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Protein

Killer cell immunoglobulin-like receptor 2DS1

Gene

KIR2DS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells.1 Publication

Caution

The KIR2DS1 gene is not directly represented on the GRCh38 primary reference genome assembly but on alternate loci of that assembly.Curated

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • innate immune response Source: Reactome
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS1Curated
Alternative name(s):
CD158 antigen-like family member H
MHC class I NK cell receptor Eb6 ActI
CD_antigen: CD158h
Gene namesi
Name:KIR2DS1Imported
Synonyms:CD158H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6333 KIR2DS1
MIMi604952 gene
neXtProtiNX_Q14954

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 304CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3806
PharmGKBiPA30118

Polymorphism and mutation databases

DMDMi13124324

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508222 – 304Killer cell immunoglobulin-like receptor 2DS1Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100By similarity
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ14954
PRIDEiQ14954

PTM databases

iPTMnetiQ14954
PhosphoSitePlusiQ14954

Expressioni

Tissue specificityi

Expressed by NK cells.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HLA-CQ299633EBI-2865976,EBI-4400689

Protein-protein interaction databases

BioGridi110007, 2 interactors
IntActiQ14954, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliQ14954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiQ14954
KOiK07982

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM KQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGTKVNGT FQANFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,618
Last modified:March 28, 2018 - v2
Checksum:iFD323A0EB48B13C2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01031891K → R2 PublicationsCorresponds to variant dbSNP:rs687485Ensembl.1
Natural variantiVAR_059419111L → V. Corresponds to variant dbSNP:rs687885Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89892 mRNA Translation: CAA61982.1
AF022046 mRNA Translation: AAB95319.1
JX008030 Genomic DNA Translation: AFV74766.1
KP420440 Genomic DNA Translation: AJI81009.1
KP420441 Genomic DNA Translation: AMR59360.1
AL133414 Genomic DNA No translation available.
KU645196 Genomic DNA Translation: ANJ04800.1
CU459006 Genomic DNA No translation available.
GU182339 Genomic DNA No translation available.
GU182352 Genomic DNA No translation available.
GU182355 Genomic DNA No translation available.
GU182359 Genomic DNA No translation available.
RefSeqiNP_055327.1, NM_014512.1
UniGeneiHs.744319

Genome annotation databases

EnsembliENST00000611996; ENSP00000482170; ENSG00000276327
ENST00000612447; ENSP00000481628; ENSG00000278304
ENST00000617661; ENSP00000483434; ENSG00000278120
ENST00000618071; ENSP00000482900; ENSG00000273603
ENST00000621207; ENSP00000482060; ENSG00000275421
ENST00000622039; ENSP00000478711; ENSG00000273517
GeneIDi3806
KEGGihsa:3806

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKI2S1_HUMAN
AccessioniPrimary (citable) accession number: Q14954
Secondary accession number(s): K7QUS8, O43471
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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