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Q148V8

- FA83H_MOUSE

UniProt

Q148V8 - FA83H_MOUSE

Protein

Protein FAM83H

Gene

Fam83h

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    May play a major role in the structural organization and calcification of developing enamel.By similarity

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW

    Keywords - Biological processi

    Biomineralization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM83H
    Gene namesi
    Name:Fam83h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2145900. Fam83h.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12091209Protein FAM83HPRO_0000324489Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei522 – 5221Phosphoserine1 Publication
    Modified residuei639 – 6391PhosphoserineBy similarity
    Modified residuei752 – 7521PhosphoserineBy similarity
    Modified residuei778 – 7781PhosphoserineBy similarity
    Modified residuei871 – 8711Phosphoserine1 Publication
    Modified residuei873 – 8731PhosphothreonineBy similarity
    Modified residuei882 – 8821Phosphoserine1 Publication
    Modified residuei893 – 8931Phosphoserine1 Publication
    Modified residuei904 – 9041Phosphoserine1 Publication
    Modified residuei915 – 9151Phosphoserine1 Publication
    Modified residuei926 – 9261Phosphoserine1 Publication
    Modified residuei937 – 9371PhosphoserineBy similarity
    Modified residuei948 – 9481Phosphoserine1 Publication
    Modified residuei959 – 9591Phosphoserine1 Publication
    Modified residuei970 – 9701Phosphoserine1 Publication
    Modified residuei977 – 9771PhosphoserineBy similarity
    Modified residuei1035 – 10351PhosphoserineBy similarity
    Modified residuei1057 – 10571PhosphoserineBy similarity
    Modified residuei1072 – 10721PhosphothreonineBy similarity
    Modified residuei1080 – 10801PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ148V8.
    PaxDbiQ148V8.
    PRIDEiQ148V8.

    PTM databases

    PhosphoSiteiQ148V8.

    Expressioni

    Tissue specificityi

    Expressed in tooth follicle, eye, liver and kidney.1 Publication

    Gene expression databases

    BgeeiQ148V8.
    CleanExiMM_AA409316.
    GenevestigatoriQ148V8.

    Interactioni

    Protein-protein interaction databases

    BioGridi222906. 1 interaction.
    IntActiQ148V8. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ148V8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM83 family.Curated

    Phylogenomic databases

    eggNOGiNOG78323.
    GeneTreeiENSGT00740000115020.
    HOGENOMiHOG000112488.
    HOVERGENiHBG107907.
    InParanoidiQ148V8.
    OMAiARHLEMD.
    OrthoDBiEOG7P2XR9.
    PhylomeDBiQ148V8.
    TreeFamiTF330777.

    Family and domain databases

    InterProiIPR012461. DUF1669.
    [Graphical view]
    PANTHERiPTHR16181. PTHR16181. 1 hit.
    PfamiPF07894. DUF1669. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q148V8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARRSQSSSQ GDNPLAPGYL PPHYKEYYRL AVDALTEGGP EAYNRFLASE     50
    GAPDFLCPEE LEHVSRHLQP PQYVAREPPE GTPSDVDMDG SSGTYWPVNS 100
    DQAVPELDLG WPLTFGFQGT EVTTLVQPPP PDSPSIKDEA RRMIRSAQQV 150
    VAVVMDMFTD VDLLSEVLEA AARRVPVYIL LDEMNAQHFL DMADKCRVNL 200
    HHVDFLRVRT VAGPTYYCRT GKSFKGHLKE KFLLVDCAVV MSGSYSFMWS 250
    FEKIHRSLAH VFQGELVSSF DEEFRILFAQ SEPLVPSAGA LARMDAYALA 300
    PYSGAGPLVG VPGVGAPTPF SFPKRAHLLF PPPREEGLGF PSFLDPDRHF 350
    LSAFRREELQ RMPGGALEPH TGLRPLARPT EAGPFGELAG PRGFFQSRHL 400
    EMDAFKRHSY ATPDGAGAVE NFAAARQVSR QTFLSHGDDF RFQTSHFQRD 450
    QLYQQHYQWD PQFAPARPQG LFEKLRAGRP GFADPDDFAL GAGHRFPELG 500
    ADVHQRLEYV PSSASREVRH GSDPAFGPSP RGLEPSGASR PNLGQRFPCQ 550
    ATLRQGLDTA SEAEPERRGG PEGRAGLRHW RLASYLSGCH GDGGEEGLPM 600
    EAEACEDEVL APGGRDLLPS AFRTPAAFPA KGPKPGSGSG GGDSSEREGP 650
    EETSLAKQDS FRSRLNPLIQ RSSRLRSSLI FASQAEGAVG TAAATTEKVQ 700
    LMHKEQTVSE TLGPSGEAVR SSASAKVAEL LEKYKGPARD PGGAGGAVTS 750
    SSHSKAVVSQ AWREEVVAPG GAGTERRSLE SCLLDLRDSF AQQLHQEAER 800
    HPGAASLTAA QLLDTLGGTD RLPSRFLSAQ GRSLSPQGRD SPPPEGLGTH 850
    QLPYSEPKGN PTPAYPERKG SPTPAYPERK GSPTPAYPER KGSPTPAYPE 900
    RKGSPTQAYP ERKGSPTSGF PNRRGSPTTG LMEQKGSPTS TYPDRRGSPV 950
    PPVPERRGSP VPPVPERRGS LTFAGESSKT GPTEEVSSGP MEVLRKGSLR 1000
    LRQLLSPKNE RRGEDEGSFP TPQENGQPES PRRPSLSRGD STEAAAEERG 1050
    SRVRLASATA NALYSSNLRD DTKAILEQIS AHGQKHRGVP APGPAHSSPD 1100
    VGRPTTAGDL APDMSDKDKC SAIFRSDSLG TQGRLSRTLP GSAEERDRLL 1150
    RRMESMRKEK RVYSRFEVFC KKDEAGSSGA GDNLADEDTR DSKMGKFVPK 1200
    ILGTFKSKK 1209
    Length:1,209
    Mass (Da):131,115
    Last modified:August 22, 2006 - v1
    Checksum:i1954B609EA75EF25
    GO

    Sequence cautioni

    The sequence AAH36149.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti873 – 8731T → A in BAC29093. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK035531 mRNA. Translation: BAC29093.1.
    BC022937 mRNA. Translation: AAH22937.1.
    BC023045 mRNA. Translation: AAH23045.1.
    BC036149 mRNA. Translation: AAH36149.1. Different initiation.
    BC117947 mRNA. Translation: AAI17948.1.
    BC117948 mRNA. Translation: AAI17949.1.
    CCDSiCCDS27559.1.
    RefSeqiNP_001161725.1. NM_001168253.1.
    NP_598848.2. NM_134087.2.
    XP_006520300.1. XM_006520237.1.
    UniGeneiMm.267178.

    Genome annotation databases

    EnsembliENSMUST00000060807; ENSMUSP00000059839; ENSMUSG00000046761.
    ENSMUST00000170153; ENSMUSP00000126453; ENSMUSG00000046761.
    GeneIDi105732.
    KEGGimmu:105732.
    UCSCiuc007wic.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK035531 mRNA. Translation: BAC29093.1 .
    BC022937 mRNA. Translation: AAH22937.1 .
    BC023045 mRNA. Translation: AAH23045.1 .
    BC036149 mRNA. Translation: AAH36149.1 . Different initiation.
    BC117947 mRNA. Translation: AAI17948.1 .
    BC117948 mRNA. Translation: AAI17949.1 .
    CCDSi CCDS27559.1.
    RefSeqi NP_001161725.1. NM_001168253.1.
    NP_598848.2. NM_134087.2.
    XP_006520300.1. XM_006520237.1.
    UniGenei Mm.267178.

    3D structure databases

    ProteinModelPortali Q148V8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222906. 1 interaction.
    IntActi Q148V8. 2 interactions.

    PTM databases

    PhosphoSitei Q148V8.

    Proteomic databases

    MaxQBi Q148V8.
    PaxDbi Q148V8.
    PRIDEi Q148V8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060807 ; ENSMUSP00000059839 ; ENSMUSG00000046761 .
    ENSMUST00000170153 ; ENSMUSP00000126453 ; ENSMUSG00000046761 .
    GeneIDi 105732.
    KEGGi mmu:105732.
    UCSCi uc007wic.2. mouse.

    Organism-specific databases

    CTDi 286077.
    MGIi MGI:2145900. Fam83h.

    Phylogenomic databases

    eggNOGi NOG78323.
    GeneTreei ENSGT00740000115020.
    HOGENOMi HOG000112488.
    HOVERGENi HBG107907.
    InParanoidi Q148V8.
    OMAi ARHLEMD.
    OrthoDBi EOG7P2XR9.
    PhylomeDBi Q148V8.
    TreeFami TF330777.

    Miscellaneous databases

    ChiTaRSi FAM83H. mouse.
    NextBioi 357852.
    PROi Q148V8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q148V8.
    CleanExi MM_AA409316.
    Genevestigatori Q148V8.

    Family and domain databases

    InterProi IPR012461. DUF1669.
    [Graphical view ]
    PANTHERi PTHR16181. PTHR16181. 1 hit.
    Pfami PF07894. DUF1669. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Urinary bladder.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-926, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta."
      Kim J.-W., Lee S.-K., Lee Z.H., Park J.-C., Lee K.-E., Lee M.-H., Park J.-T., Seo B.-M., Hu J.C.-C., Simmer J.P.
      Am. J. Hum. Genet. 82:489-494(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871; SER-882 AND SER-893, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522; SER-904; SER-915; SER-948; SER-959 AND SER-970, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFA83H_MOUSE
    AccessioniPrimary (citable) accession number: Q148V8
    Secondary accession number(s): Q8BZF6
    , Q8CI79, Q8R5C2, Q8R5D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3