Q14916 (NPT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium-dependent phosphate transport protein 1

Alternative name(s):
Na(+)/PI cotransporter 1
Na/Pi-4
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name=Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1

Gene names

Name:	SLC17A1
Synonyms:	NPT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.
Subunit structure	Interacts with PDZK1 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in kidney cortex, liver and brain but not in other tissues.
Sequence similarities	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Caution	It is uncertain whether Met-1 or Met-3 is the initiator.
Sequence caution	The sequence BAA05888.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19543.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW urate metabolic process Inferred from mutant phenotype PubMed 19503597. Source: BHF-UCL
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	sodium-dependent phosphate transmembrane transporter activity Traceable author statement PubMed 8867793. Source: ProtInc symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14916-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14916-2)

The sequence of this isoform differs from the canonical sequence as follows:
     246-299: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Sodium-dependent phosphate transport protein 1		PRO_0000220936
Regions
	Transmembrane	81 – 101	21	Helical; Potential
	Transmembrane	119 – 139	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential
	Transmembrane	301 – 321	21	Helical; Potential
	Transmembrane	339 – 359	21	Helical; Potential
	Transmembrane	365 – 385	21	Helical; Potential
	Transmembrane	401 – 421	21	Helical; Potential
	Transmembrane	433 – 453	21	Helical; Potential
Amino acid modifications
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	58	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	246 – 299	54	Missing in isoform 2.		VSP_035012
	Natural variant	76	1	S → N. Corresponds to variant rs6933573 [ dbSNP | Ensembl ].		VAR_050060
	Natural variant	269	1	T → I. Ref.1 Ref.9 Corresponds to variant rs1165196 [ dbSNP | Ensembl ].		VAR_050061
Experimental info
	Sequence conflict	37 – 38	2	RA → LM in BAA05888. Ref.9
	Sequence conflict	79	1	I → V in BAA05888. Ref.9
	Sequence conflict	100	1	Y → H in AAV98361. Ref.2
	Sequence conflict	117	1	L → P in BAF83472. Ref.3
	Sequence conflict	209	1	G → C in BAA05888. Ref.9
	Sequence conflict	215	1	L → F in AAV98361. Ref.2
	Sequence conflict	233	1	S → G in BAA05888. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: 10FE6C7E202BCFF7	FASTA	467	51,132
	10 20 30 40 50 60 MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS TDPHGLPNTS 70 80 90 100 110 120 TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY FSGIYSTKKM IGFALCLSSV 130 140 150 160 170 180 LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV ATAQFEIYVK WAPPLERGRL TSMSTSGFLL 190 200 210 220 230 240 GPFIVLLVTG VICESLGWPM VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS 250 260 270 280 290 300 SLVQQVSSSR QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN 310 320 330 340 350 360 GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI FGVCLPYLSS 370 380 390 400 410 420 TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA CSTLTGMIGG LIASTLTGLI 430 440 450 460 LKQDPESAWF KTFILMAAIN VTGLIFYLIV ATAEIQDWAK EKQHTRL
	Isoform 2 [UniParc]. Checksum: 30B74AC95A0C1CBB	FASTA	413	44,978
	10 20 30 40 50 60 MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS TDPHGLPNTS 70 80 90 100 110 120 TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY FSGIYSTKKM IGFALCLSSV 130 140 150 160 170 180 LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV ATAQFEIYVK WAPPLERGRL TSMSTSGFLL 190 200 210 220 230 240 GPFIVLLVTG VICESLGWPM VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS 250 260 270 280 290 300 SLVQQNGFLS SLPYLFAWIC GNLAGQLSDF FLTRNILSVI AVRKLFTAAG FLLPAIFGVC 310 320 330 340 350 360 LPYLSSTFYS IVIFLILAGA TGSFCLGGVF INGLDIAPRY FGFIKACSTL TGMIGGLIAS 370 380 390 400 410 TLTGLILKQD PESAWFKTFI LMAAINVTGL IFYLIVATAE IQDWAKEKQH TRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23." Chong S.S., Kristjansson K., Zoghbi H.Y., Hughes M.R. Genomics 18:355-359(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-269. Tissue: Kidney.
[2]	Zhou G., Nong W., Li H., Ke R., Zhong G., Shen C., Lin L., Yang S. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Liver.
[7]	"Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity." Soumounou Y., Gauthier C., Tenenhouse H.S. Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-113.
[8]	"Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene." Taketani Y., Miyamoto K., Chikamori M., Tanaka K., Yamamoto H., Tatsumi S., Morita K., Takeda E. Biochim. Biophys. Acta 1396:267-272(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
[9]	"Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression." Miyamoto K., Tatsumi S., Sonoda T., Yamamoto H., Minami H., Taketani Y., Takeda E. Biochem. J. 305:81-85(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-467 (ISOFORM 1), VARIANT ILE-269. Tissue: Kidney cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71355 mRNA. Translation: CAA50490.1. AY780791 mRNA. Translation: AAV98361.1. AK290783 mRNA. Translation: BAF83472.1. AL138726 Genomic DNA. Translation: CAI19543.1. Different initiation. CH471087 Genomic DNA. Translation: EAW55494.1. BC101745 mRNA. Translation: AAI01746.1. BC101747 mRNA. Translation: AAI01748.1. AF362494, AF362490, AF362492 Genomic DNA. Translation: AAL04478.1. D83236 Genomic DNA. Translation: BAA25645.1. D28532 mRNA. Translation: BAA05888.1. Different initiation.
IPI	IPI00796747. IPI00902854.
PIR	A48916. I39473.
RefSeq	NP_005065.2. NM_005074.3.
UniGene	Hs.205816.
3D structure databases
ProteinModelPortal	Q14916.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000244527.
PTM databases
PhosphoSite	Q14916.
Polymorphism databases
DMDM	205371809.
Proteomic databases
PaxDb	Q14916.
PRIDE	Q14916.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000244527; ENSP00000244527; ENSG00000124568. ENST00000427328; ENSP00000410549; ENSG00000124568. ENST00000468082; ENSP00000420546; ENSG00000124568. ENST00000476801; ENSP00000420614; ENSG00000124568.
GeneID	6568.
KEGG	hsa:6568.
UCSC	uc003nfh.4. human. uc010jqc.1. human.
Organism-specific databases
CTD	6568.
GeneCards	GC06M025785.
HGNC	HGNC:10929. SLC17A1.
MIM	182308. gene.
neXtProt	NX_Q14916.
PharmGKB	PA35820.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOVERGEN	HBG008834.
InParanoid	Q14916.
KO	K12300.
OMA	KDHPCIS.
OrthoDB	EOG48PMKJ.
PhylomeDB	Q14916.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
ArrayExpress	Q14916.
Bgee	Q14916.
CleanEx	HS_SLC17A1.
Genevestigator	Q14916.
GermOnline	ENSG00000124568. Homo sapiens.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004745. Pi_cotranspt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00894. 2A0114euk. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6568.
NextBio	25555.
SOURCE	Search...

Entry information

Entry name

NPT1_HUMAN

Accession

Primary (citable) accession number: Q14916
Secondary accession number(s): A8K418 , O60761, Q13783, Q3MIP5, Q5MJP8, Q5TB83, Q96KL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	September 2, 2008
Last modified:	April 3, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.