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Q148R4

- Q148R4_MOUSE

UniProt

Q148R4 - Q148R4_MOUSE

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Protein
Submitted name:

Protein Spink5

Gene

Spink5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. peptidase inhibitor activity Source: MGI
  2. serine-type endopeptidase inhibitor activity Source: Ensembl

GO - Biological processi

  1. epidermal cell differentiation Source: Ensembl
  2. negative regulation of proteolysis Source: MGI
  3. negative regulation of serine-type peptidase activity Source: MGI
  4. regulation of cell adhesion Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiI01.958.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Spink5Imported
Submitted name:
Serine peptidase inhibitor, Kazal type 5Imported
Gene namesi
Name:Spink5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1919682. Spink5.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cytosol Source: Ensembl
  3. endoplasmic reticulum membrane Source: Ensembl
  4. epidermal lamellar body Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ148R4.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG253835.
GeneTreeiENSGT00510000048608.
HOGENOMiHOG000015390.
HOVERGENiHBG006183.
OMAiCHENLIR.
OrthoDBiEOG7BW0M2.
TreeFamiTF336724.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 2 hits.
PF07648. Kazal_2. 11 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 13 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q148R4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTATVPMLL TLAFYLTQDA AGEKGNQDPC MKFQAQMKNG TLTCPKGNNS
60 70 80 90 100
SQSLNDIIFQ SECILCKRAL EQGAPTKIMN VKVLSRANRA TDPAKLNCES
110 120 130 140 150
FKQRRKDGDF ICPSDTSSVC GTDGKTYRSR CELCAENAKS QNHVDVKSEG
160 170 180 190 200
ECGSSHLETD MCSDFRAYVQ DGRLGCTRES DPILGPDGRT HGNRCAMCAE
210 220 230 240 250
LFLKEAKENA TRNRESRIRR DAEKELCKEF ENQVRNGRLF CTRESDPIRG
260 270 280 290 300
PDGKMHGNKC ALCAEIFMRQ FTEEKGKAEK NQKDAEERAK AKMEIQKRCS
310 320 330 340 350
EFQDRARNGT LFCTRENDPI RGLDGKTHGN LCSMCQAFFK TEAEEKKAEA
360 370 380 390 400
GSRNRRGSEE SETYAKLCDE YRKARKNGQL YCTRENAPIR GPDGKIHGNT
410 420 430 440 450
CSMCQAFFIQ EDKARAKVKR EAAKEMCSEF RNQARNGMLM CTRENDPVVG
460 470 480 490 500
PDGKRHSNKC AMCASVFLLE EEEKKKDDKT EKVDAGKAKK EAVQELCRKY
510 520 530 540 550
HTQLRNGPLR CTRRNNPIEG LDGKMYKNAC FMCWAFFQQE AKKSGAGFRP
560 570 580 590 600
KVKREVKVDC SEYLALSKRG EIFCTRENDP VRGPDGKTHG NKCAMCKAVF
610 620 630 640 650
KKENEERKRK EGENQRITSG ESSSGGNPKA KDECAQYRES MKHGQLSCTR
660 670 680 690 700
ESDPVRGVDG EHYNNKCVMC KELLQKEMEE TNKNSASRSN GTGSATGKDV
710 720 730 740 750
CDQFRSQMKN GKLLCTRESD PTRGPDGAMH GNKCAMCKER LEKEAAEKKK
760 770 780 790 800
KEDEEKRNTE TNKSDKEDKC HEYRSMQLDG RLICTRENDP VRDADGKMHV
810 820 830 840 850
NKCAMCQMMF EREANERKMR EENSRSQPTN EAKDQCGEVH NSVEDAKPRP
860 870 880 890 900
ARSSLPSIRG ISKDECSEFQ NLMKNEKLTC PETDDPVRGA DGTFYQNKCH
910 920 930 940 950
MCRDVLKNEA MKRSGLQEKS SDIRSTKEGD PEFSSSSRDS DMCKNYRILP
960 970 980 990 1000
RMGYLCPKNL NPVCGDDGQT YSNPCMLCHE NLMRQTNTRI HKQGACEESS
1010
NLKTVSTGTP ASEKMMQ
Length:1,017
Mass (Da):114,891
Last modified:August 22, 2006 - v1
Checksum:iFE32F4B2D9A4BB66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138293 Genomic DNA. No translation available.
BC118011 mRNA. Translation: AAI18012.1.
RefSeqiNP_001074649.1. NM_001081180.1.
XP_006526342.1. XM_006526279.1.
XP_006526343.1. XM_006526280.1.
UniGeneiMm.35369.

Genome annotation databases

EnsembliENSMUST00000069245; ENSMUSP00000066214; ENSMUSG00000055561.
GeneIDi72432.
KEGGimmu:72432.
UCSCiuc008eup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138293 Genomic DNA. No translation available.
BC118011 mRNA. Translation: AAI18012.1 .
RefSeqi NP_001074649.1. NM_001081180.1.
XP_006526342.1. XM_006526279.1.
XP_006526343.1. XM_006526280.1.
UniGenei Mm.35369.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I01.958.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069245 ; ENSMUSP00000066214 ; ENSMUSG00000055561 .
GeneIDi 72432.
KEGGi mmu:72432.
UCSCi uc008eup.1. mouse.

Organism-specific databases

CTDi 11005.
MGIi MGI:1919682. Spink5.

Phylogenomic databases

eggNOGi NOG253835.
GeneTreei ENSGT00510000048608.
HOGENOMi HOG000015390.
HOVERGENi HBG006183.
OMAi CHENLIR.
OrthoDBi EOG7BW0M2.
TreeFami TF336724.

Miscellaneous databases

NextBioi 336242.
PROi Q148R4.
SOURCEi Search...

Gene expression databases

Genevestigatori Q148R4.

Family and domain databases

InterProi IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF00050. Kazal_1. 2 hits.
PF07648. Kazal_2. 11 hits.
[Graphical view ]
SMARTi SM00280. KAZAL. 13 hits.
[Graphical view ]
PROSITEi PS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ148R4_MOUSE
AccessioniPrimary (citable) accession number: Q148R4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3