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Q148J6 (ARPC4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein 2/3 complex subunit 4
Alternative name(s):
Arp2/3 complex 20 kDa subunit
Short name=p20-ARC
Gene names
Name:ARPC4
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament By similarity.

Subunit structure

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cell projection By similarity.

Sequence similarities

Belongs to the ARPC4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 168167Actin-related protein 2/3 complex subunit 4
PRO_0000269565

Amino acid modifications

Modified residue21N-acetylthreonine By similarity

Secondary structure

....................... 168
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q148J6 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 273CCB230AC703DF

FASTA16819,667
        10         20         30         40         50         60 
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK 

        70         80         90        100        110        120 
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN 

       130        140        150        160 
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.
[2]"Crystal structure of Arp2/3 complex."
Robinson R.C., Turbedsky K., Kaiser D.A., Marchand J.-B., Higgs H.N., Choe S., Pollard T.D.
Science 294:1679-1684(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
[3]"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
Nolen B.J., Littlefield R.S., Pollard T.D.
Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC118263 mRNA. Translation: AAI18264.1.
RefSeqNP_001069631.1. NM_001076163.1.
UniGeneBt.106660.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00F1-168[»]
1TYQX-ray2.55F1-168[»]
1U2VX-ray2.55F1-168[»]
2P9IX-ray2.46F1-168[»]
2P9KX-ray2.59F1-168[»]
2P9LX-ray2.65F1-168[»]
2P9NX-ray2.85F1-168[»]
2P9PX-ray2.90F1-168[»]
2P9SX-ray2.68F1-168[»]
2P9UX-ray2.75F1-168[»]
3DXKX-ray2.70F1-168[»]
3DXMX-ray2.85F1-168[»]
3RSEX-ray2.65F1-168[»]
3UKRX-ray2.48F1-168[»]
3UKUX-ray2.75F1-168[»]
3ULEX-ray2.50F1-168[»]
4JD2X-ray3.08F1-168[»]
ProteinModelPortalQ148J6.
SMRQ148J6. Positions 2-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-29794N.
STRING9913.ENSBTAP00000010469.

Proteomic databases

PRIDEQ148J6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000010469; ENSBTAP00000010469; ENSBTAG00000007964.
GeneID539459.
KEGGbta:539459.

Organism-specific databases

CTD10093.

Phylogenomic databases

eggNOGNOG261545.
GeneTreeENSGT00390000016233.
HOGENOMHOG000202303.
HOVERGENHBG050582.
InParanoidQ148J6.
KOK05755.
OMAMLKHKIV.
OrthoDBEOG7VTDPM.
TreeFamTF105621.

Family and domain databases

InterProIPR008384. ARPC4.
[Graphical view]
PANTHERPTHR22629. PTHR22629. 1 hit.
PfamPF05856. ARPC4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ148J6.
NextBio20878000.

Entry information

Entry nameARPC4_BOVIN
AccessionPrimary (citable) accession number: Q148J6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references