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Protein

Killer cell immunoglobulin-like receptor 3DS1

Gene

KIR3DS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  • MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • innate immune response Source: Reactome
  • natural killer cell activation Source: UniProtKB
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DS1
Alternative name(s):
MHC class I NK cell receptor
Natural killer-associated transcript 10
Short name:
NKAT-10
Gene namesi
Name:KIR3DS1
Synonyms:NKAT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6340. KIR3DS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 340319ExtracellularSequence analysisAdd
BLAST
Transmembranei341 – 36020HelicalSequence analysisAdd
BLAST
Topological domaini361 – 38727CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiKIR3DS1.

Polymorphism and mutation databases

DMDMi2833258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 387366Killer cell immunoglobulin-like receptor 3DS1PRO_0000015092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 95By similarity
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14943.
PRIDEiQ14943.

PTM databases

PhosphoSiteiQ14943.

Expressioni

Tissue specificityi

Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line.

Gene expression databases

BgeeiQ14943.
CleanExiHS_KIR3DS1.

Interactioni

Protein-protein interaction databases

BioGridi306831. 23 interactions.
STRINGi9606.ENSP00000375608.

Structurei

3D structure databases

ProteinModelPortaliQ14943.
SMRiQ14943. Positions 28-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10261Ig-like C2-type 1Add
BLAST
Domaini137 – 20266Ig-like C2-type 2Add
BLAST
Domaini237 – 30064Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
HOVERGENiHBG074353.
InParanoidiQ14943.
OMAiCESLRTW.
PhylomeDBiQ14943.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH
60 70 80 90 100
YRHRFNNFML YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP
110 120 130 140 150
HSPTGWSAPS NPMVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF
160 170 180 190 200
EHFFLHKEWI SKDPSRLVGQ IHDGVSKANF SIGSMMRALA GTYRCYGSVT
210 220 230 240 250
HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV TLSCSSRSSY
260 270 280 290 300
DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
310 320 330 340 350
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI
360 370 380
PFTILLFFLL HRWCSNKKNA AVMDQEPAGN RSEQRGF
Length:387
Mass (Da):42,902
Last modified:November 1, 1996 - v1
Checksum:i0E75CE730D15E100
GO

Polymorphismi

The KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion and contraction over time, probably through unequal crossing-over. Thus, KIR haplotypes vary in the number and types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes. KIR3DL1 and KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1.2 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → L.
Corresponds to variant rs605219 [ dbSNP | Ensembl ].
VAR_056093
Natural varianti68 – 681V → I.
Corresponds to variant rs643347 [ dbSNP | Ensembl ].
VAR_056094
Natural varianti166 – 1661R → H.1 Publication
VAR_010377
Natural varianti203 – 2031P → S.
Corresponds to variant rs143886704 [ dbSNP | Ensembl ].
VAR_056095
Natural varianti220 – 2201L → P.
Corresponds to variant rs680891 [ dbSNP | Ensembl ].
VAR_056096
Natural varianti259 – 2591G → R.
Corresponds to variant rs1049215 [ dbSNP | Ensembl ].
VAR_056097

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76661 mRNA. Translation: AAB36589.1.
RefSeqiNP_001077008.1. NM_001083539.2.
NP_001269099.1. NM_001282170.1.
NP_001269100.1. NM_001282171.1.
UniGeneiHs.743496.

Genome annotation databases

EnsembliENST00000613279; ENSP00000484010; ENSG00000276534.
ENST00000615275; ENSP00000481993; ENSG00000276498.
ENST00000616075; ENSP00000477733; ENSG00000275037.
ENST00000616388; ENSP00000480199; ENSG00000274465.
ENST00000616583; ENSP00000483460; ENSG00000275608.
ENST00000619911; ENSP00000477859; ENSG00000274283.
GeneIDi3813.
KEGGihsa:3813.
UCSCiuc061dvg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76661 mRNA. Translation: AAB36589.1.
RefSeqiNP_001077008.1. NM_001083539.2.
NP_001269099.1. NM_001282170.1.
NP_001269100.1. NM_001282171.1.
UniGeneiHs.743496.

3D structure databases

ProteinModelPortaliQ14943.
SMRiQ14943. Positions 28-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi306831. 23 interactions.
STRINGi9606.ENSP00000375608.

PTM databases

PhosphoSiteiQ14943.

Polymorphism and mutation databases

DMDMi2833258.

Proteomic databases

PaxDbiQ14943.
PRIDEiQ14943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613279; ENSP00000484010; ENSG00000276534.
ENST00000615275; ENSP00000481993; ENSG00000276498.
ENST00000616075; ENSP00000477733; ENSG00000275037.
ENST00000616388; ENSP00000480199; ENSG00000274465.
ENST00000616583; ENSP00000483460; ENSG00000275608.
ENST00000619911; ENSP00000477859; ENSG00000274283.
GeneIDi3813.
KEGGihsa:3813.
UCSCiuc061dvg.1. human.

Organism-specific databases

CTDi3813.
GeneCardsiKIR3DS1.
H-InvDBHIX0040485.
HGNCiHGNC:6340. KIR3DS1.
MalaCardsiKIR3DS1.
MIMi604946. gene.
neXtProtiNX_Q14943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
HOVERGENiHBG074353.
InParanoidiQ14943.
OMAiCESLRTW.
PhylomeDBiQ14943.

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

GenomeRNAii3813.
PROiQ14943.
SOURCEiSearch...

Gene expression databases

BgeeiQ14943.
CleanExiHS_KIR3DS1.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Alternatively spliced forms of human killer inhibitory receptors."
    Doehring C., Samaridis J., Colonna M.
    Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Plasticity in the organization and sequences of human KIR/ILT gene families."
    Wilson M.J., Torkar M., Haude A., Milne S., Jones T., Sheer D., Beck S., Trowsdale J.
    Proc. Natl. Acad. Sci. U.S.A. 97:4778-4783(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  3. "The genomic context of natural killer receptor extended gene families."
    Trowsdale J., Barten R., Haude A., Stewart C.A., Beck S., Wilson M.J.
    Immunol. Rev. 181:20-38(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  4. Cited for: VARIANT HIS-166.

Entry informationi

Entry nameiKI3S1_HUMAN
AccessioniPrimary (citable) accession number: Q14943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.