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Reviewed, UniProtKB/Swiss-Prot Q148L6 (DHDH_BOVIN)

Last modified June 16, 2009. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
Alternative name(s):
    Dimeric dihydrodiol dehydrogenase
    D-xylose-NADP dehydrogenase
    EC=1.1.1.179
    D-xylose 1-dehydrogenase
Gene names
Name: DHDH
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the gfo/idh/mocA family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
PRO_0000315359

Sites

Site711May play an important role in coenzyme binding By similarity
Site791May play an important role in coenzyme binding By similarity
Site971May play an important role in coenzyme binding By similarity
Site1761May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
Site1801May play an important role in catalytic activity By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q148L6-1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 3D6B91F2F9220BAA

FASTA33536,583
        10         20         30         40         50         60 
MALRWGIVSA GLISSDFTTM LRMLPRSEHQ VVAVAARDLS RAKEFAKKHD IPKAYGSYEE 

        70         80         90        100        110        120 
LAKDPDVEVA YIGTQHPQHK AAVLLCLTAG KAVLCEKPMG VNAAEVREMV AEARSRGLFF 

       130        140        150        160        170        180 
MEAIWTRFFP AVEALRSVLA QGTLGDLRVV RAEFGKNLTH VHRATDWAQA GGGLLDLGIY 

       190        200        210        220        230        240 
CLQFISMVFG GQKPEKISAV GRRHETGVDD TVTVILQYPG GVHGSFTCSI SAQLSNTVSV 

       250        260        270        280        290        300 
SGTKGMAQLL DPCWSPTELV VKGEHKEFPL PPAPGKEFNF TNGMGMSYEA KHVRECLQKG 

       310        320        330 
LKESPVIPLV ESELLADILE EVRKAIGITF PQDKH

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

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Cross-references

Sequence databases

BC118168 mRNA. Translation: AAI18169.1.
IPIIPI00691440.
RefSeqNP_001069937.1.
UniGeneBt.22630

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000013337. Bos taurus. [Contig view]
GeneID617564.
KEGGbta:617564.

Phylogenomic databases

HOVERGENQ148L6.
OMAQ148L6. NILCEKP.

Enzyme and pathway databases

BRENDA1.1.1.179. 251.
1.3.1.20. 251.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDHDH_BOVIN
AccessionPrimary (citable) accession number: Q148L6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents