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Protein

Actin-related protein 2/3 complex subunit 4

Gene

ARPC4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 4
Alternative name(s):
Arp2/3 complex 20 kDa subunit
Short name:
p20-ARC
Gene namesi
Name:ARPC4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002695652 – 168Actin-related protein 2/3 complex subunit 4Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ148J6.
PRIDEiQ148J6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007964.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29794N.
STRINGi9913.ENSBTAP00000010469.

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Beta strandi28 – 30Combined sources3
Helixi37 – 40Combined sources4
Helixi44 – 46Combined sources3
Beta strandi51 – 58Combined sources8
Beta strandi60 – 75Combined sources16
Helixi81 – 96Combined sources16
Turni97 – 100Combined sources4
Beta strandi102 – 104Combined sources3
Beta strandi113 – 119Combined sources7
Helixi120 – 125Combined sources6
Helixi128 – 165Combined sources38

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00F1-168[»]
1TYQX-ray2.55F1-168[»]
1U2VX-ray2.55F1-168[»]
2P9IX-ray2.46F1-168[»]
2P9KX-ray2.59F1-168[»]
2P9LX-ray2.65F1-168[»]
2P9NX-ray2.85F1-168[»]
2P9PX-ray2.90F1-168[»]
2P9SX-ray2.68F1-168[»]
2P9UX-ray2.75F1-168[»]
3DXKX-ray2.70F1-168[»]
3DXMX-ray2.85F1-168[»]
3RSEX-ray2.65F1-168[»]
3UKRX-ray2.48F1-168[»]
3UKUX-ray2.75F1-168[»]
3ULEX-ray2.50F1-168[»]
4JD2X-ray3.08F1-168[»]
4XEIX-ray3.87F1-168[»]
4XF2X-ray5.00F/Y1-168[»]
ProteinModelPortaliQ148J6.
SMRiQ148J6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ148J6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC4 family.Curated

Phylogenomic databases

eggNOGiKOG1876. Eukaryota.
ENOG4111G2F. LUCA.
GeneTreeiENSGT00390000016233.
HOGENOMiHOG000202303.
HOVERGENiHBG050582.
InParanoidiQ148J6.
KOiK05755.
OMAiLITNNHT.
OrthoDBiEOG091G0OI8.
TreeFamiTF105621.

Family and domain databases

InterProiIPR008384. ARPC4.
[Graphical view]
PANTHERiPTHR22629. PTHR22629. 1 hit.
PfamiPF05856. ARPC4. 1 hit.
[Graphical view]
PIRSFiPIRSF039100. ARPC4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q148J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP
60 70 80 90 100
VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN
110 120 130 140 150
FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK
160
LSVNARARIV AEEFLKNF
Length:168
Mass (Da):19,667
Last modified:January 23, 2007 - v3
Checksum:i273CCB230AC703DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118263 mRNA. Translation: AAI18264.1.
RefSeqiNP_001069631.1. NM_001076163.1.
UniGeneiBt.106660.

Genome annotation databases

EnsembliENSBTAT00000010469; ENSBTAP00000010469; ENSBTAG00000007964.
GeneIDi539459.
KEGGibta:539459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118263 mRNA. Translation: AAI18264.1.
RefSeqiNP_001069631.1. NM_001076163.1.
UniGeneiBt.106660.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00F1-168[»]
1TYQX-ray2.55F1-168[»]
1U2VX-ray2.55F1-168[»]
2P9IX-ray2.46F1-168[»]
2P9KX-ray2.59F1-168[»]
2P9LX-ray2.65F1-168[»]
2P9NX-ray2.85F1-168[»]
2P9PX-ray2.90F1-168[»]
2P9SX-ray2.68F1-168[»]
2P9UX-ray2.75F1-168[»]
3DXKX-ray2.70F1-168[»]
3DXMX-ray2.85F1-168[»]
3RSEX-ray2.65F1-168[»]
3UKRX-ray2.48F1-168[»]
3UKUX-ray2.75F1-168[»]
3ULEX-ray2.50F1-168[»]
4JD2X-ray3.08F1-168[»]
4XEIX-ray3.87F1-168[»]
4XF2X-ray5.00F/Y1-168[»]
ProteinModelPortaliQ148J6.
SMRiQ148J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29794N.
STRINGi9913.ENSBTAP00000010469.

Proteomic databases

PaxDbiQ148J6.
PRIDEiQ148J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010469; ENSBTAP00000010469; ENSBTAG00000007964.
GeneIDi539459.
KEGGibta:539459.

Organism-specific databases

CTDi10093.

Phylogenomic databases

eggNOGiKOG1876. Eukaryota.
ENOG4111G2F. LUCA.
GeneTreeiENSGT00390000016233.
HOGENOMiHOG000202303.
HOVERGENiHBG050582.
InParanoidiQ148J6.
KOiK05755.
OMAiLITNNHT.
OrthoDBiEOG091G0OI8.
TreeFamiTF105621.

Enzyme and pathway databases

ReactomeiR-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

EvolutionaryTraceiQ148J6.

Gene expression databases

BgeeiENSBTAG00000007964.

Family and domain databases

InterProiIPR008384. ARPC4.
[Graphical view]
PANTHERiPTHR22629. PTHR22629. 1 hit.
PfamiPF05856. ARPC4. 1 hit.
[Graphical view]
PIRSFiPIRSF039100. ARPC4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC4_BOVIN
AccessioniPrimary (citable) accession number: Q148J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.