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Q14940 (SL9A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/hydrogen exchanger 5
Alternative name(s):
Na(+)/H(+) exchanger 5
Short name=NHE-5
Solute carrier family 9 member 5
Gene names
Name:SLC9A5
Synonyms:NHE5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length896 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction By similarity.

Subunit structure

Interacts with CHP1 and CHP2 By similarity. Interacts with ARRB2. Ref.5

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain, testis, spleen, and skeletal muscle.

Post-translational modification

Phosphorylated (Possible).

Sequence similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 896896Sodium/hydrogen exchanger 5
PRO_0000052360

Regions

Transmembrane46 – 6621Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane277 – 29721Helical; Potential
Transmembrane332 – 35221Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane399 – 41921Helical; Potential
Transmembrane429 – 44921Helical; Potential

Amino acid modifications

Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation3191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2021L → V in AAA87678. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q14940 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: B9D234BFE0922269

FASTA89699,011
        10         20         30         40         50         60 
MLRAALSLLA LPLAGAAEEP TQKPESPGEP PPGLELFRWQ WHEVEAPYLV ALWILVASLA 

        70         80         90        100        110        120 
KIVFHLSRKV TSLVPESCLL ILLGLVLGGI VLAVAKKAEY QLEPGTFFLF LLPPIVLDSG 

       130        140        150        160        170        180 
YFMPSRLFFD NLGAILTYAV VGTLWNAFTT GAALWGLQQA GLVAPRVQAG LLDFLLFGSL 

       190        200        210        220        230        240 
ISAVDPVAVL AVFEEVHVNE TLFIIVFGES LLNDAVTVVL YKVCNSFVEM GSANVQATDY 

       250        260        270        280        290        300 
LKGVASLFVV SLGGAAVGLV FAFLLALTTR FTKRVRIIEP LLVFLLAYAA YLTAEMASLS 

       310        320        330        340        350        360 
AILAVTMCGL GCKKYVEANI SHKSRTTVKY TMKTLASCAE TVIFMLLGIS AVDSSKWAWD 

       370        380        390        400        410        420 
SGLVLGTLIF ILFFRALGVV LQTWVLNQFR LVPLDKIDQV VMSYGGLRGA VAFALVILLD 

       430        440        450        460        470        480 
RTKVPAKDYF VATTIVVVFF TVIVQGLTIK PLVKWLKVKR SEHHKPTLNQ ELHEHTFDHI 

       490        500        510        520        530        540 
LAAVEDVVGH HGYHYWRDRW EQFDKKYLSQ LLMRRSAYRI RDQIWDVYYR LNIRDAISFV 

       550        560        570        580        590        600 
DQGGHVLSST GLTLPSMPSR NSVAETSVTN LLRESGSGAC LDLQVIDTVR SGRDREDAVM 

       610        620        630        640        650        660 
HHLLCGGLYK PRRRYKASCS RHFISEDAQE RQDKEVFQQN MKRRLESFKS TKHNICFTKS 

       670        680        690        700        710        720 
KPRPRKTGRR KKDGVANAEA TNGKHRGLGF QDTAAVILTV ESEEEEEESD SSETEKEDDE 

       730        740        750        760        770        780 
GIIFVARATS EVLQEGKVSG SLEVCPSPRI IPPSPTCAEK ELPWKSGQGD LAVYVSSETT 

       790        800        810        820        830        840 
KIVPVDMQTG WNQSISSLES LASPPCNQAP ILTCLPPHPR GTEEPQVPLH LPSDPRSSFA 

       850        860        870        880        890 
FPPSLAKAGR SRSESSADLP QQQELQPLMG HKDHTHLSPG TATSHWCIQF NRGSRL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain."
Baird N.R., Orlowski J., Szabo E.Z., Zaun H.C., Schultheis P.J., Menon A.G., Shull G.E.
J. Biol. Chem. 274:4377-4382(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1."
Klanke C.A., Su Y.R., Callen D.F., Wang Z., Meneton P., Baird N., Kandasamy R.A., Orlowski J., Otterud B.E., Leppert M., Shull G.E., Menon A.G.
Genomics 25:615-622(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-218.
[5]"beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform."
Szabo E.Z., Numata M., Lukashova V., Iannuzzi P., Orlowski J.
Proc. Natl. Acad. Sci. U.S.A. 102:2790-2795(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARRB2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF111173 mRNA. Translation: AAC98696.1.
CH471092 Genomic DNA. Translation: EAW83114.1.
BC142671 mRNA. Translation: AAI42672.1.
U08607 Genomic DNA. Translation: AAA87678.1.
CCDSCCDS42178.1.
RefSeqNP_004585.1. NM_004594.2.
UniGeneHs.439650.

3D structure databases

ProteinModelPortalQ14940.
SMRQ14940. Positions 197-222, 287-314, 453-495, 599-652.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112442. 5 interactions.
IntActQ14940. 1 interaction.
STRING9606.ENSP00000299798.

Chemistry

BindingDBQ14940.
ChEMBLCHEMBL3058.

Protein family/group databases

TCDB2.A.36.1.16. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSiteQ14940.

Polymorphism databases

DMDM12644417.

Proteomic databases

PaxDbQ14940.
PRIDEQ14940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299798; ENSP00000299798; ENSG00000135740.
GeneID6553.
KEGGhsa:6553.
UCSCuc002esm.3. human.

Organism-specific databases

CTD6553.
GeneCardsGC16P067282.
HGNCHGNC:11078. SLC9A5.
HPAHPA041004.
HPA041329.
MIM600477. gene.
neXtProtNX_Q14940.
PharmGKBPA35934.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0025.
HOGENOMHOG000247044.
HOVERGENHBG052615.
InParanoidQ14940.
KOK14723.
OMAKKDGVAN.
OrthoDBEOG7KQ20Z.
PhylomeDBQ14940.
TreeFamTF317212.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ14940.
BgeeQ14940.
CleanExHS_SLC9A5.
GenevestigatorQ14940.

Family and domain databases

InterProIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERPTHR10110. PTHR10110. 1 hit.
PfamPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsTIGR00840. b_cpa1. 1 hit.
ProtoNetSearch...

Other

GeneWikiSLC9A5.
GenomeRNAi6553.
NextBio25499.
PROQ14940.
SOURCESearch...

Entry information

Entry nameSL9A5_HUMAN
AccessionPrimary (citable) accession number: Q14940
Secondary accession number(s): A5PKY7, Q9Y626
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM