Q14954 (KI2S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Killer cell immunoglobulin-like receptor 2DS1

Alternative name(s):
CD158 antigen-like family member H
MHC class I NK cell receptor Eb6 ActI
CD_antigen=CD158h

Gene names

Name:	KIR2DS1
Synonyms:	CD158H

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.1. Source: UniProtKB regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	transmembrane signaling receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 304	283	Killer cell immunoglobulin-like receptor 2DS1		PRO_0000015082
Regions
	Topological domain	22 – 245	224	Extracellular Potential
	Transmembrane	246 – 264	19	Helical; Potential
	Topological domain	265 – 304	40	Cytoplasmic Potential
	Domain	42 – 107	66	Ig-like C2-type 1
	Domain	142 – 205	64	Ig-like C2-type 2
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 100		By similarity
	Disulfide bond	149 ↔ 198		By similarity
Natural variations
	Natural variant	91	1	R → K. Ref.2 Ref.3 Corresponds to variant rs687485 [ dbSNP | Ensembl ].		VAR_010318
	Natural variant	111	1	L → V. Corresponds to variant rs687885 [ dbSNP | Ensembl ].		VAR_059419

Sequences

	Sequence		Length	Mass (Da)
	Q14954 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4193A5421510AE06	FASTA	304	33,646
	10 20 30 40 50 60 MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL 70 80 90 100 110 120 HREGMFNDTL RLIGEHHDGV SKANFSISRM RQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI 130 140 150 160 170 180 VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT 190 200 210 220 230 240 FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN 250 260 270 280 290 300 PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE VSYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions." Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L. J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoid tissue.
[2]	"Human diversity in killer cell inhibitory receptor genes." Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P. Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-91.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-91.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89892 mRNA. Translation: CAA61982.1. AF022046 mRNA. Translation: AAB95319.1. AL133414 Genomic DNA. Translation: CAC40716.1.
IPI	IPI00292723.
RefSeq	NP_055327.1. NM_014512.1.
UniGene	Hs.512572.
3D structure databases
ProteinModelPortal	Q14954.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14954. 1 interaction.
Polymorphism databases
DMDM	13124324.
Proteomic databases
PRIDE	Q14954.
Protocols and materials databases
DNASU	3806.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3806.
KEGG	hsa:3806.
UCSC	uc002qum.3. human.
Organism-specific databases
CTD	3806.
GeneCards	GC19P9I0101.
HGNC	HGNC:6333. KIR2DS1.
HPA	HPA049255.
MIM	604952. gene.
neXtProt	NX_Q14954.
PharmGKB	PA30118.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG074353.
KO	K07982.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	Q14954.
GermOnline	ENSG00000125498. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013151. Immunoglobulin. [Graphical view]
Pfam	PF00047. ig. 2 hits. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3806.
NextBio	14957.
SOURCE	Search...

Entry information

Entry name

KI2S1_HUMAN

Accession

Primary (citable) accession number: Q14954
Secondary accession number(s): O43471

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.