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Q14940

- SL9A5_HUMAN

UniProt

Q14940 - SL9A5_HUMAN

Protein

Sodium/hydrogen exchanger 5

Gene

SLC9A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction By similarity.By similarity

    GO - Molecular functioni

    1. sodium:proton antiporter activity Source: ProtInc

    GO - Biological processi

    1. ion transport Source: Reactome
    2. regulation of pH Source: InterPro
    3. sodium ion transmembrane transport Source: GOC
    4. transmembrane transport Source: Reactome
    5. transport Source: ProtInc

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19314. Sodium/Proton exchangers.

    Protein family/group databases

    TCDBi2.A.36.1.16. the monovalent cation:proton antiporter-1 (cpa1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchanger 5
    Alternative name(s):
    Na(+)/H(+) exchanger 5
    Short name:
    NHE-5
    Solute carrier family 9 member 5
    Gene namesi
    Name:SLC9A5
    Synonyms:NHE5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11078. SLC9A5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35934.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 896896Sodium/hydrogen exchanger 5PRO_0000052360Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated (Possible).

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ14940.
    PRIDEiQ14940.

    PTM databases

    PhosphoSiteiQ14940.

    Expressioni

    Tissue specificityi

    Expressed in brain, testis, spleen, and skeletal muscle.

    Gene expression databases

    ArrayExpressiQ14940.
    BgeeiQ14940.
    CleanExiHS_SLC9A5.
    GenevestigatoriQ14940.

    Organism-specific databases

    HPAiHPA041004.
    HPA041329.

    Interactioni

    Subunit structurei

    Interacts with CHP1 and CHP2 By similarity. Interacts with ARRB2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi112442. 5 interactions.
    IntActiQ14940. 1 interaction.
    STRINGi9606.ENSP00000299798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14940.
    SMRiQ14940. Positions 197-222, 287-314, 453-495, 599-652.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0025.
    HOGENOMiHOG000247044.
    HOVERGENiHBG052615.
    InParanoidiQ14940.
    KOiK14723.
    OMAiKKDGVAN.
    OrthoDBiEOG7KQ20Z.
    PhylomeDBiQ14940.
    TreeFamiTF317212.

    Family and domain databases

    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR018410. Na/H_exchanger_3/5.
    IPR004709. NaH_exchanger.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PfamiPF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    PRINTSiPR01084. NAHEXCHNGR.
    PR01087. NAHEXCHNGR3.
    TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q14940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRAALSLLA LPLAGAAEEP TQKPESPGEP PPGLELFRWQ WHEVEAPYLV    50
    ALWILVASLA KIVFHLSRKV TSLVPESCLL ILLGLVLGGI VLAVAKKAEY 100
    QLEPGTFFLF LLPPIVLDSG YFMPSRLFFD NLGAILTYAV VGTLWNAFTT 150
    GAALWGLQQA GLVAPRVQAG LLDFLLFGSL ISAVDPVAVL AVFEEVHVNE 200
    TLFIIVFGES LLNDAVTVVL YKVCNSFVEM GSANVQATDY LKGVASLFVV 250
    SLGGAAVGLV FAFLLALTTR FTKRVRIIEP LLVFLLAYAA YLTAEMASLS 300
    AILAVTMCGL GCKKYVEANI SHKSRTTVKY TMKTLASCAE TVIFMLLGIS 350
    AVDSSKWAWD SGLVLGTLIF ILFFRALGVV LQTWVLNQFR LVPLDKIDQV 400
    VMSYGGLRGA VAFALVILLD RTKVPAKDYF VATTIVVVFF TVIVQGLTIK 450
    PLVKWLKVKR SEHHKPTLNQ ELHEHTFDHI LAAVEDVVGH HGYHYWRDRW 500
    EQFDKKYLSQ LLMRRSAYRI RDQIWDVYYR LNIRDAISFV DQGGHVLSST 550
    GLTLPSMPSR NSVAETSVTN LLRESGSGAC LDLQVIDTVR SGRDREDAVM 600
    HHLLCGGLYK PRRRYKASCS RHFISEDAQE RQDKEVFQQN MKRRLESFKS 650
    TKHNICFTKS KPRPRKTGRR KKDGVANAEA TNGKHRGLGF QDTAAVILTV 700
    ESEEEEEESD SSETEKEDDE GIIFVARATS EVLQEGKVSG SLEVCPSPRI 750
    IPPSPTCAEK ELPWKSGQGD LAVYVSSETT KIVPVDMQTG WNQSISSLES 800
    LASPPCNQAP ILTCLPPHPR GTEEPQVPLH LPSDPRSSFA FPPSLAKAGR 850
    SRSESSADLP QQQELQPLMG HKDHTHLSPG TATSHWCIQF NRGSRL 896
    Length:896
    Mass (Da):99,011
    Last modified:December 1, 2000 - v2
    Checksum:iB9D234BFE0922269
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021L → V in AAA87678. (PubMed:7759094)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111173 mRNA. Translation: AAC98696.1.
    CH471092 Genomic DNA. Translation: EAW83114.1.
    BC142671 mRNA. Translation: AAI42672.1.
    U08607 Genomic DNA. Translation: AAA87678.1.
    CCDSiCCDS42178.1.
    RefSeqiNP_004585.1. NM_004594.2.
    UniGeneiHs.439650.

    Genome annotation databases

    EnsembliENST00000299798; ENSP00000299798; ENSG00000135740.
    GeneIDi6553.
    KEGGihsa:6553.
    UCSCiuc002esm.3. human.

    Polymorphism databases

    DMDMi12644417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111173 mRNA. Translation: AAC98696.1 .
    CH471092 Genomic DNA. Translation: EAW83114.1 .
    BC142671 mRNA. Translation: AAI42672.1 .
    U08607 Genomic DNA. Translation: AAA87678.1 .
    CCDSi CCDS42178.1.
    RefSeqi NP_004585.1. NM_004594.2.
    UniGenei Hs.439650.

    3D structure databases

    ProteinModelPortali Q14940.
    SMRi Q14940. Positions 197-222, 287-314, 453-495, 599-652.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112442. 5 interactions.
    IntActi Q14940. 1 interaction.
    STRINGi 9606.ENSP00000299798.

    Chemistry

    BindingDBi Q14940.
    ChEMBLi CHEMBL3058.

    Protein family/group databases

    TCDBi 2.A.36.1.16. the monovalent cation:proton antiporter-1 (cpa1) family.

    PTM databases

    PhosphoSitei Q14940.

    Polymorphism databases

    DMDMi 12644417.

    Proteomic databases

    PaxDbi Q14940.
    PRIDEi Q14940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299798 ; ENSP00000299798 ; ENSG00000135740 .
    GeneIDi 6553.
    KEGGi hsa:6553.
    UCSCi uc002esm.3. human.

    Organism-specific databases

    CTDi 6553.
    GeneCardsi GC16P067282.
    HGNCi HGNC:11078. SLC9A5.
    HPAi HPA041004.
    HPA041329.
    MIMi 600477. gene.
    neXtProti NX_Q14940.
    PharmGKBi PA35934.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0025.
    HOGENOMi HOG000247044.
    HOVERGENi HBG052615.
    InParanoidi Q14940.
    KOi K14723.
    OMAi KKDGVAN.
    OrthoDBi EOG7KQ20Z.
    PhylomeDBi Q14940.
    TreeFami TF317212.

    Enzyme and pathway databases

    Reactomei REACT_19314. Sodium/Proton exchangers.

    Miscellaneous databases

    GeneWikii SLC9A5.
    GenomeRNAii 6553.
    NextBioi 25499.
    PROi Q14940.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14940.
    Bgeei Q14940.
    CleanExi HS_SLC9A5.
    Genevestigatori Q14940.

    Family and domain databases

    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR018410. Na/H_exchanger_3/5.
    IPR004709. NaH_exchanger.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    Pfami PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    PRINTSi PR01084. NAHEXCHNGR.
    PR01087. NAHEXCHNGR3.
    TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain."
      Baird N.R., Orlowski J., Szabo E.Z., Zaun H.C., Schultheis P.J., Menon A.G., Shull G.E.
      J. Biol. Chem. 274:4377-4382(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1."
      Klanke C.A., Su Y.R., Callen D.F., Wang Z., Meneton P., Baird N., Kandasamy R.A., Orlowski J., Otterud B.E., Leppert M., Shull G.E., Menon A.G.
      Genomics 25:615-622(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-218.
    5. "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform."
      Szabo E.Z., Numata M., Lukashova V., Iannuzzi P., Orlowski J.
      Proc. Natl. Acad. Sci. U.S.A. 102:2790-2795(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB2.

    Entry informationi

    Entry nameiSL9A5_HUMAN
    AccessioniPrimary (citable) accession number: Q14940
    Secondary accession number(s): A5PKY7, Q9Y626
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3