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Q148N0

- ODO1_BOVIN

UniProt

Q148N0 - ODO1_BOVIN

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Enzyme regulationi

    Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi154 – 1541CalciumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi154 – 1585By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. oxoglutarate dehydrogenase (NAD+) activity Source: Ensembl
    3. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    4. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. cerebellar cortex development Source: Ensembl
    2. glycolytic process Source: UniProtKB-KW
    3. hippocampus development Source: Ensembl
    4. olfactory bulb mitral cell layer development Source: Ensembl
    5. pyramidal neuron development Source: Ensembl
    6. striatum development Source: Ensembl
    7. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
    8. thalamus development Source: Ensembl
    9. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Calcium, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    ReactomeiREACT_221023. Lysine catabolism.
    REACT_227707. Citric acid cycle (TCA cycle).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1
    Short name:
    OGDC-E1
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:OGDH
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040MitochondrionSequence AnalysisAdd
    BLAST
    Chaini41 – 10239832-oxoglutarate dehydrogenase, mitochondrialPRO_0000310981Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei74 – 741N6-succinyllysineBy similarity
    Modified residuei401 – 4011N6-acetyllysineBy similarity
    Cross-linki534 – 534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei564 – 5641N6-succinyllysineBy similarity
    Modified residuei970 – 9701N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ148N0.
    PRIDEiQ148N0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ148N0. 1 interaction.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    GeneTreeiENSGT00530000063092.
    HOGENOMiHOG000259586.
    HOVERGENiHBG001892.
    InParanoidiQ148N0.
    KOiK00164.
    OMAiMLSGTHF.
    OrthoDBiEOG7FXZXH.
    TreeFamiTF300695.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q148N0-1 [UniParc]FASTAAdd to Basket

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    MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFGQIRCY TAPVAAEPFL     50
    SGTSSNYVEE MYYAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS 100
    PGSLSAVARA GPLVEAQPNV DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL 150
    GILDADLDSS VPADIISSTD KLGFYGLDES DLDKVFHLPT TTFIGGQESA 200
    LPLREIIRRL EMAYCQHIGV EFMFINDLEQ CQWIRQKFET PGVMQFTNEE 250
    KRTLLARLVR STRFEEFLQR KWSSEKRFGL EGCEVLIPAL KTIIDKSSEN 300
    GVDYVIMGMP HRGRLNVLAN VIRKELEQIF CQFDSKLEAA DEGSGDVKYH 350
    LGMYHRRINR VTDRNITLSL VANPSHLEAA DPVVMGKTKA EQFYCGDTEG 400
    KKVMSILLHG DAAFAGQGIV YETFHLSDLP SYTTHGTVHV VVNNQIGFTT 450
    DPRMARSSPY PTDVARVVNA PIFHVNSDDP EAVMYVCKVA AEWRSTFHKD 500
    VVVDLVCYRR NGHNEMDEPM FTQPLMYKQI RKQKPVLQKY AELLVSQGVV 550
    NQPEYEEEIS KYDKICEEAF ARSKDEKILH IKHWLDSPWP GFFTLDGQPR 600
    SMTCPSTGLT EDILTHIGNV ASSVPVEDFT IHGGLSRILK TRGELVKNRT 650
    VDWALAEYMA FGSLLKEGIH IRLSGQDVER GTFSHRHHVL HDQNVDKRTC 700
    IPMNHLWPNQ APYTVCNSSL SEYGVLGFEL GFAMASPNAL VLWEAQFGDF 750
    HNTAQCIIDQ FICPGQAKWV RQNGIVLLLP HGMEGMGPEH SSARPERFLQ 800
    MCNDDPDVLP DLKEANFDIN QLYDCNWVVV NCSTPGNFFH VLRRQILLPF 850
    RKPLIIFTPK SLLRHPEARS NFDEMLPGTH FQRVIPEDGP AAQNPGNVKR 900
    LLFCTGKVYY DLTRERKARD MVEQVAITRI EQLSPFPFDL LLQEVQKYPS 950
    AELAWCQEEH KNQGYYDYVK PRLRTTISRA KPVWYAGRDP AAAPATGNKK 1000
    THLTELQRLL DTAFDLDAFK NFS 1023
    Length:1,023
    Mass (Da):115,808
    Last modified:August 22, 2006 - v1
    Checksum:i46C5D3161D41F551
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118106 mRNA. Translation: AAI18107.1.
    RefSeqiNP_001069498.1. NM_001076030.1.
    XP_005205655.1. XM_005205598.1.
    UniGeneiBt.46406.

    Genome annotation databases

    EnsembliENSBTAT00000007922; ENSBTAP00000007922; ENSBTAG00000006029.
    GeneIDi534599.
    KEGGibta:534599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC118106 mRNA. Translation: AAI18107.1 .
    RefSeqi NP_001069498.1. NM_001076030.1.
    XP_005205655.1. XM_005205598.1.
    UniGenei Bt.46406.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q148N0. 1 interaction.

    Proteomic databases

    PaxDbi Q148N0.
    PRIDEi Q148N0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000007922 ; ENSBTAP00000007922 ; ENSBTAG00000006029 .
    GeneIDi 534599.
    KEGGi bta:534599.

    Organism-specific databases

    CTDi 4967.

    Phylogenomic databases

    eggNOGi COG0567.
    GeneTreei ENSGT00530000063092.
    HOGENOMi HOG000259586.
    HOVERGENi HBG001892.
    InParanoidi Q148N0.
    KOi K00164.
    OMAi MLSGTHF.
    OrthoDBi EOG7FXZXH.
    TreeFami TF300695.

    Enzyme and pathway databases

    Reactomei REACT_221023. Lysine catabolism.
    REACT_227707. Citric acid cycle (TCA cycle).

    Miscellaneous databases

    NextBioi 20876461.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiODO1_BOVIN
    AccessioniPrimary (citable) accession number: Q148N0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3