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Protein

Zinc finger protein 169

Gene

ZNF169

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri234 – 256C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175787-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 169
Gene namesi
Name:ZNF169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:12957. ZNF169.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi169841.
OpenTargetsiENSG00000175787.
PharmGKBiPA37539.

Polymorphism and mutation databases

BioMutaiZNF169.
DMDMi259016472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474381 – 603Zinc finger protein 169Add BLAST603

Proteomic databases

PaxDbiQ14929.
PRIDEiQ14929.

PTM databases

iPTMnetiQ14929.
PhosphoSitePlusiQ14929.

Expressioni

Tissue specificityi

Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not expressed in adult brain or spinal cord.

Gene expression databases

BgeeiENSG00000175787.
CleanExiHS_ZNF169.
ExpressionAtlasiQ14929. baseline and differential.
GenevisibleiQ14929. HS.

Organism-specific databases

HPAiHPA041769.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10234472,EBI-748961
CEP70Q8NHQ13EBI-10234472,EBI-739624
KRTAP10-7P604093EBI-10234472,EBI-10172290

Protein-protein interaction databases

BioGridi127990. 47 interactors.
IntActiQ14929. 3 interactors.
STRINGi9606.ENSP00000378792.

Structurei

3D structure databases

ProteinModelPortaliQ14929.
SMRiQ14929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri234 – 256C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14929.
KOiK09228.
OMAiFKSALIR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14929.
TreeFamiTF338096.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGLLTTRK EALMAFRDVA VAFTQKEWKL LSSAQRTLYR EVMLENYSHL
60 70 80 90 100
VSLGIAFSKP KLIEQLEQGD EPWREENEHL LDLCPEPRTE FQPSFPHLVA
110 120 130 140 150
FSSSQLLRQY ALSGHPTQIF PSSSAGGDFQ LEAPRCSSEK GESGETEGPD
160 170 180 190 200
SSLRKRPSRI SRTFFSPHQG DPVEWVEGNR EGGTDLRLAQ RMSLGGSDTM
210 220 230 240 250
LKGADTSESG AVIRGNYRLG LSKKSSLFSH QKHHVCPECG RGFCQRSDLI
260 270 280 290 300
KHQRTHTGEK PYLCPECGRR FSQKASLSIH QRKHSGEKPY VCRECGRHFR
310 320 330 340 350
YTSSLTNHKR IHSGERPFVC QECGRGFRQK IALLLHQRTH LEEKPFVCPE
360 370 380 390 400
CGRGFCQKAS LLQHQSSHTG ERPFLCLECG RSFRQQSLLL SHQVTHSGEK
410 420 430 440 450
PYVCAECGHS FRQKVTLIRH QRTHTGEKPY LCPQCGRGFS QKVTLIGHQR
460 470 480 490 500
THTGEKPYLC PDCGRGFGQK VTLIRHQRTH TGEKPYLCPK CGRAFGFKSL
510 520 530 540 550
LTRHQRTHSE EELYVDRVCG QGLGQKSHLI SDQRTHSGEK PCICDECGRG
560 570 580 590 600
FGFKSALIRH QRTHSGEKPY VCRECGRGFS QKSHLHRHRR TKSGHQLLPQ

EVF
Length:603
Mass (Da):68,488
Last modified:September 22, 2009 - v3
Checksum:iE50538A48E248AB9
GO

Sequence cautioni

The sequence AAH47702 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF82431 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91 – 99FQPSFPHLV → IPAKFSPPG in AAA70188 (PubMed:9071574).Curated9
Sequence conflicti276 – 278SLS → PSP in AAA70188 (PubMed:9071574).Curated3
Sequence conflicti343E → D in BAF82431 (PubMed:14702039).Curated1
Sequence conflicti349 – 356PECGRGFC → LSVGEAL in AAA70188 (PubMed:9071574).Curated8
Sequence conflicti376C → S in AAA70188 (PubMed:9071574).Curated1
Sequence conflicti382S → T in AAA70188 (PubMed:9071574).Curated1
Sequence conflicti470 – 471KV → NG in AAA70188 (PubMed:9071574).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02419872P → L.Corresponds to variant rs1536690dbSNPEnsembl.1
Natural variantiVAR_05906578E → K.Corresponds to variant rs35177967dbSNPEnsembl.1
Natural variantiVAR_059066152S → L.Corresponds to variant rs34433105dbSNPEnsembl.1
Natural variantiVAR_024199381R → C.Corresponds to variant rs12236219dbSNPEnsembl.1
Natural variantiVAR_059067596Q → H.1 PublicationCorresponds to variant rs12350212dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289742 mRNA. Translation: BAF82431.1. Different initiation.
AL691447 Genomic DNA. Translation: CAM16531.1.
CH471089 Genomic DNA. Translation: EAW62879.1.
BC047702 mRNA. Translation: AAH47702.1. Different initiation.
U28251 Genomic DNA. Translation: AAA70188.1.
CCDSiCCDS6709.2.
RefSeqiNP_919301.2. NM_194320.3.
XP_016869853.1. XM_017014364.1.
UniGeneiHs.387623.

Genome annotation databases

EnsembliENST00000395395; ENSP00000378792; ENSG00000175787.
GeneIDi169841.
KEGGihsa:169841.
UCSCiuc004aum.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289742 mRNA. Translation: BAF82431.1. Different initiation.
AL691447 Genomic DNA. Translation: CAM16531.1.
CH471089 Genomic DNA. Translation: EAW62879.1.
BC047702 mRNA. Translation: AAH47702.1. Different initiation.
U28251 Genomic DNA. Translation: AAA70188.1.
CCDSiCCDS6709.2.
RefSeqiNP_919301.2. NM_194320.3.
XP_016869853.1. XM_017014364.1.
UniGeneiHs.387623.

3D structure databases

ProteinModelPortaliQ14929.
SMRiQ14929.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127990. 47 interactors.
IntActiQ14929. 3 interactors.
STRINGi9606.ENSP00000378792.

PTM databases

iPTMnetiQ14929.
PhosphoSitePlusiQ14929.

Polymorphism and mutation databases

BioMutaiZNF169.
DMDMi259016472.

Proteomic databases

PaxDbiQ14929.
PRIDEiQ14929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395395; ENSP00000378792; ENSG00000175787.
GeneIDi169841.
KEGGihsa:169841.
UCSCiuc004aum.2. human.

Organism-specific databases

CTDi169841.
DisGeNETi169841.
GeneCardsiZNF169.
HGNCiHGNC:12957. ZNF169.
HPAiHPA041769.
MIMi603404. gene.
neXtProtiNX_Q14929.
OpenTargetsiENSG00000175787.
PharmGKBiPA37539.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14929.
KOiK09228.
OMAiFKSALIR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14929.
TreeFamiTF338096.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175787-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF169. human.
GenomeRNAii169841.
PROiQ14929.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175787.
CleanExiHS_ZNF169.
ExpressionAtlasiQ14929. baseline and differential.
GenevisibleiQ14929. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN169_HUMAN
AccessioniPrimary (citable) accession number: Q14929
Secondary accession number(s): A2AGP5, A8K127, Q6PI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.