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Protein

LisH domain and HEAT repeat-containing protein KIAA1468

Gene

Kiaa1468

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LisH domain and HEAT repeat-containing protein KIAA1468
Gene namesi
Name:Kiaa1468
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1922832. 2310035C23Rik.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 12161215LisH domain and HEAT repeat-containing protein KIAA1468PRO_0000313094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei20 – 201PhosphoserineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei32 – 321PhosphothreonineCombined sources
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei183 – 1831PhosphothreonineCombined sources
Modified residuei186 – 1861PhosphoserineCombined sources
Modified residuei385 – 3851PhosphoserineCombined sources
Modified residuei792 – 7921PhosphoserineCombined sources
Modified residuei1149 – 11491PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ148V7.
MaxQBiQ148V7.
PaxDbiQ148V7.
PRIDEiQ148V7.

PTM databases

iPTMnetiQ148V7.
PhosphoSiteiQ148V7.

Expressioni

Gene expression databases

CleanExiMM_2310035C23RIK.

Interactioni

Protein-protein interaction databases

BioGridi230627. 1 interaction.
IntActiQ148V7. 2 interactions.
MINTiMINT-4115287.
STRINGi10090.ENSMUSP00000083926.

Structurei

3D structure databases

ProteinModelPortaliQ148V7.
SMRiQ148V7. Positions 602-701, 969-1096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 28733LisHPROSITE-ProRule annotationAdd
BLAST
Repeati601 – 63939HEAT 1Add
BLAST
Repeati640 – 67940HEAT 2Add
BLAST
Repeati1004 – 104239HEAT 3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili197 – 23135Sequence analysisAdd
BLAST
Coiled coili358 – 39740Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 3 HEAT repeats.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IUDI. Eukaryota.
ENOG410Y5MU. LUCA.
HOVERGENiHBG062583.
InParanoidiQ148V7.
PhylomeDBiQ148V7.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR006594. LisH.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q148V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMAPGGGG SGSGVNPFLS DSDEDDDEVA ATEDRRAGLR LGAGVGLDPG
60 70 80 90 100
SAGSLSPQDP MALGSSARPG LAVEMSAAPA ALGGSGETPA RLSIDAIAAQ
110 120 130 140 150
LLRDQYLLTA LELHTELLES GRELPRLRDY FSNPGNFERQ SGTPPGMGAP
160 170 180 190 200
GIPGASIVGG AGGREPSTTS GGGQLNRAGS ISTLDSLDFA RYSDDGNRET
210 220 230 240 250
DERVAVLEFE LRKAKETIQA LRANLTKAAE HEVPLQERKN YKSSPEIQEP
260 270 280 290 300
IKPLEKRALN FLVNEFLLKN NYKLTSITFS DENDDQDFEL WDDVGLNIPK
310 320 330 340 350
PPDLLQLYRD FGNHQVTGKD LVDVASGVDE DELEALTPIL GNVPPTLDTP
360 370 380 390 400
LPIENTLLVQ KLEDKISLLN NEKWSLMEQI RRLESEMDIL KAEHFATPAV
410 420 430 440 450
GDSVQPSLVW SSQKDSEDNR QSPAVNSSDQ EKTKDVHLEI PDAADSFIPK
460 470 480 490 500
ENSSGSFPRK EREELPPSSV SNKTTLHFDQ PNRKLSPAFH QALLSFCRMS
510 520 530 540 550
ADSRLGSEVS RIADSEKSVM LMLGRCLPHI VPNVLLAKRE ELIPLILCTA
560 570 580 590 600
CLHPEPKERD QLLHILFNLI KRPDDEQRQM ILTGCVAFAR HVGPTRVEAE
610 620 630 640 650
LLPQCWEQIN HKYPERRLLV AESCGALAPY LPKEIRSSLV LSMLQQMLME
660 670 680 690 700
DKADLVREAV IKSLGIIMGY IDDPDKYQQG FELLLSALGD PSERVVSATH
710 720 730 740 750
QVFLPAYAAW TTELGNLQSH LIPTLLNKIE KLLREGEHGL DEHKLHMYLS
760 770 780 790 800
ALQSLIPSLF ALVLQNAPFS SKAKLHGEVP HIEVTRFPRP MSPLQDVSTI
810 820 830 840 850
IGSREQLAVL LQLYDYQLEH EGTTGWESLL WVVNQLLPQL IEIVGKINVT
860 870 880 890 900
STACVHEFSR FFWRLCRTFG KIFTNTKVKP QFQEILRLSE ENIDSSAGNG
910 920 930 940 950
VLTKATVPIY ATGVLTCYIQ EEDRKLLVGF LEDVMTLLSL SHAPLDSLKA
960 970 980 990 1000
SFVELGANPA YHELLLTVLW YGVVHTSALV RCTAARMFEL LVKGVNETLV
1010 1020 1030 1040 1050
AQRVVPALIT LSSDPEISVR IATIPAFGTI METVIQRELL ERVKMQLASF
1060 1070 1080 1090 1100
LEDPQYQDQH SLHTEVIRTF GRVGPNAEPR FRDEFVIPHL HKLALVNNLQ
1110 1120 1130 1140 1150
IVDSKKLDIA THLFEAYSAL SCCFISEDLM VNHFLPGLRC LRTDMEHLSP
1160 1170 1180 1190 1200
EHEVILSSMI KECEQKVENK TVQEPPGSMS IAASLVSEDT KTKFLNKMGQ
1210
LTTSGAMLAN VFQRKK
Length:1,216
Mass (Da):134,587
Last modified:August 22, 2006 - v1
Checksum:iAFDC80110D00FA71
GO
Isoform 2 (identifier: Q148V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-228: Missing.

Show »
Length:1,192
Mass (Da):131,891
Checksum:iC23ADAD7936E1485
GO
Isoform 3 (identifier: Q148V7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-109: Missing.
     990-1000: LLVKGVNETLV → VGYIILSCFYL
     1001-1216: Missing.

Note: No experimental confirmation available.
Show »
Length:968
Mass (Da):107,132
Checksum:i4C02AF6D3F72E0E7
GO

Sequence cautioni

The sequence BAC30530.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC98178.1 differs from that shown.The sequence differs from that shown because it is derived from pre-RNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821L → P in BAC27422 (PubMed:16141072).Curated
Sequence conflicti431 – 4311E → K in BAC27422 (PubMed:16141072).Curated
Sequence conflicti1202 – 12021T → A in BAC27422 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 10932Missing in isoform 3. 1 PublicationVSP_030018Add
BLAST
Alternative sequencei205 – 22824Missing in isoform 2. 2 PublicationsVSP_030019Add
BLAST
Alternative sequencei990 – 100011LLVKGVNETLV → VGYIILSCFYL in isoform 3. 1 PublicationVSP_030020Add
BLAST
Alternative sequencei1001 – 1216216Missing in isoform 3. 1 PublicationVSP_030021Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129368 Transcribed RNA. Translation: BAC98178.1. Sequence problems.
AK031484 mRNA. Translation: BAC27422.1.
AK032147 mRNA. Translation: BAC27723.1.
AK040168 mRNA. Translation: BAC30530.1. Different initiation.
BC060194 mRNA. Translation: AAH60194.1.
BC117949 mRNA. Translation: AAI17950.1.
BC117950 mRNA. Translation: AAI17951.1.
CCDSiCCDS15206.1. [Q148V7-1]
CCDS48334.1. [Q148V7-2]
RefSeqiNP_083625.1. NM_029349.1.
NP_775279.2. NM_173187.3.
UniGeneiMm.337339.

Genome annotation databases

GeneIDi227446.
KEGGimmu:227446.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129368 Transcribed RNA. Translation: BAC98178.1. Sequence problems.
AK031484 mRNA. Translation: BAC27422.1.
AK032147 mRNA. Translation: BAC27723.1.
AK040168 mRNA. Translation: BAC30530.1. Different initiation.
BC060194 mRNA. Translation: AAH60194.1.
BC117949 mRNA. Translation: AAI17950.1.
BC117950 mRNA. Translation: AAI17951.1.
CCDSiCCDS15206.1. [Q148V7-1]
CCDS48334.1. [Q148V7-2]
RefSeqiNP_083625.1. NM_029349.1.
NP_775279.2. NM_173187.3.
UniGeneiMm.337339.

3D structure databases

ProteinModelPortaliQ148V7.
SMRiQ148V7. Positions 602-701, 969-1096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230627. 1 interaction.
IntActiQ148V7. 2 interactions.
MINTiMINT-4115287.
STRINGi10090.ENSMUSP00000083926.

PTM databases

iPTMnetiQ148V7.
PhosphoSiteiQ148V7.

Proteomic databases

EPDiQ148V7.
MaxQBiQ148V7.
PaxDbiQ148V7.
PRIDEiQ148V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi227446.
KEGGimmu:227446.

Organism-specific databases

MGIiMGI:1922832. 2310035C23Rik.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IUDI. Eukaryota.
ENOG410Y5MU. LUCA.
HOVERGENiHBG062583.
InParanoidiQ148V7.
PhylomeDBiQ148V7.

Miscellaneous databases

NextBioi378600.
PROiQ148V7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_2310035C23RIK.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR006594. LisH.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-1216 (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb, Testis and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-22; THR-32 AND SER-180, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; THR-183; SER-186; SER-385; SER-792 AND SER-1149, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiK1468_MOUSE
AccessioniPrimary (citable) accession number: Q148V7
Secondary accession number(s): Q148V6
, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.