Q148L6 (DHDH_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC=1.3.1.20

Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
EC=1.1.1.179
Dimeric dihydrodiol dehydrogenase

Gene names

Name:

DHDH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase		PRO_0000315359
Sites
	Site	71	1	May play an important role in coenzyme binding By similarity
	Site	79	1	May play an important role in coenzyme binding By similarity
	Site	97	1	May play an important role in coenzyme binding By similarity
	Site	176	1	May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
	Site	180	1	May play an important role in catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q148L6 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 3D6B91F2F9220BAA	FASTA	335	36,583
	10 20 30 40 50 60 MALRWGIVSA GLISSDFTTM LRMLPRSEHQ VVAVAARDLS RAKEFAKKHD IPKAYGSYEE 70 80 90 100 110 120 LAKDPDVEVA YIGTQHPQHK AAVLLCLTAG KAVLCEKPMG VNAAEVREMV AEARSRGLFF 130 140 150 160 170 180 MEAIWTRFFP AVEALRSVLA QGTLGDLRVV RAEFGKNLTH VHRATDWAQA GGGLLDLGIY 190 200 210 220 230 240 CLQFISMVFG GQKPEKISAV GRRHETGVDD TVTVILQYPG GVHGSFTCSI SAQLSNTVSV 250 260 270 280 290 300 SGTKGMAQLL DPCWSPTELV VKGEHKEFPL PPAPGKEFNF TNGMGMSYEA KHVRECLQKG 310 320 330 LKESPVIPLV ESELLADILE EVRKAIGITF PQDKH

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118168 mRNA. Translation: AAI18169.1.
IPI	IPI00691440.
RefSeq	NP_001069937.1. NM_001076469.1.
UniGene	Bt.22630.
3D structure databases
ProteinModelPortal	Q148L6.
SMR	Q148L6. Positions 2-333.
ModBase	Search...
Protein-protein interaction databases
STRING	Q148L6.
Proteomic databases
PRIDE	Q148L6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000043087; ENSBTAP00000040682; ENSBTAG00000013337.
GeneID	617564.
KEGG	bta:617564.
Organism-specific databases
CTD	27294.
Phylogenomic databases
eggNOG	maNOG16421.
GeneTree	ENSGT00390000007946.
HOVERGEN	HBG105348.
InParanoid	Q148L6.
OMA	ACEVNGV.
OrthoDB	EOG46144D.
PhylomeDB	Q148L6.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00078.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHDH_BOVIN

Accession

Primary (citable) accession number: Q148L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program