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Q14916 (NPT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Na/Pi-4
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name=Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene names
Name:SLC17A1
Synonyms:NPT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

Subunit structure

Interacts with PDZK1 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in kidney cortex, liver and brain but not in other tissues.

Sequence similarities

Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.

Sequence caution

The sequence BAA05888.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI19543.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14916-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14916-2)

The sequence of this isoform differs from the canonical sequence as follows:
     246-299: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Sodium-dependent phosphate transport protein 1
PRO_0000220936

Regions

Transmembrane81 – 10121Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane301 – 32121Helical; Potential
Transmembrane339 – 35921Helical; Potential
Transmembrane365 – 38521Helical; Potential
Transmembrane401 – 42121Helical; Potential
Transmembrane433 – 45321Helical; Potential

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence246 – 29954Missing in isoform 2.
VSP_035012
Natural variant761S → N.
Corresponds to variant rs6933573 [ dbSNP | Ensembl ].
VAR_050060
Natural variant2691T → I. Ref.1 Ref.9
Corresponds to variant rs1165196 [ dbSNP | Ensembl ].
VAR_050061

Experimental info

Sequence conflict37 – 382RA → LM in BAA05888. Ref.9
Sequence conflict791I → V in BAA05888. Ref.9
Sequence conflict1001Y → H in AAV98361. Ref.2
Sequence conflict1171L → P in BAF83472. Ref.3
Sequence conflict2091G → C in BAA05888. Ref.9
Sequence conflict2151L → F in AAV98361. Ref.2
Sequence conflict2331S → G in BAA05888. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 10FE6C7E202BCFF7

FASTA46751,132
        10         20         30         40         50         60 
MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS TDPHGLPNTS 

        70         80         90        100        110        120 
TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY FSGIYSTKKM IGFALCLSSV 

       130        140        150        160        170        180 
LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV ATAQFEIYVK WAPPLERGRL TSMSTSGFLL 

       190        200        210        220        230        240 
GPFIVLLVTG VICESLGWPM VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS 

       250        260        270        280        290        300 
SLVQQVSSSR QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN 

       310        320        330        340        350        360 
GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI FGVCLPYLSS 

       370        380        390        400        410        420 
TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA CSTLTGMIGG LIASTLTGLI 

       430        440        450        460 
LKQDPESAWF KTFILMAAIN VTGLIFYLIV ATAEIQDWAK EKQHTRL 

« Hide

Isoform 2 [UniParc].

Checksum: 30B74AC95A0C1CBB
Show »

FASTA41344,978

References

« Hide 'large scale' references
[1]"Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23."
Chong S.S., Kristjansson K., Zoghbi H.Y., Hughes M.R.
Genomics 18:355-359(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-269.
Tissue: Kidney.
[2]Zhou G., Nong W., Li H., Ke R., Zhong G., Shen C., Lin L., Yang S.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Liver.
[7]"Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity."
Soumounou Y., Gauthier C., Tenenhouse H.S.
Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-113.
[8]"Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene."
Taketani Y., Miyamoto K., Chikamori M., Tanaka K., Yamamoto H., Tatsumi S., Morita K., Takeda E.
Biochim. Biophys. Acta 1396:267-272(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
[9]"Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression."
Miyamoto K., Tatsumi S., Sonoda T., Yamamoto H., Minami H., Taketani Y., Takeda E.
Biochem. J. 305:81-85(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-467 (ISOFORM 1), VARIANT ILE-269.
Tissue: Kidney cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71355 mRNA. Translation: CAA50490.1.
AY780791 mRNA. Translation: AAV98361.1.
AK290783 mRNA. Translation: BAF83472.1.
AL138726 Genomic DNA. Translation: CAI19543.1. Different initiation.
CH471087 Genomic DNA. Translation: EAW55494.1.
BC101745 mRNA. Translation: AAI01746.1.
BC101747 mRNA. Translation: AAI01748.1.
AF362494, AF362490, AF362492 Genomic DNA. Translation: AAL04478.1.
D83236 Genomic DNA. Translation: BAA25645.1.
D28532 mRNA. Translation: BAA05888.1. Different initiation.
CCDSCCDS4565.1. [Q14916-1]
PIRA48916.
I39473.
RefSeqNP_005065.2. NM_005074.3. [Q14916-1]
UniGeneHs.205816.

3D structure databases

ProteinModelPortalQ14916.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112456. 1 interaction.
STRING9606.ENSP00000244527.

Protein family/group databases

TCDB2.A.1.14.27. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ14916.

Polymorphism databases

DMDM205371809.

Proteomic databases

PaxDbQ14916.
PRIDEQ14916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244527; ENSP00000244527; ENSG00000124568. [Q14916-1]
ENST00000427328; ENSP00000410549; ENSG00000124568. [Q14916-2]
ENST00000468082; ENSP00000420546; ENSG00000124568. [Q14916-2]
ENST00000476801; ENSP00000420614; ENSG00000124568. [Q14916-1]
GeneID6568.
KEGGhsa:6568.
UCSCuc003nfh.4. human. [Q14916-1]
uc010jqc.1. human. [Q14916-2]

Organism-specific databases

CTD6568.
GeneCardsGC06M025785.
HGNCHGNC:10929. SLC17A1.
MIM182308. gene.
neXtProtNX_Q14916.
PharmGKBPA35820.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOVERGENHBG008834.
InParanoidQ14916.
KOK12300.
OMAFCSFRYG.
OrthoDBEOG71G9TW.
PhylomeDBQ14916.
TreeFamTF313535.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressQ14916.
BgeeQ14916.
CleanExHS_SLC17A1.
GenevestigatorQ14916.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00894. 2A0114euk. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC17A1.
GenomeRNAi6568.
NextBio25555.
PROQ14916.
SOURCESearch...

Entry information

Entry nameNPT1_HUMAN
AccessionPrimary (citable) accession number: Q14916
Secondary accession number(s): A8K418 expand/collapse secondary AC list , O60761, Q13783, Q3MIP5, Q5MJP8, Q5TB83, Q96KL8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM