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Q148V8

- FA83H_MOUSE

UniProt

Q148V8 - FA83H_MOUSE

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Protein

Protein FAM83H

Gene
Fam83h
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

May play a major role in the structural organization and calcification of developing enamel By similarity.

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM83H
Gene namesi
Name:Fam83h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2145900. Fam83h.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12091209Protein FAM83HPRO_0000324489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei522 – 5221Phosphoserine1 Publication
Modified residuei639 – 6391Phosphoserine By similarity
Modified residuei752 – 7521Phosphoserine By similarity
Modified residuei778 – 7781Phosphoserine By similarity
Modified residuei871 – 8711Phosphoserine1 Publication
Modified residuei873 – 8731Phosphothreonine By similarity
Modified residuei882 – 8821Phosphoserine1 Publication
Modified residuei893 – 8931Phosphoserine1 Publication
Modified residuei904 – 9041Phosphoserine1 Publication
Modified residuei915 – 9151Phosphoserine1 Publication
Modified residuei926 – 9261Phosphoserine1 Publication
Modified residuei937 – 9371Phosphoserine By similarity
Modified residuei948 – 9481Phosphoserine1 Publication
Modified residuei959 – 9591Phosphoserine1 Publication
Modified residuei970 – 9701Phosphoserine1 Publication
Modified residuei977 – 9771Phosphoserine By similarity
Modified residuei1035 – 10351Phosphoserine By similarity
Modified residuei1057 – 10571Phosphoserine By similarity
Modified residuei1072 – 10721Phosphothreonine By similarity
Modified residuei1080 – 10801Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ148V8.
PaxDbiQ148V8.
PRIDEiQ148V8.

PTM databases

PhosphoSiteiQ148V8.

Expressioni

Tissue specificityi

Expressed in tooth follicle, eye, liver and kidney.1 Publication

Gene expression databases

BgeeiQ148V8.
CleanExiMM_AA409316.
GenevestigatoriQ148V8.

Interactioni

Protein-protein interaction databases

BioGridi222906. 1 interaction.
IntActiQ148V8. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ148V8.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM83 family.

Phylogenomic databases

eggNOGiNOG78323.
GeneTreeiENSGT00740000115020.
HOGENOMiHOG000112488.
HOVERGENiHBG107907.
InParanoidiQ148V8.
OMAiARHLEMD.
OrthoDBiEOG7P2XR9.
PhylomeDBiQ148V8.
TreeFamiTF330777.

Family and domain databases

InterProiIPR012461. DUF1669.
[Graphical view]
PANTHERiPTHR16181. PTHR16181. 1 hit.
PfamiPF07894. DUF1669. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q148V8-1 [UniParc]FASTAAdd to Basket

« Hide

MARRSQSSSQ GDNPLAPGYL PPHYKEYYRL AVDALTEGGP EAYNRFLASE     50
GAPDFLCPEE LEHVSRHLQP PQYVAREPPE GTPSDVDMDG SSGTYWPVNS 100
DQAVPELDLG WPLTFGFQGT EVTTLVQPPP PDSPSIKDEA RRMIRSAQQV 150
VAVVMDMFTD VDLLSEVLEA AARRVPVYIL LDEMNAQHFL DMADKCRVNL 200
HHVDFLRVRT VAGPTYYCRT GKSFKGHLKE KFLLVDCAVV MSGSYSFMWS 250
FEKIHRSLAH VFQGELVSSF DEEFRILFAQ SEPLVPSAGA LARMDAYALA 300
PYSGAGPLVG VPGVGAPTPF SFPKRAHLLF PPPREEGLGF PSFLDPDRHF 350
LSAFRREELQ RMPGGALEPH TGLRPLARPT EAGPFGELAG PRGFFQSRHL 400
EMDAFKRHSY ATPDGAGAVE NFAAARQVSR QTFLSHGDDF RFQTSHFQRD 450
QLYQQHYQWD PQFAPARPQG LFEKLRAGRP GFADPDDFAL GAGHRFPELG 500
ADVHQRLEYV PSSASREVRH GSDPAFGPSP RGLEPSGASR PNLGQRFPCQ 550
ATLRQGLDTA SEAEPERRGG PEGRAGLRHW RLASYLSGCH GDGGEEGLPM 600
EAEACEDEVL APGGRDLLPS AFRTPAAFPA KGPKPGSGSG GGDSSEREGP 650
EETSLAKQDS FRSRLNPLIQ RSSRLRSSLI FASQAEGAVG TAAATTEKVQ 700
LMHKEQTVSE TLGPSGEAVR SSASAKVAEL LEKYKGPARD PGGAGGAVTS 750
SSHSKAVVSQ AWREEVVAPG GAGTERRSLE SCLLDLRDSF AQQLHQEAER 800
HPGAASLTAA QLLDTLGGTD RLPSRFLSAQ GRSLSPQGRD SPPPEGLGTH 850
QLPYSEPKGN PTPAYPERKG SPTPAYPERK GSPTPAYPER KGSPTPAYPE 900
RKGSPTQAYP ERKGSPTSGF PNRRGSPTTG LMEQKGSPTS TYPDRRGSPV 950
PPVPERRGSP VPPVPERRGS LTFAGESSKT GPTEEVSSGP MEVLRKGSLR 1000
LRQLLSPKNE RRGEDEGSFP TPQENGQPES PRRPSLSRGD STEAAAEERG 1050
SRVRLASATA NALYSSNLRD DTKAILEQIS AHGQKHRGVP APGPAHSSPD 1100
VGRPTTAGDL APDMSDKDKC SAIFRSDSLG TQGRLSRTLP GSAEERDRLL 1150
RRMESMRKEK RVYSRFEVFC KKDEAGSSGA GDNLADEDTR DSKMGKFVPK 1200
ILGTFKSKK 1209
Length:1,209
Mass (Da):131,115
Last modified:August 22, 2006 - v1
Checksum:i1954B609EA75EF25
GO

