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Q148R4

- Q148R4_MOUSE

UniProt

Q148R4 - Q148R4_MOUSE

Protein
Submitted name:

Protein Spink5

Gene

Spink5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptidase inhibitor activity Source: MGI
    2. serine-type endopeptidase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. epidermal cell differentiation Source: Ensembl
    2. negative regulation of proteolysis Source: MGI
    3. negative regulation of serine-type peptidase activity Source: MGI
    4. regulation of cell adhesion Source: MGI

    Protein family/group databases

    MEROPSiI01.958.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Spink5Imported
    Submitted name:
    Serine peptidase inhibitor, Kazal type 5Imported
    Gene namesi
    Name:Spink5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1919682. Spink5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cytosol Source: Ensembl
    3. endoplasmic reticulum membrane Source: Ensembl
    4. epidermal lamellar body Source: Ensembl
    5. perinuclear region of cytoplasm Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ148R4.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG253835.
    GeneTreeiENSGT00510000048608.
    HOGENOMiHOG000015390.
    HOVERGENiHBG006183.
    InParanoidiQ148R4.
    OMAiCHENLIR.
    OrthoDBiEOG7BW0M2.
    TreeFamiTF336724.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF00050. Kazal_1. 2 hits.
    PF07648. Kazal_2. 11 hits.
    [Graphical view]
    SMARTiSM00280. KAZAL. 13 hits.
    [Graphical view]
    PROSITEiPS00282. KAZAL_1. 2 hits.
    PS51465. KAZAL_2. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q148R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTATVPMLL TLAFYLTQDA AGEKGNQDPC MKFQAQMKNG TLTCPKGNNS     50
    SQSLNDIIFQ SECILCKRAL EQGAPTKIMN VKVLSRANRA TDPAKLNCES 100
    FKQRRKDGDF ICPSDTSSVC GTDGKTYRSR CELCAENAKS QNHVDVKSEG 150
    ECGSSHLETD MCSDFRAYVQ DGRLGCTRES DPILGPDGRT HGNRCAMCAE 200
    LFLKEAKENA TRNRESRIRR DAEKELCKEF ENQVRNGRLF CTRESDPIRG 250
    PDGKMHGNKC ALCAEIFMRQ FTEEKGKAEK NQKDAEERAK AKMEIQKRCS 300
    EFQDRARNGT LFCTRENDPI RGLDGKTHGN LCSMCQAFFK TEAEEKKAEA 350
    GSRNRRGSEE SETYAKLCDE YRKARKNGQL YCTRENAPIR GPDGKIHGNT 400
    CSMCQAFFIQ EDKARAKVKR EAAKEMCSEF RNQARNGMLM CTRENDPVVG 450
    PDGKRHSNKC AMCASVFLLE EEEKKKDDKT EKVDAGKAKK EAVQELCRKY 500
    HTQLRNGPLR CTRRNNPIEG LDGKMYKNAC FMCWAFFQQE AKKSGAGFRP 550
    KVKREVKVDC SEYLALSKRG EIFCTRENDP VRGPDGKTHG NKCAMCKAVF 600
    KKENEERKRK EGENQRITSG ESSSGGNPKA KDECAQYRES MKHGQLSCTR 650
    ESDPVRGVDG EHYNNKCVMC KELLQKEMEE TNKNSASRSN GTGSATGKDV 700
    CDQFRSQMKN GKLLCTRESD PTRGPDGAMH GNKCAMCKER LEKEAAEKKK 750
    KEDEEKRNTE TNKSDKEDKC HEYRSMQLDG RLICTRENDP VRDADGKMHV 800
    NKCAMCQMMF EREANERKMR EENSRSQPTN EAKDQCGEVH NSVEDAKPRP 850
    ARSSLPSIRG ISKDECSEFQ NLMKNEKLTC PETDDPVRGA DGTFYQNKCH 900
    MCRDVLKNEA MKRSGLQEKS SDIRSTKEGD PEFSSSSRDS DMCKNYRILP 950
    RMGYLCPKNL NPVCGDDGQT YSNPCMLCHE NLMRQTNTRI HKQGACEESS 1000
    NLKTVSTGTP ASEKMMQ 1017
    Length:1,017
    Mass (Da):114,891
    Last modified:August 22, 2006 - v1
    Checksum:iFE32F4B2D9A4BB66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138293 Genomic DNA. No translation available.
    BC118011 mRNA. Translation: AAI18012.1.
    RefSeqiNP_001074649.1. NM_001081180.1.
    XP_006526342.1. XM_006526279.1.
    XP_006526343.1. XM_006526280.1.
    UniGeneiMm.35369.

    Genome annotation databases

    EnsembliENSMUST00000069245; ENSMUSP00000066214; ENSMUSG00000055561.
    GeneIDi72432.
    KEGGimmu:72432.
    UCSCiuc008eup.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138293 Genomic DNA. No translation available.
    BC118011 mRNA. Translation: AAI18012.1 .
    RefSeqi NP_001074649.1. NM_001081180.1.
    XP_006526342.1. XM_006526279.1.
    XP_006526343.1. XM_006526280.1.
    UniGenei Mm.35369.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I01.958.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069245 ; ENSMUSP00000066214 ; ENSMUSG00000055561 .
    GeneIDi 72432.
    KEGGi mmu:72432.
    UCSCi uc008eup.1. mouse.

    Organism-specific databases

    CTDi 11005.
    MGIi MGI:1919682. Spink5.

    Phylogenomic databases

    eggNOGi NOG253835.
    GeneTreei ENSGT00510000048608.
    HOGENOMi HOG000015390.
    HOVERGENi HBG006183.
    InParanoidi Q148R4.
    OMAi CHENLIR.
    OrthoDBi EOG7BW0M2.
    TreeFami TF336724.

    Miscellaneous databases

    NextBioi 336242.
    PROi Q148R4.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q148R4.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF00050. Kazal_1. 2 hits.
    PF07648. Kazal_2. 11 hits.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 13 hits.
    [Graphical view ]
    PROSITEi PS00282. KAZAL_1. 2 hits.
    PS51465. KAZAL_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ148R4_MOUSE
    AccessioniPrimary (citable) accession number: Q148R4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3