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Protein

Killer cell immunoglobulin-like receptor 3DS1

Gene

KIR3DS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  • MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • innate immune response Source: Reactome
  • natural killer cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131040-MONOMER.
ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DS1
Alternative name(s):
MHC class I NK cell receptor
Natural killer-associated transcript 10
Short name:
NKAT-10
Gene namesi
Name:KIR3DS1
Synonyms:NKAT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6340. KIR3DS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 387CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3813.
MalaCardsiKIR3DS1.
OpenTargetsiENSG00000274283.
ENSG00000275608.
ENSG00000276498.
ENSG00000276534.

Polymorphism and mutation databases

DMDMi2833258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001509222 – 387Killer cell immunoglobulin-like receptor 3DS1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 95By similarity
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14943.
PRIDEiQ14943.

PTM databases

iPTMnetiQ14943.
PhosphoSitePlusiQ14943.

Expressioni

Tissue specificityi

Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line.

Gene expression databases

BgeeiENSG00000215764.
CleanExiHS_KIR3DS1.

Interactioni

Protein-protein interaction databases

BioGridi306831. 23 interactors.
STRINGi9606.ENSP00000375608.

Structurei

3D structure databases

ProteinModelPortaliQ14943.
SMRiQ14943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
HOVERGENiHBG074353.
InParanoidiQ14943.
OMAiNTSPCEW.
PhylomeDBiQ14943.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH
60 70 80 90 100
YRHRFNNFML YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP
110 120 130 140 150
HSPTGWSAPS NPMVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF
160 170 180 190 200
EHFFLHKEWI SKDPSRLVGQ IHDGVSKANF SIGSMMRALA GTYRCYGSVT
210 220 230 240 250
HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV TLSCSSRSSY
260 270 280 290 300
DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
310 320 330 340 350
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI
360 370 380
PFTILLFFLL HRWCSNKKNA AVMDQEPAGN RSEQRGF
Length:387
Mass (Da):42,902
Last modified:November 1, 1996 - v1
Checksum:i0E75CE730D15E100
GO

Polymorphismi

The KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion and contraction over time, probably through unequal crossing-over. Thus, KIR haplotypes vary in the number and types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes. KIR3DL1 and KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0560932S → L.Corresponds to variant rs605219dbSNPEnsembl.1
Natural variantiVAR_05609468V → I.Corresponds to variant rs643347dbSNPEnsembl.1
Natural variantiVAR_010377166R → H.1 PublicationCorresponds to variant rs375468097dbSNPEnsembl.1
Natural variantiVAR_056095203P → S.Corresponds to variant rs143886704dbSNPEnsembl.1
Natural variantiVAR_056096220L → P.Corresponds to variant rs680891dbSNPEnsembl.1
Natural variantiVAR_056097259G → R.Corresponds to variant rs1049215dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76661 mRNA. Translation: AAB36589.1.
RefSeqiNP_001077008.1. NM_001083539.2.
NP_001269099.1. NM_001282170.1.
NP_001269100.1. NM_001282171.1.
UniGeneiHs.743496.

Genome annotation databases

EnsembliENST00000613279; ENSP00000484010; ENSG00000276534.
ENST00000615275; ENSP00000481993; ENSG00000276498.
ENST00000616075; ENSP00000477733; ENSG00000275037.
ENST00000616388; ENSP00000480199; ENSG00000274465.
ENST00000616583; ENSP00000483460; ENSG00000275608.
ENST00000619911; ENSP00000477859; ENSG00000274283.
GeneIDi3813.
KEGGihsa:3813.
UCSCiuc061dvg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76661 mRNA. Translation: AAB36589.1.
RefSeqiNP_001077008.1. NM_001083539.2.
NP_001269099.1. NM_001282170.1.
NP_001269100.1. NM_001282171.1.
UniGeneiHs.743496.

3D structure databases

ProteinModelPortaliQ14943.
SMRiQ14943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi306831. 23 interactors.
STRINGi9606.ENSP00000375608.

PTM databases

iPTMnetiQ14943.
PhosphoSitePlusiQ14943.

Polymorphism and mutation databases

DMDMi2833258.

Proteomic databases

PaxDbiQ14943.
PRIDEiQ14943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613279; ENSP00000484010; ENSG00000276534.
ENST00000615275; ENSP00000481993; ENSG00000276498.
ENST00000616075; ENSP00000477733; ENSG00000275037.
ENST00000616388; ENSP00000480199; ENSG00000274465.
ENST00000616583; ENSP00000483460; ENSG00000275608.
ENST00000619911; ENSP00000477859; ENSG00000274283.
GeneIDi3813.
KEGGihsa:3813.
UCSCiuc061dvg.1. human.

Organism-specific databases

CTDi3813.
DisGeNETi3813.
GeneCardsiKIR3DS1.
H-InvDBHIX0040485.
HGNCiHGNC:6340. KIR3DS1.
MalaCardsiKIR3DS1.
MIMi604946. gene.
neXtProtiNX_Q14943.
OpenTargetsiENSG00000274283.
ENSG00000275608.
ENSG00000276498.
ENSG00000276534.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
HOVERGENiHBG074353.
InParanoidiQ14943.
OMAiNTSPCEW.
PhylomeDBiQ14943.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131040-MONOMER.
ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

GenomeRNAii3813.
PROiQ14943.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215764.
CleanExiHS_KIR3DS1.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI3S1_HUMAN
AccessioniPrimary (citable) accession number: Q14943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.