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Protein

Killer cell immunoglobulin-like receptor 2DS3

Gene

KIR2DS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Biological processi

  • cellular defense response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS3
Alternative name(s):
MHC class I NK cell receptor
Natural killer-associated transcript 7
Short name:
NKAT-7
Gene namesi
Name:KIR2DS3
Synonyms:NKAT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6335. KIR2DS3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224ExtracellularSequence analysisAdd
BLAST
Transmembranei246 – 26419HelicalSequence analysisAdd
BLAST
Topological domaini265 – 30440CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 304283Killer cell immunoglobulin-like receptor 2DS3PRO_0000015084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 100By similarity
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ14952.
PRIDEiQ14952.

PTM databases

iPTMnetiQ14952.
PhosphoSiteiQ14952.

Interactioni

Protein-protein interaction databases

IntActiQ14952. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14952.
SMRiQ14952. Positions 27-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini142 – 20564Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ14952.
KOiK07982.
PhylomeDBiQ14952.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVISMAC VGFFWLQGAW PHEGFRRKPS LLAHPGRLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGTFNDTL RLIGEHIDGV SKANFSIGRM RQDLAGTYRC
110 120 130 140 150
YGSVPHSPYQ FSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SWSSYDMYHL STEGEAHERR FSAGPKVNGT FQADFPLGPA TQGGTYRCFG
210 220 230 240 250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT
260 270 280 290 300
SVVKLPFTIL LFFLLHRWCS DKKNASVMDQ GPAGNRTVNR EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,717
Last modified:November 1, 1996 - v1
Checksum:i80693F79844F9E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76670 mRNA. Translation: AAB36598.1.
X97231 mRNA. Translation: CAA65870.1.
AF022047 mRNA. Translation: AAB95320.1.
RefSeqiNP_036445.1. NM_012313.1.
UniGeneiHs.744266.

Genome annotation databases

EnsembliENST00000611193; ENSP00000479108; ENSG00000277657.
ENST00000613265; ENSP00000480969; ENSG00000278306.
ENST00000614725; ENSP00000483315; ENSG00000277163.
GeneIDi3808.
KEGGihsa:3808.
UCSCiuc032lso.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76670 mRNA. Translation: AAB36598.1.
X97231 mRNA. Translation: CAA65870.1.
AF022047 mRNA. Translation: AAB95320.1.
RefSeqiNP_036445.1. NM_012313.1.
UniGeneiHs.744266.

3D structure databases

ProteinModelPortaliQ14952.
SMRiQ14952. Positions 27-221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14952. 1 interaction.

PTM databases

iPTMnetiQ14952.
PhosphoSiteiQ14952.

Proteomic databases

PeptideAtlasiQ14952.
PRIDEiQ14952.

Protocols and materials databases

DNASUi3808.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611193; ENSP00000479108; ENSG00000277657.
ENST00000613265; ENSP00000480969; ENSG00000278306.
ENST00000614725; ENSP00000483315; ENSG00000277163.
GeneIDi3808.
KEGGihsa:3808.
UCSCiuc032lso.2. human.

Organism-specific databases

CTDi3808.
GeneCardsiKIR2DS3.
HGNCiHGNC:6335. KIR2DS3.
MIMi604954. gene.
neXtProtiNX_Q14952.
PharmGKBiPA30120.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiQ14952.
KOiK07982.
PhylomeDBiQ14952.

Miscellaneous databases

GenomeRNAii3808.
PROiQ14952.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI2S3_HUMAN
AccessioniPrimary (citable) accession number: Q14952
Secondary accession number(s): O00644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.