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Q14954 (KI2S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 2DS1
Alternative name(s):
CD158 antigen-like family member H
MHC class I NK cell receptor Eb6 ActI
CD_antigen=CD158h
Gene names
Name:KIR2DS1
Synonyms:CD158H
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 304283Killer cell immunoglobulin-like receptor 2DS1
PRO_0000015082

Regions

Topological domain22 – 245224Extracellular Potential
Transmembrane246 – 26419Helical; Potential
Topological domain265 – 30440Cytoplasmic Potential
Domain42 – 10766Ig-like C2-type 1
Domain142 – 20564Ig-like C2-type 2

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 100 By similarity
Disulfide bond149 ↔ 198 By similarity

Natural variations

Natural variant911R → K. Ref.2 Ref.3
Corresponds to variant rs687485 [ dbSNP | Ensembl ].
VAR_010318
Natural variant1111L → V.
Corresponds to variant rs687885 [ dbSNP | Ensembl ].
VAR_059419

Sequences

Sequence LengthMass (Da)Tools
Q14954 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4193A5421510AE06

FASTA30433,646
        10         20         30         40         50         60 
MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL 

        70         80         90        100        110        120 
HREGMFNDTL RLIGEHHDGV SKANFSISRM RQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI 

       130        140        150        160        170        180 
VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT 

       190        200        210        220        230        240 
FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN 

       250        260        270        280        290        300 
PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 


VSYA 

« Hide

References

« Hide 'large scale' references
[1]"The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."
Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L.
J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphoid tissue.
[2]"Human diversity in killer cell inhibitory receptor genes."
Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P.
Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-91.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-91.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89892 mRNA. Translation: CAA61982.1.
AF022046 mRNA. Translation: AAB95319.1.
AL133414 Genomic DNA. Translation: CAC40716.1.
RefSeqNP_055327.1. NM_014512.1.
UniGeneHs.744319.

3D structure databases

ProteinModelPortalQ14954.
SMRQ14954. Positions 27-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110007. 1 interaction.
IntActQ14954. 1 interaction.

Polymorphism databases

DMDM13124324.

Proteomic databases

PRIDEQ14954.

Protocols and materials databases

DNASU3806.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3806.
KEGGhsa:3806.
UCSCuc002qum.3. human.

Organism-specific databases

CTD3806.
GeneCardsGC19P9I0101.
HGNCHGNC:6333. KIR2DS1.
HPAHPA049255.
MIM604952. gene.
neXtProtNX_Q14954.
PharmGKBPA30118.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG074353.
KOK07982.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorQ14954.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 2 hits.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi3806.
NextBio14957.
PROQ14954.
SOURCESearch...

Entry information

Entry nameKI2S1_HUMAN
AccessionPrimary (citable) accession number: Q14954
Secondary accession number(s): O43471
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries