Q14934 (NFAC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear factor of activated T-cells, cytoplasmic 4
Short name=NF-ATc4
Short name=NFATc4

Alternative name(s):
T-cell transcription factor NFAT3
Short name=NF-AT3

Gene names

Name:	NFATC4
Synonyms:	NFAT3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	902 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. Ref.1 Ref.7 Ref.9 Ref.10
Subunit structure	Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. Interacts with CREBBP, GATA4, IRAK1, MAPK8, MAPK9 and RPS6KA3. Ref.6 Ref.8 Ref.9 Ref.14
Subcellular location	Cytoplasm. Nucleus. Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Ref.13
Tissue specificity	Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. Ref.2
Domain	Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors By similarity.
Post-translational modification	Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B. Ref.7 Ref.8 Ref.9 Ref.11 Ref.13 Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through 'Lys-48'. Ref.11
Sequence similarities	Contains 1 IPT/TIG domain. Contains 1 RHD (Rel-like) domain.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular respiration Inferred from electronic annotation. Source: Compara cellular response to UV Inferred from electronic annotation. Source: Compara cellular response to lithium ion Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara inflammatory response Traceable author statement Ref.1. Source: ProtInc muscle cell development Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA cytosol Inferred from electronic annotation. Source: Compara intermediate filament cytoskeleton Inferred from direct assay. Source: HPA transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: Compara transcription coactivator activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 24 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14934-1)

Also known as: ID-IXL;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14934-2)

Also known as: IA-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MITTLPSLLPASLASISHRVTNLPSNSLSHNPGLSKPDFPGNSSPGLPSSSSPGRDLGAPAGSM

Isoform 3 (identifier: Q14934-3)

Also known as: IA-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MITTLPSLLPASLASISHRVTNLPSNSLSHNPGLSKPDFPGNSSPGLPSSSSPGRDLGAPAGSM
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 4 (identifier: Q14934-4)

Also known as: IC-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADGGADSAAQRLPEGPGRVAPGRDLGAPAGSM

Isoform 5 (identifier: Q14934-5)

Also known as: IC-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADGGADSAAQRLPEGPGRVAPGRDLGAPAGSM
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 6 (identifier: Q14934-6)

Also known as: IB-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSGRDLGAPAGSM

Isoform 7 (identifier: Q14934-7)

Also known as: IB-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSGRDLGAPAGSM
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 8 (identifier: Q14934-8)

Also known as: ID-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 9 (identifier: Q14934-9)

Also known as: IE-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MGAASCEDEELEFKLVFGEEKEAPPLGAGGLG → MPASISSIFPGPTLLLSCGS

Isoform 10 (identifier: Q14934-10)

Also known as: IE-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MGAASCEDEELEFKLVFGEEKEAPPLGAGGLG → MPASISSIFPGPTLLLSCGS
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 11 (identifier: Q14934-11)

Also known as: IA-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MITTLPSLLPASLASISHRVTNLPSNSLSHNPGLSKPDFPGNSSPGLPSSSSPGRDLGAPAGSM
     773-880: Missing.

Isoform 12 (identifier: Q14934-12)

Also known as: IEi-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: Due to an intron retention.

Isoform 13 (identifier: Q14934-13)

Also known as: IEi-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 14 (identifier: Q14934-14)

Also known as: IC-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADGGADSAAQRLPEGPGRVAPGRDLGAPAGSM
     773-880: Missing.

Isoform 15 (identifier: Q14934-15)

Also known as: IB-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSGRDLGAPAGSM
     773-880: Missing.

Isoform 16 (identifier: Q14934-16)

Also known as: ID-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     773-880: Missing.

Isoform 17 (identifier: Q14934-17)

Also known as: IE-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MGAASCEDEELEFKLVFGEEKEAPPLGAGGLG → MPASISSIFPGPTLLLSCGS
     773-880: Missing.

Isoform 18 (identifier: Q14934-18)

Also known as: IEi-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     773-880: Missing.

Note: Due to an intron retention.

Isoform 19 (identifier: Q14934-19)

Also known as: IV-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-465: Missing.

Isoform 20 (identifier: Q14934-20)

Also known as: IV-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-465: Missing.
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 21 (identifier: Q14934-21)

Also known as: IV-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-465: Missing.
     773-880: Missing.

Isoform 22 (identifier: Q14934-22)

Also known as: VI-IXL;

The sequence of this isoform differs from the canonical sequence as follows:
     1-712: Missing.

Isoform 23 (identifier: Q14934-23)

Also known as: VI-IXi;

The sequence of this isoform differs from the canonical sequence as follows:
     1-712: Missing.
     881-902: VSEIIGRDLSGFPAPPGEEPPA → GGCGTGGCECECVQEIALHVC

Note: Due to an intron retention.

Isoform 24 (identifier: Q14934-24)

Also known as: VI-IXS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-712: Missing.
     773-880: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 902

902

Nuclear factor of activated T-cells, cytoplasmic 4

PRO_0000205182

Regions

Repeat

213 – 229

17

SP 1

Repeat

277 – 293

17

SP 2; approximate

Domain

401 – 582

182

RHD

Domain

586 – 683

98

IPT/TIG

DNA binding

430 – 437

8

Region

114 – 119

6

Calcineurin-binding

Region

213 – 293

81

2 approximate SP repeats

Motif

268 – 270

3

Nuclear localization signal

Motif

672 – 674

3

Nuclear localization signal

Compositional bias

41 – 327

287

Pro-rich

Compositional bias

717 – 836

120

Pro-rich

Amino acid modifications

Modified residue

168

1

Phosphoserine; by MAPK7 and MAPK14 Ref.7 Ref.13

Modified residue

170

1

Phosphoserine; by MAPK7 and MAPK14 Ref.7 Ref.13

Modified residue

213

1

Phosphoserine; by MAPK8 and MAPK9 Ref.8

Modified residue

217

1

Phosphoserine; by MAPK8 and MAPK9 Ref.8

Modified residue

289

1

Phosphoserine; by RPS6KA3 Ref.9

Modified residue

334

1

Phosphoserine; by RPS6KA3

Natural variations

Alternative sequence

1 – 712

712

Missing in isoform 22, isoform 23 and isoform 24.

VSP_036697

Alternative sequence

1 – 465

465

Missing in isoform 19, isoform 20 and isoform 21.

VSP_036698

Alternative sequence

1 – 70

70

Missing in isoform 12, isoform 13 and isoform 18.

VSP_036699

Alternative sequence

1 – 32

32

MGAAS…AGGLG → MPASISSIFPGPTLLLSCGS in isoform 9, isoform 10 and isoform 17.

VSP_036700

Alternative sequence

1

1

M → MITTLPSLLPASLASISHRV TNLPSNSLSHNPGLSKPDFP GNSSPGLPSSSSPGRDLGAP AGSM in isoform 2, isoform 3 and isoform 11.

VSP_036701

Alternative sequence

1

1

M → MADGGADSAAQRLPEGPGRV APGRDLGAPAGSM in isoform 4, isoform 5 and isoform 14.

VSP_036702

Alternative sequence

1

1

M → MLSGRDLGAPAGSM in isoform 6, isoform 7 and isoform 15.

VSP_036703

Alternative sequence

773 – 880

108

Missing in isoform 11, isoform 14, isoform 15, isoform 16, isoform 17, isoform 18, isoform 21 and isoform 24.

VSP_036704

Alternative sequence

881 – 902

22

VSEII…EEPPA → GGCGTGGCECECVQEIALHV C in isoform 3, isoform 5, isoform 7, isoform 8, isoform 10, isoform 13, isoform 20 and isoform 23.

VSP_036705

Natural variant

160

1

G → A. Ref.1 Ref.4
Corresponds to variant rs2229309 [ dbSNP | Ensembl ].

VAR_046985

Natural variant

246

1

S → N.
Corresponds to variant rs2228231 [ dbSNP | Ensembl ].

VAR_046986

Natural variant

800

1

S → P. Ref.1 Ref.4
Corresponds to variant rs7149586 [ dbSNP | Ensembl ].

VAR_046987

Experimental info

Mutagenesis

168

1

S → A: Promotes nuclear localization and increases transcriptional activity; when associated with A-170. Ref.7

Mutagenesis

170

1

S → A: Promotes nuclear localization and increases transcriptional activity; when associated with A-168. Ref.7

Mutagenesis

213

1

S → A: Decreased transcriptional activity; when associated with A-217. Ref.8

Mutagenesis

217

1

S → A: Decreased transcriptional activity; when associated with A-213. Ref.8

Sequence conflict

359

1

E → K in BAG56726. Ref.3

Sequence conflict

646

1

L → P in BAG63617. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

902

Helix Strand Turn

Details...

Beta strand

587 – 594

8

Beta strand

602 – 610

9

Beta strand

616 – 620

5

Turn

638 – 640

3

Beta strand

645 – 649

5

Beta strand

662 – 669

8

Beta strand

671 – 673

3

Beta strand

679 – 684

6

Beta strand

687 – 689

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ID-IXL) [UniParc]. Last modified November 25, 2008. Version 2. Checksum: AE94C5D1325D24D7	FASTA	902	95,449
	10 20 30 40 50 60 MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE PPPYGAAPIG 70 80 90 100 110 120 IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS 130 140 150 160 170 180 ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 190 200 210 220 230 240 FFSDASDEAA LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG 250 260 270 280 290 300 RGPEDSWLLL SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 310 320 330 340 350 360 PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE 370 380 390 400 410 420 SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 430 440 450 460 470 480 IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA 490 500 510 520 530 540 FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 550 560 570 580 590 600 TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 610 620 630 640 650 660 GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR 670 680 690 700 710 720 PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP 730 740 750 760 770 780 PYPSYPHEDP ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV 790 800 810 820 830 840 SFLPRPFPSD PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY 850 860 870 880 890 900 NKVGPGYGPG EGAPEQEKSR GGYSSGFRDS VPIQGITLEE VSEIIGRDLS GFPAPPGEEP PA
	Isoform 2 (IA-IXL) [UniParc]. Checksum: 977A42276D24A2DD	FASTA	965	101,680
	10 20 30 40 50 60 MITTLPSLLP ASLASISHRV TNLPSNSLSH NPGLSKPDFP GNSSPGLPSS SSPGRDLGAP 70 80 90 100 110 120 AGSMGAASCE DEELEFKLVF GEEKEAPPLG AGGLGEELDS EDAPPCCRLA LGEPPPYGAA 130 140 150 160 170 180 PIGIPRPPPP RPGMHSPPPR PAPSPGTWES QPARSVRLGG PGGGAGGAGG GRVLECPSIR 190 200 210 220 230 240 ITSISPTPEP PAALEDNPDA WGDGSPRDYP PPEGFGGYRE AGGQGGGAFF SPSPGSSSLS 250 260 270 280 290 300 SWSFFSDASD EAALYAACDE VESELNEAAS RFGLGSPLPS PRASPRPWTP EDPWSLYGPS 310 320 330 340 350 360 PGGRGPEDSW LLLSAPGPTP ASPRPASPCG KRRYSSSGTP SSASPALSRR GSLGEEGSEP 370 380 390 400 410 420 PPPPPLPLAR DPGSPGPFDY VGAPPAESIP QKTRRTSSEQ AVALPRSEEP ASCNGKLPLG 430 440 450 460 470 480 AEESVAPPGG SRKEVAGMDY LAVPSPLAWS KARIGGHSPI FRTSALPPLD WPLPSQYEQL 490 500 510 520 530 540 ELRIEVQPRA HHRAHYETEG SRGAVKAAPG GHPVVKLLGY SEKPLTLQMF IGTADERNLR 550 560 570 580 590 600 PHAFYQVHRI TGKMVATASY EAVVSGTKVL EMTLLPENNM AANIDCAGIL KLRNSDIELR 610 620 630 640 650 660 KGETDIGRKN TRVRLVFRVH VPQGGGKVVS VQAASVPIEC SQRSAQELPQ VEAYSPSACS 670 680 690 700 710 720 VRGGEELVLT GSNFLPDSKV VFIERGPDGK LQWEEEATVN RLQSNEVTLT LTVPEYSNKR 730 740 750 760 770 780 VSRPVQVYFY VSNGRRKRSP TQSFRFLPVI CKEEPLPDSS LRGFPSASAT PFGTDMDFSP 790 800 810 820 830 840 PRPPYPSYPH EDPACETPYL SEGFGYGMPP LYPQTGPPPS YRPGLRMFPE TRGTTGCAQP 850 860 870 880 890 900 PAVSFLPRPF PSDPYGGRGS SFSLGLPFSP PAPFRPPPLP ASPPLEGPFP SQSDVHPLPA 910 920 930 940 950 960 EGYNKVGPGY GPGEGAPEQE KSRGGYSSGF RDSVPIQGIT LEEVSEIIGR DLSGFPAPPG EEPPA
	Isoform 3 (IA-IXi) [UniParc]. Checksum: 91DDEA6EACD24AD1	FASTA	964	101,513
	10 20 30 40 50 60 MITTLPSLLP ASLASISHRV TNLPSNSLSH NPGLSKPDFP GNSSPGLPSS SSPGRDLGAP 70 80 90 100 110 120 AGSMGAASCE DEELEFKLVF GEEKEAPPLG AGGLGEELDS EDAPPCCRLA LGEPPPYGAA 130 140 150 160 170 180 PIGIPRPPPP RPGMHSPPPR PAPSPGTWES QPARSVRLGG PGGGAGGAGG GRVLECPSIR 190 200 210 220 230 240 ITSISPTPEP PAALEDNPDA WGDGSPRDYP PPEGFGGYRE AGGQGGGAFF SPSPGSSSLS 250 260 270 280 290 300 SWSFFSDASD EAALYAACDE VESELNEAAS RFGLGSPLPS PRASPRPWTP EDPWSLYGPS 310 320 330 340 350 360 PGGRGPEDSW LLLSAPGPTP ASPRPASPCG KRRYSSSGTP SSASPALSRR GSLGEEGSEP 370 380 390 400 410 420 PPPPPLPLAR DPGSPGPFDY VGAPPAESIP QKTRRTSSEQ AVALPRSEEP ASCNGKLPLG 430 440 450 460 470 480 AEESVAPPGG SRKEVAGMDY LAVPSPLAWS KARIGGHSPI FRTSALPPLD WPLPSQYEQL 490 500 510 520 530 540 ELRIEVQPRA HHRAHYETEG SRGAVKAAPG GHPVVKLLGY SEKPLTLQMF IGTADERNLR 550 560 570 580 590 600 PHAFYQVHRI TGKMVATASY EAVVSGTKVL EMTLLPENNM AANIDCAGIL KLRNSDIELR 610 620 630 640 650 660 KGETDIGRKN TRVRLVFRVH VPQGGGKVVS VQAASVPIEC SQRSAQELPQ VEAYSPSACS 670 680 690 700 710 720 VRGGEELVLT GSNFLPDSKV VFIERGPDGK LQWEEEATVN RLQSNEVTLT LTVPEYSNKR 730 740 750 760 770 780 VSRPVQVYFY VSNGRRKRSP TQSFRFLPVI CKEEPLPDSS LRGFPSASAT PFGTDMDFSP 790 800 810 820 830 840 PRPPYPSYPH EDPACETPYL SEGFGYGMPP LYPQTGPPPS YRPGLRMFPE TRGTTGCAQP 850 860 870 880 890 900 PAVSFLPRPF PSDPYGGRGS SFSLGLPFSP PAPFRPPPLP ASPPLEGPFP SQSDVHPLPA 910 920 930 940 950 960 EGYNKVGPGY GPGEGAPEQE KSRGGYSSGF RDSVPIQGIT LEEGGCGTGG CECECVQEIA LHVC
	Isoform 4 (IC-IXL) [UniParc]. Checksum: E72E379E8F1087A2	FASTA	934	98,436
	10 20 30 40 50 60 MADGGADSAA QRLPEGPGRV APGRDLGAPA GSMGAASCED EELEFKLVFG EEKEAPPLGA 70 80 90 100 110 120 GGLGEELDSE DAPPCCRLAL GEPPPYGAAP IGIPRPPPPR PGMHSPPPRP APSPGTWESQ 130 140 150 160 170 180 PARSVRLGGP GGGAGGAGGG RVLECPSIRI TSISPTPEPP AALEDNPDAW GDGSPRDYPP 190 200 210 220 230 240 PEGFGGYREA GGQGGGAFFS PSPGSSSLSS WSFFSDASDE AALYAACDEV ESELNEAASR 250 260 270 280 290 300 FGLGSPLPSP RASPRPWTPE DPWSLYGPSP GGRGPEDSWL LLSAPGPTPA SPRPASPCGK 310 320 330 340 350 360 RRYSSSGTPS SASPALSRRG SLGEEGSEPP PPPPLPLARD PGSPGPFDYV GAPPAESIPQ 370 380 390 400 410 420 KTRRTSSEQA VALPRSEEPA SCNGKLPLGA EESVAPPGGS RKEVAGMDYL AVPSPLAWSK 430 440 450 460 470 480 ARIGGHSPIF RTSALPPLDW PLPSQYEQLE LRIEVQPRAH HRAHYETEGS RGAVKAAPGG 490 500 510 520 530 540 HPVVKLLGYS EKPLTLQMFI GTADERNLRP HAFYQVHRIT GKMVATASYE AVVSGTKVLE 550 560 570 580 590 600 MTLLPENNMA ANIDCAGILK LRNSDIELRK GETDIGRKNT RVRLVFRVHV PQGGGKVVSV 610 620 630 640 650 660 QAASVPIECS QRSAQELPQV EAYSPSACSV RGGEELVLTG SNFLPDSKVV FIERGPDGKL 670 680 690 700 710 720 QWEEEATVNR LQSNEVTLTL TVPEYSNKRV SRPVQVYFYV SNGRRKRSPT QSFRFLPVIC 730 740 750 760 770 780 KEEPLPDSSL RGFPSASATP FGTDMDFSPP RPPYPSYPHE DPACETPYLS EGFGYGMPPL 790 800 810 820 830 840 YPQTGPPPSY RPGLRMFPET RGTTGCAQPP AVSFLPRPFP SDPYGGRGSS FSLGLPFSPP 850 860 870 880 890 900 APFRPPPLPA SPPLEGPFPS QSDVHPLPAE GYNKVGPGYG PGEGAPEQEK SRGGYSSGFR 910 920 930 DSVPIQGITL EEVSEIIGRD LSGFPAPPGE EPPA
	Isoform 5 (IC-IXi) [UniParc]. Checksum: B5A8538C98F73584	FASTA	933	98,269
	10 20 30 40 50 60 MADGGADSAA QRLPEGPGRV APGRDLGAPA GSMGAASCED EELEFKLVFG EEKEAPPLGA 70 80 90 100 110 120 GGLGEELDSE DAPPCCRLAL GEPPPYGAAP IGIPRPPPPR PGMHSPPPRP APSPGTWESQ 130 140 150 160 170 180 PARSVRLGGP GGGAGGAGGG RVLECPSIRI TSISPTPEPP AALEDNPDAW GDGSPRDYPP 190 200 210 220 230 240 PEGFGGYREA GGQGGGAFFS PSPGSSSLSS WSFFSDASDE AALYAACDEV ESELNEAASR 250 260 270 280 290 300 FGLGSPLPSP RASPRPWTPE DPWSLYGPSP GGRGPEDSWL LLSAPGPTPA SPRPASPCGK 310 320 330 340 350 360 RRYSSSGTPS SASPALSRRG SLGEEGSEPP PPPPLPLARD PGSPGPFDYV GAPPAESIPQ 370 380 390 400 410 420 KTRRTSSEQA VALPRSEEPA SCNGKLPLGA EESVAPPGGS RKEVAGMDYL AVPSPLAWSK 430 440 450 460 470 480 ARIGGHSPIF RTSALPPLDW PLPSQYEQLE LRIEVQPRAH HRAHYETEGS RGAVKAAPGG 490 500 510 520 530 540 HPVVKLLGYS EKPLTLQMFI GTADERNLRP HAFYQVHRIT GKMVATASYE AVVSGTKVLE 550 560 570 580 590 600 MTLLPENNMA ANIDCAGILK LRNSDIELRK GETDIGRKNT RVRLVFRVHV PQGGGKVVSV 610 620 630 640 650 660 QAASVPIECS QRSAQELPQV EAYSPSACSV RGGEELVLTG SNFLPDSKVV FIERGPDGKL 670 680 690 700 710 720 QWEEEATVNR LQSNEVTLTL TVPEYSNKRV SRPVQVYFYV SNGRRKRSPT QSFRFLPVIC 730 740 750 760 770 780 KEEPLPDSSL RGFPSASATP FGTDMDFSPP RPPYPSYPHE DPACETPYLS EGFGYGMPPL 790 800 810 820 830 840 YPQTGPPPSY RPGLRMFPET RGTTGCAQPP AVSFLPRPFP SDPYGGRGSS FSLGLPFSPP 850 860 870 880 890 900 APFRPPPLPA SPPLEGPFPS QSDVHPLPAE GYNKVGPGYG PGEGAPEQEK SRGGYSSGFR 910 920 930 DSVPIQGITL EEGGCGTGGC ECECVQEIAL HVC
	Isoform 6 (IB-IXL) [UniParc]. Checksum: 36C042AAF575636D	FASTA	915	96,662
	10 20 30 40 50 60 MLSGRDLGAP AGSMGAASCE DEELEFKLVF GEEKEAPPLG AGGLGEELDS EDAPPCCRLA 70 80 90 100 110 120 LGEPPPYGAA PIGIPRPPPP RPGMHSPPPR PAPSPGTWES QPARSVRLGG PGGGAGGAGG 130 140 150 160 170 180 GRVLECPSIR ITSISPTPEP PAALEDNPDA WGDGSPRDYP PPEGFGGYRE AGGQGGGAFF 190 200 210 220 230 240 SPSPGSSSLS SWSFFSDASD EAALYAACDE VESELNEAAS RFGLGSPLPS PRASPRPWTP 250 260 270 280 290 300 EDPWSLYGPS PGGRGPEDSW LLLSAPGPTP ASPRPASPCG KRRYSSSGTP SSASPALSRR 310 320 330 340 350 360 GSLGEEGSEP PPPPPLPLAR DPGSPGPFDY VGAPPAESIP QKTRRTSSEQ AVALPRSEEP 370 380 390 400 410 420 ASCNGKLPLG AEESVAPPGG SRKEVAGMDY LAVPSPLAWS KARIGGHSPI FRTSALPPLD 430 440 450 460 470 480 WPLPSQYEQL ELRIEVQPRA HHRAHYETEG SRGAVKAAPG GHPVVKLLGY SEKPLTLQMF 490 500 510 520 530 540 IGTADERNLR PHAFYQVHRI TGKMVATASY EAVVSGTKVL EMTLLPENNM AANIDCAGIL 550 560 570 580 590 600 KLRNSDIELR KGETDIGRKN TRVRLVFRVH VPQGGGKVVS VQAASVPIEC SQRSAQELPQ 610 620 630 640 650 660 VEAYSPSACS VRGGEELVLT GSNFLPDSKV VFIERGPDGK LQWEEEATVN RLQSNEVTLT 670 680 690 700 710 720 LTVPEYSNKR VSRPVQVYFY VSNGRRKRSP TQSFRFLPVI CKEEPLPDSS LRGFPSASAT 730 740 750 760 770 780 PFGTDMDFSP PRPPYPSYPH EDPACETPYL SEGFGYGMPP LYPQTGPPPS YRPGLRMFPE 790 800 810 820 830 840 TRGTTGCAQP PAVSFLPRPF PSDPYGGRGS SFSLGLPFSP PAPFRPPPLP ASPPLEGPFP 850 860 870 880 890 900 SQSDVHPLPA EGYNKVGPGY GPGEGAPEQE KSRGGYSSGF RDSVPIQGIT LEEVSEIIGR 910 DLSGFPAPPG EEPPA
	Isoform 7 (IB-IXi) [UniParc]. Checksum: CBDD67F6FD13FA0B	FASTA	914	96,495
	10 20 30 40 50 60 MLSGRDLGAP AGSMGAASCE DEELEFKLVF GEEKEAPPLG AGGLGEELDS EDAPPCCRLA 70 80 90 100 110 120 LGEPPPYGAA PIGIPRPPPP RPGMHSPPPR PAPSPGTWES QPARSVRLGG PGGGAGGAGG 130 140 150 160 170 180 GRVLECPSIR ITSISPTPEP PAALEDNPDA WGDGSPRDYP PPEGFGGYRE AGGQGGGAFF 190 200 210 220 230 240 SPSPGSSSLS SWSFFSDASD EAALYAACDE VESELNEAAS RFGLGSPLPS PRASPRPWTP 250 260 270 280 290 300 EDPWSLYGPS PGGRGPEDSW LLLSAPGPTP ASPRPASPCG KRRYSSSGTP SSASPALSRR 310 320 330 340 350 360 GSLGEEGSEP PPPPPLPLAR DPGSPGPFDY VGAPPAESIP QKTRRTSSEQ AVALPRSEEP 370 380 390 400 410 420 ASCNGKLPLG AEESVAPPGG SRKEVAGMDY LAVPSPLAWS KARIGGHSPI FRTSALPPLD 430 440 450 460 470 480 WPLPSQYEQL ELRIEVQPRA HHRAHYETEG SRGAVKAAPG GHPVVKLLGY SEKPLTLQMF 490 500 510 520 530 540 IGTADERNLR PHAFYQVHRI TGKMVATASY EAVVSGTKVL EMTLLPENNM AANIDCAGIL 550 560 570 580 590 600 KLRNSDIELR KGETDIGRKN TRVRLVFRVH VPQGGGKVVS VQAASVPIEC SQRSAQELPQ 610 620 630 640 650 660 VEAYSPSACS VRGGEELVLT GSNFLPDSKV VFIERGPDGK LQWEEEATVN RLQSNEVTLT 670 680 690 700 710 720 LTVPEYSNKR VSRPVQVYFY VSNGRRKRSP TQSFRFLPVI CKEEPLPDSS LRGFPSASAT 730 740 750 760 770 780 PFGTDMDFSP PRPPYPSYPH EDPACETPYL SEGFGYGMPP LYPQTGPPPS YRPGLRMFPE 790 800 810 820 830 840 TRGTTGCAQP PAVSFLPRPF PSDPYGGRGS SFSLGLPFSP PAPFRPPPLP ASPPLEGPFP 850 860 870 880 890 900 SQSDVHPLPA EGYNKVGPGY GPGEGAPEQE KSRGGYSSGF RDSVPIQGIT LEEGGCGTGG 910 CECECVQEIA LHVC
	Isoform 8 (ID-IXi) [UniParc]. Checksum: 2F5A1C31D55440FA	FASTA	901	95,282
	10 20 30 40 50 60 MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE PPPYGAAPIG 70 80 90 100 110 120 IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS 130 140 150 160 170 180 ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 190 200 210 220 230 240 FFSDASDEAA LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG 250 260 270 280 290 300 RGPEDSWLLL SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 310 320 330 340 350 360 PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE 370 380 390 400 410 420 SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 430 440 450 460 470 480 IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA 490 500 510 520 530 540 FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 550 560 570 580 590 600 TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 610 620 630 640 650 660 GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR 670 680 690 700 710 720 PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP 730 740 750 760 770 780 PYPSYPHEDP ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV 790 800 810 820 830 840 SFLPRPFPSD PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY 850 860 870 880 890 900 NKVGPGYGPG EGAPEQEKSR GGYSSGFRDS VPIQGITLEE GGCGTGGCEC ECVQEIALHV C
	Isoform 9 (IE-IXL) [UniParc]. Checksum: CD0C3EF25B5761B6	FASTA	890	94,146
	10 20 30 40 50 60 MPASISSIFP GPTLLLSCGS EELDSEDAPP CCRLALGEPP PYGAAPIGIP RPPPPRPGMH 70 80 90 100 110 120 SPPPRPAPSP GTWESQPARS VRLGGPGGGA GGAGGGRVLE CPSIRITSIS PTPEPPAALE 130 140 150 160 170 180 DNPDAWGDGS PRDYPPPEGF GGYREAGGQG GGAFFSPSPG SSSLSSWSFF SDASDEAALY 190 200 210 220 230 240 AACDEVESEL NEAASRFGLG SPLPSPRASP RPWTPEDPWS LYGPSPGGRG PEDSWLLLSA 250 260 270 280 290 300 PGPTPASPRP ASPCGKRRYS SSGTPSSASP ALSRRGSLGE EGSEPPPPPP LPLARDPGSP 310 320 330 340 350 360 GPFDYVGAPP AESIPQKTRR TSSEQAVALP RSEEPASCNG KLPLGAEESV APPGGSRKEV 370 380 390 400 410 420 AGMDYLAVPS PLAWSKARIG GHSPIFRTSA LPPLDWPLPS QYEQLELRIE VQPRAHHRAH 430 440 450 460 470 480 YETEGSRGAV KAAPGGHPVV KLLGYSEKPL TLQMFIGTAD ERNLRPHAFY QVHRITGKMV 490 500 510 520 530 540 ATASYEAVVS GTKVLEMTLL PENNMAANID CAGILKLRNS DIELRKGETD IGRKNTRVRL 550 560 570 580 590 600 VFRVHVPQGG GKVVSVQAAS VPIECSQRSA QELPQVEAYS PSACSVRGGE ELVLTGSNFL 610 620 630 640 650 660 PDSKVVFIER GPDGKLQWEE EATVNRLQSN EVTLTLTVPE YSNKRVSRPV QVYFYVSNGR 670 680 690 700 710 720 RKRSPTQSFR FLPVICKEEP LPDSSLRGFP SASATPFGTD MDFSPPRPPY PSYPHEDPAC 730 740 750 760 770 780 ETPYLSEGFG YGMPPLYPQT GPPPSYRPGL RMFPETRGTT GCAQPPAVSF LPRPFPSDPY 790 800 810 820 830 840 GGRGSSFSLG LPFSPPAPFR PPPLPASPPL EGPFPSQSDV HPLPAEGYNK VGPGYGPGEG 850 860 870 880 890 APEQEKSRGG YSSGFRDSVP IQGITLEEVS EIIGRDLSGF PAPPGEEPPA
	Isoform 10 (IE-IXi) [UniParc]. Checksum: E7A13F58DF1121B1	FASTA	889	93,978
	10 20 30 40 50 60 MPASISSIFP GPTLLLSCGS EELDSEDAPP CCRLALGEPP PYGAAPIGIP RPPPPRPGMH 70 80 90 100 110 120 SPPPRPAPSP GTWESQPARS VRLGGPGGGA GGAGGGRVLE CPSIRITSIS PTPEPPAALE 130 140 150 160 170 180 DNPDAWGDGS PRDYPPPEGF GGYREAGGQG GGAFFSPSPG SSSLSSWSFF SDASDEAALY 190 200 210 220 230 240 AACDEVESEL NEAASRFGLG SPLPSPRASP RPWTPEDPWS LYGPSPGGRG PEDSWLLLSA 250 260 270 280 290 300 PGPTPASPRP ASPCGKRRYS SSGTPSSASP ALSRRGSLGE EGSEPPPPPP LPLARDPGSP 310 320 330 340 350 360 GPFDYVGAPP AESIPQKTRR TSSEQAVALP RSEEPASCNG KLPLGAEESV APPGGSRKEV 370 380 390 400 410 420 AGMDYLAVPS PLAWSKARIG GHSPIFRTSA LPPLDWPLPS QYEQLELRIE VQPRAHHRAH 430 440 450 460 470 480 YETEGSRGAV KAAPGGHPVV KLLGYSEKPL TLQMFIGTAD ERNLRPHAFY QVHRITGKMV 490 500 510 520 530 540 ATASYEAVVS GTKVLEMTLL PENNMAANID CAGILKLRNS DIELRKGETD IGRKNTRVRL 550 560 570 580 590 600 VFRVHVPQGG GKVVSVQAAS VPIECSQRSA QELPQVEAYS PSACSVRGGE ELVLTGSNFL 610 620 630 640 650 660 PDSKVVFIER GPDGKLQWEE EATVNRLQSN EVTLTLTVPE YSNKRVSRPV QVYFYVSNGR 670 680 690 700 710 720 RKRSPTQSFR FLPVICKEEP LPDSSLRGFP SASATPFGTD MDFSPPRPPY PSYPHEDPAC 730 740 750 760 770 780 ETPYLSEGFG YGMPPLYPQT GPPPSYRPGL RMFPETRGTT GCAQPPAVSF LPRPFPSDPY 790 800 810 820 830 840 GGRGSSFSLG LPFSPPAPFR PPPLPASPPL EGPFPSQSDV HPLPAEGYNK VGPGYGPGEG 850 860 870 880 APEQEKSRGG YSSGFRDSVP IQGITLEEGG CGTGGCECEC VQEIALHVC
	Isoform 11 (IA-IXS) [UniParc]. Checksum: AA5ED1F6E0713077	FASTA	857	90,525
	10 20 30 40 50 60 MITTLPSLLP ASLASISHRV TNLPSNSLSH NPGLSKPDFP GNSSPGLPSS SSPGRDLGAP 70 80 90 100 110 120 AGSMGAASCE DEELEFKLVF GEEKEAPPLG AGGLGEELDS EDAPPCCRLA LGEPPPYGAA 130 140 150 160 170 180 PIGIPRPPPP RPGMHSPPPR PAPSPGTWES QPARSVRLGG PGGGAGGAGG GRVLECPSIR 190 200 210 220 230 240 ITSISPTPEP PAALEDNPDA WGDGSPRDYP PPEGFGGYRE AGGQGGGAFF SPSPGSSSLS 250 260 270 280 290 300 SWSFFSDASD EAALYAACDE VESELNEAAS RFGLGSPLPS PRASPRPWTP EDPWSLYGPS 310 320 330 340 350 360 PGGRGPEDSW LLLSAPGPTP ASPRPASPCG KRRYSSSGTP SSASPALSRR GSLGEEGSEP 370 380 390 400 410 420 PPPPPLPLAR DPGSPGPFDY VGAPPAESIP QKTRRTSSEQ AVALPRSEEP ASCNGKLPLG 430 440 450 460 470 480 AEESVAPPGG SRKEVAGMDY LAVPSPLAWS KARIGGHSPI FRTSALPPLD WPLPSQYEQL 490 500 510 520 530 540 ELRIEVQPRA HHRAHYETEG SRGAVKAAPG GHPVVKLLGY SEKPLTLQMF IGTADERNLR 550 560 570 580 590 600 PHAFYQVHRI TGKMVATASY EAVVSGTKVL EMTLLPENNM AANIDCAGIL KLRNSDIELR 610 620 630 640 650 660 KGETDIGRKN TRVRLVFRVH VPQGGGKVVS VQAASVPIEC SQRSAQELPQ VEAYSPSACS 670 680 690 700 710 720 VRGGEELVLT GSNFLPDSKV VFIERGPDGK LQWEEEATVN RLQSNEVTLT LTVPEYSNKR 730 740 750 760 770 780 VSRPVQVYFY VSNGRRKRSP TQSFRFLPVI CKEEPLPDSS LRGFPSASAT PFGTDMDFSP 790 800 810 820 830 840 PRPPYPSYPH EDPACETPYL SEGFGYGMPP LYPQTGPPPS YRPGLRMFPE TRGTTVSEII 850 GRDLSGFPAP PGEEPPA
	Isoform 12 (IEi-IXL) [UniParc]. Checksum: 22978126C7D764DB	FASTA	832	88,270
	10 20 30 40 50 60 MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS ISPTPEPPAA 70 80 90 100 110 120 LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS FFSDASDEAA 130 140 150 160 170 180 LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG RGPEDSWLLL 190 200 210 220 230 240 SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP PPLPLARDPG 250 260 270 280 290 300 SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE SVAPPGGSRK 310 320 330 340 350 360 EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR IEVQPRAHHR 370 380 390 400 410 420 AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA FYQVHRITGK 430 440 450 460 470 480 MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV 490 500 510 520 530 540 RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG GEELVLTGSN 550 560 570 580 590 600 FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR PVQVYFYVSN 610 620 630 640 650 660 GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP PYPSYPHEDP 670 680 690 700 710 720 ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV SFLPRPFPSD 730 740 750 760 770 780 PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY NKVGPGYGPG 790 800 810 820 830 EGAPEQEKSR GGYSSGFRDS VPIQGITLEE VSEIIGRDLS GFPAPPGEEP PA
	Isoform 13 (IEi-IXi) [UniParc]. Checksum: CC1EEBC45F144C10	FASTA	831	88,103
	10 20 30 40 50 60 MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS ISPTPEPPAA 70 80 90 100 110 120 LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS FFSDASDEAA 130 140 150 160 170 180 LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG RGPEDSWLLL 190 200 210 220 230 240 SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP PPLPLARDPG 250 260 270 280 290 300 SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE SVAPPGGSRK 310 320 330 340 350 360 EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR IEVQPRAHHR 370 380 390 400 410 420 AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA FYQVHRITGK 430 440 450 460 470 480 MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV 490 500 510 520 530 540 RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG GEELVLTGSN 550 560 570 580 590 600 FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR PVQVYFYVSN 610 620 630 640 650 660 GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP PYPSYPHEDP 670 680 690 700 710 720 ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV SFLPRPFPSD 730 740 750 760 770 780 PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY NKVGPGYGPG 790 800 810 820 830 EGAPEQEKSR GGYSSGFRDS VPIQGITLEE GGCGTGGCEC ECVQEIALHV C
	Isoform 14 (IC-IXS) [UniParc]. Checksum: 4BF3996D8C2BA62C	FASTA	826	87,282
	10 20 30 40 50 60 MADGGADSAA QRLPEGPGRV APGRDLGAPA GSMGAASCED EELEFKLVFG EEKEAPPLGA 70 80 90 100 110 120 GGLGEELDSE DAPPCCRLAL GEPPPYGAAP IGIPRPPPPR PGMHSPPPRP APSPGTWESQ 130 140 150 160 170 180 PARSVRLGGP GGGAGGAGGG RVLECPSIRI TSISPTPEPP AALEDNPDAW GDGSPRDYPP 190 200 210 220 230 240 PEGFGGYREA GGQGGGAFFS PSPGSSSLSS WSFFSDASDE AALYAACDEV ESELNEAASR 250 260 270 280 290 300 FGLGSPLPSP RASPRPWTPE DPWSLYGPSP GGRGPEDSWL LLSAPGPTPA SPRPASPCGK 310 320 330 340 350 360 RRYSSSGTPS SASPALSRRG SLGEEGSEPP PPPPLPLARD PGSPGPFDYV GAPPAESIPQ 370 380 390 400 410 420 KTRRTSSEQA VALPRSEEPA SCNGKLPLGA EESVAPPGGS RKEVAGMDYL AVPSPLAWSK 430 440 450 460 470 480 ARIGGHSPIF RTSALPPLDW PLPSQYEQLE LRIEVQPRAH HRAHYETEGS RGAVKAAPGG 490 500 510 520 530 540 HPVVKLLGYS EKPLTLQMFI GTADERNLRP HAFYQVHRIT GKMVATASYE AVVSGTKVLE 550 560 570 580 590 600 MTLLPENNMA ANIDCAGILK LRNSDIELRK GETDIGRKNT RVRLVFRVHV PQGGGKVVSV 610 620 630 640 650 660 QAASVPIECS QRSAQELPQV EAYSPSACSV RGGEELVLTG SNFLPDSKVV FIERGPDGKL 670 680 690 700 710 720 QWEEEATVNR LQSNEVTLTL TVPEYSNKRV SRPVQVYFYV SNGRRKRSPT QSFRFLPVIC 730 740 750 760 770 780 KEEPLPDSSL RGFPSASATP FGTDMDFSPP RPPYPSYPHE DPACETPYLS EGFGYGMPPL 790 800 810 820 YPQTGPPPSY RPGLRMFPET RGTTVSEIIG RDLSGFPAPP GEEPPA
	Isoform 15 (IB-IXS) [UniParc]. Checksum: F9035684E3A5FE7E	FASTA	807	85,508
	10 20 30 40 50 60 MLSGRDLGAP AGSMGAASCE DEELEFKLVF GEEKEAPPLG AGGLGEELDS EDAPPCCRLA 70 80 90 100 110 120 LGEPPPYGAA PIGIPRPPPP RPGMHSPPPR PAPSPGTWES QPARSVRLGG PGGGAGGAGG 130 140 150 160 170 180 GRVLECPSIR ITSISPTPEP PAALEDNPDA WGDGSPRDYP PPEGFGGYRE AGGQGGGAFF 190 200 210 220 230 240 SPSPGSSSLS SWSFFSDASD EAALYAACDE VESELNEAAS RFGLGSPLPS PRASPRPWTP 250 260 270 280 290 300 EDPWSLYGPS PGGRGPEDSW LLLSAPGPTP ASPRPASPCG KRRYSSSGTP SSASPALSRR 310 320 330 340 350 360 GSLGEEGSEP PPPPPLPLAR DPGSPGPFDY VGAPPAESIP QKTRRTSSEQ AVALPRSEEP 370 380 390 400 410 420 ASCNGKLPLG AEESVAPPGG SRKEVAGMDY LAVPSPLAWS KARIGGHSPI FRTSALPPLD 430 440 450 460 470 480 WPLPSQYEQL ELRIEVQPRA HHRAHYETEG SRGAVKAAPG GHPVVKLLGY SEKPLTLQMF 490 500 510 520 530 540 IGTADERNLR PHAFYQVHRI TGKMVATASY EAVVSGTKVL EMTLLPENNM AANIDCAGIL 550 560 570 580 590 600 KLRNSDIELR KGETDIGRKN TRVRLVFRVH VPQGGGKVVS VQAASVPIEC SQRSAQELPQ 610 620 630 640 650 660 VEAYSPSACS VRGGEELVLT GSNFLPDSKV VFIERGPDGK LQWEEEATVN RLQSNEVTLT 670 680 690 700 710 720 LTVPEYSNKR VSRPVQVYFY VSNGRRKRSP TQSFRFLPVI CKEEPLPDSS LRGFPSASAT 730 740 750 760 770 780 PFGTDMDFSP PRPPYPSYPH EDPACETPYL SEGFGYGMPP LYPQTGPPPS YRPGLRMFPE 790 800 TRGTTVSEII GRDLSGFPAP PGEEPPA
	Isoform 16 (ID-IXS) [UniParc]. Checksum: 8378E0D0BB0888D2	FASTA	794	84,294
	10 20 30 40 50 60 MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE PPPYGAAPIG 70 80 90 100 110 120 IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS 130 140 150 160 170 180 ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 190 200 210 220 230 240 FFSDASDEAA LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG 250 260 270 280 290 300 RGPEDSWLLL SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 310 320 330 340 350 360 PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE 370 380 390 400 410 420 SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 430 440 450 460 470 480 IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA 490 500 510 520 530 540 FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 550 560 570 580 590 600 TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 610 620 630 640 650 660 GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR 670 680 690 700 710 720 PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP 730 740 750 760 770 780 PYPSYPHEDP ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTVSEIIGRD 790 LSGFPAPPGE EPPA
	Isoform 17 (IE-IXS) [UniParc]. Checksum: 4B73A89F510DC96E	FASTA	782	82,991
	10 20 30 40 50 60 MPASISSIFP GPTLLLSCGS EELDSEDAPP CCRLALGEPP PYGAAPIGIP RPPPPRPGMH 70 80 90 100 110 120 SPPPRPAPSP GTWESQPARS VRLGGPGGGA GGAGGGRVLE CPSIRITSIS PTPEPPAALE 130 140 150 160 170 180 DNPDAWGDGS PRDYPPPEGF GGYREAGGQG GGAFFSPSPG SSSLSSWSFF SDASDEAALY 190 200 210 220 230 240 AACDEVESEL NEAASRFGLG SPLPSPRASP RPWTPEDPWS LYGPSPGGRG PEDSWLLLSA 250 260 270 280 290 300 PGPTPASPRP ASPCGKRRYS SSGTPSSASP ALSRRGSLGE EGSEPPPPPP LPLARDPGSP 310 320 330 340 350 360 GPFDYVGAPP AESIPQKTRR TSSEQAVALP RSEEPASCNG KLPLGAEESV APPGGSRKEV 370 380 390 400 410 420 AGMDYLAVPS PLAWSKARIG GHSPIFRTSA LPPLDWPLPS QYEQLELRIE VQPRAHHRAH 430 440 450 460 470 480 YETEGSRGAV KAAPGGHPVV KLLGYSEKPL TLQMFIGTAD ERNLRPHAFY QVHRITGKMV 490 500 510 520 530 540 ATASYEAVVS GTKVLEMTLL PENNMAANID CAGILKLRNS DIELRKGETD IGRKNTRVRL 550 560 570 580 590 600 VFRVHVPQGG GKVVSVQAAS VPIECSQRSA QELPQVEAYS PSACSVRGGE ELVLTGSNFL 610 620 630 640 650 660 PDSKVVFIER GPDGKLQWEE EATVNRLQSN EVTLTLTVPE YSNKRVSRPV QVYFYVSNGR 670 680 690 700 710 720 RKRSPTQSFR FLPVICKEEP LPDSSLRGFP SASATPFGTD MDFSPPRPPY PSYPHEDPAC 730 740 750 760 770 780 ETPYLSEGFG YGMPPLYPQT GPPPSYRPGL RMFPETRGTT VSEIIGRDLS GFPAPPGEEP PA
	Isoform 18 (IEi-IXS) [UniParc]. Checksum: E589F6754CC1B54C	FASTA	724	77,115
	10 20 30 40 50 60 MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS ISPTPEPPAA 70 80 90 100 110 120 LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS FFSDASDEAA 130 140 150 160 170 180 LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG RGPEDSWLLL 190 200 210 220 230 240 SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP PPLPLARDPG 250 260 270 280 290 300 SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE SVAPPGGSRK 310 320 330 340 350 360 EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR IEVQPRAHHR 370 380 390 400 410 420 AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA FYQVHRITGK 430 440 450 460 470 480 MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV 490 500 510 520 530 540 RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG GEELVLTGSN 550 560 570 580 590 600 FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR PVQVYFYVSN 610 620 630 640 650 660 GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP PYPSYPHEDP 670 680 690 700 710 720 ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTVSEIIGRD LSGFPAPPGE EPPA
	Isoform 19 (IV-IXL) [UniParc]. Checksum: EEA72B2EDFA7E67A	FASTA	437	47,373
	10 20 30 40 50 60 MFIGTADERN LRPHAFYQVH RITGKMVATA SYEAVVSGTK VLEMTLLPEN NMAANIDCAG 70 80 90 100 110 120 ILKLRNSDIE LRKGETDIGR KNTRVRLVFR VHVPQGGGKV VSVQAASVPI ECSQRSAQEL 130 140 150 160 170 180 PQVEAYSPSA CSVRGGEELV LTGSNFLPDS KVVFIERGPD GKLQWEEEAT VNRLQSNEVT 190 200 210 220 230 240 LTLTVPEYSN KRVSRPVQVY FYVSNGRRKR SPTQSFRFLP VICKEEPLPD SSLRGFPSAS 250 260 270 280 290 300 ATPFGTDMDF SPPRPPYPSY PHEDPACETP YLSEGFGYGM PPLYPQTGPP PSYRPGLRMF 310 320 330 340 350 360 PETRGTTGCA QPPAVSFLPR PFPSDPYGGR GSSFSLGLPF SPPAPFRPPP LPASPPLEGP 370 380 390 400 410 420 FPSQSDVHPL PAEGYNKVGP GYGPGEGAPE QEKSRGGYSS GFRDSVPIQG ITLEEVSEII 430 GRDLSGFPAP PGEEPPA
	Isoform 20 (IV-IXi) [UniParc]. Checksum: ACB4E3DC2F96ED8B	FASTA	436	47,206
	10 20 30 40 50 60 MFIGTADERN LRPHAFYQVH RITGKMVATA SYEAVVSGTK VLEMTLLPEN NMAANIDCAG 70 80 90 100 110 120 ILKLRNSDIE LRKGETDIGR KNTRVRLVFR VHVPQGGGKV VSVQAASVPI ECSQRSAQEL 130 140 150 160 170 180 PQVEAYSPSA CSVRGGEELV LTGSNFLPDS KVVFIERGPD GKLQWEEEAT VNRLQSNEVT 190 200 210 220 230 240 LTLTVPEYSN KRVSRPVQVY FYVSNGRRKR SPTQSFRFLP VICKEEPLPD SSLRGFPSAS 250 260 270 280 290 300 ATPFGTDMDF SPPRPPYPSY PHEDPACETP YLSEGFGYGM PPLYPQTGPP PSYRPGLRMF 310 320 330 340 350 360 PETRGTTGCA QPPAVSFLPR PFPSDPYGGR GSSFSLGLPF SPPAPFRPPP LPASPPLEGP 370 380 390 400 410 420 FPSQSDVHPL PAEGYNKVGP GYGPGEGAPE QEKSRGGYSS GFRDSVPIQG ITLEEGGCGT 430 GGCECECVQE IALHVC
	Isoform 21 (IV-IXS) [UniParc]. Checksum: 043037F5F05D38C5	FASTA	329	36,219
	10 20 30 40 50 60 MFIGTADERN LRPHAFYQVH RITGKMVATA SYEAVVSGTK VLEMTLLPEN NMAANIDCAG 70 80 90 100 110 120 ILKLRNSDIE LRKGETDIGR KNTRVRLVFR VHVPQGGGKV VSVQAASVPI ECSQRSAQEL 130 140 150 160 170 180 PQVEAYSPSA CSVRGGEELV LTGSNFLPDS KVVFIERGPD GKLQWEEEAT VNRLQSNEVT 190 200 210 220 230 240 LTLTVPEYSN KRVSRPVQVY FYVSNGRRKR SPTQSFRFLP VICKEEPLPD SSLRGFPSAS 250 260 270 280 290 300 ATPFGTDMDF SPPRPPYPSY PHEDPACETP YLSEGFGYGM PPLYPQTGPP PSYRPGLRMF 310 320 PETRGTTVSE IIGRDLSGFP APPGEEPPA
	Isoform 22 (VI-IXL) [UniParc]. Checksum: 3B4512C612A69FDF	FASTA	190	20,104
	10 20 30 40 50 60 MDFSPPRPPY PSYPHEDPAC ETPYLSEGFG YGMPPLYPQT GPPPSYRPGL RMFPETRGTT 70 80 90 100 110 120 GCAQPPAVSF LPRPFPSDPY GGRGSSFSLG LPFSPPAPFR PPPLPASPPL EGPFPSQSDV 130 140 150 160 170 180 HPLPAEGYNK VGPGYGPGEG APEQEKSRGG YSSGFRDSVP IQGITLEEVS EIIGRDLSGF 190 PAPPGEEPPA
	Isoform 23 (VI-IXi) [UniParc]. Checksum: CE8D0B112EEF4803	FASTA	189	19,937
	10 20 30 40 50 60 MDFSPPRPPY PSYPHEDPAC ETPYLSEGFG YGMPPLYPQT GPPPSYRPGL RMFPETRGTT 70 80 90 100 110 120 GCAQPPAVSF LPRPFPSDPY GGRGSSFSLG LPFSPPAPFR PPPLPASPPL EGPFPSQSDV 130 140 150 160 170 180 HPLPAEGYNK VGPGYGPGEG APEQEKSRGG YSSGFRDSVP IQGITLEEGG CGTGGCECEC VQEIALHVC
	Isoform 24 (VI-IXS) [UniParc]. Checksum: DC673A88B52B383F	FASTA	82	8,950
	10 20 30 40 50 60 MDFSPPRPPY PSYPHEDPAC ETPYLSEGFG YGMPPLYPQT GPPPSYRPGL RMFPETRGTT 70 80 VSEIIGRDLS GFPAPPGEEP PA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins." Hoey T., Sun Y.-L., Williamson K., Xu X. Immunity 2:461-472(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANTS ALA-160 AND PRO-800. Tissue: T-cell.
[2]	"Alternative splicing and expression of human and mouse NFAT genes." Vihma H., Pruunsild P., Timmusk T. Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23 AND 24), TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 12 AND 16). Tissue: Adrenal gland and Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-902 (ISOFORMS 1/2/4/6), VARIANTS ALA-160 AND PRO-800. Tissue: Ovary and Rhabdomyosarcoma.
[5]	"Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT." Crabtree G.R. Cell 96:611-614(1999) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Requirement of two NFATc4 transactivation domains for CBP potentiation." Yang T.T.C., Davis R.J., Chow C.-W. J. Biol. Chem. 276:39569-39576(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CREBBP.
[7]	"Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases." Yang T.T.C., Xiong Q., Enslen H., Davis R.J., Chow C.-W. Mol. Cell. Biol. 22:3892-3904(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION AT SER-168 AND SER-170, MUTAGENESIS OF SER-168 AND SER-170.
[8]	"Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation." Yao K., Cho Y.-Y., Bergen H.R. III, Madden B.J., Choi B.Y., Ma W.-Y., Bode A.M., Dong Z. Cancer Res. 67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MAPK8 AND MAPK9, PHOSPHORYLATION AT SER-213 AND SER-217, MUTAGENESIS OF SER-213 AND SER-217.
[9]	"RSK2 mediates muscle cell differentiation through regulation of NFAT3." Cho Y.-Y., Yao K., Bode A.M., Bergen H.R. III, Madden B.J., Oh S.-M., Ermakova S., Kang B.S., Choi H.S., Shim J.-H., Dong Z. J. Biol. Chem. 282:8380-8392(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RPS6KA3, PHOSPHORYLATION AT SER-289 AND SER-344.
[10]	"Repression of NFAT3 transcriptional activity by estrogen receptors." Qin X., Wang X.-H., Yang Z.-H., Ding L.-H., Xu X.-J., Cheng L., Niu C., Sun H.-W., Zhang H., Ye Q.-N. Cell. Mol. Life Sci. 65:2752-2762(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination." Fan Y., Xie P., Zhang T., Zhang H., Gu D., She M., Li H. FEBS Lett. 582:4008-4014(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, UBIQUITINATION.
[12]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[13]	"Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4." Yang T.T.C., Yu R.Y.L., Agadir A., Gao G.-J., Campos-Gonzalez R., Tournier C., Chow C.-W. Mol. Cell. Biol. 28:3489-3501(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-168 AND SER-170.
[14]	"The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT." Wang D., Fasciano S., Li L. Mol. Immunol. 45:3902-3908(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IRAK1.
[15]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[16]	"Solution structure of the TIG domain from human nuclear factor of activated T-cells, cytoplasmic 4." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 585-691.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L41066 mRNA. Translation: AAA79175.1.
EU887632 mRNA. Translation: ACG55652.1.
EU887633 mRNA. Translation: ACG55653.1.
EU887634 mRNA. Translation: ACG55654.1.
EU887635 mRNA. Translation: ACG55655.1.
EU887636 mRNA. Translation: ACG55656.1.
EU887637 mRNA. Translation: ACG55657.1.
EU887638 mRNA. Translation: ACG55658.1.
EU887639 mRNA. Translation: ACG55659.1.
EU887640 mRNA. Translation: ACG55660.1.
EU887641 mRNA. Translation: ACG55661.1.
EU887642 mRNA. Translation: ACG55662.1.
EU887643 mRNA. Translation: ACG55663.1.
EU887644 mRNA. Translation: ACG55664.1.
EU887645 mRNA. Translation: ACG55665.1.
EU887646 mRNA. Translation: ACG55666.1.
EU887647 mRNA. Translation: ACG55667.1.
EU887648 mRNA. Translation: ACG55668.1.
EU887649 mRNA. Translation: ACG55669.1.
EU887650 mRNA. Translation: ACG55670.1.
EU887651 mRNA. Translation: ACG55671.1.
EU887652 mRNA. Translation: ACG55672.1.
EU887653 mRNA. Translation: ACG55673.1.
EU887654 mRNA. Translation: ACG55674.1.
EU887655 mRNA. Translation: ACG55675.1.
AK293185 mRNA. Translation: BAG56726.1.
AK302271 mRNA. Translation: BAG63617.1.
BC008857 mRNA. Translation: AAH08857.2.
BC053855 mRNA. Translation: AAH53855.1.

IPI

IPI00385215.
IPI00914604.
IPI00917067.
IPI00923386.
IPI00923387.
IPI00923404.
IPI00923405.
IPI00923412.
IPI00923417.
IPI00923426.
IPI00923428.
IPI00923439.
IPI00923440.
IPI00923465.
IPI00923469.
IPI00923488.
IPI00923509.
IPI00923559.
IPI00923568.
IPI00923580.
IPI00923589.
IPI00923591.
IPI00923608.
IPI00923620.

RefSeq

NP_001129494.1. NM_001136022.1.
NP_001185894.1. NM_001198965.1.
NP_001185895.1. NM_001198966.1.
NP_001185896.1. NM_001198967.1.
NP_004545.2. NM_004554.4.

UniGene

Hs.77810.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YRP	NMR	-	A	585-691	[»]

ProteinModelPortal

Q14934.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q14934. 4 interactions.

MINT

MINT-1535456.

PTM databases

PhosphoSite

Q14934.

Polymorphism databases

DMDM

215274090.

Proteomic databases

PaxDb

Q14934.

PRIDE

Q14934.

Protocols and materials databases

DNASU

4776.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000250373; ENSP00000250373; ENSG00000100968.
ENST00000413692; ENSP00000388910; ENSG00000100968.
ENST00000422617; ENSP00000396788; ENSG00000100968.
ENST00000424781; ENSP00000388668; ENSG00000100968.
ENST00000539237; ENSP00000439350; ENSG00000100968.
ENST00000553469; ENSP00000451502; ENSG00000100968.
ENST00000553708; ENSP00000450590; ENSG00000100968.
ENST00000553879; ENSP00000452349; ENSG00000100968.
ENST00000554050; ENSP00000451151; ENSG00000100968.
ENST00000554344; ENSP00000450469; ENSG00000100968.
ENST00000554473; ENSP00000450810; ENSG00000100968.
ENST00000554591; ENSP00000452039; ENSG00000100968.
ENST00000554661; ENSP00000450733; ENSG00000100968.
ENST00000554966; ENSP00000450644; ENSG00000100968.
ENST00000555167; ENSP00000451395; ENSG00000100968.
ENST00000555393; ENSP00000451801; ENSG00000100968.
ENST00000555453; ENSP00000450686; ENSG00000100968.
ENST00000555590; ENSP00000451224; ENSG00000100968.
ENST00000555802; ENSP00000451590; ENSG00000100968.
ENST00000556169; ENSP00000451454; ENSG00000100968.
ENST00000556279; ENSP00000452270; ENSG00000100968.
ENST00000556759; ENSP00000451183; ENSG00000100968.
ENST00000557451; ENSP00000451284; ENSG00000100968.
ENST00000557767; ENSP00000451496; ENSG00000100968.

GeneID

4776.

KEGG

hsa:4776.

UCSC

uc001wpc.3. human.
uc001wpd.3. human.
uc010alr.3. human.
uc010alt.3. human.
uc010alv.3. human.
uc010tok.2. human.
uc010tol.2. human.
uc010tom.2. human.
uc010ton.2. human.
uc010too.2. human.
uc010top.2. human.
uc010toq.2. human.
uc010tor.2. human.
uc010tot.2. human.
uc010tov.2. human.
uc010tow.2. human.
uc010tox.2. human.
uc010toy.2. human.
uc010toz.2. human.
uc010tpa.2. human.
uc010tpb.2. human.

Organism-specific databases

CTD

4776.

GeneCards

GC14P024834.

HGNC

HGNC:7778. NFATC4.

HPA

CAB032859.
HPA031641.

MIM

602699. gene.

neXtProt

NX_Q14934.

PharmGKB

PA31584.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG70055.

HOVERGEN

HBG104364.

InParanoid

Q14934.

KO

K04446.

OMA

WTPDDPW.

OrthoDB

EOG49P9XZ.

PhylomeDB

Q14934.

Gene expression databases

ArrayExpress

Q14934.

Bgee

Q14934.

CleanEx

HS_NFATC4.

Genevestigator

Q14934.

GermOnline

ENSG00000100968. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
2.60.40.340. 1 hit.

InterPro

IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_TIG_rcpt.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]

PANTHER

PTHR12533. PTHR12533. 1 hit.

Pfam

PF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]

PRINTS

PR01789. NUCFACTORATC.

SMART

SM00429. IPT. 1 hit.
[Graphical view]

SUPFAM

SSF81296. Ig_E-set. 1 hit.
SSF49417. P53_like_DNA_bnd. 1 hit.

PROSITE

PS01204. REL_1. False negative.
PS50254. REL_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q14934.

GenomeRNAi

4776.

NextBio

18420.

SOURCE

Search...

Entry information

Entry name

NFAC4_HUMAN

Accession

Primary (citable) accession number: Q14934
Secondary accession number(s): B4DDG5 , B4DY55, B5B2U7, B5B2U8, B5B2U9, B5B2V0, B5B2V1, B5B2V2, B5B2V3, B5B2V4, B5B2V5, B5B2V7, B5B2V8, B5B2V9, B5B2W0, B5B2W1, B5B2W2, B5B2W3, B5B2W4, B5B2W5, B5B2W6, B5B2W7, B5B2W8, B5B2W9, B5B2X0, Q7Z598, Q96H68

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.