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Protein

Killer cell immunoglobulin-like receptor 2DS5

Gene

KIR2DS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  • HLA-C specific inhibitory MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • innate immune response Source: Reactome
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS5
Alternative name(s):
CD158 antigen-like family member G
MHC class I NK cell receptor
Natural killer-associated transcript 9
Short name:
NKAT-9
CD_antigen: CD158g
Gene namesi
Name:KIR2DS5
Synonyms:CD158G, NKAT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:6337. KIR2DS5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224ExtracellularSequence analysisAdd
BLAST
Transmembranei246 – 26419HelicalSequence analysisAdd
BLAST
Topological domaini265 – 30440CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi2833260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 304283Killer cell immunoglobulin-like receptor 2DS5PRO_0000015086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 100By similarity
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ14953.

PTM databases

iPTMnetiQ14953.
PhosphoSiteiQ14953.

Expressioni

Gene expression databases

CleanExiHS_KIR2DS5.

Structurei

3D structure databases

ProteinModelPortaliQ14953.
SMRiQ14953. Positions 27-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini142 – 20564Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ14953.
PhylomeDBiQ14953.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLMVISMAC VAFFLLQGAW PHEGFRRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGTFNHTL RLIGEHIDGV SKGNFSIGRM TQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LPAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGPKVNRT FQADSPLDPA THGGAYRCFG
210 220 230 240 250
SFRDSPYEWS KSSDPLLVSV TGNSSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVKLPFTIL LFFLLHRWCS NKKNASVMDQ GPAGNRTVNR EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,644
Last modified:November 1, 1996 - v1
Checksum:iF0BD73BFA3DE35DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76672 mRNA. Translation: AAB36600.1.
UniGeneiHs.744266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76672 mRNA. Translation: AAB36600.1.
UniGeneiHs.744266.

3D structure databases

ProteinModelPortaliQ14953.
SMRiQ14953. Positions 27-221.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ14953.
PhosphoSiteiQ14953.

Polymorphism and mutation databases

DMDMi2833260.

Proteomic databases

PRIDEiQ14953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiKIR2DS5.
HGNCiHGNC:6337. KIR2DS5.
MIMi604956. gene.
neXtProtiNX_Q14953.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ14953.
PhylomeDBiQ14953.

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

PROiQ14953.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIR2DS5.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Alternatively spliced forms of human killer inhibitory receptors."
    Doehring C., Samaridis J., Colonna M.
    Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKI2S5_HUMAN
AccessioniPrimary (citable) accession number: Q14953
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.