Sodium/hydrogen exchanger 5 - Homo sapiens (Human)

Contribute

Send feedback

Read comments (?) or add your own

Q14940 (SL9A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium/hydrogen exchanger 5

Alternative name(s):
Na(+)/H(+) exchanger 5
Short name=NHE-5
Solute carrier family 9 member 5

Gene names

Name:	SLC9A5
Synonyms:	NHE5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	896 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction By similarity.
Subunit structure	Interacts with CHP1 and CHP2 By similarity. Interacts with ARRB2. Ref.5
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain, testis, spleen, and skeletal muscle.
Post-translational modification	Phosphorylated (Possible).
Sequence similarities	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]
Caution	The number, localization and denomination of hydrophobic domains in the Na⁺/H⁺ exchangers vary among authors.

Ontologies

Keywords
Biological process	Antiport Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of pH Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	sodium:hydrogen antiporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 896

896

Sodium/hydrogen exchanger 5

PRO_0000052360

Regions

Transmembrane

46 – 66

Helical; Potential

Transmembrane

74 – 94

Helical; Potential

Transmembrane

104 – 124

Helical; Potential

Transmembrane

135 – 155

Helical; Potential

Transmembrane

174 – 194

Helical; Potential

Transmembrane

201 – 221

Helical; Potential

Transmembrane

247 – 267

Helical; Potential

Transmembrane

277 – 297

Helical; Potential

Transmembrane

332 – 352

Helical; Potential

Transmembrane

361 – 381

Helical; Potential

Transmembrane

399 – 419

Helical; Potential

Transmembrane

429 – 449

Helical; Potential

Amino acid modifications

Glycosylation

199

N-linked (GlcNAc...) Potential

Glycosylation

319

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

202

L → V in AAA87678. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q14940 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: B9D234BFE0922269
Show »

FASTA

896

99,011

        10         20         30         40         50         60 
MLRAALSLLA LPLAGAAEEP TQKPESPGEP PPGLELFRWQ WHEVEAPYLV ALWILVASLA 

        70         80         90        100        110        120 
KIVFHLSRKV TSLVPESCLL ILLGLVLGGI VLAVAKKAEY QLEPGTFFLF LLPPIVLDSG 

       130        140        150        160        170        180 
YFMPSRLFFD NLGAILTYAV VGTLWNAFTT GAALWGLQQA GLVAPRVQAG LLDFLLFGSL 

       190        200        210        220        230        240 
ISAVDPVAVL AVFEEVHVNE TLFIIVFGES LLNDAVTVVL YKVCNSFVEM GSANVQATDY 

       250        260        270        280        290        300 
LKGVASLFVV SLGGAAVGLV FAFLLALTTR FTKRVRIIEP LLVFLLAYAA YLTAEMASLS 

       310        320        330        340        350        360 
AILAVTMCGL GCKKYVEANI SHKSRTTVKY TMKTLASCAE TVIFMLLGIS AVDSSKWAWD 

       370        380        390        400        410        420 
SGLVLGTLIF ILFFRALGVV LQTWVLNQFR LVPLDKIDQV VMSYGGLRGA VAFALVILLD 

       430        440        450        460        470        480 
RTKVPAKDYF VATTIVVVFF TVIVQGLTIK PLVKWLKVKR SEHHKPTLNQ ELHEHTFDHI 

       490        500        510        520        530        540 
LAAVEDVVGH HGYHYWRDRW EQFDKKYLSQ LLMRRSAYRI RDQIWDVYYR LNIRDAISFV 

       550        560        570        580        590        600 
DQGGHVLSST GLTLPSMPSR NSVAETSVTN LLRESGSGAC LDLQVIDTVR SGRDREDAVM 

       610        620        630        640        650        660 
HHLLCGGLYK PRRRYKASCS RHFISEDAQE RQDKEVFQQN MKRRLESFKS TKHNICFTKS 

       670        680        690        700        710        720 
KPRPRKTGRR KKDGVANAEA TNGKHRGLGF QDTAAVILTV ESEEEEEESD SSETEKEDDE 

       730        740        750        760        770        780 
GIIFVARATS EVLQEGKVSG SLEVCPSPRI IPPSPTCAEK ELPWKSGQGD LAVYVSSETT 

       790        800        810        820        830        840 
KIVPVDMQTG WNQSISSLES LASPPCNQAP ILTCLPPHPR GTEEPQVPLH LPSDPRSSFA 

       850        860        870        880        890 
FPPSLAKAGR SRSESSADLP QQQELQPLMG HKDHTHLSPG TATSHWCIQF NRGSRL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain." Baird N.R., Orlowski J., Szabo E.Z., Zaun H.C., Schultheis P.J., Menon A.G., Shull G.E. J. Biol. Chem. 274:4377-4382(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1." Klanke C.A., Su Y.R., Callen D.F., Wang Z., Meneton P., Baird N., Kandasamy R.A., Orlowski J., Otterud B.E., Leppert M., Shull G.E., Menon A.G. Genomics 25:615-622(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-218.
[5]	"beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform." Szabo E.Z., Numata M., Lukashova V., Iannuzzi P., Orlowski J. Proc. Natl. Acad. Sci. U.S.A. 102:2790-2795(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ARRB2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF111173 mRNA. Translation: AAC98696.1. CH471092 Genomic DNA. Translation: EAW83114.1. BC142671 mRNA. Translation: AAI42672.1. U08607 Genomic DNA. Translation: AAA87678.1.
IPI	IPI00001557.
RefSeq	NP_004585.1. NM_004594.2.
UniGene	Hs.439650.
3D structure databases
ProteinModelPortal	Q14940.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14940. 1 interaction.
STRING	9606.ENSP00000299798.
PTM databases
PhosphoSite	Q14940.
Polymorphism databases
DMDM	12644417.
Proteomic databases
PaxDb	Q14940.
PRIDE	Q14940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299798; ENSP00000299798; ENSG00000135740.
GeneID	6553.
KEGG	hsa:6553.
UCSC	uc002esm.3. human.
Organism-specific databases
CTD	6553.
GeneCards	GC16P067282.
HGNC	HGNC:11078. SLC9A5.
HPA	HPA041004. HPA041329.
MIM	600477. gene.
neXtProt	NX_Q14940.
PharmGKB	PA35934.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0025.
HOGENOM	HOG000247044.
HOVERGEN	HBG052615.
InParanoid	Q14940.
KO	K14723.
OMA	SHKSRTT.
OrthoDB	EOG4HQDHQ.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q14940.
Bgee	Q14940.
CleanEx	HS_SLC9A5.
Genevestigator	Q14940.
GermOnline	ENSG00000135740. Homo sapiens.
Family and domain databases
InterPro	IPR006153. Cation/H_exchanger. IPR018422. Cation/H_exchanger_CPA1. IPR018410. Na/H_exchanger_3/5. IPR004709. NaH_exchanger. [Graphical view]
PANTHER	PTHR10110. PTHR10110. 1 hit. PTHR10110:SF10. PTHR10110:SF10. 1 hit.
Pfam	PF00999. Na_H_Exchanger. 1 hit. [Graphical view]
PRINTS	PR01084. NAHEXCHNGR. PR01087. NAHEXCHNGR3.
TIGRFAMs	TIGR00840. b_cpa1. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q14940.
ChEMBL	CHEMBL3058.
GenomeRNAi	6553.
NextBio	25499.
SOURCE	Search...

Entry information

Entry name

SL9A5_HUMAN

Accession

Primary (citable) accession number: Q14940
Secondary accession number(s): A5PKY7, Q9Y626

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents