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Q14954

- KI2S1_HUMAN

UniProt

Q14954 - KI2S1_HUMAN

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Protein
Killer cell immunoglobulin-like receptor 2DS1
Gene
KIR2DS1, CD158H
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
  2. innate immune response Source: Reactome
  3. regulation of immune response Source: Reactome
  4. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS1
Alternative name(s):
CD158 antigen-like family member H
MHC class I NK cell receptor Eb6 ActI
CD_antigen: CD158h
Gene namesi
Name:KIR2DS1
Synonyms:CD158H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6333. KIR2DS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224Extracellular Reviewed prediction
Add
BLAST
Transmembranei246 – 26419Helical; Reviewed prediction
Add
BLAST
Topological domaini265 – 30440Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 304283Killer cell immunoglobulin-like receptor 2DS1
PRO_0000015082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 100 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 198 By similarity
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ14954.

Expressioni

Gene expression databases

GenevestigatoriQ14954.

Organism-specific databases

HPAiHPA049255.

Interactioni

Protein-protein interaction databases

BioGridi110007. 1 interaction.
IntActiQ14954. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14954.
SMRiQ14954. Positions 27-221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1
Add
BLAST
Domaini142 – 20564Ig-like C2-type 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
KOiK07982.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14954-1 [UniParc]FASTAAdd to Basket

« Hide

MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW    50
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM RQDLAGTYRC 100
YGSVTHSPYQ LSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS 150
SRSSYDMYHL SREGEAHERR LPAGTKVNGT FQANFPLGPA THGGTYRCFG 200
SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT 250
SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 300
VSYA 304
Length:304
Mass (Da):33,646
Last modified:November 1, 1996 - v1
Checksum:i4193A5421510AE06
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911R → K.2 Publications
Corresponds to variant rs687485 [ dbSNP | Ensembl ].
VAR_010318
Natural varianti111 – 1111L → V.
Corresponds to variant rs687885 [ dbSNP | Ensembl ].
VAR_059419

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89892 mRNA. Translation: CAA61982.1.
AF022046 mRNA. Translation: AAB95319.1.
AL133414 Genomic DNA. Translation: CAC40716.1.
RefSeqiNP_055327.1. NM_014512.1.
UniGeneiHs.744319.

Genome annotation databases

GeneIDi3806.
KEGGihsa:3806.
UCSCiuc002qum.3. human.

Polymorphism databases

DMDMi13124324.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89892 mRNA. Translation: CAA61982.1 .
AF022046 mRNA. Translation: AAB95319.1 .
AL133414 Genomic DNA. Translation: CAC40716.1 .
RefSeqi NP_055327.1. NM_014512.1.
UniGenei Hs.744319.

3D structure databases

ProteinModelPortali Q14954.
SMRi Q14954. Positions 27-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110007. 1 interaction.
IntActi Q14954. 1 interaction.

Polymorphism databases

DMDMi 13124324.

Proteomic databases

PRIDEi Q14954.

Protocols and materials databases

DNASUi 3806.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3806.
KEGGi hsa:3806.
UCSCi uc002qum.3. human.

Organism-specific databases

CTDi 3806.
GeneCardsi GC19P9I0101.
HGNCi HGNC:6333. KIR2DS1.
HPAi HPA049255.
MIMi 604952. gene.
neXtProti NX_Q14954.
PharmGKBi PA30118.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG074353.
KOi K07982.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.

Miscellaneous databases

GenomeRNAii 3806.
NextBioi 14957.
PROi Q14954.
SOURCEi Search...

Gene expression databases

Genevestigatori Q14954.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."
    Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L.
    J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoid tissue.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-91.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-91.

Entry informationi

Entry nameiKI2S1_HUMAN
AccessioniPrimary (citable) accession number: Q14954
Secondary accession number(s): O43471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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