ID   DHDH_BOVIN              Reviewed;         335 AA.
AC   Q148L6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
DE            EC=1.3.1.20;
DE   AltName: Full=Dimeric dihydrodiol dehydrogenase;
DE   AltName: Full=D-xylose-NADP dehydrogenase;
DE            EC=1.1.1.179;
DE   AltName: Full=D-xylose 1-dehydrogenase;
GN   Name=DHDH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) =
CC       catechol + NADPH.
CC   -!- CATALYTIC ACTIVITY: D-xylose + NADP(+) = D-xylono-1,5-lactone +
CC       NADPH.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the gfo/idh/mocA family.
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DR   EMBL; BC118168; AAI18169.1; -; mRNA.
DR   IPI; IPI00691440; -.
DR   RefSeq; NP_001069937.1; -.
DR   UniGene; Bt.22630; -.
DR   Ensembl; ENSBTAG00000013337; Bos taurus.
DR   GeneID; 617564; -.
DR   KEGG; bta:617564; -.
DR   HOVERGEN; Q148L6; -.
DR   OMA; Q148L6; NILCEKP.
DR   BRENDA; 1.1.1.179; 251.
DR   BRENDA; 1.3.1.20; 251.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0047837; F:D-xylose 1-dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydroge...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000683; Oxidoreductase_N.
DR   InterPro; IPR004104; OxRdtase_C.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase.
FT   CHAIN         1    335       Trans-1,2-dihydrobenzene-1,2-diol
FT                                dehydrogenase.
FT                                /FTId=PRO_0000315359.
FT   SITE         71     71       May play an important role in coenzyme
FT                                binding (By similarity).
FT   SITE         79     79       May play an important role in coenzyme
FT                                binding (By similarity).
FT   SITE         97     97       May play an important role in coenzyme
FT                                binding (By similarity).
FT   SITE        176    176       May play an important role for the
FT                                adaptation of the alcohol substrate into
FT                                the binding site (By similarity).
FT   SITE        180    180       May play an important role in catalytic
FT                                activity (By similarity).
SQ   SEQUENCE   335 AA;  36583 MW;  3D6B91F2F9220BAA CRC64;
     MALRWGIVSA GLISSDFTTM LRMLPRSEHQ VVAVAARDLS RAKEFAKKHD IPKAYGSYEE
     LAKDPDVEVA YIGTQHPQHK AAVLLCLTAG KAVLCEKPMG VNAAEVREMV AEARSRGLFF
     MEAIWTRFFP AVEALRSVLA QGTLGDLRVV RAEFGKNLTH VHRATDWAQA GGGLLDLGIY
     CLQFISMVFG GQKPEKISAV GRRHETGVDD TVTVILQYPG GVHGSFTCSI SAQLSNTVSV
     SGTKGMAQLL DPCWSPTELV VKGEHKEFPL PPAPGKEFNF TNGMGMSYEA KHVRECLQKG
     LKESPVIPLV ESELLADILE EVRKAIGITF PQDKH
//