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Protein

LisH domain and HEAT repeat-containing protein KIAA1468

Gene

Kiaa1468

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LisH domain and HEAT repeat-containing protein KIAA1468
Gene namesi
Name:Kiaa1468
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1922832. 2310035C23Rik.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003130942 – 1216LisH domain and HEAT repeat-containing protein KIAA1468Add BLAST1215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei32PhosphothreonineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei182PhosphoserineBy similarity1
Modified residuei183PhosphothreonineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei453PhosphoserineBy similarity1
Modified residuei792PhosphoserineCombined sources1
Modified residuei1149PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ148V7.
MaxQBiQ148V7.
PaxDbiQ148V7.
PeptideAtlasiQ148V7.
PRIDEiQ148V7.

PTM databases

iPTMnetiQ148V7.
PhosphoSitePlusiQ148V7.

Expressioni

Gene expression databases

CleanExiMM_2310035C23RIK.

Interactioni

Protein-protein interaction databases

BioGridi230627. 1 interactor.
IntActiQ148V7. 2 interactors.
MINTiMINT-4115287.
STRINGi10090.ENSMUSP00000083926.

Structurei

3D structure databases

ProteinModelPortaliQ148V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 287LisHPROSITE-ProRule annotationAdd BLAST33
Repeati601 – 639HEAT 1Add BLAST39
Repeati640 – 679HEAT 2Add BLAST40
Repeati1004 – 1042HEAT 3Add BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 231Sequence analysisAdd BLAST35
Coiled coili358 – 397Sequence analysisAdd BLAST40

Sequence similaritiesi

Contains 3 HEAT repeats.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IUDI. Eukaryota.
ENOG410Y5MU. LUCA.
HOVERGENiHBG062583.
InParanoidiQ148V7.
PhylomeDBiQ148V7.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR006594. LisH.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q148V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMAPGGGG SGSGVNPFLS DSDEDDDEVA ATEDRRAGLR LGAGVGLDPG
60 70 80 90 100
SAGSLSPQDP MALGSSARPG LAVEMSAAPA ALGGSGETPA RLSIDAIAAQ
110 120 130 140 150
LLRDQYLLTA LELHTELLES GRELPRLRDY FSNPGNFERQ SGTPPGMGAP
160 170 180 190 200
GIPGASIVGG AGGREPSTTS GGGQLNRAGS ISTLDSLDFA RYSDDGNRET
210 220 230 240 250
DERVAVLEFE LRKAKETIQA LRANLTKAAE HEVPLQERKN YKSSPEIQEP
260 270 280 290 300
IKPLEKRALN FLVNEFLLKN NYKLTSITFS DENDDQDFEL WDDVGLNIPK
310 320 330 340 350
PPDLLQLYRD FGNHQVTGKD LVDVASGVDE DELEALTPIL GNVPPTLDTP
360 370 380 390 400
LPIENTLLVQ KLEDKISLLN NEKWSLMEQI RRLESEMDIL KAEHFATPAV
410 420 430 440 450
GDSVQPSLVW SSQKDSEDNR QSPAVNSSDQ EKTKDVHLEI PDAADSFIPK
460 470 480 490 500
ENSSGSFPRK EREELPPSSV SNKTTLHFDQ PNRKLSPAFH QALLSFCRMS
510 520 530 540 550
ADSRLGSEVS RIADSEKSVM LMLGRCLPHI VPNVLLAKRE ELIPLILCTA
560 570 580 590 600
CLHPEPKERD QLLHILFNLI KRPDDEQRQM ILTGCVAFAR HVGPTRVEAE
610 620 630 640 650
LLPQCWEQIN HKYPERRLLV AESCGALAPY LPKEIRSSLV LSMLQQMLME
660 670 680 690 700
DKADLVREAV IKSLGIIMGY IDDPDKYQQG FELLLSALGD PSERVVSATH
710 720 730 740 750
QVFLPAYAAW TTELGNLQSH LIPTLLNKIE KLLREGEHGL DEHKLHMYLS
760 770 780 790 800
ALQSLIPSLF ALVLQNAPFS SKAKLHGEVP HIEVTRFPRP MSPLQDVSTI
810 820 830 840 850
IGSREQLAVL LQLYDYQLEH EGTTGWESLL WVVNQLLPQL IEIVGKINVT
860 870 880 890 900
STACVHEFSR FFWRLCRTFG KIFTNTKVKP QFQEILRLSE ENIDSSAGNG
910 920 930 940 950
VLTKATVPIY ATGVLTCYIQ EEDRKLLVGF LEDVMTLLSL SHAPLDSLKA
960 970 980 990 1000
SFVELGANPA YHELLLTVLW YGVVHTSALV RCTAARMFEL LVKGVNETLV
1010 1020 1030 1040 1050
AQRVVPALIT LSSDPEISVR IATIPAFGTI METVIQRELL ERVKMQLASF
1060 1070 1080 1090 1100
LEDPQYQDQH SLHTEVIRTF GRVGPNAEPR FRDEFVIPHL HKLALVNNLQ
1110 1120 1130 1140 1150
IVDSKKLDIA THLFEAYSAL SCCFISEDLM VNHFLPGLRC LRTDMEHLSP
1160 1170 1180 1190 1200
EHEVILSSMI KECEQKVENK TVQEPPGSMS IAASLVSEDT KTKFLNKMGQ
1210
LTTSGAMLAN VFQRKK
Length:1,216
Mass (Da):134,587
Last modified:August 22, 2006 - v1
Checksum:iAFDC80110D00FA71
GO
Isoform 2 (identifier: Q148V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-228: Missing.

Show »
Length:1,192
Mass (Da):131,891
Checksum:iC23ADAD7936E1485
GO
Isoform 3 (identifier: Q148V7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-109: Missing.
     990-1000: LLVKGVNETLV → VGYIILSCFYL
     1001-1216: Missing.

Note: No experimental confirmation available.
Show »
Length:968
Mass (Da):107,132
Checksum:i4C02AF6D3F72E0E7
GO

Sequence cautioni

The sequence BAC30530 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98178 differs from that shown. The sequence differs from that shown because it is derived from pre-RNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82L → P in BAC27422 (PubMed:16141072).Curated1
Sequence conflicti431E → K in BAC27422 (PubMed:16141072).Curated1
Sequence conflicti1202T → A in BAC27422 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03001878 – 109Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_030019205 – 228Missing in isoform 2. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_030020990 – 1000LLVKGVNETLV → VGYIILSCFYL in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0300211001 – 1216Missing in isoform 3. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129368 Transcribed RNA. Translation: BAC98178.1. Sequence problems.
AK031484 mRNA. Translation: BAC27422.1.
AK032147 mRNA. Translation: BAC27723.1.
AK040168 mRNA. Translation: BAC30530.1. Different initiation.
BC060194 mRNA. Translation: AAH60194.1.
BC117949 mRNA. Translation: AAI17950.1.
BC117950 mRNA. Translation: AAI17951.1.
CCDSiCCDS15206.1. [Q148V7-1]
CCDS48334.1. [Q148V7-2]
RefSeqiNP_083625.1. NM_029349.1.
NP_775279.2. NM_173187.3.
UniGeneiMm.337339.

Genome annotation databases

GeneIDi227446.
KEGGimmu:227446.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129368 Transcribed RNA. Translation: BAC98178.1. Sequence problems.
AK031484 mRNA. Translation: BAC27422.1.
AK032147 mRNA. Translation: BAC27723.1.
AK040168 mRNA. Translation: BAC30530.1. Different initiation.
BC060194 mRNA. Translation: AAH60194.1.
BC117949 mRNA. Translation: AAI17950.1.
BC117950 mRNA. Translation: AAI17951.1.
CCDSiCCDS15206.1. [Q148V7-1]
CCDS48334.1. [Q148V7-2]
RefSeqiNP_083625.1. NM_029349.1.
NP_775279.2. NM_173187.3.
UniGeneiMm.337339.

3D structure databases

ProteinModelPortaliQ148V7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230627. 1 interactor.
IntActiQ148V7. 2 interactors.
MINTiMINT-4115287.
STRINGi10090.ENSMUSP00000083926.

PTM databases

iPTMnetiQ148V7.
PhosphoSitePlusiQ148V7.

Proteomic databases

EPDiQ148V7.
MaxQBiQ148V7.
PaxDbiQ148V7.
PeptideAtlasiQ148V7.
PRIDEiQ148V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi227446.
KEGGimmu:227446.

Organism-specific databases

MGIiMGI:1922832. 2310035C23Rik.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IUDI. Eukaryota.
ENOG410Y5MU. LUCA.
HOVERGENiHBG062583.
InParanoidiQ148V7.
PhylomeDBiQ148V7.

Miscellaneous databases

PROiQ148V7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_2310035C23RIK.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR006594. LisH.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1468_MOUSE
AccessioniPrimary (citable) accession number: Q148V7
Secondary accession number(s): Q148V6
, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.