaliQ14954.
SMRiQ14954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110007. 2 interactors.
IntActiQ14954. 1 interactor.

PTM databases

iPTMnetiQ14954.

Polymorphism and mutation databases

DMDMi13124324.

Proteomic databases

PeptideAtlasiQ14954.
PRIDEiQ14954.

Protocols and materials databases

DNASUi3806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3806.
KEGGihsa:3806.

Organism-specific databases

CTDi3806.
DisGeNETi3806.
57292.
GeneCardsiKIR2DS1.
HGNCiHGNC:6333. KIR2DS1.
MIMi604952. gene.
neXtProtiNX_Q14954.
PharmGKBiPA30118.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ14954.
KOiK07982.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Miscellaneous databases

GenomeRNAii3806.
PROiQ14954.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI2S1_HUMAN
AccessioniPrimary (citable) accession number: Q14954
Secondary accession number(s): O43471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.