Sequence cautioni

The sequence AAH36149.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti873 – 8731T → A in BAC29093. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK035531 mRNA. Translation: BAC29093.1.
BC022937 mRNA. Translation: AAH22937.1.
BC023045 mRNA. Translation: AAH23045.1.
BC036149 mRNA. Translation: AAH36149.1. Different initiation.
BC117947 mRNA. Translation: AAI17948.1.
BC117948 mRNA. Translation: AAI17949.1.
CCDSiCCDS27559.1.
RefSeqiNP_001161725.1. NM_001168253.1.
NP_598848.2. NM_134087.2.
XP_006520300.1. XM_006520237.1.
UniGeneiMm.267178.

Genome annotation databases

EnsembliENSMUST00000060807; ENSMUSP00000059839; ENSMUSG00000046761.
ENSMUST00000170153; ENSMUSP00000126453; ENSMUSG00000046761.
GeneIDi105732.
KEGGimmu:105732.
UCSCiuc007wic.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK035531 mRNA. Translation: BAC29093.1 .
BC022937 mRNA. Translation: AAH22937.1 .
BC023045 mRNA. Translation: AAH23045.1 .
BC036149 mRNA. Translation: AAH36149.1 . Different initiation.
BC117947 mRNA. Translation: AAI17948.1 .
BC117948 mRNA. Translation: AAI17949.1 .
CCDSi CCDS27559.1.
RefSeqi NP_001161725.1. NM_001168253.1.
NP_598848.2. NM_134087.2.
XP_006520300.1. XM_006520237.1.
UniGenei Mm.267178.

3D structure databases

ProteinModelPortali Q148V8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222906. 1 interaction.
IntActi Q148V8. 2 interactions.

PTM databases

PhosphoSitei Q148V8.

Proteomic databases

MaxQBi Q148V8.
PaxDbi Q148V8.
PRIDEi Q148V8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060807 ; ENSMUSP00000059839 ; ENSMUSG00000046761 .
ENSMUST00000170153 ; ENSMUSP00000126453 ; ENSMUSG00000046761 .
GeneIDi 105732.
KEGGi mmu:105732.
UCSCi uc007wic.2. mouse.

Organism-specific databases

CTDi 286077.
MGIi MGI:2145900. Fam83h.

Phylogenomic databases

eggNOGi NOG78323.
GeneTreei ENSGT00740000115020.
HOGENOMi HOG000112488.
HOVERGENi HBG107907.
InParanoidi Q148V8.
OMAi ARHLEMD.
OrthoDBi EOG7P2XR9.
PhylomeDBi Q148V8.
TreeFami TF330777.

Miscellaneous databases

ChiTaRSi FAM83H. mouse.
NextBioi 357852.
PROi Q148V8.
SOURCEi Search...

Gene expression databases

Bgeei Q148V8.
CleanExi MM_AA409316.
Genevestigatori Q148V8.

Family and domain databases

InterProi IPR012461. DUF1669.
[Graphical view ]
PANTHERi PTHR16181. PTHR16181. 1 hit.
Pfami PF07894. DUF1669. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-926, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta."
    Kim J.-W., Lee S.-K., Lee Z.H., Park J.-C., Lee K.-E., Lee M.-H., Park J.-T., Seo B.-M., Hu J.C.-C., Simmer J.P.
    Am. J. Hum. Genet. 82:489-494(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871; SER-882 AND SER-893, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522; SER-904; SER-915; SER-948; SER-959 AND SER-970, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFA83H_MOUSE
AccessioniPrimary (citable) accession number: Q148V8
Secondary accession number(s): Q8BZF6
, Q8CI79, Q8R5C2, Q8R5D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi