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Q14916

- NPT1_HUMAN

UniProt

Q14916 - NPT1_HUMAN

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Protein

Sodium-dependent phosphate transport protein 1

Gene
SLC17A1, NPT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

GO - Molecular functioni

  1. sodium-dependent phosphate transmembrane transporter activity Source: ProtInc
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. phosphate ion transport Source: ProtInc
  3. sodium-dependent phosphate transport Source: GOC
  4. sodium ion transport Source: UniProtKB-KW
  5. transmembrane transport Source: Reactome
  6. urate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.27. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Na/Pi-4
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name:
Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene namesi
Name:SLC17A1
Synonyms:NPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:10929. SLC17A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10121Helical; Reviewed predictionAdd
BLAST
Transmembranei119 – 13921Helical; Reviewed predictionAdd
BLAST
Transmembranei178 – 19821Helical; Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Transmembranei257 – 27721Helical; Reviewed predictionAdd
BLAST
Transmembranei301 – 32121Helical; Reviewed predictionAdd
BLAST
Transmembranei339 – 35921Helical; Reviewed predictionAdd
BLAST
Transmembranei365 – 38521Helical; Reviewed predictionAdd
BLAST
Transmembranei401 – 42121Helical; Reviewed predictionAdd
BLAST
Transmembranei433 – 45321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Sodium-dependent phosphate transport protein 1PRO_0000220936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14916.
PRIDEiQ14916.

PTM databases

PhosphoSiteiQ14916.

Expressioni

Tissue specificityi

Expressed in kidney cortex, liver and brain but not in other tissues.

Gene expression databases

ArrayExpressiQ14916.
BgeeiQ14916.
CleanExiHS_SLC17A1.
GenevestigatoriQ14916.

Interactioni

Subunit structurei

Interacts with PDZK1 By similarity.

Protein-protein interaction databases

BioGridi112456. 1 interaction.
STRINGi9606.ENSP00000244527.

Structurei

3D structure databases

ProteinModelPortaliQ14916.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOVERGENiHBG008834.
InParanoidiQ14916.
KOiK12300.
OMAiFCSFRYG.
OrthoDBiEOG71G9TW.
PhylomeDBiQ14916.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14916-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS    50
TDPHGLPNTS TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY 100
FSGIYSTKKM IGFALCLSSV LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV 150
ATAQFEIYVK WAPPLERGRL TSMSTSGFLL GPFIVLLVTG VICESLGWPM 200
VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS SLVQQVSSSR 250
QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN 300
GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI 350
FGVCLPYLSS TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA 400
CSTLTGMIGG LIASTLTGLI LKQDPESAWF KTFILMAAIN VTGLIFYLIV 450
ATAEIQDWAK EKQHTRL 467
Length:467
Mass (Da):51,132
Last modified:September 2, 2008 - v2
Checksum:i10FE6C7E202BCFF7
GO
Isoform 2 (identifier: Q14916-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-299: Missing.

Note: No experimental confirmation available.

Show »
Length:413
Mass (Da):44,978
Checksum:i30B74AC95A0C1CBB
GO

Sequence cautioni

The sequence BAA05888.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI19543.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761S → N.
Corresponds to variant rs6933573 [ dbSNP | Ensembl ].
VAR_050060
Natural varianti269 – 2691T → I.2 Publications
Corresponds to variant rs1165196 [ dbSNP | Ensembl ].
VAR_050061

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei246 – 29954Missing in isoform 2. VSP_035012Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 382RA → LM in BAA05888. 1 Publication
Sequence conflicti79 – 791I → V in BAA05888. 1 Publication
Sequence conflicti100 – 1001Y → H in AAV98361. 1 Publication
Sequence conflicti117 – 1171L → P in BAF83472. 1 Publication
Sequence conflicti209 – 2091G → C in BAA05888. 1 Publication
Sequence conflicti215 – 2151L → F in AAV98361. 1 Publication
Sequence conflicti233 – 2331S → G in BAA05888. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71355 mRNA. Translation: CAA50490.1.
AY780791 mRNA. Translation: AAV98361.1.
AK290783 mRNA. Translation: BAF83472.1.
AL138726 Genomic DNA. Translation: CAI19543.1. Different initiation.
CH471087 Genomic DNA. Translation: EAW55494.1.
BC101745 mRNA. Translation: AAI01746.1.
BC101747 mRNA. Translation: AAI01748.1.
AF362494, AF362490, AF362492 Genomic DNA. Translation: AAL04478.1.
D83236 Genomic DNA. Translation: BAA25645.1.
D28532 mRNA. Translation: BAA05888.1. Different initiation.
CCDSiCCDS4565.1. [Q14916-1]
PIRiA48916.
I39473.
RefSeqiNP_005065.2. NM_005074.3. [Q14916-1]
UniGeneiHs.205816.

Genome annotation databases

EnsembliENST00000244527; ENSP00000244527; ENSG00000124568. [Q14916-1]
ENST00000427328; ENSP00000410549; ENSG00000124568. [Q14916-2]
ENST00000468082; ENSP00000420546; ENSG00000124568. [Q14916-2]
ENST00000476801; ENSP00000420614; ENSG00000124568. [Q14916-1]
GeneIDi6568.
KEGGihsa:6568.
UCSCiuc003nfh.4. human. [Q14916-1]
uc010jqc.1. human. [Q14916-2]

Polymorphism databases

DMDMi205371809.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71355 mRNA. Translation: CAA50490.1 .
AY780791 mRNA. Translation: AAV98361.1 .
AK290783 mRNA. Translation: BAF83472.1 .
AL138726 Genomic DNA. Translation: CAI19543.1 . Different initiation.
CH471087 Genomic DNA. Translation: EAW55494.1 .
BC101745 mRNA. Translation: AAI01746.1 .
BC101747 mRNA. Translation: AAI01748.1 .
AF362494 , AF362490 , AF362492 Genomic DNA. Translation: AAL04478.1 .
D83236 Genomic DNA. Translation: BAA25645.1 .
D28532 mRNA. Translation: BAA05888.1 . Different initiation.
CCDSi CCDS4565.1. [Q14916-1 ]
PIRi A48916.
I39473.
RefSeqi NP_005065.2. NM_005074.3. [Q14916-1 ]
UniGenei Hs.205816.

3D structure databases

ProteinModelPortali Q14916.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112456. 1 interaction.
STRINGi 9606.ENSP00000244527.

Protein family/group databases

TCDBi 2.A.1.14.27. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q14916.

Polymorphism databases

DMDMi 205371809.

Proteomic databases

PaxDbi Q14916.
PRIDEi Q14916.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244527 ; ENSP00000244527 ; ENSG00000124568 . [Q14916-1 ]
ENST00000427328 ; ENSP00000410549 ; ENSG00000124568 . [Q14916-2 ]
ENST00000468082 ; ENSP00000420546 ; ENSG00000124568 . [Q14916-2 ]
ENST00000476801 ; ENSP00000420614 ; ENSG00000124568 . [Q14916-1 ]
GeneIDi 6568.
KEGGi hsa:6568.
UCSCi uc003nfh.4. human. [Q14916-1 ]
uc010jqc.1. human. [Q14916-2 ]

Organism-specific databases

CTDi 6568.
GeneCardsi GC06M025785.
HGNCi HGNC:10929. SLC17A1.
MIMi 182308. gene.
neXtProti NX_Q14916.
PharmGKBi PA35820.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOVERGENi HBG008834.
InParanoidi Q14916.
KOi K12300.
OMAi FCSFRYG.
OrthoDBi EOG71G9TW.
PhylomeDBi Q14916.
TreeFami TF313535.

Enzyme and pathway databases

Reactomei REACT_19372. Organic anion transporters.

Miscellaneous databases

GeneWikii SLC17A1.
GenomeRNAii 6568.
NextBioi 25555.
PROi Q14916.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14916.
Bgeei Q14916.
CleanExi HS_SLC17A1.
Genevestigatori Q14916.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004745. Pi_cotranspt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00894. 2A0114euk. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23."
    Chong S.S., Kristjansson K., Zoghbi H.Y., Hughes M.R.
    Genomics 18:355-359(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-269.
    Tissue: Kidney.
  2. Zhou G., Nong W., Li H., Ke R., Zhong G., Shen C., Lin L., Yang S.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  7. "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity."
    Soumounou Y., Gauthier C., Tenenhouse H.S.
    Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-113.
  8. "Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene."
    Taketani Y., Miyamoto K., Chikamori M., Tanaka K., Yamamoto H., Tatsumi S., Morita K., Takeda E.
    Biochim. Biophys. Acta 1396:267-272(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
  9. "Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression."
    Miyamoto K., Tatsumi S., Sonoda T., Yamamoto H., Minami H., Taketani Y., Takeda E.
    Biochem. J. 305:81-85(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-467 (ISOFORM 1), VARIANT ILE-269.
    Tissue: Kidney cortex.

Entry informationi

Entry nameiNPT1_HUMAN
AccessioniPrimary (citable) accession number: Q14916
Secondary accession number(s): A8K418
, O60761, Q13783, Q3MIP5, Q5MJP8, Q5TB83, Q96KL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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